Not logged in Discovery of long-acting APOC3 siRNA for treating patients with hypertriglyceridemia Prakash, Thazha P.; Mullick, Adam E.; Riney, Stan; Yu, Jinghua; Nikan, Mehran; Quirk, Clare; Crutchfield, Amanda; Damle, Sagar S.; Klein, Stephanie; Swayze, Eric E. Share Save
Single alkyl phosphonate modification of the siRNA backbone in the seed region enhances specificity and therapeutic profile Nikan, Mehran; Li, Qingfeng; Tanowitz, Michael; Li, Hongda; Damle, Sagar; Annoual, Marie; Galindo-Murillo, Rodrigo; Low, Audrey; Klein, Stephanie; Quirk, Clare; Vasquez, Guillermo; Wan, W. Brad; Watt, Andrew T.; Migawa, Michael T.; Swayze, Eric E.; Prakash, Thazha P. Share Save
Tool to Resolve Distortions in Elemental and Isotopic Imaging Lu, Chixiang; Chen, Gu; Song, Wenxin; Chen, Kai; Hee, Charmaine; Nikan, Mehran; Guagliardo, Paul; Bennett, C. Frank; Seth, Punit; Iyer, Killugudi Swaminathan; Young, Stephen G.; Qi, Xiaojuan; Jiang, Haibo Share Save
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Inhibition of Cpeb3 ribozyme elevates CPEB3 protein expression and polyadenylation of its target mRNAs and enhances object location memory Chen, Claire C.; Han, Joseph; Chinn, Carlene A.; Rounds, Jacob S.; Li, Xiang; Nikan, Mehran; Myszka, Marie; Tong, Liqi; Passalacqua, Luiz F. M.; Bredy, Timothy; Wood, Marcelo A.; Luptak, Andrej Share Save
High-resolution visualisation of antisense oligonucleotide release from polymers in cells King, Jessica J.; Chen, Kai; Evans, Cameron W.; Norret, Marck; Almasri, Ruba; Pavlos, Nathan J.; Hui, Henry Y. L.; Lin, Qiongxiang; Bhatt, Uditi; Young, Stephen G.; Smith, Nicole M.; Nikan, Mehran; Prestidge, Clive A.; Jiang, Haibo; Iyer, K. Swaminathan Share Save
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Glucagon Like Peptide 1 Receptor Agonists for Targeted Delivery of Antisense Oligonucleotides to Pancreatic Beta Cell Knerr, Laurent; Prakash, Thazha P.; Lee, Richard; Drury, William J., III; Nikan, Mehran; Fu, Wuxia; Pirie, Elaine; De Maria, Leonardo; Valeur, Eric; Hayen, Ahlke; Olwegard-Halvarsson, Maria; Broddefalk, Johan; Ammala, Carina; Ostergaard, Michael E.; Meuller, Johan; Sundstrom, Linda; Andersson, Patrik; Janzen, David; Jansson-Lofmark, Rasmus; Seth, Punit P.; Andersson, Shalini Share Save
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Transvascular Delivery of Hydrophobically Modified siRNAs: Gene Silencing in the Rat Brain upon Disruption of the Blood-Brain Barrier Godinho, Bruno M. D. C.; Henninger, Nils; Bouley, James; Alterman, Julia F.; Haraszti, Reka A.; Gilbert, James W.; Sapp, Ellen; Coles, Andrew H.; Biscans, Annabelle; Nikan, Mehran; Echeverria, Dimas; DiFiglia, Marian; Aronin, Neil; Khvorova, Anastasia Share Save
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Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo Hassler, Matthew R.; Turanov, Anton A.; Alterman, Julia F.; Haraszti, Reka A.; Coles, Andrew H.; Osborn, Maire F.; Echeverria, Dimas; Nikan, Mehran; Salomon, William E.; Roux, Loic; Godinho, Bruno M. D. C.; Davis, Sarah M.; Morrissey, David V.; Zamore, Phillip D.; Karumanchi, S. Ananth; Moore, Melissa J.; Aronin, Neil; Khvorova, Anastasia Share Save
Pharmacokinetic Profiling of Conjugated Therapeutic Oligonucleotides: A High-Throughput Method Based Upon Serial Blood Microsampling Coupled to Peptide Nucleic Acid Hybridization Assay Godinho, Bruno M. D. C.; Gilbert, James W.; Haraszti, Reka A.; Coles, Andrew H.; Biscans, Annabelle; Roux, Loic; Nikan, Mehran; Echeverria, Dimas; Hassler, Matthew; Khvorova, Anastasia Share Save
Synthesis and Evaluation of Parenchymal Retention and Efficacy of a Metabolically Stable O-Phosphocholine-N-docosahexaenoyl-L-serine siRNA Conjugate in Mouse Brain Nikan, Mehran; Osborn, Maire F.; Coles, Andrew H.; Biscans, Annabelle; Godinho, Bruno M. D. C.; Haraszti, Reka A.; Sapp, Ellen; Echeverria, Dimas; DiFiglia, Marian; Aronin, Neil; Khvorova, Anastasia Share Save
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Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain Nikan, Mehran; Osborn, Maire F.; Coles, Andrew H.; Godinho, Bruno M. D. C.; Hall, Lauren M.; Haraszti, Reka A.; Hassler, Matthew R.; Echeverria, Dimas; Aronin, Neil; Khvorova, Anastasia Share Save
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