Not logged in Discovery of BAY 2666605, a Molecular Glue for PDE3A and SLFN12 Lewis, Timothy A.; Ellermann, Manuel; Kopitz, Charlotte; Lange, Martin; de Waal, Luc; Wu, Xiaoyun; Tersteegen, Adrian; Denner, Karsten; Lienau, Philip; Kaulfuss, Stefan; Goldoni, Silvia; Meyerson, Matthew; Greulich, Heidi; Gradl, Stefan N. Share Save
Velcrin molecular glues induce apoptosis in glioblastomas with high PDE3A and SLFN12 expression Aquilanti, Elisa; Goldoni, Silvia; Baker, Andrew; Kotynkova, Kristyna; Andersen, Sawyer; Bozinov, Vincent; Gao, Galen F.; Cherniack, Andrew D.; Lange, Martin; Lesche, Ralf; Kopitz, Charlotte; Lienau, Philip; Lewis, Timothy A.; Garrido, Marine; Gradl, Stefan; Seidel, Henrik; Tseng, Yuen-Yi; Ligon, Keith L.; Wen, Patrick Y.; Meyerson, Matthew; Greulich, Heidi Share Save
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Mechanisms of resistance to BAY 2927088, the first reversible inhibitor targeting EGFR exon 20 insertion mutations in non-small cell lung cancer Uzunbas, Gizem Karsli; McVeigh, Quinn; Gupta, Akansha; Hoyt, Stephanie; Doucette, Kristen; Keshishian, Hasmik; Carr, Steven; Yang, Xiaoping; Root, David; Cherniack, Andrew D.; Siegel, Franziska; Siegel, Stephan; Meyerson, Matthew; Greulich, Heidi Share Save
Mechanisms of uveal melanoma sensitivity to velcrin treatment and SLFN12-mediated cancer cell death Kotynkova, Kristyna; Andersen, Sawyer; Garvie, Colin; Wu, Xiaoyun; Lee, Sooncheol; McGaunn, Joseph; Kaplan, Bethany; Tseng, Moony; Cherniack, Andrew D.; Meyerson, Matthew; Greulich, Heidi Share Save
Preclinical activity of BAY 2927088 in HER2 mutant non-small cell lung cancer Siegel, Franziska; Karsli-Uzunbas, Gizem; Kotynkova, Kristyna; McVeigh, Quinn; Siegel, Stephan; Korr, Daniel; Schulze, Volker; Berger, Markus; Beckmann, Georg; Cherniack, Andrew; Meyerson, Matthew; Greulich, Heidi Share Save
Mechanisms of resistance to BAY 2927088, the first reversible inhibitor targeting EGFR exon 20 insertion mutations in non-small cell lung cancer Uzunbas, Gizem Karsli; McVeigh, Quinn; Gupta, Akansha; Hoyt, Stephanie; Cherniack, Andrew; Siegel, Franziska; Siegel, Stephan; Meyerson, Matthew; Greulich, Heidi Share Save
Loss of the epigenetic tumor suppressor SNF5 leads to cancer without genomic instability McKenna, Elizabeth S.; Sansam, Courtney G.; Cho, Yoon-Jae; Greulich, Heidi; Evans, Julia A.; Thom, Christopher S.; Moreau, Lisa A.; Biegel, Jaclyn A.; Pomeroy, Scott L.; Roberts, Charles W. M. Share Save
Velcrin-induced selective cleavage of tRNALeu(TAA) by SLFN12 causes cancer cell death Lee, Sooncheol; Hoyt, Stephanie; Wu, Xiaoyun; Garvie, Colin; McGaunn, Joseph; Shekhar, Mrinal; Totzl, Marcus; Rees, Matthew G.; Cherniack, Andrew D.; Meyerson, Matthew; Greulich, Heidi Share Save
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Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase Garvie, Colin W.; Wu, Xiaoyun; Papanastasiou, Malvina; Lee, Sooncheol; Fuller, James; Schnitzler, Gavin R.; Horner, Steven W.; Baker, Andrew; Zhang, Terry; Mullahoo, James P.; Westlake, Lindsay; Hoyt, Stephanie H.; Toetzl, Marcus; Ranaghan, Matthew J.; de Waal, Luc; McGaunn, Joseph; Kaplan, Bethany; Piccioni, Federica; Yang, Xiaoping; Lange, Martin; Tersteegen, Adrian; Raymond, Donald; Lewis, Timothy A.; Carr, Steven A.; Cherniack, Andrew D.; Lemke, Christopher T.; Meyerson, Matthew; Greulich, Heidi Share Save
