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R

Robert J. Konrad

Eli Lilly and Company
H指数:51
被引数:8,987

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Unraveling the physiological impact of ANGPTL8 loss-of-function variants in humans

解析人类ANGPTL8功能缺失变异的生理影响

Scientific Reports
IF3.9
2026-04-290
OA
Arkan Abadi; Yan Q. Chen; Shareef Khalid; Kylia Williams; Eugene Y. Zhen; Hongxia Li; Robert Siegel; Maryalice Hartley; Thomas Patrick Beyer; Danisha DeBowles; Yue-Wei Qian; Asif Rahseed; Maleeha Zaman Khan; Muhammad Jahanzaib; Muhammad Rehan Mian; Riffat Sultana; Anjum Jalal; Shahid Abbas; Ambreen Muddassir; Saima Naz Mohsin; Shahid Mukhtar; Adil Mahmood; Timothy P. Ryan; Laura F. Michael; Giacomo Ruotolo; Danish Saleheen; Yi Wen; Robert J. Konrad; Pallav Bhatnagar
Angiopoietin-like 3 monomers are abundant in human plasma but are unable to inhibit endothelial lipase

血管生成素样蛋白3单体在人类血浆中含量丰富，但无法抑制内皮脂酶

JCI INSIGHT
IF6.1
2025-12-080
OA
Walker, Sydney G.; Chen, Van Q.; Sylvers-Davie, Kelli L.; Dou, Alex; V. Zhen, Eugene; Qian, Vuewei; Wen, Vi; Ehsani, Mariam; Smith, Sydney; Thapa, Rakshya; Mercer, Maxwell J.; Langmack, Lucy; Bhattarai, Bharat Raj; Ploug, Michael; Konrad, Robert J.; Davies, Brandon S. J.
Affinity Capture Elution Coupled with Cell-based Cyclic Adenosine Monophosphate Assay as a Platform Method for Detection of Neutralizing Antibodies to Incretin Molecules

亲和捕获-洗脱结合细胞基环腺苷酸测定法，作为一种检测抑制素分子中和抗体的平台方法

The AAPS Journal
IF0
2025-10-130
PRE
Nichole A. Reynolds; Yan Q. Chen; Richard E. Higgs; Boris Calderon; Jeff W. Cramer; Nicoletta Bivi; Michael E. Hodsdon; Heather A. Bullock; Travis E. Shockley; Victoria L. Peek; Justin K. Mack; Deven Lemen; Victoria Copeland; Andrea Ferrante; Robert J. Konrad; Garrett Mullins; Yi Wen
Associations of ANGPTL Proteins and Complexes with Progression of Coronary Artery Calcification and Coronary Events

ANGPTL蛋白及其复合物与冠状动脉钙化进展及冠状动脉事件的关系

Atherosclerosis
IF5.7
2025-08-130
PRE
Günther Silbernagel; Halle Higbie; Tanja Meininger; Deven Lemen; Hongxia Li; Yan Q. Chen; Yi Wen; Eugene Y. Zhen; Yue-Wei Qian; Polina Korovianskaia; Hans J. Trampisch; Hubert Scharnagl; Winfried März; Andreas Stang; Raimund Erbel; Robert J. Konrad; Börge Schmidt
Decreases in circulating ANGPTL3/8 concentrations following retatrutide treatment parallel reductions in serum lipids

接受雷特拉曲肽治疗后，循环中ANGPTL3/8浓度的降低与血清脂质的减少相平行。

diabetes obesity metabolism
IF0
2025-07-290
OAAI
Yi Wen PhD; Deven Lemen BS; Yanzhu Lin PhD; Yan Q. Chen MD; Ajit Regmi BS; William C. Roell PhD; Melissa K. Thomas MD; Mark L. Hartman MD; Tamer Coskun MD; Zvonko Milicevic MD; Axel Haupt MD; Giacomo Ruotolo MD; Robert J. Konrad MD
ANGPTL3/8 is an atypical unfoldase that regulates intravascular lipolysis by catalyzing unfolding of lipoprotein lipase

ANGPTL3/8是一种非典型的展开酶，通过催化脂蛋白脂肪酶的展开来调节血管内脂解作用。

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2025-03-201
OA
Kumari, Anni; Larsen, Sanne W. R.; Bondesen, Signe; Qian, Yuewei; Tian, Hao D.; Walker, Sydney G.; Davies, Brandon S. J.; Remaley, Alan T.; Young, Stephen G.; Konrad, Robert J.; Jorgensen, Thomas J. D.; Ploug, Michael
Carboxyl- terminal sequences in APOA5 are important for suppressing ANGPTL3/8 activity

APOA5中的羧基末端序列对于抑制ANGPTL3/8活性很重要

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2024-04-163
PRE
Chen, Yan Q.; Yang, Ye; Zhen, Eugene Y.; Beyer, Thomas P.; Li, Hongxia; Wen, Yi; Ehsani, Mariam; Jackson, Nicholas; Xie, Katherine; Jung, Hyesoo; Scheithauer, Julia L.; Kumari, Anni; Birrane, Gabriel; Russell, Anna M.; Balasubramaniam, Deepa; Liao, Zhongping; Siegel, Robert W.; Qian, Yuewei; Ploug, Michael; Young, Stephen G.; Konrad, Robert J.
Hypertriglyceridemia in Apoa5-'- mice results from reduced amounts of lipoprotein lipase in the capillary lumen
JOURNAL OF CLINICAL INVESTIGATION
IF13.6
2023-12-018
OAAI
Yang, Ye; Beigneux, Anne P.; Song, Wenxin; Nguyen, Le Phuong; Jung, Hyesoo; Tu, Yiping; Weston, Thomas A.; Tran, Caitlyn M.; Xie, Katherine; Yu, Rachel G.; Tran, Anh P.; Miyashita, Kazuya; Nakajima, Katsuyuki; Murakami, Masami; Chen, Yan Q.; Zhen, Eugene Y.; Kim, Joonyoung R.; Kim, Paul H.; Birrane, Gabriel; Tontonoz, Peter; Ploug, Michael; Konrad, Robert J.; Fong, Loren G.; Young, Stephen G.

研究方向

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Yan Chen
H 指数:31论文数:103被引数:3,467
Y
Yuewei Qian
H 指数:32论文数:93被引数:6,236
J
Jason S. Troutt
H 指数:18论文数:46被引数:1,927
R
Robert W. Siegel
H 指数:30论文数:84被引数:5,316
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John H. Sloan
H 指数:28论文数:89被引数:3,587
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William E. Alborn
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Yuejun Zhen
H 指数:27论文数:55被引数:2,805
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Guoqing Cao
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M
Mariam Ehsani
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G
Giacomo Ruotolo
H 指数:42论文数:129被引数:6,751