Not logged in MTA-Cooperative PRMT5 Inhibitors Demonstrate Efficacy in MTAP-Deleted MPNST Models and Enhance Chemotherapy Response Zhang, Xiaochun; Borcherding, Dana; Zhang, Minjie; Lyn, Yang; Wang, Guangfeng; He, Kevin; Oztosun, Gorkem; Sachdeva, Ishita; Yang, Liuzhan; Yang, Kuangying; Yuen, Alex; Dibenedetto, Heather; Tsai, Alice; Huang, Alan; Maxwell, John; Cottrell, Kevin; Briggs, Kimberly; Hirbe, Angela Share Save
TNG456 is a next-generation, brain-penetrant, MTA-cooperative PRMT5 inhibitor for the treatment of solid tumors, including glioblastoma, with MTAP loss Briggs, Kimberly; Tsai, Alice; Zhang, Minjie; Zhang, Wenhai; Huang, Alan; Andersen, Jannik; Cottrell, Kevin Share Save
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Discovery of TNG-6132, a potent, selective, and orally bioavailable USP1 inhibitor Throner, Scott; Feng, Tianshu; Andersen, Jannik N.; Bandi, Madhavi; Engel, Justin L.; Gong, Shanzhong; Gotur, Deepali; Gu, Lina; Huang, Alan; Lazarides, Katherine; Maxwell, John P.; McCarren, Patrick; McMillan, Brian J.; Pham, Truc, V; Simoneau, Antoine; Tsai, Alice; Whittington, Douglas A.; Wilker, Erik; Zhang, Minjie; Zhang, Wenhai Share Save
Discovery of TNG462: A Highly Potent and Selective MTA-Cooperative PRMT5 Inhibitor to Target Cancers with MTAP Deletion Cottrell, Kevin M.; Briggs, Kimberly J.; Tsai, Alice; Tonini, Matthew R.; Whittington, Douglas A.; Gong, Shanzhong; Liang, Colin; Mccarren, Patrick; Zhang, Minjie; Zhang, Wenhai; Huang, Alan; Maxwell, John P. Share Save
MTA-Cooperative PRMT5 Inhibitors: Mechanism Switching Through Structure-Based Design Cottrell, Kevin M.; Whittington, Douglas A.; Briggs, Kimberly J.; Jahic, Haris; Ali, Janid A.; Amor, Alvaro J.; Gotur, Deepali; Tonini, Matthew R.; Zhang, Wenhai; Huang, Alan; Maxwell, John P. Share Save
Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with MTAP-Deleted Cancers Cottrell, Kevin M.; Briggs, Kimberly J.; Whittington, Douglas A.; Jahic, Haris; Ali, Janid A.; Davis, Charles B.; Gong, Shanzhong; Gotur, Deepali; Gu, Lina; McCarren, Patrick; Tonini, Matthew R.; Tsai, Alice; Wilker, Erik W.; Yuan, Hongling; Zhang, Minjie; Zhang, Wenhai; Huang, Alan; Maxwell, John P. Share Save
LIG1 inactivation selectively inhibits growth of BRCA1 mutant cells in vitro and in vivo Martires, Lauren; Ahronian, Leanne G.; Pratt, Charlotte; Das, Nikitha; Zhang, Xiaobin; Whittington, Douglas A.; Zhang, Hongxiang; Shen, Binzhang; Come, Jon; McCarren, Patrick; Liu, Mu-Sen; Min, Chengyin; Feng, Tianshu; Jahic, Haris; Brophy, Eric; Aird, Daniel; Andersen, Jannik N.; Huang, Alan; Li, Fang; Mallender, William D.; Nicholson, Hilary E. Share Save
TNG917 is a clinical-grade, potent and selective inhibitor of EHMT1/2 for the treatment of immune cold tumors Lu, Alvin; Haines, Brian; Lei, Ji; Zhang, Wenhai; Zhang, Minjie; Whittington, Douglas A.; Ferdinez, Maria Lucia; Yu, Yi; Meier, Samuel R.; Choi, Ashley; Bejnood, Alborz; Bandi, Madhavi; Lazarides, Katherine; Pan, Xuewen; Gu, Lina; Tsai, Alice W.; Sudsakorn, Sirimas; Liang, Colin; Come, Jon; Williams, Brett; Throner, Scott; Vacca, Joseph; Maxwell, John P.; Anderson, Jannik N.; Huang, Alan; Min, Chengyin; Chen, Yingnan P. Share Save
Unbiased in vitro and in vivo drug anchor screens identify mechanisms of resistance and sensitization for MTA-cooperative PRMT5 inhibitors in MTAP-deleted cancer models Lombardo, Steven; Tonini, Matthew R.; Grove, Lauren; Fenoglio, Silvia; Tepper, James; Shen, Binzhang; Stowe, Hannah; Liu, Shangtao; Meier, Samuel R.; Choi, Ashley H.; Khendu, Tenzing; Yu, Yi; Cottrell, Kevin M.; Maxwell, John P.; Andersen, Jannik N.; Huang, Alan; Briggs, Kimberly J.; Teng, Teng Share Save
