Not logged in Discovery of long-acting APOC3 siRNA for treating patients with hypertriglyceridemia Prakash, Thazha P.; Mullick, Adam E.; Riney, Stan; Yu, Jinghua; Nikan, Mehran; Quirk, Clare; Crutchfield, Amanda; Damle, Sagar S.; Klein, Stephanie; Swayze, Eric E. Share Save
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Single alkyl phosphonate modification of the siRNA backbone in the seed region enhances specificity and therapeutic profile Nikan, Mehran; Li, Qingfeng; Tanowitz, Michael; Li, Hongda; Damle, Sagar; Annoual, Marie; Galindo-Murillo, Rodrigo; Low, Audrey; Klein, Stephanie; Quirk, Clare; Vasquez, Guillermo; Wan, W. Brad; Watt, Andrew T.; Migawa, Michael T.; Swayze, Eric E.; Prakash, Thazha P. Share Save
Conjugation to a transferrin receptor 1-binding Bicycle peptide enhances ASO and siRNA potency in skeletal and cardiac muscles Ostergaard, Michael E.; Carrer, Michele; Anderson, Brooke A.; Afetian, Megan; Bakooshli, Mohsen A.; Santos, Jinro A.; Klein, Stephanie K.; Capitanio, Juliana; Freestone, Graeme C.; Tanowitz, Michael; Galindo-Murillo, Rodrigo; Gaus, Hans J.; Dwyer, Chrissa A.; Jackson, Michaela; Jafar-nejad, Paymaan; Rigo, Frank; Seth, Punit P.; Gaynor, Katherine U.; Stanway, Steven J.; Urbonas, Liudvikas; St. Denis, Megan A.; Pellegrino, Simone; Bezerra, Gustavo A.; Rigby, Michael; Gowans, Ellen; Van Rietschoten, Katerine; Beswick, Paul; Skynner, Michael J.; Swayze, Eric E. Share Save
Toxicologic Pathology Forum: Opinion on Interpretive Challenges for Procedure-Related Effects Associated With Direct Central Nervous System Delivery of Oligonucleotides to Rodents, Dogs, and Nonhuman Primates Berman-Booty, Lisa D.; Klein, Stephanie K.; Mazur, Curt; Schroeder, Joseph; Korte, Sven; Ludwig, Florian T.; Romeike, Annette; Bolon, Brad; Grieves, Jessica L. Share Save
Systematic screening identifies therapeutic antisense oligonucleotides for Hutchinson-Gilford progeria syndrome (vol 27, pg 526, 2021) Puttaraju, Madaiah; Jackson, Michaela; Klein, Stephanie; Shilo, Asaf; Bennett, C. Frank; Gordon, Leslie; Rigo, Frank; Misteli, Tom Share Save
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Age-dependent SMN expression in disease-relevant tissue and implications for SMA treatment Ramos, Daniel M.; d'Ydewalle, Constantin; Gabbeta, Vijayalakshmi; Dakka, Amal; Klein, Stephanie K.; Norris, Daniel A.; Matson, John; Taylor, Shannon J.; Zaworski, Phillip G.; Prior, Thomas W.; Snyder, Pamela J.; Valdivia, David; Hatem, Christine L.; Waters, Ian; Gupte, Nikhil; Swoboda, Kathryn J.; Rigo, Frank; Bennett, C. Frank; Naryshkin, Nikolai; Paushkin, Sergey; Crawford, Thomas O.; Sumner, Charlotte J. Share Save
Targeting castration-resistant prostate cancer with androgen receptor antisense oligonucleotide therapy De Velasco, Marco A.; Kura, Yurie; Sakai, Kazuko; Hatanaka, Yuji; Davies, Barry R.; Campbell, Hayley; Klein, Stephanie; Kim, Youngsoo; MacLeod, A. Robert; Sugimoto, Koichi; Yoshikawa, Kazuhiro; Nishio, Kazuto; Uemura, Hirotsugu Share Save
Enhanced Potency of GalNAc-Conjugated Antisense Oligonucleotides in Hepatocellular Cancer Models Kim, Youngsoo; Jo, Minji; Schmidt, Joanna; Luo, Xiaolin; Prakash, Thazha P.; Zhou, Tianyuan; Klein, Stephanie; Xiao, Xiaokun; Post, Noah; Yin, Zhengfeng; MacLeod, A. Robert Share Save
Discovery and characterization of AZD8701, a high affinity antisense oligonucleotide targeting FOXP3 to relieve immunosuppression in cancer Sinclair, Charles; Revenko, Alexey S.; Johnson, R. B.; Peter, Alison; Taylor, Molly A.; Hettrick, Lisa A.; Klein, Stephanie; Solanki, Anisha; Chapman, Melissa; Yates, James; Angell, Helen K.; Watt, Andrew; Gattis, Danielle; Monia, Brett P.; Barry, Simon T.; Lyne, Paul; Edbrooke, Mark; Goldberg, Frederick; Macleod, A. R. Share Save
High-affinity antisense oligonucleotides targeting Foxp3 inhibit immunosuppressive function of regulatory T-cells and produce antitumor effects in syngeneic tumor models Sinclair, Charles; Revenko, Alexey S.; Peter, Alison; Johnson, Robert B.; Hettrick, Lisa A.; Taylor, Molly; Staniszewska, Anna; Hughes, Adina; Sandin, Lisa; Klein, Stephanie; Watt, Andrew; Barry, Simon; Monia, Brett T.; Lyne, Paul; Macleod, A. Robert; Edbrooke, Mark Share Save
Dynamic changes and molecular analysis of cell death in the spinal cord of SJL mice infected with the BeAn strain of Theiler's murine encephalomyelitis virus Gerhauser, Ingo; Li, Lin; Li, Dandan; Klein, Stephanie; Elmarabet, Suliman Ahmed; Deschl, Ulrich; Kalkuhl, Arno; Baumgaertner, Wolfgang; Ulrich, Reiner; Beineke, Andreas Share Save
High-affinity antisense oligonucleotides targeting Foxp3 inhibit immunosuppressive function of regulatory T cells and produce anti-tumor effects in syngeneic tumor models Revenko, Alexey S.; Sinclair, Charles; Ben Johnson; Hettrick, Lisa; Peter, Alison; Staniszewska, Anna; Hughes, Adina; Sandin, Linda; Taylor, Molly; Klein, Stephanie; Watt, Andy; Monia, Brett; Edbrooke, Mark; MacLeod, A. Robert Share Save
Targeting KRAS-dependent tumors with AZD4785, a high-affinity therapeutic antisense oligonucleotide inhibitor of KRAS Ross, Sarah J.; Revenko, Alexey S.; Hanson, Lyndsey L.; Ellston, Rebecca; Staniszewska, Anna; Whalley, Nicky; Pandey, Sanjay K.; Revill, Mitchell; Rooney, Claire; Buckett, Linda K.; Klein, Stephanie K.; Hudson, Kevin; Monia, Brett P.; Zinda, Michael; Blakey, David C.; Lyne, Paul D.; Macleod, A. Robert Share Save
Continuous, low intensity systemic dosing maximizes the therapeutic margin of Eg5/KSP inhibition in an orthotopic model of urothelial cell carcinoma Williams, Leigh; Ellston, Rebecca; Trueman, Dawn; Musgrove, Helen; Ruston, Linette; Aquila, Brian; Pease, Elizabeth; Klein, Stephanie; Davies, Barry R. Share Save
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