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Phenotype-Led Identification of IL-10 Upregulators in Human CD4+ T-cells and Elucidation of Their Pharmacology as Highly Selective CDK8/CDK19 Inhibitors Nicolle, Simon; Barker, Mike; Barrett, John; Campbell, Matthew; Wojno-Picon, Justyna; Atkinson, Stephen J.; Aylott, Helen; Kessedjian, Hripsimee; He, Yanan; Messenger, Cassie; Roberts, Emma; Spitzfaden, Claus; Le, Joelle; Zinn, Nico; Werner, Thilo; Dumpelfeld, Birgit; Bantscheff, Marcus; Somers, Don O.; Reid, Heather; Thang, Kevin; Gobbetti, Thomas; Lewis, Huw D. Share Save
Discovery and Characterisation of Highly Cooperative FAK-Degrading PROTACs Law, Robert P.; Nunes, Joao; Chung, Chun-wa; Bantscheff, Marcus; Buda, Karol; Dai, Han; Evans, John P.; Flinders, Adam; Klimaszewska, Diana; Lewis, Antonia J.; Muelbaier, Marcel; Scott-Stevens, Paul; Stacey, Peter; Tame, Christopher J.; Watt, Gillian F.; Zinn, Nico; Queisser, Markus A.; Harling, John D.; Benowitz, Andrew B. Share Save
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An integrated multiomic and quantitative label-free microscopy-based approach to study pro-fibrotic signalling in ex vivo human precision-cut lung slices Khan, Muzamil Majid; Poeckel, Daniel; Halavatyi, Aliaksandr; Zukowska-Kasprzyk, Joanna; Stein, Frank; Vappiani, Johanna; Sevin, Daniel C.; Tischer, Christian; Zinn, Nico; Eley, Jessica D.; Gudmann, Natasja Staehr; Muley, Thomas; Winter, Hauke; Fisher, Andrew J.; Nanthakumar, Carmel B.; Bergamini, Giovanna; Pepperkok, Rainer Share Save
The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis (vol 10, 6, 2019) Woodcock, Hannah V.; Eley, Jessica D.; Guillotin, Delphine; Plate, Manuela; Nanthakumar, Carmel B.; Martufi, Matteo; Peace, Simon; Joberty, Gerard; Poeckel, Daniel; Good, Robert B.; Taylor, Adam R.; Zinn, Nico; Redding, Matthew; Forty, Ellen J.; Hynds, Robert E.; Swanton, Charles; Karsdal, Morten; Maher, Toby M.; Fisher, Andrew; Bergamini, Giovanna; Marshall, Richard P.; Blanchard, Andy D.; Mercer, Paul F.; Chambers, Rachel C. Share Save
Extended pharmacodynamic responses observed upon PROTAC-mediated degradation of RIPK2 Mares, Alina; Miah, Afjal H.; Smith, Ian E. D.; Rackham, Mark; Thawani, Aditya R.; Cryan, Jenni; Haile, Pamela A.; Votta, Bartholomew J.; Beal, Allison M.; Capriotti, Carol; Reilly, Michael A.; Fisher, Don T.; Zinn, Nico; Bantscheff, Marcus; MacDonald, Thomas T.; Vossenkamper, Anna; Dace, Phoebe; Churcher, Ian; Benowitz, Andrew B.; Watt, Gillian; Denyer, Jane; Scott-Stevens, Paul; Harling, John D. Share Save
Biological plasticity rescues target activity in CRISPR knock outs Smits, Arne H.; Ziebell, Frederik; Joberty, Gerard; Zinn, Nico; Mueller, William F.; Clauder-Muenster, Sandra; Eberhard, Dirk; Savitski, Maria Falth; Grandi, Paola; Jakob, Petra; Michon, Anne-Marie; Sun, Hanice; Tessmer, Karen; Buerckstuemmer, Tilmann; Bantscheff, Marcus; Steinmetz, Lars M.; Drewes, Gerard; Huber, Wolfgang Share Save
Discovery of GSK8612, a Highly Selective and Potent TBK1 Inhibitor Thomson, Douglas W.; Poeckel, Daniel; Zinn, Nico; Rau, Christina; Strohmer, Katrin; Wagner, Anne J.; Graves, Alan P.; Perrin, Jessica; Bantscheff, Marcus; Duempelfeld, Birgit; Kasparcova, Viera; Ramanjulu, Joshi M.; Pesiridis, G. Scott; Muelbaier, Marcel; Bergamini, Giovanna Share Save