Inducible activation of sgRNA libraries in tumor xenografts empowers large-scale in vivo target discovery screens Fenoglio, Silvia; Tepper, James; Grove, Lauren; Uijttewaal, Esther C. H.; Bejnood, Alborz; Yu, Yi; Wu, Hsin-Jung; Devault, Annabel; Liu, Shangtao; Shen, Binzhang; Meier, Samuel R.; Choi, Ashley H.; Khendu, Tenzing; Stowe, Hannah; Zhang, Minjie; Haines, Brian B.; Huang, Alan; Andersen, Jannik N.; Pan, Xuewen; Elling, Ulrich; Teng, Teng Share Save
TNG348, a selective USP1 inhibitor, shows strong preclinical combination activity with PARP inhibitors and other agents targeting DNA repair Simoneau, Antoine; Pratt, Charlotte; Corner, Grace; Wu, Hsin-Jung; Choi, Ashley; Khendu, Tenzing; Meier, Samuel; Yu, Yi; Liu, Shangtao; Zhang, Wenhai; Whittington, Douglas; Mallender, William; Sudsakorn, Sirimas; Chen, Yingnan; Haines, Brian; Throner, Scott; Crystal, Adam; Huang, Alan; Maxwell, John; Andersen, Jannik Share Save
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TNG908, a brain-penetrant MTA-cooperative PRMT5 inhibitor, is efficacious in preclinical glioblastoma models Zhang, Minjie; Tsai, Alice; Cottrell, Kevin M.; Haines, Brian B.; Wilker, Erik; DiBenedetto, Heather; Weitzman, Ron; Huang, Alan; Davis, Charles B.; Maxwell, John P.; Briggs, Kimberly J. Share Save
Characterization of the clinical development candidate TNG348 as a potent and selective inhibitor of USP1 for the treatment of BRCA1/2mut cancers Simoneau, Antoine; Wu, Hsin-Jung; Bandi, Madhavi; Lazarides, Katherine; Sun, Sining; Liu, Shangtao; Meier, Samuel; Choi, Ashley; Zhang, Hongxiang; Shen, Binzhang; Whittington, Douglas; Sudsakorn, Sirimas; Zhang, Wenhai; Yu, Yi; Liu, Yong; Liang, Colin; Palmieri, Michael; Chen, Yingnan; Haines, Brian; Tsai, Alice; Zhang, Minjie; Huang, Alan; Andersen, Jannik; Feng, Tianshu; Throner, Scott; Maxwell, John Share Save
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WHOLE GENOME CRISPR-CAS9 SCREENS IN A CANCER CELL LINE PANEL CO-CULTURED WITH ANTIGEN-SPECIFIC CYTOTOXIC CD8 T CELLS ARE A POWERFUL ENGINE FOR IMMUNO-ONCOLOGY DRUG TARGET DISCOVERY Gueroussov, Serge; Min, Chengyin; Huang, Alan; Meier, Samuel; Finkler, Jessica; Ji, Lei; Choi, Ashley; Khendu, Tenzing; Subramanya, Disha; Liu, Shangtao; Shen, Binzhang; Teng, Teng; Pan, Xuewen; Yu, Yi Share Save
Ubiquitinated PCNA Drives USP1 Synthetic Lethality in Cancer Simoneau, Antoine; Engel, Justin L.; Bandi, Madhavi; Lazarides, Katherine; Liu, Shangtao; Meier, Samuel R.; Choi, Ashley H.; Zhang, Hongxiang; Shen, Binzhang; Martires, Lauren; Gotur, Deepali; Pham, Truc, V; Li, Fang; Gu, Lina; Gong, Shanzhong; Zhang, Minjie; Wilker, Erik; Pan, Xuewen; Whittington, Douglas A.; Throner, Scott; Maxwell, John P.; Chen, Yingnan; Yu, Yi; Huang, Alan; Andersen, Jannik N.; Feng, Tianshu Share Save
VRK1 Is a Synthetic-Lethal Target in VRK2-Deficient Glioblastoma Shields, Julie A.; Meier, Samuel R.; Bandi, Madhavi; Mulkearns-Hubert, Erin E.; Hajdari, Nicole; Ferdinez, Maria Dam; Engel, Justin L.; Silver, Daniel J.; Shen, Binzhang; Zhang, Wenhai; Hubert, Christopher G.; Mitchell, Kelly; Shakya, Sajina; Zhao, Shan-Chuan; Bejnood, Alborz; Zhang, Minjie; Sjin, Robert Tjin Tham; Wilker, Erik; Lathia, Justin D.; Andersen, Jannik N.; Chen, Yingnan; Li, Fang; Weber, Barbara; Huang, Alan; Emmanuel, Natasha Share Save
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