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陈

陈小华 (Xiaohua Chen)

chinese academy of sciences

48H-index
200Paper Count
8.5KCitation Count
Published Papers 85
Publication Date
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Genetically Encoded Lysine-Selective Photocyclization Enables Phage Display Selection of Cyclic Peptide Binders
errAngewandte Chemie International Edition
IF16.9
err2026-07-09
err0
PREAI
errXiao-Qin Yang; Wei Ming; Ze-Hao Zhang; Xiang Liu; Li-Wen Bai; Zheng-Hui Li; Rong Huang; Xiao-Hua Chen; Xinxiang Lei
errShare
errSave
Multiplexed Photo-Cross-Linking Reveals Comprehensive Midnolin Interactome: Insights into Ubiquitin-Independent Degradation and Functional Diversity
errJournal of the American Chemical Society
IF15.6
err2026-03-12
err0
PREAI
errYali Xu; Wensi Zhao; Jingjing Fu; Zihao Liu; Hui-Jun Nie; Jun Zhang; Jingli Guo; Minjia Tan; Xiao-Hua Chen
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errSave
The antibacterial mechanism and cell damage mechanism of natural antibacterial agents from different sources and their applications in food
errJournal of Food Measurement and Characterization
IF3.3
err2025-11-24
err0
PREAI
errZaixiang Lou; Xu Cheng; Jiale Dong; Wenna Dai; Xiaohua Chen; Hongxin Wang
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errSave
Tau post-translational modifications in Alzheimer's disease: insights into pathogenesis, therapeutic strategies, and diagnostic advances
errAgeing Research Reviews
IF12.4
err2025-10-24
err0
PREAI
errHuiwen Lei; Xiaohua Chen; Longzhu Ruan; Xuena Liu; Fei Ye; Kejing Li; Wei Cheng; Boyi Yu; Qiang Li; Cuixia Di
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errSave
Mechanisms of constitutive and agonist-induced 5-HT2B internalization, persistent endosomal signaling and paradoxical regulation of agonist pharmacology
errCELLULAR SIGNALLING
IF3.7
err2025-07-01
err0
PREAI
errGaidarov, Ibragim; Frazer, John; Chen, Xiaohua; Dang, Huong; Cordova, Isabel; Liaw, Chen; Sage, Carleton; Unett, David J.
errShare
errSave
Visible-Light-Controlled Lysine-Selective Crosslinking Decodes Protein Complexes and Dynamic Interactomes in Live Cells
errAngewandte Chemie International Edition
IF0
err2025-06-18
err0
PREAI
errDr. Yali Xu; Dr. Hao Hu; Yu Ran; Dr. Wensi Zhao; Dr. An-Di Guo; Dr. Hui-Jun Nie; Dr. Linhui Zhai; Guang-Liang Yin; Jintao Cheng; Shengna Tao; Prof. Bing Yang; Prof. Minjia Tan; Prof. Xiao-Hua Chen
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errSave
Chemoproteomics reveals proteome-wide covalent and non-covalent targets of withaferin A
errACTA PHARMACOLOGICA SINICA
IF8.4
err2025-02-03
err0
PREAI
errNie, HJ; Fu, YJ; Long, S; Wang, JY; Zhao, WS; Zhai, LH; Yang, YL; Tan, MJ; Hu, H; Chen, XH
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errSave
Investigating the frequency of neural autoantibodies in refractory focal epilepsy
errSEIZURE-EUROPEAN JOURNAL OF EPILEPSY
IF2.8
err2025-02-01
err0
PREAI
errGillinder, Lisa; Craig, Donald; Powell, Tamara; Walsh, Stephen; Phamnguyen, John; Wilson, Ian; Chen, Xiaohua; Gillis, David; Mccombe, Pamela
errShare
errSave
Discovery Small-Molecule p300 Inhibitors Derived from a Newly Developed Indazolone-Focused DNA-Encoded Library
errBIOCONJUGATE CHEMISTRY
IF3.9
err2024-08-08
err1
PREAI
errSuo, Yanrui; Li, Kaige; Ling, Xing; Yan, Kenian; Lu, Weiwei; Yue, Jinfeng; Chen, Xiaohua; Duan, Zhiqiang; Lu, Xiaojie
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errSave
A region-confined PROTAC nanoplatform for spatiotemporally tunable protein degradation and enhanced cancer therapy
errNATURE COMMUNICATIONS
IF15.7
err2024-08-04
err3
errOAAI
errGao, Jing; Jiang, Xingyu; Lei, Shumin; Cheng, Wenhao; Lai, Yi; Li, Min; Yang, Lei; Liu, Peifeng; Chen, Xiao-hua; Huang, Min; Yu, Haijun; Xu, Huixiong; Xu, Zhiai
