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A TRAILR2/CDH3 bispecific antibody demonstrates selective apoptosis and tumor regression in CDH3-positive pancreatic cancer Jung, Peter; Glaser, Stefan P.; Han, Jing; Popa, Alexandra; Pisarsky, Laura; Feng, Ningping; Geyer, Antonia; Haderk, Franziska; Alpar, Donat; Bristow, Christopher; Schmittner, Susanne; Traexler, Paula-Elena; Mahendra, Mikhila; Poehn, Birgit; Gandhi, Poojabahen; Fiorelli, Roberto; Awate, Sanket; Budano, Nicole; Martin, Florian; Albrecht, Christoph; Drobits-Handl, Barbara; Anand, Sathanandam S.; Kasturirangan, Srinath; Trapani, Francesca; Schweifer, Norbert; Marszalek, Joseph R.; Tontsch-Grunt, Ulrike; Pearson, Mark; Heffernan, Timothy P.; Kraut, Norbert; Vellano, Christopher P.; Garcia-Martinez, Juan Manuel Share Save
A TRAILR2/CDH3 bispecific antibody demonstrates selective apoptosis and tumor regression in CDH3-positive pancreatic cancer Jung, P.; Glaser, S. P.; Han, J.; Popa, A.; Pisarsky, L.; Feng, N.; Geyer, A.; Haderk, F.; Alpar, D.; Bristow, C.; Drobits-Handl, B.; Kasturirangan, S.; Trapani, F.; Marszalek, J. R.; Tontsch-Grunt, U.; Pearson, M.; Heffernan, T. P.; Kraut, N.; Vellano, C. P.; Garcia-Martinez, J. M. Share Save
Molecular basis of GDF15 induction and suppression by drugs in cardiomyocytes and cancer cells toward precision medicine Winter, Lisa-Maria; Reinhardt, Diana; Schatter, Ariane; Tissen, Vivien; Wiora, Heike; Gerlach, Daniel; Tontsch-Grunt, Ulrike; Colbatzky, Florian; Stierstorfer, Birgit; Yun, Seong-Wook Share Save
An orally-available monovalent SMAC mimetic compound as a broad-spectrum antiviral Mei, Miao; Impagnatiello, Maria-Antonietta; Jiao, Jun; Reiser, Ulrich; Tontsch-Grunt, Ulrike; Zhang, Ju; Nicklin, Paul; Yu, Bingke; Wang, Yu; He, Yuan; Tan, Xu Share Save
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Targeting IAP in cancer: BI 891065 a potent small molecule SMAC mimetic that synergizes with immune checkpoint inhibition Aichinger, Martin; Santoro, Valeria; Slavic-Obradovic, Ksenija; Ruhland, Stefanie; Wernitznig, Andreas; Neudolt, Andrea; Schaefer, Markus; Kallenda, Sabine; Zach, Daniel; Olt, Sabine; Salomon, Carina; Rieser, Sarah; Weissenboeck, Martina; Ebner, Florian; Schlattl, Andreas; De Almeida, Melanie Talata; Langlois, Rebecca; Sykora, Martina; Reschke, Markus; Zichner, Thomas; Gerlach, Daniel; Jude, Julian; Fellner, Michaela; Scharn, Dirk; Kraut, Norbert; Moll, Juergen; Zuber, Johannes; Carotta, Sebastian; Impagnatiello, Maria Antonietta; Tontsch-Grunt, Ulrike Share Save
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Synergistic activity of BET inhibitor BI 894999 with PLK inhibitor volasertib in AML in vitro and in vivo Tontsch-Grunt, Ulrike; Rudolph, Dorothea; Waizenegger, Irene; Baum, Anke; Gerlach, Daniel; Engelhardt, Harald; Wurm, Melanie; Savarese, Fabio; Schweifer, Norbert; Kraut, Norbert Share Save
