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L

Lars K. Nielsen

Technical University of Denmark

77H-index
477Paper Count
2.0WCitation Count
Published Papers 201
Publication Date
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Extracellular vesicle depletion improves transient gene expression performance and alters cellular transcriptional responses in CHO cell
errBIOMEDICINE & PHARMACOTHERAPY
IF7.5
err2026-07-07
err0
errOAAI
errMarzia Rahimi; Pol Pérez-Rubio; Juliana Vargas-Gracia; Paul J. Kempen; Lars K. Nielsen; Jesús Lavado-García
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Annotating the pangenome reveals the diversity in the genetic basis for metabolic enzymes
errScience Advances
IF12.5
err2026-07-01
err0
errOAAI
errOmid Ardalani; Patrick V. Phaneuf; Kalpathy J. Krishnan; David Pride; Lars K. Nielsen; Bernhard O. Palsson
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Gas–liquid mass-transfer modeling in industrial-scale bioreactors: A standardized framework and critical assessment
errChemical Engineering Journal Advances
IF7.1
err2025-12-12
err0
errOAAI
errVíctor Puig I. Laborda; Johan Le Nepvou De Carfort; Ulrich Krühne; Krist V. Gernaey; John M. Kavanagh; David F. Fletcher; Lars K. Nielsen
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Rare metabolic gene essentiality is a determinant of microniche adaptation in Eschherichia coli
errPLOS PATHOGENS
IF4.9
err2025-12-08
err0
PREAI
errArdalani, Omid; Phaneuf, Patrick V.; Krishnan, Jayanth; Chauhan, Siddharth M.; Pride, David; Zielinski, Daniel C.; Monk, Jonathan M.; Nielsen, Lars K.; Palsson, Bernhard O.
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Resolving single-cell gene expression by pseudo-temporal integration of transcriptomic and proteomic datasets
errMolecular & Cellular Proteomics
IF5.5
err2025-11-27
err0
errOAAI
errCraig P. Barry; Gert H. Talbo; Aiden Beauglehole; Dmitry Ovchinnikov; Trent Munro; Stephen Mahler; Kym Baker; Lars K. Nielsen; Tim R. Mercer; Esteban Marcellin
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Targeted UDP-glucose ceramide glucosyltransferase stable overexpression induces a metabolic switch improving cell performance at high cell density
errFrontiers in Bioengineering and Biotechnology
IF4.8
err2025-10-13
err0
errOAAI
errMarzia Rahimi; Lars K. Nielsen; Jesús Lavado-García
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Flow-informed clustering of bioreactor volumes to build CFD-based compartment models
errChemical Engineering Science
IF4.3
err2025-09-04
err0
errOAAI
errJohan Le Nepvou De Carfort; Víctor Puig I Laborda; Lars Keld Nielsen; Krist V. Gernaey; Ulrich Krühne
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A Multi-Level Systems Biology Analysis of Aldrin’s Metabolic Effects on Prostate Cancer Cells
errProteomes 2023, Vol. 11, Page 11
IF3.6
err2025-08-22
err0
PREAI
errCarmen Bedia; Nuria Dalmau; Lars K. Nielsen; Romà Tauler; Igor Marín de Mas
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Comparative Genomic Assessment of the Cupriavidus necator Species for One-Carbon Based Biomanufacturing
errMicrobial Biotechnology
IF5.2
err2025-07-25
err0
errOAAI
errMagnus G. Jespersen; Emil Funk Vangsgaard; Mariana Arango Saavedra; Stefano Donati; Lars K. Nielsen
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Mixture design as a tool for improving full-to-empty particle ratios across various GOIs in rAAV production
errGene Therapy
IF4.5
err2025-06-20
err0
errOAAI
errKonstantina Tzimou; Pol Hulsbus-Andreu; Ece Bahar Yildirim; Lars K. Nielsen; Jesús Lavado-García
