Not logged in Discovery and optimization of thiazole-based quorum sensing inhibitors as potent blockers of Pseudomonas aeruginosa pathogenicity Abdelsamie, Ahmed S.; Hamed, Mostafa M.; Schuetz, Christian; Roehrig, Teresa; Kany, Andreas M.; Schmelz, Stefan; Blankenfeldt, Wulf; Hirsch, Anna K. H.; Hartmann, Rolf W.; Empting, Martin Share Save
Inhibitors of the Elastase LasB for the Treatment of Pseudomonas aeruginosa Lung Infections Konstantinovic, Jelena; Kany, Andreas M.; Alhayek, Alaa; Abdelsamie, Ahmed S.; Sikandar, Asfandyar; Voos, Katrin; Yao, Yiwen; Andreas, Anastasia; Shafiei, Roya; Loretz, Brigitta; Schoenauer, Esther; Bals, Robert; Brandstetter, Hans; Hartmann, Rolf W.; Ducho, Christian; Lehr, Claus-Michael; Beisswenger, Christoph; Mueller, Rolf; Rox, Katharina; Haupenthal, Joerg; Hirsch, Anna K. H. Share Save
Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof-of-Principle Hamed, Mostafa M.; Abdelsamie, Ahmed S.; Rox, Katharina; Schuetz, Christian; Kany, Andreas M.; Roehrig, Teresa; Schmelz, Stefan; Blankenfeldt, Wulf; Arce-Rodriguez, Alejandro; Borrero-de Acuna, Jose Manuel; Jahn, Dieter; Rademacher, Jessica; Ringshausen, Felix C.; Cramer, Nina; Tuemmler, Burkhard; Hirsch, Anna K. H.; Hartmann, Rolf W.; Empting, Martin Share Save
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Structure-Based Design of α-Substituted Mercaptoacetamides as Inhibitors of the Virulence Factor LasB from Pseudomonas aeruginosa Kaya, Cansu; Walter, Isabell; Alhayek, Alaa; Shafiei, Roya; Jezequel, Gwenaelle; Andreas, Anastasia; Konstantinovic, Jelena; Schoenauer, Esther; Sikandar, Asfandyar; Haupenthal, Joerg; Mueller, Rolf; Brandstetter, Hans; Hartmann, Rolf W.; Hirsch, Anna K. H. Share Save
N-Aryl Mercaptopropionamides as Broad-Spectrum Inhibitors of Metallo-β-Lactamases Kaya, Cansu; Konstantinovic, Jelena; Kany, Andreas M.; Andreas, Anastasia; Kramer, Jan S.; Brunst, Steffen; Weizel, Lilia; Rotter, Marco J.; Frank, Denia; Yahiaoui, Samir; Mueller, Rolf; Hartmann, Rolf W.; Haupenthal, Joerg; Proschak, Ewgenij; Wichelhaus, Thomas A.; Hirsch, Anna K. H. Share Save
Substrate-Inspired Fragment Merging and Growing Affords Efficacious LasB Inhibitors Kaya, Cansu; Walter, Isabell; Yahiaoui, Samir; Sikandar, Asfandyar; Alhayek, Alaa; Konstantinovic, Jelena; Kany, Andreas M.; Haupenthal, Jorg; Koehnke, Jesko; Hartmann, Rolf W.; Hirsch, Anna K. H. Share Save
17β-Hydroxysteroid Dehydrogenase Type 1 Inhibition: A Potential Treatment Option for Non-Small Cell Lung Cancer Gargano, Emanuele M.; Mohamed, Abdelrahman; Abdelsamie, Ahmed S.; Mangiatordi, Giuseppe F.; Drzewiecka, Hanna; Jagodzinski, Pawel P.; Mazzini, Arcangela; van Koppen, Chris J.; Laschke, Matthias W.; Nicolotti, Orazio; Carotti, Angelo; Marchais-Oberwinkler, Sandrine; Hartmann, Rolf W.; Frotscher, Martin Share Save
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From Celecoxib to a Novel Class of Phosphodiesterase 5 Inhibitors: Trisubstituted Pyrazolines as Novel Phosphodiesterase 5 Inhibitors with Extremely High Potency and Phosphodiesterase Isozyme Selectivity Abdel-Halim, Mohammad; Sigler, Sara; Racheed, Nora A. S.; Hefnawy, Amr; Fathalla, Reem K.; Hammam, Mennatallah A.; Maher, Ahmed; Maxuitenko, Yulia; Keeton, Adam B.; Hartmann, Rolf W.; Engel, Matthias; Piazza, Gary A.; Abadi, Ashraf H. Share Save