Triple Angiokinase Inhibitor Nintedanib Directly Inhibits Tumor Cell Growth and Induces Tumor Shrinkage via Blocking Oncogenic Receptor Tyrosine Kinases Hilberg, Frank; Tontsch-Grunt, Ulrike; Baum, Anke; Le, Anh T.; Doebele, Robert C.; Lieb, Simone; Gianni, Davide; Voss, Tilman; Garin-Chesa, Pilar; Haslinger, Christian; Kraut, Norbert Share Save
The novel BET bromodomain inhibitor BI 894999 represses super-enhancer-associated transcription and synergizes with CDK9 inhibition in AML Gerlach, Daniel; Tontsch-Grunt, Ulrike; Baum, Anke; Popow, Johannes; Scharn, Dirk; Hofmann, Marco H.; Engelhardt, Harald; Kaya, Onur; Beck, Janina; Schweifer, Norbert; Gerstberger, Thomas; Zuber, Johannes; Savarese, Fabio; Kraut, Norbert Share Save
Combination of the novel BET inhibitor BI 894999 with CDK9 inhibition suggests a promising regimen for the treatment of AML Tontsch-Grunt, U.; Savarese, F.; Baum, A.; Scharn, D.; Gerlach, D.; Hofmann, M. H.; Popow, J.; Schweifer, N.; Engelhardt, H.; Musa, H.; Lee, C. P.; Munzert, G. M.; Kraut, N. Share Save
Pharmacological Profile of BI 847325, an Orally Bioavailable, ATP-Competitive Inhibitor of MEK and Aurora Kinases Sini, Patrizia; Guertler, Ulrich; Zahn, Stephan K.; Baumann, Christoph; Rudolph, Dorothea; Baumgartinger, Rosa; Strauss, Eva; Haslinger, Christian; Tontsch-Grunt, Ulrike; Waizenegger, Irene C.; Solca, Flavio; Bader, Gerd; Zoephel, Andreas; Treu, Matthias; Reiser, Ulrich; Garin-Chesa, Pilar; Boehmelt, Guido; Kraut, Norbert; Quant, Jens; Adolf, Guenther R. Share Save
Efficacy and Mechanism of Action of Volasertib, a Potent and Selective Inhibitor of Polo-Like Kinases, in Preclinical Models of Acute Myeloid Leukemia Rudolph, Dorothea; Impagnatiello, Maria Antonietta; Blaukopf, Claudia; Sommer, Christoph; Gerlich, Daniel W.; Roth, Mareike; Tontsch-Grunt, Ulrike; Wernitznig, Andreas; Savarese, Fabio; Hofmann, Marco H.; Albrecht, Christoph; Geiselmann, Lena; Reschke, Markus; Garin-Chesa, Pilar; Zuber, Johannes; Moll, Juergen; Adolf, Guenther R.; Kraut, Norbert Share Save
Pharmacological characterization of BI 847325, a dual inhibitor of MEK and Aurora kinases Sini, Patrizia; Guertler, Ulrich; Zahn, Stephan K.; Boehmelt, Guido; Garin-Chesa, Pilar; Kraut, Robert; Rudolph, Dorothea; Solca, Flavio; Tontsch-Grunt, Ulrike; Waizenegger, Irene C.; Adolf, Guenther R. Share Save
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Design, Synthesis, and Evaluation of Indolinones as Triple Angiokinase Inhibitors and the Discovery of a Highly Specific 6-Methoxycarbonyl-Substituted Indolinone (BIBF 1120) Roth, Gerald J.; Heckel, Armin; Colbatzky, Florian; Handschuh, Sandra; Kley, Joerg; Lehmann-Lintz, Thorsten; Lotz, Ralf; Tontsch-Grunt, Ulrike; Walter, Rainer; Hilberg, Frank Share Save
BIBF 1120: Triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy Hilberg, Frank; Roth, Gerald J.; Krssak, Martin; Kautschitsch, Susanna; Sommergruber, Wolfgang; Tontsch-Grunt, Ulrike; Garin-Chesa, Pilar; Bader, Gerd; Zoephel, Andreas; Quant, Jens; Heckel, Armin; Rettig, Wolfgang J. Share Save
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