Not logged inAcyl-CoA Synthetase 5 Knockout and Inhibitors Protect Against Diet-Induced Obesity in Mice by Activating the Ileal Brake
Powell, David R.; Van Sligtenhorst, Isaac; Main, Alan; Jin, Haihong; Carson, Kenneth G.; Shi, Zhi-Cai; Swaffield, Jonathan; Smith, Melinda; Harris, Angela; Gopinathan, Suma; Platt, Kenneth A.; Wade, Jeffrey; Zambrowicz, Brian; Mcdonald, Patricia; Orton, Darren; Kuttippurathu, Lakshmi; Mullens, Michael; Greer, Jennifer; Yang, Qi Melissa; Ding, Zhi-Ming .png)
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SaveDiscovery of 6-[(3S,4S)-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 InhibitorCzako, Barbara; Sun, Yuting; McAfoos, Timothy; Cross, Jason B.; Leonard, Paul G.; Burke, Jason P.; Carroll, Christopher L.; Feng, Ningping; Harris, Angela L.; Jiang, Yongying; Kang, Zhijun; Kovacs, Jeffrey J.; Mandal, Pijus; Meyers, Brooke A.; Mseeh, Faika; Parker, Connor A.; Yu, Simon S.; Williams, Christopher C.; Wu, Qi; Di Francesco, Maria Emilia; Draetta, Giulio; Heffernan, Timothy; Marszalek, Joseph R.; Kohl, Nancy E.; Jones, Philip Share Save Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) ApoenzymeHamilton, Matthew M.; Mseeh, Faika; McAfoos, Timothy J.; Leonard, Paul G.; Reyna, Naphtali J.; Harris, Angela L.; Xu, Alan; Han, Michelle; Soth, Michael J.; Czako, Barbara; Theroff, Jay P.; Mandal, Pijus K.; Burke, Jason P.; Virgin-Downey, Brett; Petrocchi, Alessia; Pfaffinger, Dana; Rogers, Norma E.; Parker, Connor A.; Yu, Simon S.; Jiang, Yongying; Krapp, Stephan; Lammens, Alfred; Trevitt, Graham; Tremblay, Martin R.; Mikule, Keith; Wilcoxen, Keith; Cross, Jason B.; Jones, Philip; Marszalek, Joseph R.; Lewis, Richard T. Share Save Sequential Administration of XPO1 and ATR Inhibitors Enhances Therapeutic Response in TP53-mutated Colorectal CancerInoue, Akira; Robinson, Frederick S.; Minelli, Rosalba; Tomihara, Hideo; Rizi, Bahar Salimian; Rose, Johnathon L.; Kodama, Takahiro; Srinivasan, Sanjana; Harris, Angela L.; Zuniga, Andy M.; Mullinax, Robert A.; Ma, Xiaoyan; Seth, Sahil; Daniele, Joseph R.; Peoples, Michael D.; Loponte, Sara; Akdemir, Kadir C.; Khor, Tin Oo; Feng, Ningping; Roszik, Jason; Sobieski, Mary M.; Brunell, David; Stephan, Clifford; Giuliani, Virginia; Deem, Angela K.; Shingu, Takashi; Deribe, Yonathan Lissanu; Menter, David G.; Heffernan, Timothy P.; Viale, Andrea; Bristow, Christopher A.; Kopetz, Scott; Draetta, Giulio F.; Genovese, Giannicola; Carugo, Alessandro Share Save Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward OsimertinibSun, Yuting; Meyers, Brooke A.; Czako, Barbara; Leonard, Paul; Mseeh, Faika; Harris, Angela L.; Wu, Qi; Johnson, Sarah; Parker, Connor A.; Cross, Jason B.; Di Francesco, Maria Emilia; Bivona, Benjamin J.; Bristow, Christopher A.; Burke, Jason P.; Carrillo, Caroline C.; Carroll, Christopher L.; Chang, Qing; Feng, Ningping; Gao, Guang; Gera, Sonal; Giuliani, Virginia; Huang, Justin K.; Jiang, Yongying; Kang, Zhijun; Kovacs, Jeffrey J.; Liu, Chiu-Yi; Lopez, Anastasia M.; Ma, Xiaoyan; Mandal, Pijus K.; McAfoos, Timothy; Miller, Meredith