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Design of a Targeted Covalent Probe to Interrogate the DNA Polymerase Activity of Polθ Bubenik, Monica; Mader, Pavel; Orlicky, Stephen; Perryman, Alexander L.; Hamel, Martine; Godbout, Claude; Falgueyret, Jean-Pierre; Kurinov, Igor; Wong, Cassandra; Gingras, Anne Claude; Mamane, Yael; Zinda, Michael; Morris, Stephen J.; Gallant, Michel; Sfeir, Agnel; Black, W. Cameron; Durocher, Daniel; Zimmermann, Michal; Sicheri, Frank Share Save
Discovery of RP-1664: A First-in-Class Orally Bioavailable, Selective PLK4 Inhibitor Vallee, Frederic; Casas-Selves, Matias; Bubenik, Monica; Duplessis, Martin; Sow, Boubacar; Suarez, Catalina; Sangiorgi, Bruno; Li, Li; Hyer, Marc; Papp, Robert; Leclaire, Marie-Eve; Perryman, Alexander L.; Liu, Bingcan; Surprenant, Simon; Mochirian, Philippe; Pau, Victor; Maderova, Zdenka; Mader, Pavel; Yin, Shou Yun; Goodfellow, Elliot; Roulston, Anne; Stocco, Rino; Godbout, Claude; Baruah, Prasamit; Bonneau-Fortin, Alexanne; Schonhoft, Joseph D.; Nejad, Parham; Norman, David; Truong, Vouy Linh; Crane, Sheldon; Attia, Mohamed A.; Mao, Daniel; Sicheri, Frank; Marshall, C. Gary; Zimmermann, Michal; Bendahan, David; Gallant, Michel; Black, W. Cameron Share Save
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Identification of RP-6685, an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Polθ Bubenik, Monica; Mader, Pavel; Mochirian, Philippe; Vallee, Frederic; Clark, Jillian; Truchon, Jean-Francois; Perryman, Alexander L.; Pau, Victor; Kurinov, Igor; Zahn, Karl E.; Leclaire, Marie-Eve; Papp, Robert; Mathieu, Marie-Claude; Hamel, Martine; Duffy, Nicole M.; Godbout, Claude; Casas-Selves, Matias; Falgueyret, Jean-Pierre; Baruah, Prasamit S.; Nicolas, Olivier; Stocco, Rino; Poirier, Hugo; Martino, Giovanni; Fortin, Alexanne Bonneau; Roulston, Anne; Chefson, Amandine; Dorich, Stephane; St-Onge, Miguel; Patel, Purvish; Pellerin, Charles; Ciblat, Stephane; Pinter, Thomas; Barabe, Francis; El Bakkouri, Majida; Parikh, Paranjay; Gervais, Christian; Sfeir, Agnel; Mamane, Yael; Morris, Stephen J.; Black, W. Cameron; Sicheri, Frank; Gallant, Michel Share Save
Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4 Chana, Chetan K.; Maisonneuve, Pierre; Posternak, Ganna; Grinberg, Nicolas G. A.; Poirson, Juline; Ona, Samara M.; Ceccarelli, Derek F.; Mader, Pavel; St-Cyr, Daniel J.; Pau, Victor; Kurinov, Igor; Tang, Xiaojing; Deng, Dongjing; Cui, Weiren; Su, Wenji; Kuai, Letian; Soll, Richard; Tyers, Mike; Rost, Hannes L.; Batey, Robert A.; Taipale, Mikko; Gingras, Anne-Claude; Sicheri, Frank Share Save
Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306 Szychowski, Janek; Papp, Robert; Dietrich, Evelyne; Liu, Bingcan; Vallee, Frederic; Leclaire, Marie-Eve; Fourtounis, Jimmy; Martino, Giovanni; Perryman, Alexander L.; Pau, Victor; Yin, Shou Yun; Mader, Pavel; Roulston, Anne; Truchon, Jean-Francois; Marshall, C. Gary; Diallo, Mohamed; Duffy, Nicole M.; Stocco, Rino; Godbout, Claude; Bonneau-Fortin, Alexanne; Kryczka, Rosie; Bhaskaran, Vivek; Mao, Daniel; Orlicky, Stephen; Beaulieu, Patrick; Turcotte, Pascal; Kurinov, Igor; Sicheri, Frank; Mamane, Yael; Gallant, Michel; Black, W. Cameron Share Save
Bora phosphorylation substitutes in trans for T-loop phosphorylation in Aurora A to promote mitotic entry Tavernier, N.; Thomas, Y.; Vigneron, S.; Maisonneuve, P.; Orlicky, S.; Mader, P.; Regmi, S. G.; Van Hove, L.; Levinson, N. M.; Gasmi-Seabrook, G.; Joly, N.; Poteau, M.; Velez-Aguilera, G.; Gavet, O.; Castro, A.; Dasso, M.; Lorca, T.; Sicheri, F.; Pintard, L. Share Save
