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S

Stephen J. Pettitt

Institute of Cancer Research
H指数:31
被引数:5,626

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PUM3 is an essential suppressor of replication stress in homologous recombination deficient breast cancer

PUM3是同源重组缺陷型乳腺癌中复制应激所必需的抑制因子

Nature Communications
IF15.7
2026-09-210
OAAI
Valeria Amodeo; Daniel Weekes; Nicolae Balan; Rebeca Uceda Castro; Nadja D’Uonno; Asha Konde; Elodie Noel; Luisa Robbez-Masson; Jennifer Trendell; Maya Shlomi; Callum Walker; Anjan Venkatesh; Colm J. Ryan; Sarah C. Moser; Jos Jonkers; Laurence H. Pearl; Antony W. Oliver; Dragomir B. Krastev; Syed Haider; Anita Grigoriadis; Stephen J. Pettitt; Christopher J. Lord; Andrew N. J. Tutt
The anion channel GPR89 is a tumor-specific dependency in breast cancer

GPR89阴离子通道是乳腺癌的肿瘤特异性依赖

Nature Communications
IF15.7
2026-08-240
OA
Riccardo Ferro; Alexandra Carroll; Ana M. Mendes-Pereira; Virinder Reen; George Vlachogiannis; Rebeca Uceda-Castro; Dragomir Krastev; Valeria Amodeo; Stephen Pettitt; Nadja D’Uonno; Ioanna Mavrommati; Blanca Navarro; Luke Hitchen; Jennifer Trendell; Ana Stojiljkovic; Cynthia Prince; Narinder Janghra; Ioannis Roxanis; Patrycja Gazinska; Daniel Larcombe-Young; Rebecca Marlow; Stefano Annunziato; Jos Jonkers; Tejashree Rajaram Kanitkar; Amadeus Xu; Nirmesh Patel; Nalan Liv; John Alexander; Jelmar Quist; Mercedes Pardo; Theodoros I. Roumeliotis; Jyoti S. Choudhary; Daniel Weekes; Pierfrancesco Marra; Joanna I. Loizou; Rachael Natrajan; Anita Grigoriadis; Mallur Srivatsan Madhusudhan; Syed Haider; Christopher J. Lord; Andrew Tutt
Tumour specific HORMAD1 expression perturbs mitotic arrest and drives sensitivity to mitotic kinase inhibitors

肿瘤特异性HORMAD1表达扰乱有丝分裂停滞并驱动对有丝分裂激酶抑制剂的敏感性

Nature Communications
IF15.7
2026-03-110
OAAI
Callum Walker; Gabriel Kollarovic; Daniel Weekes; Jennifer Trendell; Ricarda M. Hoffmann; Alexia Martin; Riccardo Ferro; Blanca Navarro-Llinas; Luke Hitchen; Mercedes Pardo Calvo; Nicolae Balan; Harriet Kemp; Alexandra Carroll; Kathryn Davidson; Sarmi Nath; Nadja D’Uonno; Ruifang Lu; Chris Starling; Marieke Otten; Nino Iakobachvili; Chiara Marcozzi; Ilhan Rahman; Jelmar Quist; Lu Yu; Dragomir B. Krastev; Valeria Amodeo; Ioannis Roxanis; Anita Grigoriadis; Richard Bayliss; Jyoti Choudhary; Syed Haider; Jonathon Pines; Stephen J. Pettitt; Christopher J. Lord; Andrew N. J. Tutt
Correction to: Elevated APOBEC3B expression drives a kataegic-like mutation signature and replication stress-related therapeutic vulnerabilities in p53-defective cells

更正：APOBEC3B表达升高驱动一种 kataegic-like 突变特征和与复制应激相关的治疗易损性，发生在p53缺陷细胞中。

British Journal of Cancer
IF6.8
2026-02-160
PRE
Jenni Nikkilä; Rahul Kumar; James Campbell; Inger Brandsma; Helen N. Pemberton; Fredrik Wallberg; Kinga Nagy; Ildikó Scheer; Beata G. Vertessy; Artur A. Serebrenik; Valentina Monni; Reuben S. Harris; Stephen J. Pettitt; Alan Ashworth; Christopher J. Lord
NASP modulates histone turnover to drive PARP inhibitor resistance

