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J

James S. Fraser

university of california san francisco

64H指数
537论文数
2.3W被引数
收录论文 94
发表时间
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Development of a random background to understand ligand optimization开发随机背景以理解配体优化
errNature
IF48.5
err2026-09-16
err0
errOAAI
errXinyu Xu; Olivier Mailhot; Galen J. Correy; Xi-Ping Huang; Joao M. Braz; Da Shi; Karthik Srinivasan; Kara Zielinski; Yuliia Holota; Yuliia Kuziv; Christos Iliopoulos-Tsoutsouvas; Nathan D. Levinzon; Yagmur U. Doruk; Moira M. Rachman; Morgan E. Diolaiti; Maisie G. V. Stevens; Fangyu Liu; Katie L. Holland; Harald Hübner; Jing Wang; Yujin Wu; Alan Ashworth; Alexandros Makriyannis; Yuqi Zhang; Yurii S. Moroz; Peter Gmeiner; Robert Abel; Aashish Manglik; Allan I. Basbaum; Bryan L. Roth; James S. Fraser; Brian K. Shoichet
err分享
err收藏
Humanizing acidic mammalian chitinase variants establish lung immune conditioning and control environmentally driven inflammation and fibrosis人源化酸性哺乳动物几丁质酶变体建立肺免疫调节，并控制环境因素驱动的炎症和纤维化
errCell Reports
IF6.9
err2026-08-12
err0
errOAAI
errYilin Wang; Haerin Jung; Do-Hyun Kim; Eilene Liu; Donovan Watza; Samuel I. Risma; Kira L. Florczak; Leah M. Kim; Zeena Bou Reslan; Ananya Gupta; Ruppal Soni; Roberto Efraín Díaz; Richard M. Locksley; James S. Fraser; Janet S. Lee; Steven J. Van Dyken
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Structure-based discovery of inhibitors of Mac1 domain of nonstructural protein-3 of SARS-CoV-2 by machine learning-augmented screening of chemical space基于机器学习增强的化学空间筛选，发现SARS-CoV-2非结构蛋白-3的Mac1结构域抑制剂的结构方法
errScientific Reports
IF3.9
err2026-08-03
err0
errOAAI
errFuqiang Ban; Rahul Ravichandran; Galen J. Correy; Oleksandra Herasymenko; Madhushika Silva; Suzanne Ackloo; Albina Bolotokova; Irene Chau; Elisa Gibson; Rachel Harding; Ashley Hutchinson; Peter Loppnau; James S. Fraser; Matthieu Schapira; Artem Cherkasov; Francesco Gentile
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Mapping the avoid-ome: a systematic open-science approach to predictive ADMET绘制规避组：一种系统性的开放科学方法用于预测ADMET
errNature Communications
IF15.7
err2026-05-25
err0
errOAAI
errJames S. Fraser; Steven Edgar; L. Naomi Handly; Sriram Kosuri; John D. Chodera; Mark Murcko; W. Patrick Walters
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Emergence of specific binding and catalysis from a designed generalist binding protein从设计的通用型结合蛋白中产生特异性结合和催化作用
errNature Chemistry
IF20.2
err2026-05-04
err0
PREAI
errYuda Chen; Sagar Bhattacharya; Lena Bergmann; Galen J. Correy; Sophia K. Tan; Kaipeng Hou; Justin T. Biel; Lei Lu; Ian Bakanas; Jason E. Gestwicki; Alexander N. Volkov; Ivan V. Korendovych; Nicholas F. Polizzi; James S. Fraser; William F. DeGrado
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err收藏
Blind Challenges Let Us See the Path Forward for Predictive Models
errJournal of Chemical Information and Modeling
IF5.3
err2026-02-06
err0
errOAAI
errJohn D. Chodera; W. Patrick Walters; Sriram Kosuri; James S. Fraser
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CACHE Challenge #3: Targeting the Nsp3 Macrodomain of SARS-CoV-2缓存挑战 #3: 以SARS-CoV-2的Nsp3宏域为目标
errJournal of Chemical Information and Modeling
IF5.3
err2026-01-21
err0
errOAAI
