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Simon J. F. Macdonald

rgdscience ltd, second floor, 2 walsworth road, hitchin, hertfordshire sg4 9s, u.k.

41H-index
189Paper Count
6.3KCitation Count
Published Papers 73
Publication Date
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Crossing the Divide: A Transitional Undergraduate Research Project in Medicinal Chemistry
errJournal of Chemical Education
IF2.9
err2025-10-23
err0
errOAAI
errL. Palmer; A. Beekman; A. Ganesan; S. MacDonald; R. Hatley; P. J. McDermott
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Core Modifications of GSK3335103 toward Orally Bioavailable αvβ6 Inhibitors with Improved Synthetic Tractability
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-10-17
err0
PREAI
errHryczanek, Heather F.; Barrett, John; Barrett, Tim N.; Burley, Glenn A.; Cookson, Rosa E.; Hatley, Richard J. D.; Measom, Nicholas D.; Roper, James A.; Rowedder, James E.; Slack, Robert J.; Smieja, Connor B.; Macdonald, Simon J. F.
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Discovery and Development of Highly Potent and Orally Bioavailable Nonpeptidic αvβ6 Integrin Inhibitors
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-09-13
err1
PREAI
errProcopiou, Panayiotis A.; Barrett, John; Crawford, Matthew H. J.; Hatley, Richard J. D.; Hancock, Ashley P.; Pritchard, John M.; Rowedder, James E.; Copley, Royston C. B.; Slack, Robert J.; Sollis, Steven L.; Thorp, Lee R.; Lippa, Rhys A.; Macdonald, Simon J. F.; Barrett, Tim N.
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IMPACT OF DELIRIUM IN THE PEDIATRIC INTENSIVE CARE UNIT TWO MONTHS AFTER DISCHARGE
errCRITICAL CARE MEDICINE
IF6
err2023-12-14
err0
PREAI
errThibault, Celine; Macdonald, Simon; Du Pont-Thibodeau, Genevieve; Jutras, Camille; Roumeliotis, Nadia; Harrington, Karen; Farrell, Catherine; Lacroix, Jacques; Ducharme-Crevier, Laurence
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Medicinal chemistry in big pharma has a gender diversity problem
errFUTURE MEDICINAL CHEMISTRY
IF3.4
err2022-09-13
err2
PREAI
errMacdonald, Simon J. F.
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errSave
Structure-Based Design of a Novel Class of Autotaxin InhibitorsBased on Endogenous Allosteric Modulators
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2022-04-20
err14
errOAAI
errClark, Jennifer M.; Salgado-Polo, Fernando; Macdonald, Simon J. F.; Barrett, Tim N.; Perrakis, Anastassis; Jamieson, Craig
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How Diverse Is Medicinal Chemistry? Insights into Race, Ethnicity, Origin, Gender, and Geography
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2021-12-21
err2
PREAI
errHatley, Richard J. D.; McLachlan, Steve P.; Baster, Kathleen; Gelder, Lucy C.; Macdonald, Simon J. F.
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errSave
Pharmacological characterisation of GSK3335103, an oral αvβ6 integrin small molecule RGD-mimetic inhibitor for the treatment of fibrotic disease
errEUROPEAN JOURNAL OF PHARMACOLOGY
IF4.7
err2021-12-01
err8
PREAI
errWilkinson, Alex L.; John, Alison E.; Barrett, John W.; Gower, E.; Morrison, Valerie S.; Man, Yim; Pun, K. Tao; Roper, James A.; Luckett, Jeni C.; Borthwick, Lee A.; Barksby, Ben S.; Burgoyne, Rachel A.; Barnes, Rory; Fisher, Andrew J.; Procopiou, Panayiotis A.; Hatley, Richard J. D.; Barrett, Tim N.; Marshall, Richard P.; Macdonald, Simon J. F.; Jenkins, R. Gisli; Slack, Robert J.
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errSave
Emerging therapeutic opportunities for integrin inhibitors
errNATURE REVIEWS DRUG DISCOVERY
IF101.8
err2021-09-17
err277
errOAAI
errSlack, R. J.; Macdonald, S. J. F.; Roper, J. A.; Jenkins, R. G.; Hatley, R. J. D.