NASP通过调节组蛋白周转来驱动PARP抑制剂耐药性。

Nature
IF48.5
2025-08-130
PRE
Sarah C. Moser; Anna Khalizieva; Josef Roehsner; Elisabeth Pottendorfer; Milo L. Kaptein; Giulia Ricci; Vivek Bhardwaj; Onno B. Bleijerveld; Liesbeth Hoekman; Ingrid van der Heijden; Simone di Sanzo; Alexander Fish; Aleksandra Chikunova; Judith H. I. Haarhuis; Roel Oldenkamp; Luisa Robbez-Masson; Justin Sprengers; Daniel J. Vis; Lodewyk F. A. Wessels; Marieke van de Ven; Stephen J. Pettitt; Andrew N. J. Tutt; Christopher J. Lord; Benjamin D. Rowland; Moritz Völker-Albert; Francesca Mattiroli; Thijn R. Brummelkamp; Abdelghani Mazouzi; Jos Jonkers
The PARP inhibitor talazoparib synergizes with reovirus to induce cancer killing and tumour control in vivo in mouse models

PARP抑制剂talazoparib与呼肠孤病毒协同作用，在小鼠模型中体内诱导癌症杀伤和肿瘤控制

Nature Communications
IF15.7
2025-07-080
OAAI
Joan Kyula-Currie; Victoria Roulstone; James Wright; Francesca Butera; Arnaud Legrand; Richard Elliott; Martin McLaughlin; Galabina Bozhanova; Dragomir Krastev; Stephen Pettitt; Tencho Tenev; Magnus Dillon; Shane Foo; Emmanuel C. Patin; Victoria Jennings; Charleen Chan Wah Hak; Elizabeth Appleton; Amarin Wongariyapak; Malin Pedersen; Antonio Rullan; Jyoti Choudhary; Chris Bakal; Pascal Meier; Christopher J. Lord; Alan Melcher; Kevin J. Harrington
CDK12 loss drives prostate cancer progression, transcription-replication conflicts, and synthetic lethality with paralog CDK13
CELL REPORTS MEDICINE
IF10.6
2024-10-010
OAAI
Tien, Jean Ching-Yi; Luo, Jie; Chang, Yu; Zhang, Yuping; Cheng, Yunhui; Wang, Xiaoju; Yang, Jianzhang; Mannan, Rahul; Mahapatra, Somnath; Shah, Palak; Wang, Xiao-Ming; Todd, Abigail J.; Eyunni, Sanjana; Cheng, Caleb; Rebernick, Ryan J.; Xiao, Lanbo; Bao, Yi; Neiswender, James; Brough, Rachel; Pettitt, Stephen J.; Cao, Xuhong; Miner, Stephanie J.; Zhou, Licheng; Wu, Yi-Mi; Labanca, Estefania; Wang, Yuzhuo; Parolia, Abhijit; Cieslik, Marcin; Robinson, Dan R.; Wang, Zhen; Feng, Felix Y.; Chou, Jonathan; Lord, Christopher J.; Ding, Ke; Chinnaiyan, Arul M.
CDK12 loss promotes prostate cancer development while exposing vulnerabilities to paralog-based synthetic lethality
MOLECULAR CANCER THERAPEUTICS
IF5.5
2024-06-100
PRE
Tien, Jean C.; Chang, Yu; Zhang, Yuping; Chou, Jonathan; Cheng, Yunhui; Wang, Xiaoju; Yang, Jianzhang; Mannan, Rahul; Shah, Palak; Wang, Xiao-Ming; Todd, Abbey; Eyunni, Sanjana; Cheng, Caleb; Cao, Xuhong; Bao, Yi; Neiswender, James; Brough, Rachel; Pettitt, Stephen; Labanca, Estefania; Wang, Yuzhuo; Cieslik, Marcin; Lord, Christopher J.; Ding, Ke; Chinnaiyan, Arul M.
Functional assessment of RAD51 foci and replication fork dynamics in PARPi resistant BRCA1/2 mutated breast cancer
CANCER RESEARCH
IF16.6
2024-05-020
PRE
Harvey-Jones, Elizabeth; Raghunandan, Maya; Robbez-Masson, Luisa; Alaguthurai, Thanussuyah; Llop-Guevara, Alba; Trendell, Jennifer; Rodriguez, Olga; Guzman, Marta; Weekes, Daniel; deRenty, Christelle; Knight, Eleanor; Marlow, Rebecca; Starling, Christopher; Liu, Ruifang; Ravindran, Nivedita; Roxanis, Ioannis; Lukashchuk, Natalia; Serra, Violeta; Pettitt, Stephen; Lord, Christopher; Tutt, Andrew N. J.
Longitudinal pro fi ling identi fi es co-occurring BRCA1/2 reversions, TP53BP1, RIF1 and PAXIP1 mutations in PARP inhibitor-resistant advanced breast cancer
ANNALS OF ONCOLOGY
IF65.4
2024-04-0113
OA
Harvey-Jones, E.; Raghunandan, M.; Robbez-Masson, L.; Magraner-Pardo, L.; Alaguthurai, T.; Yablonovitch, A.; Yen, J.; Xiao, H.; Brough, R.; Frankum, J.; Song, F.; Yeung, J.; Savy, T.; Gulati, A.; Alexander, J.; Kemp, H.; Starling, C.; Konde, A.; Marlow, R.; Cheang, M.; Proszek, P.; Hubank, M.; Cai, M.; Trendell, J.; Lu, R.; Liccardo, R.; Ravindran, N.; Llop-Guevara, A.; Rodriguez, O.; Balmana, J.; Lukashchuk, N.; Dorschner, M.; Drusbosky, L.; Roxanis, I.; Serra, V.; Haider, S.; Pettitt, S. J.; Lord, C. J.; Tutt, A. N. J.
MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells

MND1和PSMC3IP控制有丝分裂细胞的PARP抑制剂敏感性

CELL REPORTS
IF6.9
2023-05-013
OA
Zelceski, Anabel; Francica, Paola; Lingg, Lea; Mutlu, Merve; Stok, Colin; Liptay, Martin; Alexander, John; Baxter, Joseph S.; Brough, Rachel; Gulati, Aditi; Haider, Syed; Raghunandan, Maya; Song, Feifei; Sridhar, Sandhya; Forment, Josep, V; O'Connor, Mark J.; Davies, Barry R.; van Vugt, Marcel A. T. M.; Krastev, Dragomir B.; Pettitt, Stephen J.; Tutt, Andrew N. J.; Rottenberg, Sven; Lord, Christopher J.
Longitudinal analysis of PARP inhibitor and platinum resistance in BRCA1/2m breast cancer using liquid biopsy
CANCER RESEARCH
IF16.6
2023-04-043
PRE
Harvey-Jones, Elizabeth; Raghunandan, Maya; Robbez-Masson, Luisa; Thanussuyah, Alaguthurai; Liccardo, Roberta; Yablonovitch, Arielle; Cai, Mingyang; Drusbosky, Leylah; Dorschner, Michael; Pardo, Lorena Magraner; Marlow, Rebecca; Konde, Asha; Trendell, Jennifer; Alexander, John; Haider, Syed; Starling, Chris; Roxanis, Ioannis; Yen, Jennifer; Pettitt, Stephen J.; Lord, Christopher J.; Tutt, Andrew N.
SMG8/SMG9 Heterodimer Loss Modulates SMG1 Kinase to Drive ATR Inhibitor Resistance
CANCER RESEARCH
IF16.6
2022-10-237
OAAI
Llorca-Cardenosa, Marta J.; Aronson, Lauren I.; Krastev, Dragomir B.; Nieminuszczy, Jadwiga; Alexander, John; Song, Feifei; Dylewska, Malgorzata; Broderick, Ronan; Brough, Rachel; Zimmermann, Astrid; Zenke, Frank T.; Gurel, Bora; Riisnaes, Ruth; Ferreira, Ana; Roumeliotis, Theodoros; Choudhary, Jyoti; Pettitt, Stephen J.; de Bono, Johann; Cervantes, Andres; Haider, Syed; Niedzwiedz, Wojciech; Lord, Christopher J.; Chong, Irene Y.

研究方向

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C
Christopher J. Lord
H 指数:98论文数:708被引数:4.5万
R
Rachel Brough
H 指数:35论文数:264被引数:9,554
D
Dragomir B. Krastev
H 指数:18论文数:109被引数:3,015
A
Andrew Tutt
H 指数:103论文数:781被引数:8.7万
J
Jessica Frankum
H 指数:24论文数:198被引数:4,030
S
Syed Haider
H 指数:52论文数:432被引数:1.4万
A
Alan Ashworth
H 指数:121论文数:1,006被引数:6.7万
H
Helen N. Pemberton
H 指数:21论文数:162被引数:4,748
I
Ilirjana Bajrami
H 指数:24论文数:183被引数:3,783
J
James Campbell
H 指数:39论文数:104被引数:6,372