A.; Mullinax, Robert A.; Peoples, Michael; Ramamoorthy, Vandhana; Seth, Sahil; Spencer, Nakia D.; Suzuki, Erika; Williams, Christopher C.; Yu, Simon S.; Zuniga, Andy M.; Draetta, Giulio F.; Marszalek, Joseph R.; Heffernan, Timothy P.; Kohl, Nancy E.; Jones, Philip Share Save Discovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical PropertiesSoth, Michael J.; Le, Kang; Di Francesco, Maria Emilia; Hamilton, Matthew M.; Liu, Gang; Burke, Jason P.; Carroll, Chris L.; Kovacs, Jeffrey J.; Bardenhagen, Jennifer P.; Bristow, Christopher A.; Cardozo, Mario; Czako, Barbara; de Stanchina, Elisa; Feng, Ningping; Garvey, Jill R.; Gay, Jason P.; Do, Mary K. Geck; Greer, Jennifer; Han, Michelle; Harris, Angela; Herrera, Zachary; Huang, Sha; Giuliani, Virginia; Jiang, Yongying; Johnson, Sarah B.; Johnson, Troy A.; Kang, Zhijun; Leonard, Paul G.; Liu, Zhen; McAfoos, Timothy; Miller, Meredith; Morlacchi, Pietro; Mullinax, Robert A.; Palmer, Wylie S.; Pang, Jihai; Rogers, Norma; Rudin, Charles M.; Shepard, Hannah E.; Spencer, Nakia D.; Theroff, Jay; Wu, Qi; Xu, Alan; Yau, Ju Anne; Draetta, Giulio; Toniatti, Carlo; Heffernan, Timothy P.; Jones, Philip Share Save Discovery of IACS-9439, a Potent, Exquisitely Selective, and Orally Bioavailable Inhibitor of CSF1RCzako, Barbara; Marszalek, Joseph. R.; Burke, Jason P.; Mandal, Pijus; Leonard, Paul G.; Cross, Jason B.; Mseeh, Faika; Jiang, Yongying; Chang, Edward Q.; Suzuki, Erika; Kovacs, Jeffrey J.; Feng, Ningping; Gera, Sonal; Harris, Angela L.; Liu, Zhen; Mullinax, Robert A.; Pang, Jihai; Parker, Connor A.; Spencer, Nakia D.; Yu, Simon S.; Wu, Qi; Tremblay, Martin R.; Mikule, Keith; Wilcoxen, Keith; Heffernan, Timothy P.; Draetta, Giulio F.; Jones, Philip Share Save Discovery of IACS-13909, an allosteric SHP2 inhibitor that overcomes multiple mechanisms underlying osimertinib resistanceSun, Yuting; Meyers, Brooke A.; Johnson, Sarah B.; Harris, Angela L.; Czako, Barbara; Cross, Jason B.; Leonard, Paul G.; Mseeh, Faika; Di Francesco, Maria E.; Parker, Connor A.; Wu, Qi; Bristow, Christopher A.; Burke, Jason P.; Carrillo, Caroline C.; Carroll, Christopher L.; Chang, Qing; Feng, Ningping; Gera, Sonal; Guang, Gao; Huang, Justin Kwang-Lay; Jiang, Yongying; Kang, Zhijun; Kovacs, Jeffrey J.; Ma, Xiaoyan; Mandal, Pijus K.; McAfoos, Timothy; Mullinax, Robert A.; Peoples, Michael D.; Ramamoorthy, Vandhana; Seth, Sahil; Suzuki, Erika; Williams, Christopher Conrad; Yu, Simon S.; Zuniga, Andy M.; Draetta, Giulio F.; Marszalek, Joseph R.; Heffernan, Timothy P.; Kohl, Nancy E.; Jones, Philip Share Save IACS-9779, a development candidate that inhibits 2,3-dioxygenase (IDO) activity by blocking heme incorporation into IDO apoenzymeMseeh, Faika; Hamilton, Matthew M.; Marszalek, Joseph R.; Rogers, Norma E.; Parker, Connor A.; Yu, Simon S.; Liu, Zhen; Reyna, Naphtali J.; McAfoos, Timothy; Virgin-Downey, Brett W.; Leonard, Paul G.; Cross, Jason B.; Feng, Ningping; Harris, Angela L.; Zuniga, Andy M.; Mikule, Keith; Tremblay, Martin; Jiang, Yongying; Mahendra, Mikhila; Pang, Jihai; Wu, Qi; Xu, Quanyun; Heffernan, Timothy