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J

Jian Jin

icahn school of medicine at mount sinai

74H-index
488Paper Count
2.2WCitation Count
Published Papers 221
Publication Date
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An EZH2–SREBP2 axis promotes cholesterol biosynthesis and represents a noncanonical vulnerability in tumorigenesis
errNature Cell Biology
IF19.1
err2026-08-14
err0
PREAI
errArum Kim; Bo Pan; Xufen Yu; Xing Gao; Nelli Khudaverdyan; Fatemeh Taherian; Chenxi Xu; Haiqing Zhong; Yan Xiong; H. Ümit Kaniskan; Masoud Vedadi; Jikui Song; Jian Jin; Ling Cai; Gang Greg Wang
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Discovery of New OTUB1 Covalent Ligands via Structure–Activity Relationship Studies for Targeted Protein Stabilization
errJournal of Medicinal Chemistry
IF6.8
err2026-05-04
err0
PREAI
errXiangyang Song; Qiong Wu; Li Chen; Hiroyuki Inuzuka; Yue Zhong; Yihang Qi; Yindan Lin; Md Kabir; Yan Xiong; Wenyi Wei; Jian Jin
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Discovery of a Highly Potent and Selective ENL Degrader
errJournal of Medicinal Chemistry
IF6.8
err2026-04-23
err0
PREAI
errKaixiu Luo; Zhaoyu Xue; Lihuai Qin; Zhefan Wang; Pengcheng Gao; Ling Xie; Yangzhou Su; Xian Chen; H. Ümit Kaniskan; Hong Wen; Jian Jin
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A dual role of EZH2 in regulating A-to-I RNA editing and mRNA stability through ADAR
errNature Communications
IF15.7
err2026-03-26
err0
errOAAI
errYang Yi; Yanqiang Li; Rui Wang; Xufen Yu; Qi Liu; Chaehyun Yum; Yang Zhang; Yuanyuan Qiao; Aileen Szczepanski; Siqi Wu; Qiaqia Li; Ladan Fazli; Jiangchuan Shen; Xin Wang; Xiaoling Li; Ping Mu; Edward M. Schaeffer; Heather A. Hundley; Hengyao Niu; Arul M. Chinnaiyan; Lu Wang; Jinjun Shi; Jian Jin; Xuesen Dong; Wei Zhao; Kaifu Chen; Qi Cao
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A gated hydrophobic funnel within BAX binds bioactive lipids to potentiate pro-apoptotic function
errNature Communications
IF15.7
err2026-02-25
err0
errOAAI
errJesse D. Gelles; Yiyang Chen; Mark P. A. Luna-Vargas; Ariele Viacava Follis; Md Abdullah Al Noman; Md Kabir; Stella G. Bayiokos; Jarvier N. Mohammed; Tara M. Sebastian; Ngoc Dung Pham; Yi Shi; Jian Jin; Richard W. Kriwacki; Jerry Edward Chipuk
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Discovery of KRAS-G12D Degraders via Exploration of Various E3 Ligases
errEuropean Journal of Medicinal Chemistry
IF5.9
err2026-02-03
err0
PREAI
errHyerin Yim; Xiangyang Song; Yue Zhong; Jacqueline Hu; Yan Xiong; Jian Jin
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EZH2 crosstalk with RNA methylation promotes prostate cancer progression through modulation of m6A autoregulation pathway
errJournal of Clinical Investigation
IF13.6
err2026-01-16
err2
errOAAI
errYi, Yang; Fry, Joshua; Yum, Chaehyun; Wang, Rui; Wu, Siqi; Narayan, Sharath; Liu, Qi; Zhang, Xingxing; Oo, Htoo Zarni; Xie, Ning; Li, Yanqiang; Gao, Xinlei; Yu, Xufen; Hu, Xiaoping; Li, Qiaqia; Keseroglu, Kemal; Ozbudak, Ertugrul M.; Abdulkadir, Sarki A.; Chen, Kaifu; Jin, Jian; Zhao, Jonathan C.; Dong, Xuesen; Arango, Daniel; Yang, Rendong; Cao, Qi
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SGSS05-NS3, a covalent SETD8 inhibitor that activates p53 pathway in neuroblastoma
errJournal of Experimental & Clinical Cancer Research
IF12.8
err2025-12-19
err0
errOAAI
errZhihui Liu; Sukriti Bagchi; Chunhua Yan; Ying Hu; Gil Blum; Anqi Ma; Jian Jin; Minkui Luo; Sebastiano Di Bella; Francesco Verona; Ettore Appella; Giuseppe Giannini; Carol J. Thiele; Veronica Veschi
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Tumor microenvironment-targeted PROTAC nanoparticle self-assembly broadly predicted by structural descriptors
errSCIENCE ADVANCES
IF12.5
err2025-12-05
err0
PREAI
errVogt, Kristen C.; Panagiotakopoulou, Magdalini; Honu, Mandana T. Manzari; Perea, Ana Marie; Hu, Xiaoping; Yu, Xufen; Raziuddin, Raashed; Laplant, Quincey; Ruiz, Stephen; Raju, G. Praveen; Jin, Jian; Scheinberg, David A.; Heller, Daniel A.
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Association of ambient particulate matter exposure with preterm birth and gestational age in a retrospective sibling-matched Chinese cohort
errEcotoxicology and Environmental Safety
IF6.1
err2025-12-05
err0
errOAAI
errHui Chang; Huanhuan Zhang; Yuanfang Zhao; Yangyang Yuan; Junze Deng; Jian Jin; Yi Wei; Mingyi Xue; Zengli Yu; Xin Zhao
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errSave
In-situ growth of nano-sized calcium species on black liquor-derived biochar for efficient remediation of Cd2+ and Pb2+ in water
