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N

Naomi Guppy

The Institute of Cancer Research
H指数:20
被引数:1,176

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IAP antagonist tolinapant (ASTX660) in combination with pembrolizumab in advanced solid tumors: a phase I trial

IAP拮抗剂托利那潘特（ASTX660）联合帕博利珠单抗治疗晚期实体瘤：一项I期临床试验

Nature Communications
IF15.7
2026-09-300
OA
Crescens Tiu; Wing Yau; Tencho Tenev; Daniel Lionarons; Ching Leung; Victoria Sanchez-Perez; Giovanni Codacci-Pisanelli; Xiaoran Lai; Anna Zachariou; Aasia Hussain; Toby Prout; Mona Parmar; Bindu Baikady; Maria Goicoechea; Scott Layzell; Naomi Guppy; Ioannis Roxanis; Thomas Lund; Diego Carlos Dos Reis; Camila Pereira Almeida; Tatiany Luiza Silveira; Ana Ferreira; Bora Gurel; Claudia Bertan; Mateus Crespo; Penny Flohr; Ann-Marie Baker; Trevor Graham; Luis Zapata; Claudio Salas; Soham Mandal; Alan Dunlop; Martin Sims; George Ward; Tomoko Smyth; Simone Jueliger; Matthew Davis; Ilya Potapov; Aram Oganesian; Danna Chan; Mattias Leino; Subham Basu; Andre Samson; James M. Murphy; Nina Tunariu; Edward W. Johnston; Alistair Ring; Nick Turner; Andrew N. J. Tutt; Amanda Swain; Anna Minchom; Adam Sharp; Alec Paschalis; Udai Banerji; Johann de Bono; Bristi Basu; Christina Yap; Syed Haider; Juanita Lopez; Pascal Meier
Co-occurrence of transcriptionally distinct persister cell states underpins neoadjuvant therapy resistance in triple‑negative breast cancer

转录异质性持久细胞状态的共发生是三阴性乳腺癌新辅助治疗耐药的基础

Genome Medicine
IF11.2
2026-04-090
OA
Yu Zhang; Fatemeh Ahmadi Moughari; Ioanna Mavrommati; Nora J. Doleschall; Kate Moore; Gareth Muirhead; Ram Rajaram Srinivasan; Ping Gong; Jonathan T. Lei; Amy Fleming; Hwei Minn Khoo; Naomi Guppy; Gabrielle Elshtein; Mohammed Inayatullah; Vijay K. Tiwari; Lacey E. Dobrolecki; Michael T. Lewis; Syed Haider; Rachael Natrajan
Necroptosis in both tumour and stromal compartments determines responsiveness to immunogenic cell death-based immunotherapy

肿瘤和基质区室中的坏死性凋亡决定了对免疫原性细胞死亡为基础的免疫治疗的反应性

Nature Communications
IF15.7
2026-03-010
OA
Fernando, Winnie; Clucas, Jarama; Rizzo, Alberto; Singer, Ramsay; Goode, Emily; Tiu, Crescens; Layzell, Scott; Konecnik, Joshua; Wilson, Rebecca; John, Sidonie Wicky; Jouny, Samuel; Guppy, Naomi; Boulat, Victoire; Mannion, Jonathan; Goicoechea, Maria; Tan, Shaun; Lawson, Sam; Starling, Chris; Elshtein, Gabrielle; Ravindran, Nivedita; Montgomery, Anna B.; Andres-Ejarque, Rosa; Allen, Mark; Lumbard, Steven; Wallberg, Fredrik; Betteridge, Kai; Scrimgeour, Ross; Robertson, David; Ward, George; Sims, Martin; Smyth, Tomoko; Samson, Andre L.; Murphy, James M.; Ivankovic, Daniela Kolarevic; Arwert, Esther N.; Calado, Dinis P.; Grigoriadis, Anita; Smalley, Matthew J.; Melcher, Alan; Haider, Syed; Lawrence, Toby; Roxanis, Ioannis; Tutt, Andrew N. J.; Tenev, Tencho; Meier, Pascal
SPP1 is required for maintaining mesenchymal cell fate in pancreatic cancer