errOleksandra Herasymenko; Madhushika Silva; Galen J. Correy; Abd Al-Aziz A. Abu-Saleh; Suzanne Ackloo; Cheryl Arrowsmith; Alan Ashworth; Fuqiang Ban; Hartmut Beck; Kevin P. Bishop; Hugo J. Bohórquez; Albina Bolotokova; Marko Breznik; Irene Chau; Yu Chen; Artem Cherkasov; Wim Dehaen; Dennis Della Corte; Katrin Denzinger; Niklas P. Doering; Kristina Edfeldt; Aled Edwards; Darren Fayne; Francesco Gentile; Elisa Gibson; Ozan Gokdemir; Anders Gunnarsson; Judith Günther; John J. Irwin; Jan Halborg Jensen; Rachel J. Harding; Alexander Hillisch; Laurent Hoffer; Anders Hogner; Ashley Hutchinson; Shubhangi Kandwal; Andrea Karlova; Kushal Koirala; Sergei Kotelnikov; Dima Kozakov; Juyong Lee; Soowon Lee; Uta Lessel; Sijie Liu; Xuefeng Liu; Peter Loppnau; Jens Meiler; Rocco Moretti; Yurii S. Moroz; Charuvaka Muvva; Tudor I. Oprea; Brooks Paige; Amit Pandit; Keunwan Park; Gennady Poda; Mykola V. Protopopov; Vera Pütter; Rahul Ravichandran; Didier Rognan; Edina Rosta; Yogesh Sabnis; Thomas Scott; Almagul Seitova; Purshotam Sharma; François Sindt; Minghu Song; Casper Steinmann; Rick Stevens; Valerij Talagayev; Valentyna V. Tararina; Olga Tarkhanova; Damon Tingey; John F. Trant; Dakota Treleaven; Alexander Tropsha; Patrick Walters; Jude Wells; Yvonne Westermaier; Gerhard Wolber; Lars Wortmann; Shuangjia Zheng; James S. Fraser; Matthieu Schapira
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Rosace-AA: enhancing interpretation of deep mutational scanning data with amino acid substitution and position-specific insights
errBioinformatics Advances
IF2.8
err2026-01-01
err2
PREAI
errRao, Jingyou; Wang, Mingsen; Howard, Matthew K.; Macdonald, Christian; Fraser, James S.; Coyote-Maestas, Willow; Pimentel, Harold
err分享
err收藏
Autoregulation of the MET receptor tyrosine kinase by its intracellular juxtamembrane domainMET受体酪氨酸激酶通过其细胞内近膜域进行自身调控
errBIOCHEMICAL JOURNAL
IF4.3
err2025-12-01
err0
errOAAI
errLinossi, Edmond M.; Espinoza, Carla A.; Estevam, Gabriella O.; Fraser, James S.; Jura, Natalia
err分享
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Discovery of AVI-6451, a Potent and Selective Inhibitor of the SARS-CoV-2 ADP-Ribosylhydrolase Mac1 with Oral Efficacy In Vivo
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2025-12-01
err0
PREAI
errJaishankar, Priyadarshini; Correy, Galen J.; Matsui, Yusuke; Togo, Takaya; Rachman, Moira M.; Stevens, Maisie G. V.; Hantz, Eric R.; Zheng, Jeffrey; Diolaiti, Morgan E.; Montano, Mauricio; Taha, Taha Y.; Rosecrans, Julia; Pampel, Julius; Krogan, Nevan J.; Shoichet, Brian K.; Ashworth, Alan; Ott, Melanie; Fraser, James S.; Renslo, Adam R.
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The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2Mac1 ADP-核糖基水解酶是SARS-CoV-2的 therapeutic target。
errELIFE
IF0
err2025-11-19
err1
errOAAI
errSuryawanshi, Rahul K.; Jaishankar, Priyadarshini; Correy, Galen J.; Rachman, Moira M.; O'leary, Patrick C.; Taha, Taha Y.; Matsui, Yusuke; Zapatero-Belinchon, Francisco J.; Mccavitt-Malvido, Maria; Doruk, Yagmur U.; Stevens, Maisie Gv; Diolaiti, Morgan E.; Jogalekar, Manasi P.; Chen, Huadong; Richards, Alicia L.; Kongpracha, Pornparn; Bali, Sofia; Montano, Mauricio; Rosecrans, Julia; Matthay, Michael; Togo, Takaya; Gonciarz, Ryan L.; Gopalkrishnan, Saumya; Neitz, R. Jeffrey; Krogan, Nevan J.; Swaney, Danielle L.; Shoichet, Brian K.; Ott, Melanie; Renslo, Adam R.; Ashworth, Alan; Fraser, James S.
