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T

Tibor van Welsem

Netherlands Cancer Institute
H指数:20
被引数:2,263

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Histone methyltransferase DOT1L maintains cell state and restricts cytotoxic potential of CD8 T cells

组蛋白甲基转移酶DOT1L维持细胞状态并限制CD8 T细胞的细胞毒性潜力

Science Advances
IF12.5
2025-12-120
OA
Muddassir Malik; Willem-Jan de Leeuw; Muhammad Assad Aslam; Eliza Mari Kwesi-Maliepaard; Teun van den Brand; Bram van den Broek; Maxime Kempers; Liesbeth Hoekman; Natalie Proost; Tibor van Welsem; Nikolina Bąbała; Elselien Frijlink; Elzo de Wit; Jannie Borst; Heinz Jacobs; Fred van Leeuwen
The histone methyltransferase DOT1L prevents antigen-independent differentiation and safeguards epigenetic identity of CD8+ T cells

组蛋白甲基转移酶DOT1L可防止抗原非依赖性分化并保护CD8 T细胞的表观遗传身份

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2020-08-0632
OAAI
Kwesi-Maliepaard, Eliza Mari; Aslam, Muhammad Assad; Alemdehy, Mir Farshid; van den Brand, Teun; McLean, Chelsea; Vlaming, Hanneke; van Welsem, Tibor; Korthout, Tessy; Lancini, Cesare; Hendriks, Sjoerd; Ahrends, Tomasz; van Dinther, Dieke; den Haan, Joke M. M.; Borst, Jannie; de Wit, Elzo; van Leeuwen, Fred; Jacobs, Heinz
Conserved crosstalk between histone deacetylation and H3K79 methylation generates DOT1L-dose dependency in HDAC1-deficient thymic lymphoma

组蛋白去乙酰化和H3K79甲基化之间的保守串扰在HDAC1-deficient胸腺淋巴瘤中产生DOT1L-dose依赖性

EMBO JOURNAL
IF8.3
2019-06-1730
OAAI
Vlaming, Hanneke; McLean, Chelsea M.; Korthout, Tessy; Alemdehy, Mir Farshid; Hendriks, Sjoerd; Lancini, Cesare; Palit, Sander; Klarenbeek, Sjoerd; Kwesi-Maliepaard, Eliza Mari; Molenaar, Thom M.; Hoekman, Liesbeth; Schmidlin, Thierry T.; Altelaar, A. F. Maarten; van Welsem, Tibor; Dannenberg, Jan-Hermen; Jacobs, Heinz; van Leeuwen, Fred
Progressive methylation of ageing histones by Dot1 functions as a timer

Dot1作为计时器对衰老组蛋白的逐步甲基化

EMBO REPORTS
IF6.2
2011-07-1553
OAAI
De Vos, Dirk; Frederiks, Floor; Terweij, Marit; van Welsem, Tibor; Verzijlbergen, Kitty F.; Iachina, Ekaterina; de Graaf, Erik L.; Altelaar, A. F. Maarten; Oudgenoeg, Gideon; Heck, Albert J. R.; Krijgsveldz, Jeroen; Bakker, Barbara M.; van Leeuwen, Fred

研究方向

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F
Fred van Leeuwen
H 指数:41论文数:126被引数:6,062
H
Hanneke Vlaming
H 指数:10论文数:25被引数:548
M
Maarten Altelaar
H 指数:60论文数:414被引数:1.2万
T
Tessy Korthout
H 指数:8论文数:18被引数:230
H
Heinz Jacobs
H 指数:41论文数:126被引数:6,223
E
Eliza Mari Kwesi‐Maliepaard
H 指数:6论文数:16被引数:209
K
Kitty F. Verzijlbergen
H 指数:11论文数:24被引数:685
F
Floor Frederiks
H 指数:8论文数:18被引数:533
T
Tineke L. Lenstra
H 指数:27论文数:70被引数:2,631
A
Albert J. R. Heck
H 指数:132论文数:1,171被引数:7.1万