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J

James S. Fraser

University of California San Francisco
H指数:64
被引数:2.3万

个人简介

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教育背景

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工作经历

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荣誉奖项

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Development of a random background to understand ligand optimization

开发随机背景以理解配体优化

Nature
IF48.5
2026-09-160
OAAI
Xinyu Xu; Olivier Mailhot; Galen J. Correy; Xi-Ping Huang; Joao M. Braz; Da Shi; Karthik Srinivasan; Kara Zielinski; Yuliia Holota; Yuliia Kuziv; Christos Iliopoulos-Tsoutsouvas; Nathan D. Levinzon; Yagmur U. Doruk; Moira M. Rachman; Morgan E. Diolaiti; Maisie G. V. Stevens; Fangyu Liu; Katie L. Holland; Harald Hübner; Jing Wang; Yujin Wu; Alan Ashworth; Alexandros Makriyannis; Yuqi Zhang; Yurii S. Moroz; Peter Gmeiner; Robert Abel; Aashish Manglik; Allan I. Basbaum; Bryan L. Roth; James S. Fraser; Brian K. Shoichet
Humanizing acidic mammalian chitinase variants establish lung immune conditioning and control environmentally driven inflammation and fibrosis

人源化酸性哺乳动物几丁质酶变体建立肺免疫调节，并控制环境因素驱动的炎症和纤维化

Cell Reports
IF6.9
2026-08-120
OAAI
Yilin Wang; Haerin Jung; Do-Hyun Kim; Eilene Liu; Donovan Watza; Samuel I. Risma; Kira L. Florczak; Leah M. Kim; Zeena Bou Reslan; Ananya Gupta; Ruppal Soni; Roberto Efraín Díaz; Richard M. Locksley; James S. Fraser; Janet S. Lee; Steven J. Van Dyken
Structure-based discovery of inhibitors of Mac1 domain of nonstructural protein-3 of SARS-CoV-2 by machine learning-augmented screening of chemical space

基于机器学习增强的化学空间筛选，发现SARS-CoV-2非结构蛋白-3的Mac1结构域抑制剂的结构方法

Scientific Reports
IF3.9
2026-08-030
OA
Fuqiang Ban; Rahul Ravichandran; Galen J. Correy; Oleksandra Herasymenko; Madhushika Silva; Suzanne Ackloo; Albina Bolotokova; Irene Chau; Elisa Gibson; Rachel Harding; Ashley Hutchinson; Peter Loppnau; James S. Fraser; Matthieu Schapira; Artem Cherkasov; Francesco Gentile
CACHE Challenge #3: Targeting the Nsp3 Macrodomain of SARS-CoV-2

缓存挑战 #3: 以SARS-CoV-2的Nsp3宏域为目标

Journal of Chemical Information and Modeling
IF5.3
2026-01-210
OAAI
Oleksandra Herasymenko; Madhushika Silva; Galen J. Correy; Abd Al-Aziz A. Abu-Saleh; Suzanne Ackloo; Cheryl Arrowsmith; Alan Ashworth; Fuqiang Ban; Hartmut Beck; Kevin P. Bishop; Hugo J. Bohórquez; Albina Bolotokova; Marko Breznik; Irene Chau; Yu Chen; Artem Cherkasov; Wim Dehaen; Dennis Della Corte; Katrin Denzinger; Niklas P. Doering; Kristina Edfeldt; Aled Edwards; Darren Fayne; Francesco Gentile; Elisa Gibson; Ozan Gokdemir; Anders Gunnarsson; Judith Günther; John J. Irwin; Jan Halborg Jensen; Rachel J. Harding; Alexander Hillisch; Laurent Hoffer; Anders Hogner; Ashley Hutchinson; Shubhangi Kandwal; Andrea Karlova; Kushal Koirala; Sergei Kotelnikov; Dima Kozakov; Juyong Lee; Soowon Lee; Uta Lessel; Sijie Liu; Xuefeng Liu; Peter Loppnau; Jens Meiler; Rocco Moretti; Yurii S. Moroz; Charuvaka Muvva; Tudor I. Oprea; Brooks Paige; Amit Pandit; Keunwan Park; Gennady Poda; Mykola V. Protopopov; Vera Pütter; Rahul Ravichandran; Didier Rognan; Edina Rosta; Yogesh Sabnis; Thomas Scott; Almagul Seitova; Purshotam Sharma; François Sindt; Minghu Song; Casper Steinmann; Rick Stevens; Valerij Talagayev; Valentyna V. Tararina; Olga Tarkhanova; Damon Tingey; John F. Trant; Dakota Treleaven; Alexander Tropsha; Patrick Walters; Jude Wells; Yvonne Westermaier; Gerhard Wolber; Lars Wortmann; Shuangjia Zheng; James S. Fraser; Matthieu Schapira
Discovery of AVI-6451, a Potent and Selective Inhibitor of the SARS-CoV-2 ADP-Ribosylhydrolase Mac1 with Oral Efficacy In Vivo
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2025-12-010
PRE
Jaishankar, Priyadarshini; Correy, Galen J.; Matsui, Yusuke; Togo, Takaya; Rachman, Moira M.; Stevens, Maisie G. V.; Hantz, Eric R.; Zheng, Jeffrey; Diolaiti, Morgan E.; Montano, Mauricio; Taha, Taha Y.; Rosecrans, Julia; Pampel, Julius; Krogan, Nevan J.; Shoichet, Brian K.; Ashworth, Alan; Ott, Melanie; Fraser, James S.; Renslo, Adam R.
The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2

Mac1 ADP-核糖基水解酶是SARS-CoV-2的 therapeutic target。

ELIFE
IF0
2025-11-191
OA
Suryawanshi, Rahul K.; Jaishankar, Priyadarshini; Correy, Galen J.; Rachman, Moira M.; O'leary, Patrick C.; Taha, Taha Y.; Matsui, Yusuke; Zapatero-Belinchon, Francisco J.; Mccavitt-Malvido, Maria; Doruk, Yagmur U.; Stevens, Maisie Gv; Diolaiti, Morgan E.; Jogalekar, Manasi P.; Chen, Huadong; Richards, Alicia L.; Kongpracha, Pornparn; Bali, Sofia; Montano, Mauricio; Rosecrans, Julia; Matthay, Michael; Togo, Takaya; Gonciarz, Ryan L.; Gopalkrishnan, Saumya; Neitz, R. Jeffrey; Krogan, Nevan J.; Swaney, Danielle L.; Shoichet, Brian K.; Ott, Melanie; Renslo, Adam R.; Ashworth, Alan; Fraser, James S.

研究方向

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G
G.J. Correy
H 指数:14论文数:204被引数:1,271
N
Nevan J. Krogan
H 指数:129论文数:759被引数:6.9万
H
Henry van den Bedem
H 指数:34论文数:267被引数:4,961
M
Michael C. Thompson
H 指数:32论文数:112被引数:4,115
A
Alan Ashworth
H 指数:121论文数:1,006被引数:6.7万
R
Roberto Efraín Díaz
H 指数:18论文数:109被引数:1,210
J
J.T. Biel
H 指数:15论文数:111被引数:3,181
B
Brian K. Shoichet
H 指数:114论文数:422被引数:5.4万
B
Benjamin A. Barad
H 指数:14论文数:55被引数:2,349
N
Natalia Jura
H 指数:41论文数:151被引数:1.3万