P.; Jones, Philip; Lewis, Richard T. Share Save Resistance to neoadjuvant chemotherapy in triple-negative breast cancer mediated by a reversible drug-tolerant stateEcheverria, Gloria V.; Ge, Zhongqi; Seth, Sahil; Zhang, Xiaomei; Jeter-Jones, Sabrina; Zhou, Xinhui; Cai, Shirong; Tu, Yizheng; McCoy, Aaron; Peoples, Michael; Sun, Yuting; Qiu, Huan; Chang, Qing; Bristow, Christopher; Carugo, Alessandro; Shao, Jiansu; Ma, Xiaoyan; Harris, Angela; Mundi, Prabhjot; Lau, Rosanna; Ramamoorthy, Vandhana; Wu, Yun; Alvarez, Mariano J.; Califano, Andrea; Moulder, Stacy L.; Symmans, William F.; Marszalek, Joseph R.; Heffernan, Timothy P.; Chang, Jeffrey T.; Piwnica-Worms, Helen Share Save Resistance to neoadjuvant chemotherapy in triple negative breast cancer mediated by a reversible drug-tolerant stateEcheverria, G. V.; Ge, Z.; Seth, S.; Jeter-Jones, S. L.; Zhang, X.; Zhou, X.; Cai, S.; Tu, Y.; Mccoy, A.; Peoples, M.; Lau, R.; Shao, J.; Sun, Y.; Bristow, C.; Carugo, A.; Ma, X.; Harris, A.; Wu, Y.; Moulder, S.; Symmans, W. F.; Marszalek, J. R.; Heffernan, T. P.; Chang, J. T.; Piwnica-Worms, H. Share Save Discovery of an imidazopyridine series of potent human IDO1 inhibitors with robust target engagement in a preclinical tumor modelPetrocchi, Alessia; Reyna, Naphtali J.; Mseeh, Faika; Parker, Connor A.; Yu, Simon; Xu, Quanyun; Feng, Ningping; Leonard, Paul; Rogers, Norma; Cross, Jason B.; Harris, Angela L.; Jiang, Yongying; Khor, Tin Oo; Mahendra, Mikhila G.; Pang, Jihai; Wu, Qi; Zuniga, Andy M.; McAfoos, Timothy; McAfoos, Timothy; Hamilton, Matthew M.; Marszalek, Joe R.; Mikule, Keith; Vancutsem, Paul; Wilcoxen, Keith; Tremblay, Martin; Jones, Philip; Lewis, Richard T. Share Save Promoting an anti-tumor immune environment with a novel, exquisitely selective CSF1R inhibitorSuzuki, Erika; Kovacs, Jeffrey J.; Spencer, Nakia D.; Sonal, Sonal; Feng, Ningping; Harris, Angela L.; Mullinax, Robert A.; Zuniga, Andy M.; Johnson, Sarah B.; Mahendra, Mikhila; Khor, Tin Oo; Mseeh, Faika; Liu, Zhen; Burke, Jason P.; Mikule, Keith; Tremblay, Martin; Heffernan, Timothy P.; Jones, Philip; Czako, Barbara; Marszalek, Joseph R. Share Save LX2761, a Sodium/Glucose Cotransporter 1 Inhibitor Restricted to the Intestine, Improves Glycemic Control in MicePowell, David R.; Smith, Melinda G.; Doree, Deon D.; Harris, Angela L.; Greer, Jennifer; DaCosta, Christopher M.; Thompson, Andrea; Jeter-Jones, Sabrina; Xiong, Wendy; Carson, Kenneth G.; Goodwin, Nicole C.; Harrison, Bryce A.; Rawlins, David B.; Strobel, Eric D.; Gopinathan, Suma; Wilson, Alan; Mseeh, Faika; Zambrowicz, Brian; Ding, Zhi-Ming Share Save LX4211 Increases Serum Glucagon-Like Peptide 1 and Peptide YY Levels by Reducing Sodium/Glucose Cotransporter 1 (SGLT1)-Mediated Absorption of Intestinal GlucosePowell, David R.; Smith, Melinda; Greer, Jennifer; Harris, Angela; Zhao, Sharon; DaCosta, Christopher; Mseeh, Faika; Shadoan, Melanie K.; Sands, Arthur; Zambrowicz, Brian; Ding, Zhi-Ming Share Save 
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