SPP1对于维持胰腺癌的间充质细胞命运是必需的。

Nature
IF48.5
2025-09-240
OA
Huafu Li; Linxiang Lan; Hengxing Chen; May Zaw Thin; Hari Ps; Jessica K. Nelson; Ian M. Evans; E. Josue Ruiz; Rongjie Cheng; Li Tran; Mark Allen; Jian Ma; Tingzhuang Yi; Chunming Wang; Yulong He; Naomi Guppy; Anguraj Sadanandam; Shao-Zhen Lin; Changhua Zhang; Axel Behrens
Anti-EGFR Antibody-Drug Conjugate Carrying an Inhibitor Targeting CDK Restricts Triple-Negative Breast Cancer Growth
CLINICAL CANCER RESEARCH
IF10.2
2024-05-216
OAAI
Cheung, Anthony; Chenoweth, Alicia M.; Johansson, Annelie; Laddach, Roman; Guppy, Naomi; Trendell, Jennifer; Esapa, Benjamina; Mavousian, Antranik; Navarro-Llinas, Blanca; Haider, Syed; Romero-Clavijo, Pablo; Hoffmann, Ricarda M.; Andriollo, Paolo; Rahman, Khondaker M.; Jackson, Paul; Tsoka, Sophia; Irshad, Sheeba; Roxanis, Ioannis; Grigoriadis, Anita; Thurston, David E.; Lord, Christopher J.; Tutt, Andrew N. J.; Karagiannis, Sophia N.
SF3B1 hotspot mutations confer sensitivity to PARP inhibition through a defective replication stress response
MOLECULAR CANCER THERAPEUTICS
IF5.5
2023-12-010
PRE
Bland, Philip; Saville, Harry; Wai, Patty T.; Curnow, Lucinda; Nieminuszczy, Jadwiga; Ravindran, Nivedita; Barker, Holly E.; Wright, James; Yu, Lu; Mavrommati, Ioanna; Peck, Barrie; Gazinska, Patrycja; Pemberton, Helen N.; Gulati, Aditi; Guppy, Naomi; Roxanis, Ioannis; Pratt, Guy; Oldreive, Ceri; Stankovic, Tatjana; Barlow, Samantha; Kalirai, Helen; Coupland, Sarah E.; Broderick, Ronan; Alsafadi, Samar; Houy, Alexandre; Stern, Marc-Henri; Pettit, Stephen; Choudhary, Jyoti S.; Haider, Syed; Niedzwiedz, Wojciech; Lord, Christopher J.; Natrajan, Rachael
SF3B1 hotspot mutations confer sensitivity to PARP inhibition by eliciting a defective replication stress response
NATURE GENETICS
IF31.8
2023-07-3118
OAAI
Bland, Philip; Saville, Harry; Wai, Patty T.; Curnow, Lucinda; Muirhead, Gareth; Nieminuszczy, Jadwiga; Ravindran, Nivedita; John, Marie Beatrix; Hedayat, Somaieh; Barker, Holly E.; Wright, James; Yu, Lu; Mavrommati, Ioanna; Read, Abigail; Peck, Barrie; Allen, Mark; Gazinska, Patrycja; Pemberton, Helen N.; Gulati, Aditi; Nash, Sarah; Noor, Farzana; Guppy, Naomi; Roxanis, Ioannis; Pratt, Guy; Oldreive, Ceri; Stankovic, Tatjana; Barlow, Samantha; Kalirai, Helen; Coupland, Sarah E.; Broderick, Ronan; Alsafadi, Samar; Houy, Alexandre; Stern, Marc-Henri; Pettit, Stephen; Choudhary, Jyoti S.; Haider, Syed; Niedzwiedz, Wojciech; Lord, Christopher J.; Natrajan, Rachael
Mutations in the RNA Splicing Factor SF3B1 drive endocrine therapy resistance and confer a targetable replication stress response defect through PARP inhibition
CANCER RESEARCH
IF16.6
2023-03-010
PRE
Bland, Phil; Saville, Harry; Read, Abigail; Wai, Patty; Muirhead, Gareth; Curnow, Lucinda; Nieminuszczy, Jadwiga; Ravindran, Nivedita; John, Marie; Hedayat, Somaieh; Barker, Holly; Wright, James; Yu, Lu; Mavrommati, Ioanna; Peck, Barrie; Allen, Mark; Gazinska, Patrycja; Pemberton, Helen; Gulati, Aditi; Nash, Sarah; Noor, Farzana; Guppy, Naomi; Roxanis, Ioannis; Barlow, Samantha; Kalirai, Helen; Coupland, Sarah; Broderick, Ronan; Alsafadi, Samar; Houy, Alexandre; Stern, Marc-Henri; Pettit, Stephen; Choudhary, Jyoti; Haider, Syed; Niedzwiedz, Wojciech; Lord, Christopher; Natrajan, Rachael
Ubiquitylation of MLKL at lysine 219 positively regulates necroptosis-induced tissue injury and pathogen clearance
NATURE COMMUNICATIONS
IF15.7
2021-06-0752
OAAI
Garcia, Laura Ramos; Tenev, Tencho; Newman, Richard; Haich, Rachel O.; Liccardi, Gianmaria; John, Sidonie Wicky; Annibaldi, Alessandro; Yu, Lu; Pardo, Mercedes; Young, Samuel N.; Fitzgibbon, Cheree; Fernando, Winnie; Guppy, Naomi; Kim, Hyojin; Liang, Lung-Yu; Lucet, Isabelle S.; Kueh, Andrew; Roxanis, Ioannis; Gazinska, Patrycja; Sims, Martin; Smyth, Tomoko; Ward, George; Bertin, John; Beal, Allison M.; Geddes, Brad; Choudhary, Jyoti S.; Murphy, James M.; Ball, K. Aurelia; Upton, Jason W.; Meier, Pascal
3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast Cancer
CANCER RESEARCH
IF16.6
2021-02-1510
OA
Peck, Barrie; Bland, Philip; Mavrommati, Ioanna; Muirhead, Gareth; Cottom, Hannah; Wai, Patty T.; Maguire, Sarah L.; Barker, Holly E.; Morrison, Eamonn; Kriplani, Divya; Yu, Lu; Gibson, Amy; Falgari, Giulia; Brennan, Keith; Farnie, Gillian; Buus, Richard; Marlow, Rebecca; Novo, Daniela; Knight, Eleanor; Guppy, Naomi; Kolarevic, Daniela; Susnjar, Snezana; Milijic, Natasa Medic; Naidoo, Kalnisha; Gazinska, Patrycja; Roxanis, Ioannis; Pancholi, Sunil; Martin, Lesley-Ann; Holgersen, Erle M.; Cheang, Maggie C. U.; Noor, Farzana; Postel-Vinay, Sophie; Quinn, Gerard; McDade, Simon; Krasny, Lukas; Huang, Paul; Daley, Frances; Wallberg, Fredrik; Choudhary, Jyoti S.; Haider, Syed; Tutt, Andrew N.; Natrajan, Rachael
RIPK1-mediated immunogenic cell death promotes anti-tumour immunity against soft-tissue sarcoma

