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SaveShare Save Share Save Discovery of INCB126503 as a Potent and Selective FGFR2/3 Inhibitor
Nguyen, MH; Wang, AL; Truong, L; Zhang, K; Ye, HF; Zhao, P; Horsey, A; Frascella, M; Leffet, L; Federowicz, K; Behshad, E; Witten, MR; Qi, C; Xu, Y; Jalluri, R; Harris, JJ; Hess, R; Sayers, B; Lin, LP; Yeleswaram, S; Zhang, GF; Kim, S; Covington, M; Diamond, S; Yao, WQ; Vechorkin, O Share Save Share Save Share Save Discovery of Orally Bioavailable FGFR2/FGFR3 Dual Inhibitors via Structure-Guided Scaffold Repurposing ApproachNguyen, Minh H.; Ye, Hai -Fen; Xu, Yao; Truong, Lisa; Horsey, April; Zhao, Peng; Styduhar, Evan D.; Frascella, Michelle; Leffet, Lynn; Federowicz, Kelly; Behshad, Elham; Wang, Anlai; Zhang, Ke; Witten, Michael R.; Qi, Chao; Jalluri, Ravi; Lai, Cheng-Tsung; Atasoylu, Onur; Harris, Jennifer J.; Hess, Rodrigo; Lin, Luping; Zhang, Guofeng; Covington, Maryanne; Diamond, Sharon; Yao, Wenqing; Vechorkin, Oleg Share Save Discovery of Potent and Selective Inhibitors of Wild-Type and Gatekeeper Mutant Fibroblast Growth Factor Receptor (FGFR) 2/3Shvartsbart, Artem; Roach, Jeremy J.; Witten, Michael R.; Koblish, Holly; Harris, Jennifer J.; Covington, Maryanne; Hess, Rodrigo; Lin, Luping; Frascella, Michelle; Truong, Lisa; Leffet, Lynn; Conlen, Patricia; Beshad, Elham; Klabe, Ron; Katiyar, Kamna; Kaldon, Laura; Young-Sciame, Ruth; He, Xin; Petusky, Susan; Chen, Kwang-Jong; Horsey, April; Lei, Hsiang-Ting; Epling, Leslie B.; Deller, Marc C.; Vechorkin, Oleg; Yao, Wenqing Share Save Discovery of Novel Pyrazolopyrimidines as Potent, Selective, and Orally Bioavailable Inhibitors of ALK2Nguyen, Minh H.; Atasoylu, Onur; Wu, Liangxing; Kapilashrami, Kanishk; Pusey, Michelle; Gallagher, Karen; Lai, Cheng-Tsung; Zhao, Peng; Barbosa, Joseph; Liu, Kai; He, Chunhong; Zhang, Colin; Styduhar, Evan D.; Witten, Michael R.; Chen, Yaoyu; Lin, Luping; Yang, Yan-ou; Covington, Maryanne; Diamond, Sharon; Yeleswaram, Swamy; Yao, Wenqing Share Save DENV NS1 and MMP-9 cooperate to induce vascular leakage by altering endothelial cell adhesion and tight junctionPan, Pan; Li, Geng; Shen, Miaomiao; Yu, Zhenyang; Ge, Weiwei; Lao, Zizhao; Fan, Yaohua; Chen, Keli; Ding, Zhihao; Wang, Wenbiao; Wan, Pin; Shereen, Muhammad Adnan; Luo, Zhen; Chen, Xulin; Zhang, Qiwei; Lin, Luping; Wu, Jianguo Share Save The role of HPK1 in the regulation of T cell function and anti-tumor immune activityChen, Yaoyu; Rios-Doria, Jonathan; Pusey, Michelle; Lasky, Kerri; Ye, Min; Thekkat, Pramod; Gallagher, Karen; Stump, Kristine; Conlen, Patricia; Gardiner, Christine; Wang, Hui; Sokolsky, Alexander; Rupar, Mark; Lin, Luping; Behshad, Elham; Covington, Maryanne; Koblish, Holly; Vechorkin, Oleg; Yao, Wenqing; Kim, Sunkyu; Chen, Yingnan Share Save Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and CancersChatterjee, Nilanjana; Pazarentzos, Evangelos; Mayekar, Manasi K.; Gui, Philippe; Allegakoen, David V.; Hrustanovic, Gorjan; Olivas, Victor; Lin, Luping; Verschueren, Erik; Johnson, Jeffrey R.; Hofree, Matan; Yan, Jenny J.; Newton, Billy W.; Dollen, John V.; Earnshaw, Charles H.; Flanagan, Jennifer; Chan, Elton; Asthana, Saurabh; Ideker, Trey; Wu, Wei; Suzuki, Junji; Barad, Benjamin A.; Kirichok, Yuriy; Fraser, James S.; Weiss, William A.; Krogan, Nevan