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Lee M. Graves

University of North Carolina

62H-index
375Paper Count
1.1WCitation Count
Published Papers 120
Publication Date
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Small molecule activators of the mitochondrial protease ClpP induce senescence in triple-negative breast cancer cells and sensitize cells to the Bcl-2 inhibitor venetoclax
errCell Death & Disease
IF9.6
err2026-06-29
err0
errOAAI
errSabrina C. D. Daglish; Owen G. Canterbury; Paul R. Graves; Sarah A. Carter; Sydney M. Beese; Brandon L. Mouery; Maggie A. Hynek; Elizabeth C. Moorman; Andrei J. Mistreanu; Aadra P. Bhatt; Nestor Tellez; Mitchell T. Butler; Lucas J. Aponte-Collazo; Emily M. J. Fennell; Laura E. Herring; Scott Lyons; C. Allie Mills; Hani Ashamalla; Edwin J. Iwanowicz; John P. Morris IV; James E. Bear; Yoshimi Endo Greer; Stanley Lipkowitz; Lee M. Graves
errShare
errSave
Utilizing ClpP Activators to Induce Senescence in Triple-Negative Breast Cancer and Identify Senolytics for Senescent Cancer Cells
errJournal of Pharmacology and Experimental Therapeutics
IF3.8
err2026-05-01
err0
PREAI
errDaglish, Sabrina; Canterbury, Owen G.; Moorman, Elizabeth; Graves, Paul R.; Hardy, Brian; Pearce, Kenneth H.; Graves, Lee M.
errShare
errSave
Defining the MYC-regulated transcriptome and kinome that support KRAS- and ERK-dependent growth of pancreatic cancer
errSCIENCE SIGNALING
IF6.6
err2025-09-30
err0
PREAI
errHibshman, Priya S.; Stalnecker, Clint A.; Klomp, Jeffrey A.; Drizyte-Miller, Kristina; Klomp, Jennifer E.; Edwards, A. Cole; Pita, Lily M.; Hodge, Richard G.; Diehl, J. Nathaniel; Mouery, Ryan D.; Mouery, Brandon L.; Snare, Kayla R.; Waters, Andrew M.; Peng, Sen; Barker, Natalie K.; Pierobon, Mariaelena; Rashid, Naim U.; Tran, Nhan L.; Herring, Laura A.; Graves, Lee M.; Petricoin, Emanuel F.; Bryant, Kirsten L.; Cox, Adrienne D.; Der, Channing J.
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errSave
Multi-omics signature of healthy versus unhealthy lifestyles reveals associations with diseases
errHuman Genomics
IF4.3
err2025-09-01
err0
errOAAI
errGrace Fu; Blake R. Rushing; Lee Graves; David C. Nieman; Matteo Pellegrini; Matthew Soldano; Michael J. Thompson; Camila A. Sakaguchi; Wimal Pathmasiri; Susan J. Sumner
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errSave
Dose Optimization of ClpP Agonists Using an In Vitro Microfluidic Perfusion Platform and In Silico Pharmacokinetic-Pharmacodynamic Modeling
erraaps journal
IF0
err2025-06-13
err0
PREAI
errRonald W. Bucher; Lee M. Graves; Derek W. Bartlett
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errSave
Chemoproteomic Profiling of C. albicans for Characterization of Antifungal Kinase Inhibitors
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2025-03-20
err0
PREAI
errShirley, David J.; Nandakumar, Meganathan; Cabrera, Aurora; Yiu, Bonnie; Puumala, Emily; Liu, Zhongle; Robbins, Nicole; Whitesell, Luke; Smith, Jeffrey L.; Lyons, Scott; Mordant, Angie L.; Herring, Laura E.; Graves, Lee M.; Counago, Rafael M.; Drewry, David H.; Cowen, Leah E.
