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SaveShare Save An orally available P1′-5-fluorinated Mpro inhibitor blocks SARS-CoV-2 replication without booster and exhibits high genetic barrier
Higashi-Kuwata, Nobuyo; Bulut, Haydar; Hayashi, Hironori; Tsuji, Kohei; Ogata-Aoki, Hiromi; Kiso, Maki; Takamune, Nobutoki; Kishimoto, Naoki; Hattori, Shin-ichiro; Ishii, Takahiro; Kobayakawa, Takuya; Nakano, Kenta; Shimizu, Yukiko; Das, Debananda; Saruwatari, Junji; Hasegawa, Kazuya; Murayama, Kazutaka; Sukenaga, Yoshikazu; Takamatsu, Yuki; Yoshimura, Kazuhisa; Aoki, Manabu; Furusawa, Yuri; Okamura, Tadashi; Yamayoshi, Seiya; Kawaoka, Yoshihiro; Misumi, Shogo; Tamamura, Hirokazu; Mitsuya, Hiroaki Share Save Share Save Structural and virologic mechanism of the emergence of resistance to M pro inhibitors in SARS-CoV-2Hattori, Shin-ichiro; Bulut, Haydar; Hayashi, Hironori; Kishimoto, Naoki; Takamune, Nobutoki; Hasegawa, Kazuya; Furusawa, Yuri; Yamayoshi, Seiya; Murayama, Kazutaka; Tamamura, Hirokazu; Li, Mi; Wlodawer, Alexander; Kawaoka, Yoshihiro; Misumi, Shogo; Mitsuya, Hiroaki Share Save Share Save Discovery of Potent DAG-Lactone Derivatives as HIV Latency Reversing AgentsIshii, Takahiro; Kobayakawa, Takuya; Matsuda, Kouki; Nigorikawa, Kiyomi; Bolah, Peter; Noborio, Airi; Tsuji, Kohei; Ohashi, Nami; Yoshimura, Kazuhisa; Nomura, Wataru; Mitsuya, Hiroaki; Maeda, Kenji; Tamamura, Hirokazu Share Save Biochemical and Structural Properties of Entecavir-Resistant Hepatitis B Virus Polymerase with L180M/M204V Mutations (vol 95, e02401-20, 2021)Nakajima, Shogo; Watashi, Koichi; Kato, Takanobu; Muramatsu, Masamichi; Wakita, Takaji; Tamura, Noriko; Hattori, Shin-ichiro; Maeda, Kenji; Mitsuya, Hiroaki; Yasutake, Yoshiaki; Toyoda, Tetsuya Share Save Exploration of P1 and P4 modifications of nirmatrelvir: Design, synthesis, biological evaluation, and X-ray structural studies of SARS-CoV-2 Mpro inhibitorsGhosh, Arun K.; Yadav, Monika; Iddum, Satyanarayana; Ghazi, Somayeh; Lendy, Emma K.; Jayashankar, Uttara; Beechboard, Sydney N.; Takamatsu, Yuki; Hattori, Shin-ichiro; Aamano, Masayuki; Higashi-Kuwata, Nobuyo; Mitsuya, Hiroaki; Mesecar, Andrew D. Share Save High diagnostic accuracy of quantitative SARS-CoV-2 spike-binding-IgG assay and correlation with in vitro viral neutralizing activityIwamoto, Noriko; Takamatsu, Yuki; Asai, Yusuke; Tsuchiya, Kiyoto; Matsuda, Kouki; Oshiro, Yusuke; Inamura, Natsumi; Terada, Mari; Nemoto, Takashi; Kimura, Moto; Saito, Sho; Morioka, Shinichiro; Kenji, Maeda; Mitsuya, Hiroaki; Ohmagari, Norio Share Save Discovery of a nasal spray steroid, tixocortol, as an inhibitor of SARS-CoV-2 main protease and viral replicationDavis, David A.; Nair, Ashwin; Astter, Yana; Treco, Emma; Peyser, Brian; Gussio, Rick; Nguyen, Tam; Eaton, Brett; Postnikova, Elena; Murphy, Michael; Shrestha, Prabha; Bulut, Haydar; Hattorri, Shin-Ichiro; Mitsuya, Hiroaki; Yarchoan, Robert Share