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Aijun Shen

Lingang Laboratory
H-index:24
Citation Count:1,975
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Design, Synthesis, and Anti-inflammatory Activity Evaluation for Hydrazide-Based HDAC6 Targeted Protein Degraders

基于酰肼的HDAC6靶向蛋白质降解剂的设计、合成及抗炎活性评价

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2025-11-010
PRE
Sun, Simin; Yue, Kairui; Liu, Enqiang; Sheng, Danmei; Chen, Yuxin; Li, Tianqi; Shen, Aijun; Jia, Geng; Jiang, Yuqi; Li, Xiaoyang
An mRNA Vaccine for Herpes Zoster and Its Efficacy Evaluation in Naïve/Primed Murine Models

带状疱疹mRNA疫苗及其在初免/加强免疫小鼠模型中的疗效评价

VACCINES
IF3.4
2025-03-190
OA
Jiang, Linglei; Zhou, Wenshuo; Liu, Fei; Li, Wenhui; Xu, Yan; Liang, Zhenwei; Cao, Man; Hou, Li; Liu, Pengxuan; Wu, Feifei; Shen, Aijun; Zhang, Zhiyuan; Zhang, Xiaodi; Zhao, Haibo; Pan, Xinping; Wu, Tengjie; Jia, William; Zhang, Yuntao
Discovery, SAR Study of GST Inhibitors from a Novel Quinazolin-4(1H)-one Focused DNA-Encoded Library
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2023-08-085
PRE
Wen, Xin; Zhang, Minmin; Duan, Zhiqiang; Suo, Yanrui; Lu, Weiwei; Jin, Rui; Mu, Baiyang; Li, Kaige; Zhang, Xu; Meng, Linghua; Hong, Yu; Wang, Xingyu; Hu, Hangchen; Zhu, Jian; Song, Weixiao; Shen, Aijun; Lu, Xiaojie
Discovery of (S)-N-(2-Amino-4-fluorophenyl)-4-(1-(3-(4-((dimethylamino)methyl)phenyl)-6-oxopyridazin-1(6H)-yl)ethyl)benzamide as Potent Class I Selective HDAC Inhibitor for Oral Anticancer Drug Candidate
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2023-05-158
PRE
Li, Daqiang; Zhang, Zhuo; Li, Yalei; Wang, Xinyi; Zhong, Hanyue; Yang, Huajie; Xi, Yong; Liu, Hongchun; Shen, Aijun; Hu, Youhong
Adjusted degradation of BRD4 S and BRD4 L based on fine structural modifications of the pyrrolopyridone scaffold

基于吡咯并吡啶酮支架的精细结构修饰，调整了BRD4 S和BRD4 L的降解

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2022-06-0110
PRE
Chen, Jingjing; He, Huixin; Wei, Aihuan; Li, Yalei; Cheng, Gang; Qin, Hui; Zhong, Hanyue; Liu, Hongchun; Geng, Meiyu; Shen, Aijun; Hu, Youhong
Single-cell lipidomics with high structural specificity by mass spectrometry
NATURE COMMUNICATIONS
IF15.7
2021-05-17114
OAAI
Li, Zishuai; Cheng, Simin; Lin, Qiaohong; Cao, Wenbo; Yang, Jing; Zhang, Minmin; Shen, Aijun; Zhang, Wenpeng; Xia, Yu; Ma, Xiaoxiao; Ouyang, Zheng
Discovery of selective HDAC/BRD4 dual inhibitors as epigenetic probes
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2021-01-0142
PREAI
Chen, Jingjing; Li, Yalei; Zhang, Jie; Zhang, Minmin; Wei, Aihuan; Liu, Hongchun; Xie, Zhicheng; Ren, Wenming; Duan, Wenwen; Zhang, Zhuo; Shen, Aijun; Hu, Youhong
Tumor cells suppress radiation-induced immunity by hijacking caspase 9 signaling (vol 21, pg 546, 2020)
NATURE IMMUNOLOGY
IF27.6
2020-09-161
OAAI
Han, Chuanhui; Liu, Zhida; Zhang, Yunjia; Shen, Aijun; Dong, Chunbo; Zhang, Anli; Moore, Casey; Ren, Zhenhua; Lu, Changzheng; Cao, Xuezhi; Zhang, Chun-Li; Qiao, Jian; Fu, Yang-Xin
Targeting tumors with IL-21 reshapes the tumor microenvironment by proliferating PD-1intTim-3-CD8+ T cells
JCI INSIGHT
IF6.1
2020-04-0944
OA
Deng, Sisi; Sun, Zhichen; Qiao, Jian; Liang, Yong; Liu, Longchao; Dong, Chunbo; Shen, Aijun; Wang, Yang; Tang, Hong; Fu, Yang-Xin; Peng, Hua
Tumor cells suppress radiation-induced immunity by hijacking caspase 9 signaling