J.; Tulpule, Asmin; Sabnis, Amit J.; Bivona, Trever G. Share Save Novel small-molecule antagonists of the PD-1/PD-L1 axis that mediate cell surface PD-L1 dimerization and internalizationLiu, Phillip C. C.; Wynn, Richard; Wu, Liangxing; Volgina, Alla; Zolotarjova, Nina; Lin, Luping; Thekkat, Pramod; Margulis, Alex; Klabe, Ronald; Yao, Wenqing; Xiao, Kaijiong; Li, Jingwei; He, Xin; Rupar, Mark; Chang, Hong; Waeltz, Paul; Li, Yanlong; Scherle, Peggy; Huber, Reid; Hollis, Gregory Share Save Share Save Activity of the selective FGFR 1, 2 and 3 inhibitor INCB054828 in genetically-defined models of triple-negative breast cancerLiu, Phillip C. C.; Lehmann, Brian D.; Ruggeri, Bruce; DiMatteo, Darlise; Schafer, Johanna M.; Lu, Jin; Lee, Sang Hyun; Lin, Luping; Burn, Timothy C.; Diamond, Melody; Volgina, Alla; Wu, Liangxing; Hollis, Gregory; Huber, Reid; Pietenpol, Jennifer A.; Scherle, Peggy Share Save Novel computational method for predicting polytherapy switching strategies to overcome tumor heterogeneity and evolutionJonsson, Vanessa D.; Blakely, Collin M.; Lin, Luping; Asthana, Saurabh; Matni, Nikolai; Olivas, Victor; Pazarentzos, Evangelos; Gubens, Matthew A.; Bastian, Boris C.; Taylor, Barry S.; Doyle, John C.; Bivona, Trever G. Share Save Preclinical efficacy of a RAF inhibitor that evades paradoxical MAPK pathway activation in protein kinase BRAF-mutant lung cancerOkimoto, Ross A.; Lin, Luping; Olivas, Victor; Chan, Elton; Markegard, Evan; Rymar, Andrey; Neel, Dana; Chen, Xiao; Hemmati, Golzar; Bollag, Gideon; Bivona, Trever G. Share Save RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK-positive lung cancerHrustanovic, Gorjan; Olivas, Victor; Pazarentzos, Evangelos; Tulpule, Asmin; Asthana, Saurabh; Blakely, Collin M.; Okimoto, Ross A.; Lin, Luping; Neel, Dana S.; Sabnis, Amit; Flanagan, Jennifer; Chan, Elton; Varella-Garcia, Marileila; Aisner, Dara L.; Vaishnavi, Aria; Ou, Sai-Hong I.; Collisson, Eric A.; Ichihara, Eiki; Mack, Philip C.; Lovly, Christine M.; Karachaliou, Niki; Rosell, Rafael; Riess, Jonathan W.; Doebele, Robert C.; Bivona, Trever G. Share Save The Hippo effector YAP promotes resistance to RAF and MEK targeted therapiesLin, Luping; Sabnis, Amit; Chan, Elton; Olivas, Victor; Cade, Lindsay; Pazarentzos, Evangelos; Asthana, Saurabh; Neel, Dana; Yan, Jenny Jiacheng; Lu, Xinyuan; Pham, Luu; Wang, Mingxue; Karachaliou, Niki; Cao, Maria G.; Manzano, Jose L.; Ramirez, Jose L.; Torres, Jose M.; Buttitta, Fiamma; Rudin, Charles M.; Collisson, Eric A.; Algazi, Alain; Robinson, Eric; Osman, Iman; Munoz-Couselo, Eva; Cortes, Javier; Frederick, Dennie T.; Cooper, Zachary A.; McMahon, Martin; Marchetti, Antonio; Rosell, Rafael; Flaherty, Keith T.; Wargo, Jennifer A.; Bivona, Trever G. Share Save NF-κB-Activating Complex Engaged in Response to EGFR Oncogene Inhibition Drives Tumor Cell Survival and Residual Disease in Lung CancerBlakely, Collin M.; Pazarentzos, Evangelos; Olivas, Victor; Asthana, Saurabh; Yan, Jenny Jiacheng; Tan, Irena; Hrustanovic, Gorjan; Chan, Elton; Lin, Luping; Neel, Dana S.; Newton, William; Bobb, Kathryn L.; Fouts, Timothy R.; Meshulam, Jeffrey; Gubens, Matthew A.; Jablons, David M.; Johnson, Jeffrey R.; Bandyopadhyay, Sourav; Krogan, Nevan J.; Bivona, Trever G. Share Save 
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