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M

Marc Hild

novartis biomedical research
H指数:27
被引数:1.0万

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A conformation-sensitive product inhibitor of HDAC1/2 potentiates WNT signaling

HDAC1/2的构象敏感型产物抑制剂可增强WNT信号通路

Nature Chemical Biology
IF13.7
2026-11-110
PRE
Olga Charlat; Ling Li; Zheng Zhou; Rohan EJ Beckwith; Lijian Feng; Liqing Geng; Aleem Fazal; Jason R. Thomas; Jason Murphy; Nicolas Pizzato; Fabian Wu; Judith Knehr; Sebastian Bergling; Helen T. Pham; Daniel Fuller; Deborah I. Scheffer; Zijun Chen; Jun Gao; Daniel S. Palacios; Stephen M. Canham; Gregory A. Michaud; Claude Shelton; Scott M. Brittain; Marc Hild; Kristie Wetzel; Paola Capodieci; Frederic Sigoillot; Jeremy L. Jenkins; Jeffery A. Porter; En Li; John A. Tallarico; Markus Schirle; Barna D. Fodor; Justin Gu; Feng Cong
High-throughput screen of 100 000 small molecules in C9ORF72 ALS neurons identifies spliceosome modulators that mobilize G4C2 repeat RNA into nuclear export and repeat associated non-canonical translation