err分享
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An ILC2-chitinase circuit restores lung homeostasis after epithelial injury
errJOURNAL OF IMMUNOLOGY
IF3.4
err2025-11-01
err0
PREAI
errJung, Haerin; Kim, Dohyun; Diaz, Roberto Efrain; White, Michael; Rucknagel, Summer; Mosby, Lauryn; Wang, Yilin; Reddy, Sanjana; Winkler, Emma S.; Hassan, Ahmed; Ying, Baoling; Diamond, Michael; Locksley, Richard M.; Fraser, James; Van Dyken, Steven
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err收藏
Coupled equilibria of dimerization and lipid binding modulate SARS Cov 2 Orf9b interactions and interferon response二聚化和脂质结合的耦合平衡调节SARS Cov 2 Orf9b相互作用和干扰素反应
errELIFE
IF0
err2025-09-17
err0
errOAAI
errSan Felipe, C. J.; Batra, Jyoti; Muralidharan, Monita; Malpotra, Shivali; Anand, Durga; Bauer, Rachel; Verba, Kliment A.; Swaney, Danielle L.; Krogan, Nevan J.; Grabe, Michael; Fraser, James S.
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err收藏
Initial leads to combat streptogramin resistance generated from X-ray fragment screening against VatD通过针对VatD的X射线片段筛选获得的初始先导化合物，用于对抗链阳菌素耐药性。
errStructure
IF4.3
err2025-09-12
err0
PREAI
errPooja Asthana; Sonya Lee; Christian M. MacDonald; Ian B. Seiple; James S. Fraser
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err收藏
Hybrid Antibiotics Targeting the Bacterial Ribosome靶向细菌核糖体的杂合抗生素
errACS CENTRAL SCIENCE
IF10.4
err2025-09-01
err1
PREAI
errYeon, Seul Ki; Pellegrino, Jenna; Raskar, Tushar; Tran, Minh L. N.; Dandan, Mohamad; Guerin, Francois; Einsiedler, Manuel; Cattoir, Vincent; Fraser, James S.; Seiple, Ian B.
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err收藏
Bacteriophages inhibit and evade cGAS-like immune function in bacteria噬菌体抑制和逃避细菌的cGAS样免疫功能
errCell
IF42.5
err2025-08-22
err0
errOAAI
errErin Huiting; Xueli Cao; Jie Ren; Januka S. Athukoralage; Zhaorong Luo; Sukrit Silas; Na An; Héloïse Carion; Yu Zhou; James S. Fraser; Yue Feng; Joseph Bondy-Denomy
err分享
err收藏
Where and how to house big data on small fragments如何在小片段上存储大数据
errNATURE COMMUNICATIONS
IF15.7
err2025-05-05
err0
errOAAI
errErlanson, Daniel A.; Burley, Stephen K.; Fearon, Daren; Fraser, James S.; Kreitler, Dale; Nonato, Maria Cristina; Sakai, Naoki; Wollenhaupt, Jan; Weiss, Manfred S.
err分享
err收藏
Advances in uncovering the mechanisms of macromolecular conformational entropy揭示大分子构象熵机制方面的进展
errNATURE CHEMICAL BIOLOGY
IF13.7
err2025-04-24
err1
PREAI
errWankowicz, Stephanie A.; Fraser, James S.
err分享
err收藏
MET variants with activating N-lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation
errMOLECULAR ONCOLOGY
IF4.5
err2025-02-20
err0
errOAAI
errGuerin, Celia; Vinchent, Audrey; Fernandes, Marie; Damour, Isabelle; Laratte, Agathe; Tellier, Remi; Estevam, Gabriella O.; Meneboo, Jean-Pascal; Villenet, Celine; Descarpentries, Clotilde; Fraser, James S.; Figeac, Martin; Cortot, Alexis B.; Rouleau, Etienne; Tulasne, David
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Mapping kinase domain resistance mechanisms for the MET receptor tyrosine kinase via deep mutational scanning
errELIFE
IF0
err2025-02-17
err0
errOAAI
errEstevam, Gabriella O.; Linossi, Edmond; Rao, Jingyou; Macdonald, Christian B.; Ravikumar, Ashraya; Chrispens, Karson M.; Capra, John A.; Coyote-Maestas, Willow; Pimentel, Harold; Collisson, Eric A.; Jura, Natalia; Fraser, James S.
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研究方向

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合作学者
合作期刊
J
Joseph Schlessinger
H 指数: 174 · 论文数: 719
M
Michael Diamond
H 指数: 160 · 论文数: 1.5K
M
Michele Parrinello
H 指数: 155 · 论文数: 924
B
Bryan L. Roth
H 指数: 139 · 论文数: 971
N
Nevan J. Krogan
H 指数: 129 · 论文数: 749
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