Mechanistic insights into cancer cell killing through interaction of phosphodiesterase 3A and schlafen family member 12 (vol 295, pg 3431, 2020) Wu, Xiaoyun; Schnitzler, Gavin R.; Gao, Galen F.; Diamond, Brett; Baker, Andrew R.; Kaplan, Bethany; Williamson, Kaylyn; Westlake, Lindsay; Lorrey, Selena; Lewis, Timothy A.; Garvie, Colin W.; Lange, Martin; Hayat, Sikander; Seidel, Henrik; Doench, John; Cherniack, Andrew D.; Kopitz, Charlotte; Meyerson, Matthew; Greulich, Heidi Share Save
Mechanistic insights into cancer cell killing through interaction of phosphodiesterase 3A and schlafen family member 12 Wu, Xiaoyun; Schnitzler, Gavin R.; Gao, Galen F.; Diamond, Brett; Baker, Andrew R.; Kaplan, Bethany; Williamson, Kaylyn; Westlake, Lindsay; Lorrey, Selena; Lewis, Timothy A.; Garvie, Colin W.; Lange, Martin; Hayat, Sikander; Seidel, Henrik; Doench, John; Cherniack, Andrew D.; Kopitz, Charlotte; Meyerson, Matthew; Greulich, Heidi Share Save
Discovering the anticancer potential of non-oncology drugs by systematic viability profiling Corsello, Steven M.; Nagari, Rohith T.; Spangler, Ryan D.; Rossen, Jordan; Kocak, Mustafa; Bryan, Jordan G.; Humeidi, Ranad; Peck, David; Wu, Xiaoyun; Tang, Andrew A.; Wang, Vickie M.; Bender, Samantha A.; Lemire, Evan; Narayan, Rajiv; Montgomery, Philip; Ben-David, Uri; Garvie, Colin W.; Chen, Yejia; Rees, Matthew G.; Lyons, Nicholas J.; McFarland, James M.; Wong, Bang T.; Wang, Li; Dumont, Nancy; O'Hearn, Patrick J.; Stefan, Eric; Doench, John G.; Harrington, Caitlin N.; Greulich, Heidi; Meyerson, Matthew; Vazquez, Francisca; Subramanian, Aravind; Roth, Jennifer A.; Bittker, Joshua A.; Boehm, Jesse S.; Mader, Christopher C.; Tsherniak, Aviad; Golub, Todd R. Share Save
Optimization of PDE3A Modulators for SLFN12-Dependent Cancer Cell Killing Lewis, Timothy A.; de Waal, Luc; Wu, Xiaoyun; Youngsaye, Willmen; Wengner, Antje; Kopitz, Charlotte; Lange, Martin; Gradl, Stefan; Ellermann, Manuel; Lienau, Philip; Schreiber, Stuart L.; Greulich, Heidi; Meyerson, Matthew Share Save
Colorectal adenocarcinoma-derived EGFR mutants are oncogenic and sensitive to EGFR-targeted monoclonal antibodies, cetuximab and panitumumab Kim, Nayoung; Cho, Daseul; Kim, Hyunjin; Kim, Sujin; Cha, Young-je; Greulich, Heidi; Bass, Adam; Cho, Hyun-Soo; Cho, Jeonghee Share Save
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Small-molecule modulators of PDE3/SLFN12 to kill cancer cells Lewis, Timothy A.; de Waal, Luc; Wu, Xiaoyun; Ellerman, Manuel; Kopitz, Charlotte; Wengner, Antje; Eis, Knut; Lange, Martin; Tersteegen, Adrian; Lienau, Philip; Greulich, Heidi; Meyerson, Matthew Share Save
PDE3A modulation for cancer therapy Wu, Xiaoyun; Lewis, Timothy; de Waal, Luc; Gao, Galen; Zhang, Jian; Schenone, Monica; Garvie, Colin; Diamond, Brett; Lorrey, Selena; Cherniack, Andrew; Corsello, Steven; Burgin, Alex; Golub, Todd; Schreiber, Stuart; Meyerson, Matthew; Greulich, Heidi Share Save
Characterizing genomic alterations in cancer by complementary functional associations Kim, Jong Wook; Botvinnik, Olga B.; Abudayyeh, Omar; Birger, Chet; Rosenbluh, Joseph; Shrestha, Yashaswi; Abazeed, Mohamed E.; Hammerman, Peter S.; DiCara, Daniel; Konieczkowski, David J.; Johannessen, Cory M.; Liberzon, Arthur; Alizad-Rahvar, Amir Reza; Alexe, Gabriela; Aguirre, Andrew; Ghandi, Mahmoud; Greulich, Heidi; Vazquez, Francisca; Weir, Barbara A.; Van Allen, Eliezer M.; Tsherniak, Aviad; Shao, Diane D.; Zack, Travis I.; Noble, Michael; Getz, Gad; Beroukhim, Rameen; Garraway, Levi A.; Ardakani, Masoud; Romualdi, Chiara; Sales, Gabriele; Barbie, David A.; Boehm, Jesse S.; Hahn, William C.; Mesirov, Jill P.; Tamayo, Pablo Share Save
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