对100 000个小分子进行高通量筛选，在C9ORF72 ALS神经元中鉴定出可促使G4C2重复RNA进入核输出并引发与重复相关的非规范翻译的剪接体调节剂。

NUCLEIC ACIDS RESEARCH
IF13.1
2025-04-101
PRE
Luteijn, Maartje J.; Bhaskar, Varun; Trojer, Dominic; Schuerz, Melanie; Mahboubi, Hicham; Handl, Cornelia; Pizzato, Nicolas; Pfeifer, Martin; Dafinca, Ruxandra; Voshol, Hans; Giorgetti, Elisa; Manneville, Carole; Garnier, Isabelle P. M.; Mueller, Matthias; Zeng, Fanning; Buntin, Kathrin; Markwalder, Roger; Schroeder, Harald; Weiler, Jan; Khar, Dora; Schuhmann, Tim; Groot-Kormelink, Paul J.; Keller, Caroline Gubser; Farmer, Pierre; MacKay, Angela; Beibel, Martin; Roma, Guglielmo; D'Ario, Giovanni; Merkl, Claudia; Schebesta, Michael; Hild, Marc; Elwood, Fiona; Vahsen, Bjoern F.; Ripin, Nina; Clery, Antoine; Allain, Frederic; Labow, Mark; Gabriel, Daniela; Chao, Jeffrey A.; Talbot, Kevin; Nash, Mark; Hunziker, Juerg; Meisner-Kober, Nicole C.
An orally available, brain penetrant, small molecule lowers huntingtin levels by enhancing pseudoexon inclusion
NATURE COMMUNICATIONS
IF15.7
2022-03-0363
OAAI
Keller, Caroline Gubser; Shin, Youngah; Monteys, Alex Mas; Renaud, Nicole; Beibel, Martin; Teider, Natalia; Peters, Thomas; Faller, Thomas; St-Cyr, Sophie; Knehr, Judith; Roma, Guglielmo; Reyes, Alejandro; Hild, Marc; Lukashev, Dmitriy; Theil, Diethilde; Dales, Natalie; Cha, Jang-Ho; Borowsky, Beth; Dolmetsch, Ricardo; Davidson, Beverly L.; Sivasankaran, Rajeev
CYP27A1-dependent anti-melanoma activity of limonoid natural products targets mitochondrial metabolism
CELL CHEMICAL BIOLOGY
IF7.2
2021-10-0118
OAAI
Cho, Hyelim; Shen, Qiong; Zhang, Lydia H.; Okumura, Mikiko; Kawakami, Akinori; Ambrose, Jessi; Sigoillot, Frederic; Miller, Howard R.; Gleim, Scott; Cobos-Correa, Amanda; Wang, Ying; Piechon, Philippe; Roma, Guglielmo; Eggimann, Fabian; Moore, Charles; Aspesi, Peter, Jr.; Mapa, Felipa A.; Burks, Heather; Ross, Nathan T.; Krastel, Philipp; Hild, Marc; Maimone, Thomas J.; Fisher, David E.; Nomura, Daniel K.; Tallarico, John A.; Canham, Stephen M.; Jenkins, Jeremy L.; Forrester, William C.
Discovery of Small Molecule Splicing Modulators of Survival Motor Neuron-2 (SMN2) for the Treatment of Spinal Muscular Atrophy (SMA)
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2018-11-08108
OAAI
Cheung, Atwood K.; Hurley, Brian; Kerrigan, Ryan; Shu, Lei; Chin, Donovan N.; Shen, Yiping; O'Brien, Gary; Sung, Moo Je; Hou, Ying; Axford, Jake; Cody, Emma; Sun, Robert; Fazal, Aleem; Fridrich, Cary; Sanchez, Carina C.; Tomlinson, Ronald C.; Jain, Monish; Deng, Lin; Hoffmaster, Keith; Song, Cheng; Van Hoosear, Mailin; Shin, Youngah; Servais, Rebecca; Towler, Christopher; Hild, Marc; Curtis, Daniel; Dietrich, William F.; Hamann, Lawrence G.; Briner, Karin; Chen, Karen S.; Kobayashi, Dione; Sivasankaran, Rajeev; Dales, Natalie A.
High-Throughput Functional Analysis Distinguishes Pathogenic, Nonpathogenic, and Compensatory Transcriptional Changes in Neurodegeneration
CELL SYSTEMS
IF7.7
2018-07-0125
OA
Al-Ramahi, Ismael; Lu, Boxun; Di Paola, Simone; Pang, Kaifang; de Haro, Maria; Peluso, Ivana; Gallego-Flores, Tatiana; Malik, Nazish T.; Erikson, Kelly; Bleiberg, Benjamin A.; Avalos, Matthew; Fan, George; Rivers, Laura Elizabeth; Laitman, Andrew M.; Diaz-Garcia, Javier R.; Hild, Marc; Palacino, James; Liu, Zhandong; Medina, Diego L.; Botas, Juan
SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice (vol 11, pg 511, 2015)
NATURE CHEMICAL BIOLOGY
IF13.7
2016-03-182
OAAI
Palacino, James; Swalley, Susanne E.; Song, Cheng; Cheung, Atwood K.; Shu, Lei; Zhang, Xiaolu; Van Hoosear, Mailin; Shin, Youngah; Chin, Donovan N.; Keller, Caroline Gubser; Beibel, Martin; Renaud, Nicole A.; Smith, Thomas M.; Salcius, Michael; Shi, Xiaoying; Hild, Marc; Servais, Rebecca; Jain, Monish; Deng, Lin; Bullock, Caroline; McLellan, Michael; Schuierer, Sven; Murphy, Leo; Blommers, Marcel J. J.; Blaustein, Cecile; Berenshteyn, Frada; Lacoste, Arnaud; Thomas, Jason R.; Roma, Guglielmo; Michaud, Gregory A.; Tseng, Brian S.; Porter, Jeffery A.; Myer, Vic E.; Tallarico, John A.; Hamann, Lawrence G.; Curtis, Daniel; Fishman, Mark C.; Dietrich, William F.; Dales, Natalie A.; Sivasankaran, Rajeev
SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice (vol 11, pg 511, 2015)
NATURE CHEMICAL BIOLOGY
IF13.7
2015-08-184
OAAI
Palacino, James; Swalley, Susanne E.; Song, Cheng; Cheung, Atwood K.; Shu, Lei; Zhang, Xiaolu; Van Hoosear, Mailin; Shin, Youngah; Chin, Donovan N.; Keller, Gubser; Beibel, Martin; Renaud, Nicole A.; Smith, Thomas M.; Salcius, Michael; Shi, Xiaoying; Hild, Marc; Servais, Rebecca; Jain, Monish; Deng, Lin; Bullock, Caroline; McLellan, Michael; Schuierer, Sven; Murphy, Leo; Blommers, Marcel J. J.; Blaustein, Cecile; Berenshteyn, Frada; Lacoste, Arnaud; Thomas, Jason R.; Roma, Guglielmo; Michaud, Gregory A.; Tseng, Brian S.; Porter, Jeffery A.; Myer, Vic E.; Tallarico, John A.; Hamann, Lawrence G.; Curtis, Daniel; Fishman, Mark C.; Dietrich, William F.; Dales, Natalie A.; Sivasankaran, Rajeev
SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice
NATURE CHEMICAL BIOLOGY
IF13.7
2015-06-01375
PREAI
Palacino, James; Swalley, Susanne E.; Song, Cheng; Cheung, Atwood K.; Shu, Lei; Zhang, Xiaolu; Van Hoosear, Mailin; Shin, Youngah; Chin, Donovan N.; Keller, Caroline Gubser; Beibel, Martin; Renaud, Nicole A.; Smith, Thomas M.; Salcius, Michael; Shi, Xiaoying; Hild, Marc; Servais, Rebecca; Jain, Monish; Deng, Lin; Bullock, Caroline; McLellan, Michael; Schuierer, Sven; Murphy, Leo; Blommers, Marcel J. J.; Blaustein, Cecile; Berenshteyn, Frada; Lacoste, Arnaud; Thomas, Jason R.; Roma, Guglielmo; Michaud, Gregory A.; Tseng, Brian S.; Porter, Jeffery A.; Myer, Vic E.; Tallarico, John A.; Hamann, Lawrence G.; Curtis, Daniel; Fishman, Mark C.; Dietrich, William F.; Dales, Natalie A.; Sivasankaran, Rajeev

研究方向

暂未获取到该数据
J
John A. Tallarico
H 指数:49论文数:126被引数:1.1万
J
Jeremy L. Jenkins
H 指数:46论文数:155被引数:8,602
C
Caroline Gubser Keller
H 指数:19论文数:52被引数:2,524
G
Guglielmo Roma
H 指数:44论文数:174被引数:1.0万
G
Gregory A. Michaud
H 指数:22论文数:53被引数:4,894
R
Rajeev Sivasankaran
H 指数:17论文数:35被引数:4,829
N
Natalie A. Dales
H 指数:16论文数:37被引数:2,455
M
Martin Beibel
H 指数:27论文数:120被引数:4,785
Y
Youngah Shin
H 指数:18论文数:76被引数:2,529
M
Martin Hénault
H 指数:16论文数:46被引数:1,087