肿瘤细胞通过劫持caspase 9信号抑制辐射诱导的免疫

NATURE IMMUNOLOGY
IF27.6
2020-03-30100
PREAI
Han, Chuanhui; Liu, Zhida; Zhang, Yunjia; Shen, Aijun; Dong, Chunbo; Zhang, Anli; Moore, Casey; Ren, Zhenhua; Lu, Changzheng; Cao, Xuezhi; Zhang, Chun-Li; Qiao, Jian; Fu, Yang-Xin
Targeting Hsp90 with FS-108 circumvents gefitinib resistance in EGFR mutant non-small cell lung cancer cells (vol 37, pg 1587, 2020)
ACTA PHARMACOLOGICA SINICA
IF8.4
2020-02-213
OAAI
Wang, Yue-qin; Shen, Ai-jun; Sun, Jing-ya; Wang, Xin; Liu, Hong-chun; Zhang, Min-min; Chen, Dan-qi; Xiong, Bing; Shen, Jing-kang; Geng, Mei-yu; Zheng, Min; Ding, Jian
A novel long non-coding RNA-ARA: Adriamycin resistance-associated (vol 87, pg 254, 2014)
BIOCHEMICAL PHARMACOLOGY
IF5.6
2020-02-010
PREAI
Jiang, Min; Huang, Ou; Xie, Zuoquan; Wu, Shuchao; Zhang, Xi; Shen, Aijun; Liu, Hongchun; Chen, Xiaosong; Wu, Jiayi; Lou, Ying; Mao, Yan; Sun, Kan; Hu, Shudong; Geng, Meiyu; Shen, Kunwei
Hypofractionated EGFR tyrosine kinase inhibitor limits tumor relapse through triggering innate and adaptive immunity
SCIENCE IMMUNOLOGY
IF16.3
2019-08-0229
PREAI
Liu, Zhida; Han, Chuanhui; Dong, Chunbo; Shen, Aijun; Hsu, Eric; Ren, Zhenhua; Lu, Changzheng; Liu, Longchao; Zhang, Anli; Timmerman, Casey; Pu, Yang; Wang, Yang; Chen, Mingyi; Qiao, Jian; Fu, Yang-Xin
NQO1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance
NATURE COMMUNICATIONS
IF15.7
2019-07-1964
OAAI
Li, Xiaoguang; Liu, Zhida; Zhang, Anli; Han, Chuanhui; Shen, Aijun; Jiang, Lingxiang; Boothman, David A.; Qiao, Jian; Wang, Yang; Huang, Xiumei; Fu, Yang-Xin
Notch 1/2/3 mutation as a potential biomarker for immunotherapy in smokers with non-small cell lung cancer via increasing tumor mutational burden
CANCER RESEARCH
IF16.6
2019-07-010
PRE
Hong, Xiaohua; Shen, Aijun; Xu, Yu; Li, Chengcheng; Wang, Guoqiang; Liu, Li; Qi, Chuang
The Secretome Engages STAT3 to Favor a Cytokine-rich Microenvironment in Mediating Acquired Resistance to FGFR Inhibitors
MOLECULAR CANCER THERAPEUTICS
IF5.5
2019-03-0111
OAAI
Wang, Xinyi; Ai, Jing; Liu, Hongyan; Peng, Xia; Chen, Hui; Chen, Yi; Su, Yi; Shen, Aijun; Huang, Xun; Ding, Jian; Geng, Meiyu
EGFR tyrosine kinase inhibitor limits tumor relapse through enhancing anti-tumor T cell responses
CANCER RESEARCH
IF16.6
2018-07-010
PRE
Liu, Zhida; Han, Chuanhui; Shen, Aijun; Dong, Chunbo; Qiao, Jian; Fu, Yang-Xin
Design, synthesis and pharmacological evaluation of ALK and Hsp90 dual inhibitors bearing resorcinol and 2,4-diaminopyrimidine motifs

带有间苯二酚和2，4-二氨基嘧啶基序的ALK和Hsp90双重抑制剂的设计，合成和药理评价

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2018-05-0129
PREAI
Geng, Kaijun; Liu, Hongchun; Song, Zilan; Zhang, Chi; Zhang, Minmin; Yang, Hong; Cao, Jingchen; Geng, Meiyu; Shen, Aijun; Zhang, Ao
Identification and Therapeutic Intervention of Coactivated Anaplastic Lymphoma Kinase, Fibroblast Growth Factor Receptor 2, and Ephrin Type-A Receptor 5 Kinases in Hepatocellular Carcinoma
HEPATOLOGY
IF15.8
2018-03-2415
OAAI
Wang, Xin; Zhang, Minmin; Ping, Fangfang; Liu, Hongchun; Sun, Jingya; Wang, Yueqin; Shen, Aijun; Ding, Jian; Geng, Meiyu
A tightly controlled Src-YAP signaling axis determines therapeutic response to dasatinib in renal cell carcinoma
THERANOSTICS
IF13.3
2018-01-0138
OAAI
Sun, Jingya; Wang, Xin; Tang, Boyun; Liu, Hongchun; Zhang, Minmin; Wang, Yueqin; Ping, Fangfang; Ding, Jian; Shen, Aijun; Geng, Meiyu

Research Directions

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耿
耿美玉
H-index:56Papers:546Citations:1.2万
H
Hong‐Chun Liu
H-index:30Papers:178Citations:2,770
丁
丁健
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孙
孙静亚
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J
Jian Qiao
H-index:30Papers:77Citations:4,841
Z
Zhida Liu
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C
Chunbo Dong
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黄敏 cover
黄敏
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韩传辉 cover
韩传辉
H-index:17Papers:51Citations:1,938
M
Minmin Zhang
H-index:18Papers:78Citations:796