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errSave
Writing Your Next Medicinal Chemistry Article: Journal Bibliometrics and Guiding Principles for Industrial Authors
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2020-10-26
err3
errOAAI
errHatley, Richard J. D.; Procopiou, Panayiotis A.; McLachlan, Steven P.; Westendorf, Laura E.; Meanwell, Nicholas A.; Ewing, William R.; Macdonald, Simon J. F.
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errSave
Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis
errNATURE COMMUNICATIONS
IF15.7
err2020-09-16
err79
errOAAI
errJohn, Alison E.; Graves, Rebecca H.; Pun, K. Tao; Vitulli, Giovanni; Forty, Ellen J.; Mercer, Paul F.; Morrell, Josie L.; Barrett, John W.; Rogers, Rebecca F.; Hafeji, Maryam; Bibby, Lloyd I.; Gower, Elaine; Morrison, Valerie S.; Man, Yim; Roper, James A.; Luckett, Jeni C.; Borthwick, Lee A.; Barksby, Ben S.; Burgoyne, Rachel A.; Barnes, Rory; Le, Joelle; Flint, David J.; Pyne, Susan; Habgood, Anthony; Organ, Louise A.; Joseph, Chitra; Edwards-Pritchard, Rochelle C.; Maher, Toby M.; Fisher, Andrew J.; Gudmann, Natasja Staehr; Leeming, Diana J.; Chambers, Rachel C.; Lukey, Pauline T.; Marshall, Richard P.; Macdonald, Simon J. F.; Jenkins, R. Gisli; Slack, Robert J.
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Late-Stage Functionalization by Chan-Lam Amination: Rapid Access to Potent and Selective Integrin Inhibitors
errCHEMISTRY-A EUROPEAN JOURNAL
IF3.7
err2020-05-26
err10
errOAAI
errRobinson, Henry; Oatley, Steven A.; Rowedder, James E.; Slade, Pawel; Macdonald, Simon J. F.; Argent, Stephen P.; Hirst, Jonathan D.; McInally, Thomas; Moody, Christopher J.
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Molecular Simulation of αvβ6 Integrin Inhibitors
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2020-05-18
err6
errOAAI
errGuest, Ellen E.; Oatley, Steven A.; Macdonald, Simon J. F.; Hirst, Jonathan D.
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Sprinkling the pixie dust: reflections on innovation and innovators in medicinal chemistry and drug discovery
errDRUG DISCOVERY TODAY
IF7.5
err2020-03-01
err3
PREAI
errMacdonald, Simon J. F.; Hatley, Richard J. D.
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errSave
Free-Wilson Analysis of Comprehensive Data on Phosphoinositide-3-kinase (PI3K) Inhibitors Reveals Importance of N-Methylation for PI3Kδ Activity
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2019-10-24
err7
PREAI
errBarnes, Lydia; Blaber, Hollie; Brooks, David T. K.; Byers, Lewis; Buckley, Daniel; Byron, Zoe C.; Chilvers, Richard G.; Cochrane, Liam; Cooney, Edward; Damian, Heather A.; Francis, Luke; He, Daniel Fu; Grace, Jack M. J.; Green, Harley J.; Hogarth, Edmund J. P.; Jusu, Leyla; Killalea, C. Elizabeth; King, Oliver; Lambert, Joseph; Lee, Zoe J.; Lima, Nuria S.; Long, Christina L.; Mackinnon, May-Li; Mahdy, Shusha; Matthews-Wright, Jolyon; Millward, Makenzie J.; Meehan, Matthew F.; Merrett, Christopher; Morrison, Lisa; Parke, Hal R. I.; Payne, Charlotte; Payne, Lawrence; Pike, Craig; Seal, Alexander; Senior, Aaron J.; Smith, Keenan M.; Stanelyte, Kamile; Stillibrand, Joe; Szpara, Rachel; Taday, Freya F. H.; Threadgould, Antony M.; Trainor, Rohan J.; Waters, Jordan; Williams, Oliver; Wong, Carrie K. W.; Wood, Katherine; Barton, Nick; Gruszka, Anna; Henley, Zoe; Rowedder, James E.; Cookson, Rosa; Jones, Katherine L.; Nadin, Alan; Smith, Ian E.; Macdonald, Simon J. F.; Nortcliffe, Andrew
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Discovery of an Orally Bioavailable Pan αv Integrin Inhibitor for Idiopathic Pulmonary Fibrosis
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2019-09-09
err10
PREAI
errAnderson, Niall A.; Campos, Sebastien; Butler, Sharon; Copley, Royston C. B.; Duncan, Ian; Harrison, Stephen; Le, Joelle; Maghames, Rosemary; Pastor-Garcia, Aleix; Pritchard, John M.; Rowedder, James E.; Smith, Claire E.; Thomas, Jack; Vitulli, Giovanni; Macdonald, Simon J. F.