errShare
errSave
TARGETING MITOCHONDRIAL PROTEASE IN DIFFUSE GLIOMAS
errNEURO-ONCOLOGY
IF13.4
err2024-11-11
err0
PREAI
errKim, Olga; Sergi, Zach; Yu, Guangyang; Li, Qi; Lu, Peng; Hsia, Ru-Ching; Robey, Robert; Chari, Raj; Wang, Herui; Tran, Bao; Andresson, Thorkell; Gottesman, Michael; Liu, Zhenggang; Graves, Lee; Iwanowicz, Edwin; Wu, Jing
errShare
errSave
TR-107, an Agonist of Caseinolytic Peptidase Proteolytic Subunit, Disrupts Mitochondrial Metabolism and Inhibits the Growth of Human Colorectal Cancer Cells
errMOLECULAR CANCER THERAPEUTICS
IF5.5
err2024-09-05
err2
PREAI
errGiarrizzo, Michael; Lacomb, Joseph F.; Patel, Hetvi R.; Reddy, Rohan G.; Haley, John D.; Graves, Lee M.; Iwanowicz, Edwin J.; Bialkowska, Agnieszka B.
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errSave
Small Molecule ClpP-Agonists Block Mitochondrial GRSF1 Entry by Degrading Import Machinery
errJOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
IF3.8
err2024-06-01
err0
PREAI
errMistreanu, Andrei; Canterbury, Owen G.; Fennell, Emily M.; Daglish, Sabrina C.; Graves, Paul R.; Graves, Lee M.
errShare
errSave
TR-107 and erastin produce synergistic inhibition of colorectal cancer cell viability in vitro
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errGiarrizzo, Michael; LaComb, Joseph F.; Patel, Hetvi R.; Bialkowska, Agnieszka B.; Reddy, Rohan; Graves, Lee M.; Iwanowicz, Edwin J.
errShare
errSave
Open Source Antibiotics: Simple Diarylimidazoles Are Potent against Methicillin-Resistant Staphylococcus aureus
errACS INFECTIOUS DISEASES
IF3.8
err2023-11-22
err2
errOAAI
errKlug, Dana M.; Tse, Edwin G.; Silva, Daniel G.; Cao, Yafeng; Charman, Susan A.; Chauhan, Jyoti; Crighton, Elly; Dichiara, Maria; Drake, Chris; Drewry, David; da Silva Emery, Flavio; Ferrins, Lori; Graves, Lee; Hopkins, Emily; Kresina, Thomas A. C.; Lorente-Macias, Alvaro; Perry, Benjamin; Phipps, Richard; Quiroga, Bruno; Quotadamo, Antonio; Sabatino, Giada N.; Sama, Anthony; Schatzlein, Andreas; Simpson, Quillon J.; Steele, Jonathan; Shanu-Wilson, Julia; Sjo, Peter; Stapleton, Paul; Swain, Christopher J.; Vaideanu, Alexandra; Xie, Huanxu; Zuercher, William; Todd, Matthew H.
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errSave
Investigation of the Host Kinome Response to Coronavirus Infection Reveals PI3K/mTOR Inhibitors as Betacoronavirus Antivirals
errJOURNAL OF PROTEOME RESEARCH
IF3.6
err2023-08-27
err8
PREAI
errFritch, Ethan J.; Mordant, Angie L.; Gilbert, Thomas S. K.; Wells, Carrow I.; Yang, Xuan; Barker, Natalie K.; Madden, Emily A.; Dinnon, Kenneth H., III; Hou, Yixuan J.; Tse, Longping V.; Castillo, Izabella N.; Sims, Amy C.; Moorman, Nathaniel J.; Lakshmanane, Premkumar; Willson, Timothy M.; Herring, Laura E.; Graves, Lee M.; Baric, Ralph S.
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errSave
A LIVING EX VIVO PLATFORM FOR FUNCTIONAL, PERSONALIZED PEDIATRIC BRAIN CANCER DIAGNOSIS
errNEURO-ONCOLOGY
IF13.4
err2023-06-12
err0
errOAAI
errMann, Breanna; Zhang, Xiaopei; Bell, Noah; Adefolaju, Adebimpe; Thang, Morrent; Dasari, Rajaneekar; Kanchi, Krishna; Valdivia, Alain; Yang, Yang; Quinsey, Carolyn; Rauf, Yasmeen; Kram, David; Cassidy, Noah; Viziri, Cyrus; Corcoran, David L.; Rego, Stephan; Jiang, Yuchao; Graves, Lee M.; Dunn, Denise; Floyd, Scott; Baldwin, Albert; Hingtgen, Shawn; Satterlee, Andrew
errShare
errSave
A living ex vivo platform for functional, personalized brain cancer diagnosis
errCELL REPORTS MEDICINE
IF10.6
err2023-06-01
err5
errOAAI
errMann, Breanna; Zhang, Xiaopei; Bell, Noah; Adefolaju, Adebimpe; Thang, Morrent; Dasari, Rajaneekar; Kanchi, Krishna; Valdivia, Alain; Yang, Yang; Buckley, Andrew; Lettry, Vivien; Quinsey, Carolyn; Rauf, Yasmeen; Kram, David; Cassidy, Noah; Vaziri, Cyrus; Corcoran, David L.; Rego, Stephen; Jiang, Yuchao; Graves, Lee M.; Dunn, Denise; Floyd, Scott; Baldwin, Albert; Hingtgen, Shawn; Satterlee, Andrew B.