errJournal of Water Process Engineering
IF6.7
err2025-11-29
err0
PREAI
errZhizhou Pan; Jian Jin; Chengmei Lu; Yi Zhang
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errSave
Targeted destruction of VISTA boosts anti-tumor immunotherapy
errCell Research
IF25.9
err2025-11-13
err0
PREAI
errLi Chen; Xia Bu; Yishuang Sun; Daoyuan Huang; Yong Chen; Tao Hou; Xiaoping Hu; Jingchao Wang; Peiqiang Yan; Yihang Qi; Weiwei Jiang; Yan Xiong; Jing Liu; Yang Gao; Mengxi Huan; Bin Wang; Qianjia Liu; Xiaoming Dai; Fabin Dang; John M. Asara; Masanori Fujimoto; Hiroyuki Inuzuka; Jian Jin; Jinfang Zhang; Gordon J. Freeman; Wenyi Wei
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errSave
Quinoline-Based DNA Methyltransferase Inhibitors Featuring Basic Side Chains: Design, Synthesis, and Insight in Biochemical and Anticancer Cell Properties
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2025-11-01
err0
PREAI
errZwergel, Clemens; Lambona, Chiara; Fioravanti, Rossella; Raucci, Alessia; Fiorentino, Francesco; Nchugoua Tchieh, Guilaine; Jallet, Corinne; Lacroix, Laurent; Pierrettori, Michela; Pellegrini, Francesca Romana; Xiong, Yan; Jin, Jian; Arimondo, Paola; Trisciuoglio, Daniela; Mai, Antonello; Valente, Sergio
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Retraction Note: ROCK1 mechano-signaling dependency of human malignancies driven by TEAD/YAP activation
errNature Communications
IF15.7
err2025-10-20
err0
errOAAI
errDavide Esposito; Ila Pant; Yao Shen; Rui F. Qiao; Xiaobao Yang; Yiyang Bai; Jian Jin; Poulikos I. Poulikakos; Stuart A. Aaronson
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Loss of tumor cell MHC class II drives MAPK inhibitor insensitivity ofBRAF-mutant anaplastic thyroid cancers
errJOURNAL OF CLINICAL INVESTIGATION
IF13.6
err2025-10-15
err0
errOAAI
errTiedje, Vera; Greenberg, Jillian; Qin, Tianyue; Im, Soo-Peon; Krishnamoorthy, Gnana P.; Boucai, Laura; Xu, Bin; French, Jena D.; Sherman, Eric J.; Ho, Alan L.; De Stanchina, Elisa; Socci, Nicholas D.; Jin, Jian; Ghossein, Ronald A.; Knauf, Jeffrey A.; Koche, Richard P.; Fagin, James A.
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Targeting the Mitochondrial Protease ClpP for Anticancer Therapy
errJournal of Medicinal Chemistry
IF6.8
err2025-10-01
err0
PREAI
errZhongli Xu; Dmitry Pokushalov; Md Kabir; Youngeun Lee; Mrittika Chattopadhyay; Edmund C. Jenkins; Cessarina Choo; H. Ümit Kaniskan; Doris Germain; Jian Jin
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Combinatorial DNMTs and EZH2 inhibition reprograms the H3K27me3 and DNAme-mediated onco-epigenome to suppress multiple myeloma proliferation
errScientific Reports
IF3.9
err2025-08-27
err0
errOAAI
errAlba Atienza Párraga; Patrick Nylund; Klev Diamanti; Berta Garrido-Zabala; Stefania Iliana Tziola; Louella Vasquez; Paul Theodor Pyl; Doroteya Raykova; Aron Skaftason; Anqi Ma; Jian Jin; José Ignacio Martín-Subero; Fredrik Öberg; Elke De Bruyne; Jan Komorowski; Helena Jernberg Wiklund; Antonia Kalushkova
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SOX11 Modulates BCR Signaling Through the PAX5/CD19 Axis for Therapeutic Targeting in BTK Resistant Mantle Cell Lymphoma
errBlood Advances
IF7.1
err2025-08-25
err0
errOAAI
errRudra Prasad Dutta; Heng-Huan Lee; Violetta V. Leshchenko; Ravi Prakash Shukla; Fangfang Yan; Yang Liu; H. Ümit Kaniskan; Xing Qiu; Jian Jin; Lapo Alinari; Michael Wang; Samir Parekh
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Deubiquitinase-Targeting Chimeras Mediated Stabilization of Tumor Suppressive E3 Ligase Proteins as a Strategy for Cancer Therapy
errJournal of the American Chemical Society
IF15.6
err2025-08-06
err0
PREAI
errLi Chen; Zhijie Deng; Yan Xiong; Jing Liu; Daoyuan Huang; Jingchao Wang; Yong Chen; Hiroyuki Inuzuka; Ling Xie; Xian Chen; Jian Jin; Wenyi Wei
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errSave
Discovery of the First-in-class Aurora B Kinase Selective Degrader
errEuropean Journal of Medicinal Chemistry
IF5.9
err2025-07-24
err0
PREAI
errXiaoping Hu; Kevin Graciano; Jianping Hu; Chang Liu; Jiuyi Zhang; Ling Xie; Xian Chen; Yan Xiong; Jian Jin; Jia Xu
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Research Directions

No research directions
Co-authors
Cooperation Journals
王
王军 (Jun Wang)
H-index: 222 · Papers: 3.2K
M
Marc G. Caron
H-index: 175 · Papers: 810
G
Gordon J. Freeman
H-index: 174 · Papers: 1.1K
K
Kun‐Liang Guan
H-index: 168 · Papers: 621
S
Stuart L. Schreiber
H-index: 166 · Papers: 1.3K
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