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Profile of a Highly Selective Quaternized Pyrrolidine Betaine αvβ6 Integrin Inhibitor-(3S)-3-(3-(3,5-Dimethyl-1H-pyrazol-1-yl)phenyl)-4-((1S and 1R,3R)-1-methyl-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-ium-1-yl)butanoate Synthesized by Stereoselective Methylation
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2019-08-05
err5
errOAAI
errBarrett, Tim N.; Taylor, Jonathan A.; Barker, Daniel; Procopiou, Panayiotis A.; Thompson, James D. F.; Barrett, John; Le, Joelle; Lynn, Sean M.; Pogany, Peter; Pratley, Cassie; Pritchard, John M.; Roper, James A.; Rowedder, James E.; Slack, Robert J.; Vitulli, Giovanni; Macdonald, Simon J. F.; Kerr, William J.
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The Design of Potent, Selective and Drug-Like RGD αvβ1 Small-Molecule Inhibitors Derived from non-RGD α4β1 Antagonists
errCHEMMEDCHEM
IF3.4
err2019-07-01
err8
PREAI
errHatley, Richard J. D.; Barrett, Tim N.; Slack, Robert J.; Watson, Morag E.; Baillache, Daniel J.; Gruszka, Anna; Washio, Yoshiaki; Rowedder, James E.; Pogany, Peter; Pal, Sandeep; Macdonald, Simon J. F.
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Discovery of (S)-3-(3-(3,5-Dimethyl-1H-pyrazol-1-yl)phenyl)-4-((R)-3(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)butanoic Acid, a Nonpeptidic αvβ6 Integrin Inhibitor for the Inhaled Treatment of Idiopathic Pulmonary Fibrosis
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2018-09-14
err38
PREAI
errProcopiou, Panayiotis A.; Anderson, Niall A.; Barrett, John; Barrett, Tim N.; Crawford, Matthew H. J.; Fallon, Brendan J.; Hancock, Ashley P.; Le, Joelle; Lemma, Seble; Marshall, Richard P.; Morrell, Josie; Pritchard, John M.; Rowedder, James E.; Saklatvala, Paula; Slack, Robert J.; Sollis, Steven L.; Suckling, Colin J.; Thorp, Lee R.; Vitulli, Giovanni; Macdonald, Simon J. F.
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An αv-RGD Integrin Inhibitor Toolbox: Drug Discovery Insight, Challenges and Opportunities
errANGEWANDTE CHEMIE-INTERNATIONAL EDITION
IF16.9
err2018-02-21
err104
PREAI
errHatley, Richard J. D.; Macdonald, Simon J. F.; Slack, Robert J.; Le, Joelle; Ludbrook, Steven B.; Lukey, Pauline T.
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Research Directions

No research directions
Co-authors
Cooperation Journals
S
Stephen A. Harrison
H-index: 116 · Papers: 774
C
Christopher J. Schofield
H-index: 112 · Papers: 1.3K
J
Jack Gauldie
H-index: 104 · Papers: 707
T
Toby M. Maher
H-index: 94 · Papers: 990
I
Ian E. Smith
H-index: 83 · Papers: 694
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