Save Efficacy and Safety of Treatment with Plasma from COVID-19-Recovered IndividualsTerada, Mari; Saito, Sho; Kutsuna, Satoshi; Kinoshita-Iwamoto, Noriko; Togano, Tomiteru; Hangaishi, Akira; Shiratori, Katsuyuki; Takamatsu, Yuki; Maeda, Kenji; Ishizaka, Yukihito; Ohtsu, Hiroshi; Satake, Masahiro; Mitsuya, Hiroaki; Ohmagari, Norio Share Save Share Save Structure-Activity Relationship Studies of SARS-CoV-2 Main Protease Inhibitors Containing 4-Fluorobenzothiazole-2-carbonyl MoietiesTsuji, Kohei; Ishii, Takahiro; Kobayakawa, Takuya; Higashi-Kuwata, Nobuyo; Shinohara, Kouki; Azuma, Chika; Miura, Yutaro; Nakano, Hiroki; Wada, Naoya; Hattori, Shin-ichiro; Bulut, Haydar; Mitsuya, Hiroaki; Tamamura, Hirokazu Share Save Preinfection Neutralizing Antibodies, Omicron BA.5 Breakthrough Infection, and Long COVID: A Propensity Score-Matched AnalysisYamamoto, Shohei; Matsuda, Kouki; Maeda, Kenji; Horii, Kumi; Okudera, Kaori; Oshiro, Yusuke; Inamura, Natsumi; Nemoto, Takashi; Takeuchi, Junko S.; Li, Yunfei; Konishi, Maki; Tsuchiya, Kiyoto; Gatanaga, Hiroyuki; Oka, Shinichi; Mizoue, Tetsuya; Sugiyama, Haruhito; Aoyanagi, Nobuyoshi; Mitsuya, Hiroaki; Sugiura, Wataru; Ohmagari, Norio Share Save HIV-1 Resistance to Islatravir/Tenofovir Combination Therapy in Wild-Type or NRTI-Resistant Strains of Diverse HIV-1 SubtypesCilento, Maria E.; Wen, Xin; Reeve, Aaron B.; Ukah, Obiaara B.; Snyder, Alexa A.; Carrillo, Ciro M.; Smith, Cole P.; Edwards, Kristin; Wahoski, Claudia C.; Kitzler, Deborah R.; Kodama, Eiichi N.; Mitsuya, Hiroaki; Parniak, Michael A.; Tedbury, Philip R.; Sarafianos, Stefan G. Share Save Synthesis and evaluation of DAG-lactone derivatives with HIV-1 latency reversing activityIshii, Takahiro; Kobayakawa, Takuya; Matsuda, Kouki; Tsuji, Kohei; Ohashi, Nami; Nakahata, Shingo; Noborio, Airi; Yoshimura, Kazuhisa; Mitsuya, Hiroaki; Maeda, Kenji; Tamamura, Hirokazu Share Save GRL-142 binds to and impairs HIV-1 integrase nuclear localization signal and potently suppresses highly INSTI-resistant HIV-1 variantsAoki, Manabu; Aoki-Ogata, Hiromi; Bulut, Haydar; Hayashi, Hironori; Takamune, Nobutoki; Kishimoto, Naoki; Tanaka, Hiroki; Higashi-Kuwata, Nobuyo; Hattori, Shin-ichiro; Das, Debananda; Rao, Kalapala Venkateswara; Iwama, Kazuya; Davis, David A.; Hasegawa, Kazuya; Murayama, Kazutaka; Yarchoan, Robert; Ghosh, Arun K.; Pau, Alice K.; Machida, Shinichi; Misumi, Shogo; Mitsuya, Hiroaki Share Save Exploration of imatinib and nilotinib-derived templates as the P2-Ligand for HIV-1 protease inhibitors: Design, synthesis, protein X-ray structural studies, and biological evaluationGhosh, Arun K.; Mishevich, Jennifer L.; Kovela, Satish; Shaktah, Ryan; Ghosh, Ajay K.; Johnson, Megan; Wang, Yuan-Fang; Wong-Sam, Andres; Agniswamy, Johnson; Amano, Masayuki; Takamatsu, Yuki; Hattori, Shin-ichiro; Weber, Irene T.; Mitsuya, Hiroaki Share Save Share Save 
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