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errSave
Targeting Mitochondrial DNA Transcription by POLRMT Inhibition or Depletion as a Potential Strategy for Cancer Treatment
errBIOMEDICINES
IF3.9
err2023-05-31
err3
errOAAI
errDaglish, Sabrina C. D.; Fennell, Emily M. J.; Graves, Lee M.
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errSave
Determination of KRAS- and ERK-regulated phosphoproteomes in KRAS-mutant cancers
errMOLECULAR CANCER RESEARCH
IF4.7
err2023-05-01
err0
PREAI
errKlomp, Jennifer E.; Klomp, Jeff A.; Diehl, Nathaniel J.; Edwards, Cole A.; Drizyte-Miller, Kristina; Hibshman, Priya S.; Yang, Runying; Morales, Alexis J.; Taylor, Khalilah E.; Pierobon, Mariaelena; Petricoin, Emanuel F., III; Jared, Johnson L.; Huntsman, Emily M.; Yaron, Tomer M.; Vaha-Koskela, Markus; Herring, Laura E.; Prevatte, Alex W.; Barker, Natalie K.; Graves, Lee M.; Krister, Wennerberg; Cantley, Lewis C.; Christensen, James G.; Cox, Adrienne D.; Der, Channing J.; Stalnecker, Clint A.
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errSave
Potent human ClpP protease agonists with anticancer properties bind the enzyme with improved structural complementarity and alter the mitochondrial N-terminome
errCANCER RESEARCH
IF16.6
err2023-04-04
err0
PREAI
errMabanglo, Mark F.; Wong, Keith S.; Barghash, Marim M.; Graves, Lee M.; Iwanowicz, Edwin J.; Houry, Walid A.
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errSave
Phosphorylation of threonine 61 by cyclin A/Cdk1 triggers degradation of stem-loop binding protein at the end of S phase
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err77
errOAAI
errKoseoglu, M. Murat; Graves, Lee M.; Marzluff, William F.
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errSave
Regulation of the Rho Family Small GTPase Wrch-1/RhoU by C-Terminal Tyrosine Phosphorylation Requires Src
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-20
err27
errOAAI
errAlan, Jamie K.; Berzat, Anastacia C.; Dewar, Brian J.; Graves, Lee M.; Cox, Adrienne D.
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errSave
Multi-omic profiling reveals the ataxia protein sacsin is required for integrin trafficking and synaptic organization
errCELL REPORTS
IF6.9
err2022-11-01
err8
errOAAI
errRomano, Lisa E. L.; Aw, Wen Yih; Hixson, Kathryn M.; Novoselova, Tatiana V.; Havener, Tammy M.; Howell, Stefanie; Taylor-Blake, Bonnie; Hall, Charlotte L.; Xing, Lei; Beri, Josh; Nethisinghe, Suran; Perna, Laura; Hatimy, Abubakar; Altadonna, Ginevra Chioccioli; Graves, Lee M.; Herring, Laura E.; Hickey, Anthony J.; Thalassions, Konstantinos; Chapple, J. Paul; Wolter, Justin M.
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errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
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Lewis C. Cantley
H-index: 214 · Papers: 1.4K
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Charles M. Perou
H-index: 193 · Papers: 2.0K
D
David A. Brenner
H-index: 150 · Papers: 779
W
William C. Hahn
H-index: 147 · Papers: 1.1K
R
Ralph S. Baric
H-index: 147 · Papers: 1.1K
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