Not logged inDiscovery of NODX-010, a novel, potent PARG inhibitor demonstrating robust in vivo efficacy and the potential for new clinical settings that benefit patients with tumours resistant to PARP inhibitors
James, D.; Debunne, M.; Engel, J.; Unger, A.; Degenhart, C.; Habenberger, P.; Choidas, A.; Ballaschk, F.; Koch, U.; Eickhoff, J.; Dinkel, K.; Waddell, I. .png)
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SavePyrrolopyrimidine based CSF1R inhibitors: Attempted departure from FlatlandBjornstad, Frithjof; Havik, Simen; Aarhus, Thomas Ihle; Mahdi, Iktedar; Unger, Anke; Habenberger, Peter; Degenhart, Carsten; Eickhoff, Jan; Klebl, Bert M.; Sundby, Eirik; Hoff, Bard Helge Share Save An Antiherpesviral Host-Directed Strategy Based on CDK7 Covalently Binding Drugs: Target-Selective, Picomolar-Dose, Cross-Virus ReactivityYu, DongHoon; Wagner, Sabrina; Schuetz, Martin; Jeon, Yeejin; Seo, Mooyoung; Kim, Jaeseung; Brueckner, Nadine; Kicuntod, Jintawee; Tillmanns, Julia; Wangen, Christina; Hahn, Friedrich; Kaufer, Benedikt B.; Neipel, Frank; Eickhoff, Jan; Klebl, Bert; Nam, Kiyean; Marschall, Manfred Share Save ComplexEye: a multi-lens array microscope for high-throughput embedded immune cell migration analysisCibir, Zuelal; Hassel, Jacqueline; Sonneck, Justin; Kowitz, Lennart; Beer, Alexander; Kraus, Andreas; Hallekamp, Gabriel; Rosenkranz, Martin; Raffelberg, Pascal; Olfen, Sven; Smilowski, Kamil; Burkard, Roman; Helfrich, Iris; Tuz, Ali Ata; Singh, Vikramjeet; Ghosh, Susmita; Sickmann, Albert; Klebl, Anne-Kathrin; Eickhoff, Jan Eike; Klebl, Bert; Seidl, Karsten; Chen, Jianxu; Grabmaier, Anton; Viga, Reinhard; Gunzer, Matthias Share Save Combined Treatment with Host-Directed and Anticytomegaloviral Kinase Inhibitors: Mechanisms, Synergisms and Drug Resistance BarriersWild, Markus; Karner, Dubravka; Eickhoff, Jan; Wagner, Sabrina; Kicuntod, Jintawee; Chang, William; Barry, Peter; Jonjic, Stipan; Rovis, Tihana Lenac; Marschall, Manfred Share Save A highly selective purine-based inhibitor of CSF1R potently inhibits osteoclast differentiationAarhus, Thomas Ihle; Eickhoff, Jan; Klebl, Bert; Unger, Anke; Boros, Joanna; Choidas, Axel; Zischinsky, Mia -Lisa; Wolowczyk, Camilla; Bjorkoy, Geir; Sundby, Eirik; Hoff, Bard Helge Share Save Characterization of the Antibacterial Activity of Quinone-Based Compounds Originating from the Alnumycin Biosynthetic Gene Cluster of a Streptomyces IsolateSagurna, Leonie; Heinrich, Sascha; Kaufmann, Lara-Sophie; Rueckert-Reed, Christian; Busche, Tobias; Wolf, Alexander; Eickhoff, Jan; Klebl, Bert; Kalinowski, Joern; Bandow, Julia E. Share Save IFNa primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilizationAndlovic, Blaz; Heilmann, Geronimo; Ninck, Sabrina; Andrei, Sebastian A.; Centorrino, Federica; Higuchi, Yusuke; Kato, Nobuo; Brunsveld, Luc; Arkin, Michelle; Menninger, Sascha; Choidas, Axel; Wolf, Alexander; Klebl, Bert; Kaschani, Farnusch; Kaiser, Markus; Eickhoff, Jan; Ottmann, Christian Share Save Synthesis and Development of Highly Selective Pyrrolo[2,3-d]pyrimidine CSF1R Inhibitors Targeting the Autoinhibited FormAarhus, Thomas Ihle; Bjornstad, Frithjof; Wolowczyk, Camilla; Larsen, Kristin Uhlving; Rognstad, Line; Leithaug, Trygve; Unger, Anke; Habenberger, Peter; Wolf, Alexander; Bjorkoy, Geir; Pridans, Clare; Eickhoff, Jan; Klebl, Bert; Hoff, Bard H.; Sundby, Eirik Share Save Assessment of Covalently Binding Warhead Compounds in the Validation of the Cytomegalovirus Nuclear Egress Complex as an Antiviral TargetTillmanns, Julia; Haege, Sigrun; Borst, Eva Maria; Wardin, Julia; Eickhoff, Jan; Klebl, Bert; Wagner, Sabrina; Wangen, Christina; Hahn, Friedrich; Socher, Eileen; Marschall, Manfred Share Save Cyclin-Dependent Kinase 7 Controls mRNA Synthesis by Affecting Stability of Preinitiation Complexes, Leading to Altered Gene Expression, Cell Cycle Progression, and Survival of Tumor CellsKelso, Timothy W. R.; Baumgart, Karen; Eickhoff, Jan; Albert, Thomas; Antrecht, Claudia; Lemcke, Sarah; Klebl, Bert; Meisterernst, Michael