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Evaluating Apoptotic Gene Efficiency for CHO Culture Performance Using Targeted Integration
errACS SYNTHETIC BIOLOGY
IF3.9
err2025-04-23
err0
errOAAI
errCatalán-Tatjer, D; Ganesan, SK; Martínez-Monje, I; Grav, LM; Lavado-García, J; Nielsen, LK
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errSave
Unsupervised learning bioreactor regimes
errCOMPUTERS & CHEMICAL ENGINEERING
IF3.9
err2025-03-01
err0
errOAAI
errLaborda, Victor Puig, I; Puiman, Lars; Groves, Teddy; Haringa, Cees; Nielsen, Lars Keld
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Unlocking DOE potential by selecting the most appropriate design for rAAV optimization
errMOLECULAR THERAPY
IF12
err2024-12-01
err0
errOAAI
errTzimou, Konstantina; Catalan-Tatjer, David; Nielsen, Lars K.; Lavado-Garcia, Jesus
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Single-Batch Expression of an Experimental Recombinant Snakebite Antivenom Based on an Oligoclonal Mixture of Human Monoclonal Antibodies
errBIOTECHNOLOGY JOURNAL
IF3.1
err2024-10-09
err2
errOAAI
errAdams, Anna C.; Grav, Lise M.; Ahmadi, Shirin; Dahl, Camilla Holst; Ljungars, Anne; Laustsen, Andreas H.; Nielsen, Lars K.
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Pangenome reconstruction of Lactobacillaceae metabolism predicts species-specific metabolic traits
errMSYSTEMS
IF4.6
err2024-07-23
err2
errOAAI
errArdalani, O.; Phaneuf, P. V.; Mohite, O. S.; Nielsen, L. K.; Palsson, B. O.
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Unravelling the essential elements for recombinant adeno-associated virus (rAAV) production in animal cell-based platforms
errBIOTECHNOLOGY ADVANCES
IF12.5
err2024-07-01
err2
errOAAI
errCatalan-Tatjer, David; Tzimou, Konstantina; Nielsen, Lars K.; Lavado-Garcia, Jesus
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errSave
Bayesian Regression Facilitates Quantitative Modeling of Cell Metabolism
errACS SYNTHETIC BIOLOGY
IF3.9
err2024-04-05
err0
errOAAI
errGroves, Teddy; Cowie, Nicholas Luke; Nielsen, Lars Keld
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Adaptive laboratory evolution of Clostridium autoethanogenum to metabolize CO2 and H2 enhances growth rates in chemostat and unravels proteome and metabolome alterations
errMICROBIAL BIOTECHNOLOGY
IF5.2
err2024-04-03
err0
errOAAI
errHeffernan, James; Garcia Gonzalez, R. Axayactl; Mahamkali, Vishnu; McCubbin, Tim; Daygon, Dara; Liu, Lian; Palfreyman, Robin; Harris, Audrey; Koepke, Michael; Valgepea, Kaspar; Nielsen, Lars Keld; Marcellin, Esteban
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Harnessing metabolic plasticity in CHO cells for enhanced perfusion cultivation
errBIOTECHNOLOGY AND BIOENGINEERING
IF3.6
err2023-12-11
err0
errOAAI
errNoebel, Matthias; Barry, Craig; Macdonald, Michael A.; Baker, Kym; Shave, Evan; Mahler, Stephen; Munro, Trent; Martinez, Veronica S.; Nielsen, Lars K.; Marcellin, Esteban
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Synergistic investigation of natural and synthetic C1-trophic microorganisms to foster a circular carbon economy
errNATURE COMMUNICATIONS
IF15.7
err2023-10-21
err6
errOAAI
errOrsi, Enrico; Nikel, Pablo Ivan; Nielsen, Lars Keld; Donati, Stefano
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Research Directions

No research directions
Co-authors
Cooperation Journals
B
Bernhard Ø. Palsson
H-index: 166 · Papers: 1.2K
J
Jens Nielsen
H-index: 161 · Papers: 1.5K
S
Sang Yup Lee
H-index: 137 · Papers: 3.1K
P
Philip Hugenholtz
H-index: 133 · Papers: 875
J
John S. Mattick
H-index: 124 · Papers: 490
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