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Gabriel M. Simon

Francis Crick Institute

38H-index
143Paper Count
9.6KCitation Count
Published Papers 35
Publication Date
Complexoform-restricted covalent TRMT112 ligands that allosterically agonize METTL5
err2026-01-08
err0
errOAAI
errF. Wieland Goetzke; Steffen M. Bernard; Cheng-Wei Ju; Jonathan Pollock; Kristen E. DeMeester; Jacob Gross; Gabriel M. Simon; Chuan He; Bruno Melillo; Benjamin F. Cravatt
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Covalent inhibitors of the PI3Kα RAS binding domain impair tumor growth driven by RAS and HER2
errSCIENCE
IF45.8
err2025-11-13
err0
PREAI
errKlebba, Joseph E.; Roy, Nilotpal; Bernard, Steffen M.; Grabow, Stephanie; Hoffman, Melissa A.; Miao, Hui; Tamiya, Junko; Wang, Jinwei; Berry, Cynthia; Esparza-Oros, Antonio; Lin, Richard; Liu, Yongsheng; Pariollaud, Marie; Parker, Holly; Mochalkin, Igor; Rana, Sareena; Snead, Aaron N.; Walton, Eric J.; Wyrick, Taylor E.; Aitichson, Erick; Bedke, Karl; Brannon, Jacyln C.; Chick, Joel M.; Hee, Kenneth; Horning, Benjamin D.; Ismail, Mohamed; Lamb, Kelsey N.; Lin, Wei; Lu, Justine; Pastuszka, Martha K.; Pollock, Jonathan; Sigler, John J.; Tomaschko, Mona; Tran, Eileen; Yue, Chanyu; Kinsella, Todd M.; Molina-Arcas, Miriam; Cook, Brian N.; Simon, Gabriel M.; Weinstein, David S.; Downward, Julian; Patricelli, Matthew P.
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Imaging features of recently identified low-grade vascular neoplasia of the liver: hepatic small vessel neoplasm and anastomosing hemangioma
err2025-09-04
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errOAAI
errMaïté Lewin; Rauda Aldhaheri; Aurélie Beaufrère; Christophe Desterke; Anita Paisant; Ivan Bricault; Paul Borde; Gabriel Simon; Mickaël Lesurtel; Daniel Cherqui; Clara Prud’Homme; Valérie Vilgrain; Astrid Laurent-Bellue
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Identification of VVD-214/RO7589831, a Clinical-Stage, Covalent Allosteric Inhibitor of WRN Helicase for the Treatment of MSI-High Cancers
err2025-09-01
err0
PREAI
errKikuchi, Shota; Green, Jason C.; Rogness, Don C.; Lam, Betty; Owyang, Zachary A.; Malmstrom, Robert D.; Tabatabaei, Ali; Snead, Aaron N.; Hoffman, Melissa A.; Bernard, Steffen M.; Ashby, Paige; Lamb, Kelsey N.; Horning, Benjamin D.; Baltgalvis, Kristen A.; Symons, Kent T.; Glaza, Thomas A.; Wu, Chu-Chiao; Song, Xiaodan; Pastuszka, Martha K.; Sigler, John J.; Pollock, Jonathan; Burgess, Laurence; Simon, Gabriel M.; Patricelli, Matthew P.; Weinstein, David S.
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Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase
err2024-06-10
err0
PREAI
errPatricelli, Matthew P.; Baltgalvis, Kristen A.; Lamb, Kelsey N.; Symons, Kent T.; Wu, Chu-Chiao; Hoffman, Melissa A.; Snead, Aaron N.; Song, Xiaodan; Glaza, Thomas; Kikuchi, Shota; Green, Jason C.; Rogness, Donald C.; Lam, Betty; Rodriguez-Aguirre, Maria E.; Woody, David R.; Eissler, Christie L.; Rodilles, Socorro; Negron, Seth M.; Bernard, Steffen M.; Tran, Eileen; Pollock, Jonathan; Tabatabaei, Ali; Contreras, Victor; Williams, Heather N.; Pastuszka, Martha K.; Sigler, John J.; Pettazzoni, Piergiorgio; Rudolph, Markus G.; Classen, Moritz; Brugger, Doris; Claiborne, Christopher; Plancher, Jean-Marc; Cuartas, Isabel; Seoane, Joan; Burgess, Laurence E.; Abraham, Robert T.; Weinstein, David S.; Simon, Gabriel M.; Kinsella, Todd M.
