Not logged in MSUT2 regulates tau spreading via adenosinergic signaling mediated ASAP1 pathway in neurons Xu, Hong; Qiu, Qi; Hu, Peng; Hoxha, Kevt'her; Jang, Elliot; O'Reilly, Mia; Kim, Christopher; He, Zhuohao; Marotta, Nicholas; Changolkar, Lakshmi; Zhang, Bin; Wu, Hao; Schellenberg, Gerard D.; Kraemer, Brian; Luk, Kelvin C.; Lee, Edward B.; Trojanowski, John Q.; Brunden, Kurt R.; Lee, Virginia M. -Y. Share Save
Design, Synthesis, and Evaluation of An Anti-trypanosomal [1,2,4]Triazolo[1,5-a]pyrimidine Probe for Photoaffinity Labeling Studies Lucero, Bobby; Francisco, Karol R.; Varricchio, Carmine; Liu, Lawrence J.; Yao, Yuemang; Brancale, Andrea; Brunden, Kurt R.; Caffrey, Conor R.; Ballatore, Carlo Share Save
A microtubule stabilizer ameliorates protein pathogenesis and neurodegeneration in mouse models of repetitive traumatic brain injury Zhao, Xinyi; Zeng, Wen; Xu, Hong; Sun, Zihan; Hu, Yingxin; Peng, Beibei; McBride, Jennifer D.; Duan, Jiangtao; Deng, Juan; Zhang, Bin; Kim, Soo-Jung; Zoll, Bryan; Saito, Takashi; Sasaguri, Hiroki; Saido, Takaomi C.; Ballatore, Carlo; Yao, Haishan; Wang, Zhaoyin; Trojanowski, John Q.; Brunden, Kurt R.; Lee, Virginia M. -Y.; He, Zhuohao Share Save
Structure-Activity Relationships, Tolerability and Efficacy of Microtubule-Active 1,2,4-Triazolo[1,5-a]pyrimidines as Potential Candidates to Treat Human African Trypanosomiasis Monti, Ludovica; Liu, Lawrence J.; Varricchio, Carmine; Lucero, Bobby; Alle, Thibault; Yang, Wenqian; Bem-Shalom, Ido; Gilson, Michael; Brunden, Kurt R.; Brancale, Andrea; Caffrey, Conor R.; Ballatore, Carlo Share Save
Preclinical characterization and IND-enabling safety studies for PNT001, an antibody that recognizes cis-pT231 tau Foster, Kelly; Manca, Matteo; McClure, Kim; Koivula, Pyry; Trojanowski, John Q.; Havas, Daniel; Chancellor, Sarah; Goldstein, Lee; Brunden, Kurt R.; Kraus, Allison; Ahlijanian, Michael K. Share Save
Abundant copathologies of polyglucosan bodies, frontotemporal lobar degeneration with TDP-43 inclusions and ageing-related tau astrogliopathy in a family with a GBE1 mutation Uemura, Maiko T.; Suh, Eun Ran; Robinson, John L.; Brunden, Kurt R.; Grossman, Murray; Irwin, David J.; Lee, Virginia M. -Y.; Trojanowski, John Q.; Lee, Edward B.; Van Deerlin, Vivianna M. Share Save
Microtubule-Stabilizing 1,2,4-Triazolo[1,5-a]pyrimidines as Candidate Therapeutics for Neurodegenerative Disease: Matched Molecular Pair Analyses and Computational Studies Reveal New Structure-Activity Insights Alle, Thibault; Varricchio, Carmine; Yao, Yuemang; Lucero, Bobby; Nzou, Goodwell; Demuro, Stefania; Muench, Megan; Vuong, Khoa D.; Oukoloff, Killian; Cornec, Anne-Sophie; Francisco, Karol R.; Caffrey, Conor R.; Lee, Virginia M. -Y.; Smith III, Amos B.; Brancale, Andrea; Brunden, Kurt R.; Ballatore, Carlo Share Save
Distinct characteristics of limbic-predominant age-related TDP-43 encephalopathy in Lewy body disease Uemura, Maiko T.; Robinson, John L.; Cousins, Katheryn A. Q.; Tropea, Thomas F.; Kargilis, Daniel C.; McBride, Jennifer D.; Suh, EunRan; Xie, Sharon X.; Xu, Yan; Porta, Silvia; Uemura, Norihito; Van Deerlin, Vivianna M.; Wolk, David A.; Irwin, David J.; Brunden, Kurt R.; Lee, Virginia M. -Y.; Lee, Edward B.; Trojanowski, John Q. Share Save
