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D

Dragomir B. Krastev

The Institute of Cancer Research
H指数:18
被引数:3,035

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A genome-scale adaptation map identifies the FANCM-RMI1/2 complex as an opposing modulator of cell fitness upon BRCA1 or BRCA2 loss

基因组规模适应性图谱鉴定FANCM-RMI1/2复合物为BRCA1或BRCA2缺失时细胞适应性的拮抗调节因子

Molecular Cell
IF16.6
2026-10-060
OAAI
François Dossin; Mikael Attia; Fabricio Montero Zúñiga; Daniel González-Acosta; Rachel Brough; Fei Fei Song; Dragomir B. Krastev; Maya Raghunandan; Stephen J. Pettitt; Aurélien Boré; Amaury Vaysse; Raphaël Margueron; Massimo Lopes; Andrew N.J. Tutt; Christopher J. Lord; Ludovic Deriano
PUM3 is an essential suppressor of replication stress in homologous recombination deficient breast cancer

PUM3是同源重组缺陷型乳腺癌中复制应激所必需的抑制因子

Nature Communications
IF15.7
2026-09-210
OAAI
Valeria Amodeo; Daniel Weekes; Nicolae Balan; Rebeca Uceda Castro; Nadja D’Uonno; Asha Konde; Elodie Noel; Luisa Robbez-Masson; Jennifer Trendell; Maya Shlomi; Callum Walker; Anjan Venkatesh; Colm J. Ryan; Sarah C. Moser; Jos Jonkers; Laurence H. Pearl; Antony W. Oliver; Dragomir B. Krastev; Syed Haider; Anita Grigoriadis; Stephen J. Pettitt; Christopher J. Lord; Andrew N. J. Tutt
The anion channel GPR89 is a tumor-specific dependency in breast cancer

GPR89阴离子通道是乳腺癌的肿瘤特异性依赖

Nature Communications
IF15.7
2026-08-240
OA
Riccardo Ferro; Alexandra Carroll; Ana M. Mendes-Pereira; Virinder Reen; George Vlachogiannis; Rebeca Uceda-Castro; Dragomir Krastev; Valeria Amodeo; Stephen Pettitt; Nadja D’Uonno; Ioanna Mavrommati; Blanca Navarro; Luke Hitchen; Jennifer Trendell; Ana Stojiljkovic; Cynthia Prince; Narinder Janghra; Ioannis Roxanis; Patrycja Gazinska; Daniel Larcombe-Young; Rebecca Marlow; Stefano Annunziato; Jos Jonkers; Tejashree Rajaram Kanitkar; Amadeus Xu; Nirmesh Patel; Nalan Liv; John Alexander; Jelmar Quist; Mercedes Pardo; Theodoros I. Roumeliotis; Jyoti S. Choudhary; Daniel Weekes; Pierfrancesco Marra; Joanna I. Loizou; Rachael Natrajan; Anita Grigoriadis; Mallur Srivatsan Madhusudhan; Syed Haider; Christopher J. Lord; Andrew Tutt
Mitotic single-stranded DNA suppression by DDIAS

DDIAS介导的有丝分裂单链DNA抑制

Molecular Cell
IF16.6
2026-08-240
PRE
Yibo Xue; Faisal Bin Rashed; Daniel Y.L. Mao; Kento T. Abe; Zhen-Yuan Lin; Dragomir B. Krastev; Dheva Setiaputra; Lisa Hoeg; Clara Bonnet; Arun Kumar; Antranik Mavousian; Arussa Maan; Elizabeth Harvey-Jones; Stephen J. Pettitt; Andrew N.J. Tutt; Christopher J. Lord; Frank Sicheri; Anne-Claude Gingras; Daniel Durocher
Nucleophagy removes cytotoxic trapped PARP1

核质吞噬清除细胞毒性被困的PARP1

Nature Cell Biology
IF19.1
2026-06-020
OAAI
Gwendoline Hoslett; Sara Tribble; Pauline Lascaux; Stelios Koukouravas; Ignacio Torrecilla; Wei Song; Cynthia X. Hou; Junyi Li; Martín González-Fernández; Giuliana De Gregoriis; Rebecca A. Dagg; Darragh O’Brien; Andrea Pierangelini; Thibaud Martial; Alvin Wei Tian Ng; Nuno Raimundo; Ira Milosevic; Raimundo Freire; Yuliang Li; Sven Rottenberg; Dragomir B. Krastev; Christopher J. Lord; Madalena Tarsounas; Kristijan Ramadan
Tumour specific HORMAD1 expression perturbs mitotic arrest and drives sensitivity to mitotic kinase inhibitors