A New PqsR Inverse Agonist Potentiates Tobramycin Efficacy to Eradicate Pseudomonas aeruginosa Biofilms Schuetz, Christian; Ho, Duy-Khiet; Hamed, Mostafa Mohamed; Abdelsamie, Ahmed Saad; Roehrig, Teresa; Herr, Christian; Kany, Andreas Martin; Rox, Katharina; Schmelz, Stefan; Siebenbuerger, Lorenz; Wirth, Marius; Boerger, Carsten; Yahiaoui, Samir; Bals, Robert; Scrima, Andrea; Blankenfeldt, Wulf; Horstmann, Justus Constantin; Christmann, Rebekka; Murgia, Xabier; Koch, Marcus; Berwanger, Aylin; Loretz, Brigitta; Hirsch, Anna Katharina Herta; Hartmann, Rolf Wolfgang; Lehr, Claus-Michael; Empting, Martin Share Save
Phosphonate as a Stable Zinc-Binding Group for Pathoblocker Inhibitors of Clostridial Collagenase H (ColH) Voos, Katrin; Schoenauer, Esther; Alhayek, Alaa; Haupenthal, Joerg; Andreas, Anastasia; Mueller, Rolf; Hartmann, Rolf W.; Brandstetter, Hans; Hirsch, Anna K. H.; Ducho, Christian Share Save
Micro-rheological properties of lung homogenates correlate with infection severity in a mouse model of Pseudomonas aeruginosa lung infection Murgia, Xabier; Kany, Andreas M.; Herr, Christian; Ho, Duy-Khiet; De Rossi, Chiara; Bals, Robert; Lehr, Claus-Michael; Hirsch, Anna K. H.; Hartmann, Rolf W.; Empting, Martin; Roehrig, Teresa Share Save
Evaluation of Bacterial RNA Polymerase Inhibitors in a Staphylococcus aureus-Based Wound Infection Model in SKH1 Mice Haupenthal, Joerg; Kautz, Yannik; Elgaher, Walid A. M.; Paetzold, Linda; Roehrig, Teresa; Laschke, Matthias W.; Tschernig, Thomas; Hirsch, Anna K. H.; Molodtsov, Vadim; Murakami, Katsuhiko S.; Hartmann, Rolf W.; Bischoff, Markus Share Save
A hydrogel-based in vitro assay for the fast prediction of antibiotic accumulation in Gram-negative bacteria Richter, Robert; Kamal, Mohamed A. M.; Garcia-Rivera, Mariel A.; Kaspar, Jerome; Junk, Maximilian; Elgaher, Walid A. M.; Srikakulam, Sanjay Kumar; Gress, Alexander; Beckmann, Anja; Grissmer, Alexander; Meier, Carola; Vielhaber, Michael; Kalinina, Olga; Hirsch, Anna K. H.; Hartmann, Rolf W.; Bronstrup, Mark; Schneider-Daum, Nicole; Lehr, Claus-Michael Share Save
Synthesis, Optimization, Antifungal Activity, Selectivity, and CYP51 Binding of New 2-Aryl-3-azolyl-1-indolyl-propan-2-ols Lebouvier, Nicolas; Pagniez, Fabrice; Na, Young Min; Shi, Da; Pinson, Patricia; Marchivie, Mathieu; Guillon, Jean; Hakki, Tarek; Bernhardt, Rita; Yee, Sook Wah; Simons, Claire; Leze, Marie-Pierre; Hartmann, Rolf W.; Mularoni, Angelique; Le Baut, Guillaume; Krimm, Isabelle; Abagyan, Ruben; Le Pape, Patrice; Le Borgne, Marc Share Save
N-Aryl-3-mercaptosuccinimides as Antivirulence Agents Targeting Pseudomonas aeruginosa Elastase and Clostridium Collagenases Konstantinovic, Jelena; Yahiaoui, Samir; Alhayek, Alaa; Haupenthal, Joerg; Schoenauer, Esther; Andreas, Anastasia; Kany, Andreas M.; Mueller, Rolf; Koehnke, Jesko; Berger, Fabian K.; Bischoff, Markus; Hartmann, Rolf W.; Brandstetter, Hans; Hirsch, Anna K. H. Share Save
Squalenyl Hydrogen Sulfate Nanoparticles for Simultaneous Delivery of Tobramycin and an Alkylquinolone Quorum Sensing Inhibitor Enable the Eradication of P. aeruginosa Biofilm Infections Ho, Duy-Khiet; Murgia, Xabier; De Rossi, Chiara; Christmann, Rebekka; Huefner de Mello Martins, Antonio G.; Koch, Marcus; Andreas, Anastasia; Herrmann, Jennifer; Mueller, Rolf; Empting, Martin; Hartmann, Rolf W.; Desmaele, Didier; Loretz, Brigitta; Couvreur, Patrick; Lehr, Claus-Michael Share Save
Cystobactamid 507: Concise Synthesis, Mode of Action, and Optimization toward More Potent Antibiotics Elgaher, Walid A. M.; Hamed, Mostafa M.; Baumann, Sascha; Herrmann, Jennifer; Siebenbuerger, Lorenz; Krull, Jana; Cirnski, Katarina; Kirschning, Andreas; Broenstrup, Mark; Mueller, Rolf; Hartmann, Rolf W. Share Save
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