Effects of microglial depletion and TREM2 deficiency on Aβ plaque burden and neuritic plaque tau pathology in 5XFAD mice Delizannis, Argyro Thalia; Nonneman, Annelies; Tsering, Wangchen; De Bondt, An; Van den Wyngaert, Ilse; Zhang, Bin; Meymand, Emily; Olufemi, Modupe F.; Koivula, Pyry; Maimaiti, Shaniya; Trojanowski, John Q.; Lee, Virginia M-Y; Brunden, Kurt R. Share Save
Evaluation of the Structure-Activity Relationship of Microtubule-Targeting 1,2,4-Triazolo[1,5-a]pyrimidines Identifies New Candidates for Neurodegenerative Tauopathies Oukoloff, Killian; Nzou, Goodwell; Varricchio, Carmine; Lucero, Bobby; Alle, Thibault; Kovalevich, Jane; Monti, Ludovica; Cornec, Anne-Sophie; Yao, Yuemang; James, Michael J.; Trojanowski, John Q.; Lee, Virginia M-Y; Smith, Amos B., III; Brancale, Andrea; Brunden, Kurt R.; Ballatore, Carlo Share Save
In vitro amplification of pathogenic tau conserves disease-specific bioactive characteristics Xu, Hong; O'Reilly, Mia; Gibbons, Garrett S.; Changolkar, Lakshmi; McBride, Jennifer D.; Riddle, Dawn M.; Zhang, Bin; Stieber, Anna; Nirschl, Jeffrey; Kim, Soo-Jung; Hoxha, Kevt-her; Brunden, Kurt R.; Schellenberg, Gerard D.; Trojanowski, John Q.; Lee, Virginia M. -Y. Share Save
Congeners Derived from Microtubule-Active Phenylpyrimidines Produce a Potent and Long-Lasting Paralysis of Schistosoma mansoni In Vitro Monti, Ludovica; Cornec, Anne-Sophie; Oukoloff, Killian; Kovalevich, Jane; Prijs, Kristen; Alle, Thibault; Brunden, Kurt R.; Smith, Amos B., III; El-Sakkary, Nelly; Liu, Lawrence J.; Syed, Ali; Skinner, Danielle E.; Ballatore, Carlo; Caffrey, Conor R. Share Save
Compound screening in cell-based models of tau inclusion formation: Comparison of primary neuron and HEK293 cell assays Crowe, Alex; Henderson, Mark J.; Anderson, Johnathon; Titus, Steven A.; Zakharov, Alexey; Simeonov, Anton; Buist, Arjan; Delay, Charlotte; Moechars, Diederik; Trojanowski, John Q.; Lee, Virginia M. -Y.; Brunden, Kurt R. Share Save
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A brain-penetrant triazolopyrimidine enhances microtubule-stability, reduces axonal dysfunction and decreases tau pathology in a mouse tauopathy model Zhang, Bin; Yao, Yuemang; Cornec, Anne-Sophie; Oukoloff, Killian; James, Michael J.; Koivula, Pyry; Trojanowski, John Q.; Smith, Amos B., III; Lee, Virginia M. -Y.; Ballatore, Carlo; Brunden, Kurt R. Share Save
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Evaluation of Oxetan-3-ol, Thietan-3-ol, and Derivatives Thereof as Bioisosteres of the Carboxylic Acid Functional Group Lassalas, Pierrik; Oukoloff, Killian; Makani, Vishruti; James, Michael; Van Tran; Yao, Yuemang; Huang, Longchuan; Vijayendran, Krishna; Monti, Ludovica; Trojanowski, John Q.; Lee, Virginia M. -Y.; Kozlowski, Marisa C.; Smith, Amos B., III; Brunden, Kurt R.; Ballatore, Carlo Share Save
Multitargeted Imidazoles: Potential Therapeutic Leads for Alzheimer's and Other Neurodegenerative Diseases Cornec, Anne-Sophie; Monti, Ludovica; Kovalevich, Jane; Makani, Vishruti; James, Michael J.; Vijayendran, Krishna G.; Oukoloff, Killian; Yao, Yuemang; Lee, Virginia M. -Y.; Trojanowski, John Q.; Smith, Amos B., III; Brunden, Kurt R.; Ballatore, Carlo Share Save
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