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errSave
Direct detection of acetylcholinesterase by Fe(HCOO)2.6(OH)0.3. H2O nanosheets with oxidase-like activity on a smartphone platform
errTALANTA
IF6.1
err2024-07-01
err0
PREAI
errCao, Yongbin; Chen, Yuanyuan; Zhou, Yue; Chen, Xiaohua; Peng, Jian
errShare
errSave
Discovery of Orally Bioavailable and Potent CDK9 Inhibitors for Targeting Transcription Regulation in Triple-Negative Breast Cancer
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-06-17
err0
PREAI
errWang, Wen-Jing; Gao, Lixin; Wang, Simei; Huang, Wensi; Meng, Xin-Yu; Hu, Hao; Chen, Ziqiang; Sun, Jingya; Yuan, Yali; Zhou, Yubo; Diao, Xingxing; Huang, Ruimin; Li, Jia; Chen, Xiao-Hua
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errSave
Accelerating PROTACs Discovery Through a Direct-to-Biology Platform Enabled by Modular Photoclick Chemistry
errADVANCED SCIENCE
IF14.1
err2024-04-30
err0
errOAAI
errYan, Ke-Nian; Nie, Yong-Qiang; Wang, Jia-Yu; Yin, Guang-Liang; Liu, Qia; Hu, Hao; Sun, Xiaoxia; Chen, Xiao-Hua
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errSave
Tumor-targeted PROTAC prodrug nanoplatform enables precise protein degradation and combination cancer therapy
errACTA PHARMACOLOGICA SINICA
IF8.4
err2024-04-12
err8
PREAI
errZou, Zhi-feng; Yang, Lei; Nie, Hui-jun; Gao, Jing; Lei, Shu-min; Lai, Yi; Zhang, Fan; Wagner, Ernst; Yu, Hai-jun; Chen, Xiao-hua; Xu, Zhi-ai
errShare
errSave
Spatiotemporal and direct capturing global substrates of lysine-modifying enzymes in living cells
errNATURE COMMUNICATIONS
IF15.7
err2024-02-17
err4
errOAAI
errHu, Hao; Hu, Wei; Guo, An-Di; Zhai, Linhui; Ma, Song; Nie, Hui-Jun; Zhou, Bin-Shan; Liu, Tianxian; Jia, Xinglong; Liu, Xing; Yao, Xuebiao; Tan, Minjia; Chen, Xiao-Hua
errShare
errSave
The linkage misalignment of productive services and firms' domestic value-added ratio--Evidence from Chinese micro-firm data
errTECHNOLOGICAL FORECASTING AND SOCIAL CHANGE
IF13.3
err2024-02-01
err3
PREAI
errZhang, Chonghui; Yuan, Lingjing; Yu, Xiao; Chen, Xiaohua
errShare
errSave
Carrier systems of radiopharmaceuticals and the application in cancer therapy
errCELL DEATH DISCOVERY
IF7
err2024-01-09
err18
errOAAI
errZhang, Taotao; Lei, Huiwen; Chen, Xiaohua; Dou, Zhihui; Yu, Boyi; Su, Wei; Wang, Wei; Jin, Xiaodong; Katsube, Takanori; Wang, Bing; Zhang, Hong; Li, Qiang; Di, Cuixia
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errSave
Sensitive and rapid detection of bacterial endotoxin with a functional carbon nanotube field-effect transistor biosensor
errTALANTA
IF6.1
err2024-01-01
err7
PREAI
errCui, Qing; Li, Jiahao; Li, Yutao; Tang, Lina; Li, Kun; Li, Tingxian; Chen, Xiaohua; Zhang, Zhiyong; Zhang, Guo-Jun
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errSave
Multiomics analysis of metabolic heterogeneity in cervical cancer cell lines with or without HPV
errFRONTIERS IN ONCOLOGY
IF3.3
err2023-11-23
err1
errOAAI
errLiu, Xu; Zhu, Yaqi; Huang, Sheng; Shi, Tingyu; Li, Tanghua; Lan, Yanan; Cao, Xiaojian; Wu, Yingtao; Ding, Jinya; Chen, Xiaohua
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errSave
Macrocyclizing DNA-Linked Peptides via Three-Component Cyclization and Photoinduced Chemistry
errORGANIC LETTERS
IF5
err2023-06-29
err10
PREAI
errBao, Yandan; Xing, Minyan; Matthew, Naylor; Chen, Xiaohua; Wang, Xuan; Lu, Xiaojie
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errSave

Research Directions

药物化学化学生物学蛋白质相互作用和蛋白质稳态调控研究有机化学分子及细胞生物学蛋白质工程化学蛋白质组学蛋白质间相互作用和靶标确证研究靶向蛋白降解技术的创新药物研发活细胞中蛋白质相互作用工具箱蛋白质功能及靶标发现研究生物大分子靶向降解筛选技术难成药靶标小分子降解剂发现蛋白质稳态调控及其作用机制研究高效分子胶降解剂发现创新药物研究
Co-authors
Cooperation Journals
G
Gordon B. Mills
H-index: 231 · Papers: 3.5K
C
Chris Sander
H-index: 191 · Papers: 849
K
Kanyi Pu
H-index: 131 · Papers: 389
Y
Yiling Lu
H-index: 129 · Papers: 799
J
Joan S. Brugge
H-index: 126 · Papers: 597
View more