Share Save A cell-based chemical-genetic screen for amino acid stress response inhibitors reveals torins reverse stress kinase GCN2 signalingBrueggenthies, Johanna B.; Fiore, Alessandra; Russier, Marion; Bitsina, Christina; Broetzmann, Julian; Kordes, Susanne; Menninger, Sascha; Wolf, Alexander; Conti, Elena; Eickhoff, Jan E.; Murray, Peter J. Share Save Kinase Chemodiversity from the Arctic: The BreitfussinsHansen, Kine O.; Andersen, Jeanette H.; Bayer, Annette; Pandey, Sunil K.; Lorentzen, Marianne; Jorgensen, Kare B.; Sydnes, Mane O.; Guttormsen, Yngve; Baumann, Matthias; Koch, Uwe; Klebl, Bert; Eickhoff, Jan; Haug, Bengt Erik; Isaksson, Johan; Hansen, Espen H. Share Save Discovery of the Hedgehog Pathway Inhibitor Pipinib that Targets PI4KIIIβKremer, Lea; Hennes, Elisabeth; Brause, Alexandra; Ursu, Andrei; Robke, Lucas; Matsubayashi, Hideaki T.; Nihongaki, Yuta; Flegel, Jana; Mejdrova, Ivana; Eickhoff, Jan; Baumann, Matthias; Nencka, Radim; Janning, Petra; Kordes, Susanne; Schoeler, Hans R.; Sterneckert, Jared; Inoue, Takanari; Ziegler, Slava; Waldmann, Herbert Share Save Dual Inhibition of GSK3β and CDK5 Protects the Cytoskeleton of Neurons from Neuroinflammatory-Mediated Degeneration In Vitro and In VivoReinhardt, Lydia; Kordes, Susanne; Reinhardt, Peter; Glatza, Michael; Baumann, Matthias; Drexler, Hannes C. A.; Menninger, Sascha; Zischinsky, Gunther; Eickhoff, Jan; Froeb, Claudia; Bhattarai, Prabesh; Arulmozhivarman, Guruchandar; Marrone, Lara; Janosch, Antje; Adachi, Kenjiro; Stehling, Martin; Anderson, Eric N.; Abo-Rady, Masin; Bickle, Marc; Pandey, Udai Bhan; Reimer, Michell M.; Kizil, Caghan; Schoeler, Hans R.; Nussbaumer, Peter; Klebl, Bert; Sterneckert, Jared L. Share Save Gasdermin D plays a vital role in the generation of neutrophil extracellular trapsSollberger, Gabriel; Choidas, Axel; Burn, Garth Lawrence; Habenberger, Peter; Di Lucrezia, Raffaella; Kordes, Susanne; Menninger, Sascha; Eickhoff, Jan; Nussbaumer, Peter; Klebl, Bert; Krueger, Renate; Herzig, Alf; Zychlinsky, Arturo Share Save Identification of Atuveciclib (BAY 1143572), the First Highly Selective, Clinical PTEFb/CDK9 Inhibitor for the Treatment of CancerLuecking, Ulrich; Scholz, Arne; Lienau, Philip; Siemeister, Gerhard; Kosemund, Dirk; Bohlmann, Rolf; Briem, Hans; Terebesi, Ildiko; Meyer, Kirstin; Prelle, Katja; Denner, Karsten; Boemer, Ulf; Schaefer, Martina; Eis, Knut; Valencia, Ray; Ince, Stuart; von Nussbaum, Franz; Mumberg, Dominik; Ziegelbauer, Karl; Klebl, Bert; Choidas, Axel; Nussbaumer, Peter; Baumann, Matthias; Schultz-Fademrecht, Carsten; Ruehter, Gerd; Eickhoff, Jan; Brands, Michael Share Save Modulators of 14-3-3 Protein-Protein InteractionsStevers, Loes M.; Sijbesma, Eline; Botta, Maurizio; MacKintosh, Carol; Obsil, Tomas; Landrieu, Isabelle; Cau, Ylenia; Wilson, Andrew J.; Karawajczyk, Anna; Eickhoff, Jan; Davis, Jeremy; Hann, Michael; O'Mahony, Gavin; Doveston, Richard G.; Brunsveld, Luc; Ottmann, Christian Share Save Systematic Kinase Inhibitor Profiling Identifies CDK9 as a Synthetic Lethal Target in NUT Midline CarcinomaBraegelmann, Johannes; Dammert, Marcel A.; Dietlein, Felix; Heuckmann, Johannes M.; Choidas, Axel; Boehm, Stefanie; Richters, Andre; Basu, Debjit; Tischler, Verena; Lorenz, Carina; Habenberger, Peter; Fang, Zhizhou; Ortiz-Cuaran, Sandra; Leenders, Frauke; Eickhoff, Jan; Koch, Uwe; Getlik, Matthaeus; Termathe, Martin; Sallouh, Muhammad; Greff, Zoltan; Varga, Zoltan; Balke-Want, Hyatt; French, Christopher A.; Peifer, Martin; Reinhardt, H. Christian; Orfi, Laszlo; Keri, Gyorgy; Ansen, Sascha; Heukamp, Lukas C.; Buettner, Reinhard; Rauh, Daniel; Klebl, Bert M.; Thomas, Roman K.; Sos, Martin L. Share Save Stabilization of protein-protein interactions in drug discoveryAndrei, Sebastian A.; Sijbesma, Eline; Hann, Michael; Davis, Jeremy; O'Mahony, Gavin; Perry, Matthew W. D.; Karawajczyk, Anna; Eickhoff, Jan; Brunsveld, Luc; Doveston, Richard G.; Milroy, Lech-Gustav; Ottmann, Christian Share Save 
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