The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis Woodcock, Hannah V.; Eley, Jessica D.; Guillotin, Delphine; Plate, Manuela; Nanthakumar, Carmel B.; Martufi, Matteo; Peace, Simon; Joberty, Gerard; Poeckel, Daniel; Good, Robert B.; Taylor, Adam R.; Zinn, Nico; Redding, Matthew; Forty, Ellen J.; Hynds, Robert E.; Swanton, Charles; Karsdal, Morten; Maher, Toby M.; Bergamini, Giovanna; Marshall, Richard P.; Blanchard, Andy D.; Mercer, Paul F.; Chambers, Rachel C. Share Save
Discovery of a First-in-Class Gut-Restricted RET Kinase Inhibitor as a Clinical Candidate for the Treatment of IBS Eidam, Hilary Schenck; Russell, John; Raha, Kaushik; DeMartino, Michael; Qin, Donghui; Guan, Huiping Amy; Zhang, Zhiliu; Zhen, Gong; Yu, Haiyu; Wu, Chengde; Pan, Yan; Joberty, Gerard; Zinn, Nico; Laquerre, Sylvie; Robinson, Sharon; White, Angela; Giddings, Amanda; Mohammadi, Ehsan; Greenwood-Van Meerveld, Beverly; Oliff, Allen; Kumar, Sanjay; Cheung, Mui Share Save
Systematic analysis of protein turnover in primary cells Mathieson, Toby; Franken, Holger; Kosinski, Jan; Kurzawa, Nils; Zinn, Nico; Sweetman, Gavain; Poeckel, Daniel; Ratnu, Vikram S.; Schramm, Maike; Becher, Isabelle; Steidel, Michael; Noh, Kyung-Min; Bergamini, Giovanna; Beck, Martin; Bantscheff, Marcus; Savitski, Mikhail M. Share Save
IDENTIFICATION OF A RET KINASE INHIBITOR, GSK589, AS A PERIPHERAL ANALGESIC FOR THE TREATMENT VISCERAL PAIN ASSOCIATED WITH IRRITABLE BOWEL SYNDROME Russell, John; Mohammadi, Ehsan; Ligon, Casey O.; Latorre, Rocco; Joberty, Gerard; Zinn, Nico; Castellino, Steve; Hoang, Bao; Krull, David L.; DeMartino, Michael P.; Cheung, Mui; Oliff, Allen; Greenwood-Van Meerveld, Beverley; Kumar, Sanjay Share Save
Targeted and selective degradation of estrogen receptor (ER) alpha by PROTACs Flanagan, J. J.; Rossi, A. K.; Anderoli, M.; Willard, R. R.; Gordon, D.; Harling, J.; Churcher, I.; Smith, I.; Zinn, N.; Bantscheff, M.; Crews, C. M.; Crew, A.; Coleman, K. G.; Winkler, J. D.; Qian, Y. Share Save
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CZ415, a Highly Selective mTOR Inhibitor Showing in Vivo Efficacy in a Collagen Induced Arthritis Model Cansfield, Andrew D.; Ladduwahetty, Tammy; Sunose, Mihiro; Ellard, Katie; Lynch, Rosemary; Newton, Anthea L.; Lewis, Ann; Bennett, Gavin; Zinn, Nico; Thomson, Douglas W.; Rueger, Anne J.; Feutrill, John T.; Rausch, Oliver; Watt, Alan P.; Bergamini, Giovanna Share Save
Catalytic in vivo protein knockdown by small-molecule PROTACs Bondeson, Daniel P.; Mares, Alina; Smith, Ian E. D.; Ko, Eunhwa; Campos, Sebastien; Miah, Afjal H.; Mulholland, Katie E.; Routly, Natasha; Buckley, Dennis L.; Gustafson, Jeffrey L.; Zinn, Nico; Grandi, Paola; Shimamura, Satoko; Bergamini, Giovanna; Faelth-Savitski, Maria; Bantscheff, Marcus; Cox, Carly; Gordon, Deborah A.; Willard, Ryan R.; Flanagan, John J.; Casillas, Linda N.; Votta, Bartholomew J.; den Besten, Willem; Famm, Kristoffer; Kruidenier, Laurens; Carter, Paul S.; Harling, John D.; Churcher, Ian; Crews, Craig M. Share Save
Biophysical Studies on Interactions and Assembly of Full-size E3 Ubiquitin Ligase SUPPRESSOR OF CYTOKINE SIGNALING 2 (SOCS2)-ELONGIN BC-CULLIN 5-RING BOX PROTEIN 2 (RBX2) Bulatov, Emil; Martin, Esther M.; Chatterjee, Sneha; Knebel, Axel; Shimamura, Satoko; Konijnenberg, Albert; Johnson, Clare; Zinn, Nico; Grandi, Paola; Sobott, Frank; Ciulli, Alessio Share Save
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