肿瘤特异性HORMAD1表达扰乱有丝分裂停滞并驱动对有丝分裂激酶抑制剂的敏感性

Nature Communications
IF15.7
2026-03-110
OAAI
Callum Walker; Gabriel Kollarovic; Daniel Weekes; Jennifer Trendell; Ricarda M. Hoffmann; Alexia Martin; Riccardo Ferro; Blanca Navarro-Llinas; Luke Hitchen; Mercedes Pardo Calvo; Nicolae Balan; Harriet Kemp; Alexandra Carroll; Kathryn Davidson; Sarmi Nath; Nadja D’Uonno; Ruifang Lu; Chris Starling; Marieke Otten; Nino Iakobachvili; Chiara Marcozzi; Ilhan Rahman; Jelmar Quist; Lu Yu; Dragomir B. Krastev; Valeria Amodeo; Ioannis Roxanis; Anita Grigoriadis; Richard Bayliss; Jyoti Choudhary; Syed Haider; Jonathon Pines; Stephen J. Pettitt; Christopher J. Lord; Andrew N. J. Tutt
Autocrine interferon poisoning mediates ADAR1-dependent synthetic lethality in BRCA1/2-mutant cancers
Nature Communications
IF15.7
2025-07-290
OAAI
Roman M. Chabanon; Liudmila Shcherbakova; Magali Lacroix-Triki; Marine Aglave; Jean Zeghondy; Victor Kriaa; Antoine Gougé; Marlène Garrido; Elodie Edmond; Ludovic Bigot; Dragomir B. Krastev; Rachel Brough; Stephen J. Pettitt; Thibault Thomas-Bonafos; Robert Samstein; Christophe Massard; Marc Deloger; Andrew NJ Tutt; Fabrice Barlesi; Yohann Loriot; Suzette Delaloge; Marcel Tawk; Cindy Degerny; Yea-Lih Lin; Barbara Pistilli; Philippe Pasero; Christopher J. Lord; Sophie Postel-Vinay
The PARP inhibitor talazoparib synergizes with reovirus to induce cancer killing and tumour control in vivo in mouse models

PARP抑制剂talazoparib与呼肠孤病毒协同作用，在小鼠模型中体内诱导癌症杀伤和肿瘤控制

Nature Communications
IF15.7
2025-07-080
OAAI
Joan Kyula-Currie; Victoria Roulstone; James Wright; Francesca Butera; Arnaud Legrand; Richard Elliott; Martin McLaughlin; Galabina Bozhanova; Dragomir Krastev; Stephen Pettitt; Tencho Tenev; Magnus Dillon; Shane Foo; Emmanuel C. Patin; Victoria Jennings; Charleen Chan Wah Hak; Elizabeth Appleton; Amarin Wongariyapak; Malin Pedersen; Antonio Rullan; Jyoti Choudhary; Chris Bakal; Pascal Meier; Christopher J. Lord; Alan Melcher; Kevin J. Harrington
PPP2R1A mutations cause ATR inhibitor sensitivity in ovarian clear cell carcinoma

PPP2R1A突变导致卵巢透明细胞癌对ATR抑制剂的敏感性。

ONCOGENE
IF7.3
2025-02-121
OA
Stewart, James; Krastev, Dragomir B.; Brough, Rachel; Zatreanu, Diana; Song, Feifei; Baxter, Joseph S.; Sridhar, Sandhya; Frankum, Jessica; Konde, Asha; Haider, Syed; Alexander, John; Betteridge, Kai; Gulati, Aditi; Attygalle, Ayoma D.; Vroobel, Katherine; Natrajan, Rachael; Khalique, Saira; Roumeliotis, Theodoros I.; Choudhary, Jyoti S.; Yeung, Jason; Wicks, Andrew J.; Marlow, Rebecca; Banerjee, Susana; Pettitt, Stephen J.; Tutt, Andrew N. J.; Lord, Christopher J.
MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells

MND1和PSMC3IP控制有丝分裂细胞的PARP抑制剂敏感性

CELL REPORTS
IF6.9
2023-05-013
OA
Zelceski, Anabel; Francica, Paola; Lingg, Lea; Mutlu, Merve; Stok, Colin; Liptay, Martin; Alexander, John; Baxter, Joseph S.; Brough, Rachel; Gulati, Aditi; Haider, Syed; Raghunandan, Maya; Song, Feifei; Sridhar, Sandhya; Forment, Josep, V; O'Connor, Mark J.; Davies, Barry R.; van Vugt, Marcel A. T. M.; Krastev, Dragomir B.; Pettitt, Stephen J.; Tutt, Andrew N. J.; Rottenberg, Sven; Lord, Christopher J.
SMG8/SMG9 Heterodimer Loss Modulates SMG1 Kinase to Drive ATR Inhibitor Resistance
CANCER RESEARCH
IF16.6
2022-10-237
OAAI
Llorca-Cardenosa, Marta J.; Aronson, Lauren I.; Krastev, Dragomir B.; Nieminuszczy, Jadwiga; Alexander, John; Song, Feifei; Dylewska, Malgorzata; Broderick, Ronan; Brough, Rachel; Zimmermann, Astrid; Zenke, Frank T.; Gurel, Bora; Riisnaes, Ruth; Ferreira, Ana; Roumeliotis, Theodoros; Choudhary, Jyoti; Pettitt, Stephen J.; de Bono, Johann; Cervantes, Andres; Haider, Syed; Niedzwiedz, Wojciech; Lord, Christopher J.; Chong, Irene Y.
The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin

泛素依赖性ATPase p97从染色质中去除细胞毒性捕获的PARP1

NATURE CELL BIOLOGY
IF19.1
2022-01-1087
OAAI
Krastev, Dragomir B.; Li, Shudong; Sun, Yilun; Wicks, Andrew; Hoslett, Gwendoline; Weekes, Daniel; Badder, Luned M.; Knight, Eleanor G.; Marlow, Rebecca; Calvo, Mercedes Pardo; Yu, Lu; Talele, Tanaji T.; Bartek, Jiri; Choudhary, Jyoti; Pommier, Yves; Pettitt, Stephen J.; Tutt, Andrew; Ramadan, Kristijan; Lord, Christopher J.

研究方向

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C
Christopher J. Lord
H 指数:98论文数:710被引数:4.5万
S
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H 指数:31论文数:216被引数:5,694
R
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A
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F
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S
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F
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