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Chemoproteomic-enabled discovery of VVD-214, a synthetic lethal allosteric inhibitor of WRN helicase
err2024-04-05
err1
PREAI
errKikuchi, Shota; Pettazzoni, Piergiorgio; Baltgalvis, Kristen A.; Lamb, Kelsey N.; Symons, Kent T.; Wu, Chu-Chiao; Hoffman, Melissa A.; Snead, Aaron N.; Song, Xiaodan; Glaza, Thomas; Green, Jason C.; Rogness, Donald C.; Lam, Betty; Rodriguez-Aguirre, Maria E.; Woody, David R.; Eissler, Christie L.; Rodiles, Socorro; Negron, Seth M.; Bernard, Steffen M.; Tran, Eileen; Pollock, Jonathan; Tabatabaei, Ali; Contreras, Victor; Williams, Heather N.; Pastuszka, Martha K.; Sigler, John J.; Rudolph, Markus G.; Classen, Moritz; Brugger, Doris; Claiborne, Christopher; Plancher, Jean-Marc; Cuartas, Isabel; Seoane, Joan; Burgess, Laurence E.; Abraham, Robert T.; Weinstein, David S.; Simon, Gabriel M.; Patricelli, Matthew P.; Kinsella, Todd M.
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Proteomic Ligandability Maps of Spirocycle Acrylamide Stereoprobes Identify Covalent ERCC3 Degraders
err2024-04-03
err6
PREAI
errLiu, Zhonglin; Remsberg, Jarrett R.; Li, Haoxin; Njomen, Evert; Demeester, Kristen E.; Tao, Yongfeng; Xia, Guoqin; Hayward, Rachel E.; Yoo, Minjin; Nguyen, Tracey; Simon, Gabriel M.; Schreiber, Stuart L.; Melillo, Bruno; Cravatt, Benjamin F.
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Proteomic discovery of chemical probes that perturb protein complexes in human cells
err2023-05-01
err33
errOAAI
errLazear, Michael R.; Remsberg, Jarrett R.; Jaeger, Martin G.; Rothamel, Katherine; Her, Hsuan-lin; DeMeester, Kristen E.; Njomen, Evert; Hogg, Simon J.; Rahman, Jahan; Whitby, Landon R.; Won, Sang Joon; Schafroth, Michael A.; Ogasawara, Daisuke; Yokoyama, Minoru; Lindsey, Garrett L.; Li, Haoxin; Germain, Jason; Barbas, Sabrina; Vaughan, Joan; Hanigan, Thomas W.; Vartabedian, Vincent F.; Reinhardt, Christopher J.; Dix, Melissa M.; Koo, Seong Joo; Heo, Inha; Teijaro, John R.; Simon, Gabriel M.; Ghosh, Brahma; Abdel-Wahab, Omar; Ahn, Kay; Saghatelian, Alan; Melillo, Bruno; Schreiber, Stuart L.; Yeo, Gene W.; Cravatt, Benjamin F.
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Selective inhibitors of JAK1 targeting an isoform-restricted allosteric cysteine (Sepetember, 10.1038/s41589-022-01098-0, 2022)
err2022-09-30
err0
errOAAI
errKavanagh, Madeline E.; Horning, Benjamin D.; Khattri, Roli; Roy, Nilotpal; Lu, Justine P.; Whitby, Landon R.; Ye, Elva; Brannon, Jaclyn C.; Parker, Albert; Chick, Joel M.; Eissler, Christie L.; Wong, Ashley J.; Rodriguez, Joe L.; Rodiles, Socorro; Masuda, Kim; Teijaro, John R.; Simon, Gabriel M.; Patricelli, Matthew P.; Cravatt, Benjamin F.