RIPK1-mediated免疫原性细胞死亡促进对软组织肉瘤的抗肿瘤免疫

EMBO MOLECULAR MEDICINE
IF8.3
2020-05-1824
OAAI
Smith, Henry G.; Jamal, Kunzah; Dayal, Jasbani H. S.; Tenev, Tencho; Kyula-Currie, Joan; Guppy, Naomi; Gazinska, Patrycja; Roulstone, Victoria; Liccardi, Gianmaria; Davies, Emma; Roxanis, Ioannis; Melcher, Alan A.; Hayes, Andrew J.; Inman, Gareth J.; Harrington, Kevin J.; Meier, Pascal
ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response (vol 87, pg 925, 2020)
NATURE GENETICS
IF31.8
2020-01-315
OAAI
Nagarajan, Sankari; Rao, Shalini V.; Sutton, Joseph; Cheeseman, Danya; Dunn, Shanade; Papachristou, Evangelia K.; Prada, Jose-Enrique Gonzalez; Couturier, Dominique-Laurent; Kumar, Sanjeev; Kishore, Kamal; Chilamakuri, Chandra Sekhar Reddy; Glont, Silvia-Elena; Goode, Emily Archer; Brodie, Cara; Guppy, Naomi; Natrajan, Rachael; Bruna, Alejandra; Caldas, Carlos; Russell, Alasdair; Siersbaek, Rasmus; Yusa, Kosuke; Chernukhin, Igor; Carroll, Jason S.
ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response
NATURE GENETICS
IF31.8
2020-01-06120
OAAI
Nagarajan, Sankari; Rao, Shalini V.; Sutton, Joseph; Cheeseman, Danya; Dunn, Shanade; Papachristou, Evangelia K.; Prada, Jose-Enrique Gonzalez; Couturier, Dominique-Laurent; Kumar, Sanjeev; Kishore, Kamal; Chilamakuri, Chandra Sekhar Reddy; Glont, Silvia-Elena; Archer Goode, Emily; Brodie, Cara; Guppy, Naomi; Natrajan, Rachael; Bruna, Alejandra; Caldas, Carlos; Russell, Alasdair; Siersbaek, Rasmus; Yusa, Kosuke; Chernukhin, Igor; Carroll, Jason S.
LOSS OF BAP1 FUNCTION LEADS TO TRAIL SENSITIVITY IN MESOTHELIOMA
THORAX
IF7.7
2018-11-161
PREAI
Kumar, N.; Kolluri, K. K.; Alifrangis, C.; Ishii, Y.; Price, S.; Michaut, M.; Williams, S.; Barthorpe, S.; Lightfoot, H.; Busacca, S.; Sharkey, A.; Yuan, Z.; Sage, E. K.; Vallath, S.; Le Quesne, J.; Tice, D. A.; Alrifai, D.; von Karstedt, S.; Montinaro, A.; Guppy, N.; Waller, D. A.; Nakas, A.; Good, R.; Holmes, A.; Walczak, H.; Fennell, D. A.; Garnett, M.; Iorio, F.; Wessels, L.; McDermott, U.; Janes, S. M.

研究方向

暂未获取到该数据
R
Rachael Natrajan
H 指数:66论文数:389被引数:1.5万
P
Patrycja Gazińska
H 指数:30论文数:253被引数:4,508
S
Syed Haider
H 指数:52论文数:432被引数:1.4万
I
Ioanna Mavrommati
H 指数:9论文数:35被引数:651
L
Lu Yu
H 指数:45论文数:262被引数:7,519
J
Jyoti S. Choudhary
H 指数:69论文数:458被引数:2.6万
H
Holly E. Barker
H 指数:21论文数:173被引数:5,596
P
Patty T. Wai
H 指数:15论文数:53被引数:1,191
B
Barrie Peck
H 指数:21论文数:119被引数:5,215
I
Ioannis Roxanis
H 指数:19论文数:201被引数:1,567