Functional characterization of a PROTAC directed against BRAF mutant V600E Posternak, Ganna; Tang, Xiaojing; Maisonneuve, Pierre; Jin, Ting; Lavoie, Hugo; Daou, Salima; Orlicky, Stephen; de Rugy, Theo Goullet; Caldwell, Lauren; Chan, Kin; Aman, Ahmed; Prakesch, Michael; Poda, Gennady; Mader, Pavel; Wong, Cassandra; Maier, Stefan; Kitaygorodsky, Julia; Larsen, Brett; Colwill, Karen; Yin, Zhe; Ceccarelli, Derek F.; Batey, Robert A.; Taipale, Mikko; Kurinov, Igor; Uehling, David; Wrana, Jeff; Durocher, Daniel; Gingras, Anne-Claude; Al-Awar, Rima; Therrien, Marc; Sicheri, Frank Share Save
Identification and characterization of the first fragment hits for SETDB1 Tudor domain Mader, Pavel; Mendoza-Sanchez, Rodrigo; Iqbal, Aman; Dong, Aiping; Dobrovetsky, Elena; Corless, Victoria B.; Liew, Sean K.; Houliston, Scott R.; De Freitas, Renato Ferreira; Smil, David; Dela Sena, Carlo C.; Kennedy, Steven; Diaz, Diego B.; Wu, Hong; Dombrovski, Ludmila; Allali-Hassani, Abdellah; Min, Jinrong; Schapira, Matthieu; Vedadi, Masoud; Brown, Peter J.; Santhakumar, Vijayaratnam; Yudin, Andrei K.; Arrowsmith, Cheryl H. Share Save
Targeting chromatin regulation for cancer therapy: progress towards chemical probes for methyl-lysine readers James, Lindsey I.; Stuckey, Jake I.; Baughman, Brandi M.; Perfetti, Michael T.; Pattenden, Samantha G.; Dickson, Brad M.; Norris, Jacqueline L.; Cui, Gaofeng; Mader, Pavel; Dong, Aiping; Mu, Yunxiang; Rothbart, Scott B.; Strahl, Brian D.; Min, Jinrong; Brown, Peter J.; Kireev, Dmitri B.; Janzen, William P.; McBride, Kevin M.; Bedford, Mark T.; Mer, Georges; Arrowsmith, Cheryl H.; Frye, Stephen V. Share Save
Identification of a Fragment-like Small Molecule Ligand for the Methyl-lysine Binding Protein, 53BP1 Perfetti, Michael T.; Baughman, Brandi M.; Dickson, Bradley M.; Mu, Yunxiang; Cui, Gaofeng; Mader, Pavel; Dong, Aiping; Norris, Jacqueline L.; Rothbart, Scott B.; Strahl, Brian D.; Brown, Peter J.; Janzen, William P.; Arrowsmith, Cheryl H.; Mer, Georges; McBride, Kevin M.; James, Lindsey I.; Frye, Stephen V. Share Save
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Synthesis, Structure-Activity Relationship Studies, and X-ray Crystallographic Analysis of Arylsulfonamides as Potent Carbonic Anhydrase Inhibitors Gitto, Rosaria; Damiano, Francesca M.; Mader, Pavel; De Luca, Laura; Ferro, Stefania; Supuran, Claudiu T.; Vullo, Daniela; Brynda, Jiri; Rezacova, Pavlina; Chimirri, Alba Share Save
Structural Basis for the Interaction Between Carbonic Anhydrase and 1,2,3,4-tetrahydroisoquinolin-2-ylsulfonamides Mader, Pavel; Brynda, Jiri; Gitto, Rosaria; Agnello, Stefano; Pachl, Petr; Supuran, Claudiu T.; Chimirri, Alba; Rezacova, Pavlina Share Save
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Identification of 3,4-Dihydroisoquinoline-2(1H)-sulfonamides as Potent Carbonic Anhydrase Inhibitors: Synthesis, Biological Evaluation, and Enzyme-Ligand X-ray Studies Gitto, Rosaria; Agnello, Stefano; Ferro, Stefania; De Luca, Laura; Vullo, Daniela; Brynda, Jiri; Mader, Pavel; Supuran, Claudia T.; Chimirri, Alba Share Save
Stabilization of antibody structure upon association to a human carbonic anhydrase epitope studied by X-ray crystallography, microcalorimetry, and molecular dynamics simulations Kral, Vlastimil; Mader, Pavel; Collard, Renata; Fabry, Milan; Horejsi, Magdalena; Rezacova, Pavlina; Kozisek, Milan; Zavada, Jan; Sedlacek, Juraj; Rulisek, Lubomir; Brynda, Jiri Share Save
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