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Selective inhibitors of JAK1 targeting an isoform-restricted allosteric cysteine
err2022-09-12
err47
errOAAI
errKavanagh, Madeline E.; Horning, Benjamin D.; Khattri, Roli; Roy, Nilotpal; Lu, Justine P.; Whitby, Landon R.; Ye, Elva; Brannon, Jaclyn C.; Parker, Albert; Chick, Joel M.; Eissler, Christie L.; Wong, Ashley P.; Rodriguez, Joe L.; Rodiles, Socorro; Masuda, Kim; Teijaro, John R.; Simon, Gabriel M.; Patricelli, Matthew P.; Cravatt, Benjamin F.
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DCAF11 Supports Targeted Protein Degradation by Electrophilic Proteolysis-Targeting Chimeras
err2021-03-30
err107
errOAAI
errZhang, Xiaoyu; Luukkonen, Lena M.; Eissler, Christie L.; Crowley, Vincent M.; Yamashita, Yu; Schafroth, Michael A.; Kikuchi, Shota; Weinstein, David S.; Symons, Kent T.; Nordin, Brian E.; Rodriguez, Joe L.; Wucherpfennig, Thomas G.; Bauer, Ludwig G.; Dix, Melissa M.; Stamos, Dean; Kinsella, Todd M.; Simon, Gabriel M.; Baltgalvis, Kristen A.; Cravatt, Benjamin F.
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Parallel Murine and Human Plaque Proteomics Reveals Pathways of Plaque Rupture
err2020-09-25
err20
errOAAI
errVaisar, Tomas; Hu, Jie H.; Airhart, Nathan; Fox, Kate; Heinecke, Jay; Nicosia, Roberto F.; Kohler, Ted; Potter, Zachary E.; Simon, Gabriel M.; Dix, Melissa M.; Cravatt, Benjamin F.; Gharib, Sina A.; Dichek, David A.
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ABHD4-dependent developmental anoikis safeguards the embryonic brain
err2020-08-31
err15
errOAAI
errLaszlo, Zsofia I.; Lele, Zsolt; Zoldi, Miklos; Miczan, Vivien; Mogor, Fruzsina; Simon, Gabriel M.; Mackie, Ken; Kacskovics, Imre; Cravatt, Benjamin F.; Katona, Istvan
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Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan
err2019-03-25
err45
errOAAI
errChen, Alice L.; Lum, Kenneth M.; Lara-Gonzalez, Pablo; Ogasawara, Daisuke; Cognetta, Armand B.; To, Alan; Parsons, William H.; Simon, Gabriel M.; Desai, Arshad; Petrascheck, Michael; Bar-Peled, Liron; Cravatt, Benjamin F.
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Monoacylglycerol Lipase Inhibition in Human and Rodent Systems Supports Clinical Evaluation of Endocannabinoid Modulators
err2018-12-01
err23
errOAAI
errClapper, Jason R.; Henry, Cassandra L.; Niphakis, Micah J.; Knize, Anna M.; Coppola, Aundrea R.; Simon, Gabriel M.; Ngo, Nhi; Herbst, Rachel A.; Herbst, Dylan M.; Reed, Alex W.; Cisar, Justin S.; Weber, Olivia D.; Viader, Andreu; Alexander, Jessica P.; Cunningham, Mark L.; Jones, Todd K.; Fraser, Iain P.; Grice, Cheryl A.; Ezekowitz, R. Alan B.; O'Neill, Gary P.; Blankman, Jacqueline L.
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Identification of ABX-1431, a Selective Inhibitor of Monoacylglycerol Lipase and Clinical Candidate for Treatment of Neurological Disorders
err2018-08-01
err109
errOAAI
errCisar, Justin S.; Weber, Olivia D.; Clapper, Jason R.; Blankman, Jacqueline L.; Henry, Cassandra L.; Simon, Gabriel M.; Alexander, Jessica P.; Jones, Todd K.; Ezekowitz, R. Alan B.; O'Neill, Gary P.; Grice, Cheryl A.
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Quantitative Chemical Proteomic Profiling of the in Vivo Targets of Reactive Drug Metabolites
err2017-06-21
err31
errOAAI
errWhitby, Landon R.; Obach, R. Scott; Simon, Gabriel M.; Hayward, Matthew M.; Cravatt, Benjamin F.
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Determining target engagement in living systems
err2013-03-18
err225
errOAAI
errSimon, Gabriel M.; Niphakis, Micah J.; Cravatt, Benjamin F.
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