Not logged in Share Save
Novel Scaffold Unlocks Potent Cross-Peptidase and Cross-Species Inhibitors as Promising Antimalarial Agents Mansouri, Mahta; De Paoli, Amanda; Giannangelo, Carlo; Chowdury, Mrittika; Ngo, Anna; Shackleford, David M.; Webb, Chaille T.; Lowes, Kym N.; Creek, Darren J.; Charman, Susan A.; Koning-Ward, Tania De F.; Mcgowan, Sheena; Scammells, Peter J. Share Save
Share Save
Optimization of Species-Selective Reversible Proteasome Inhibitors for the Treatment of Malaria Gahalawat, Suraksha; Ray, Sneha; Zhang, Xiaoyu; Deng, Xiaoyi; Han, Yan; Chen, Zhe; Lawong, Aloysus; Shackleford, David M.; Katneni, Kasiram; Chen, Gong; Li, Peng; Ng, Alice; Zhong, Longjin; Hu, Meiyu; Mcinerney, Mitchell; Wang, Wen; Saunders, Jessica; Collins, Daniel; Jayaseelan, Jaya; Noack, Cassandra L.; Maity, Bikash; De, Nirupam; Laleu, Benoit; Campbell, Simon F.; Phillips, Margaret A.; Charman, Susan A.; Ready, Joseph M. Share Save
Identification of α-Azacyclic Acetamide-Based Inhibitors of P. falciparum Na+ Pump (PfATP4) with Fast-Killing Asexual Blood-Stage Antimalarial Activity by Phenotypic Screening Casas Jr, Arturo; Imlay, Leah S.; Thathy, Vandana; Fairhurst, Kate J.; Lehane, Adele M.; Lawong, Aloysus K.; Deni, Ioanna; Striepen, Josefine; Lee, Seungheon; Kumar, Ashwani; Xing, Chao; Niederstrasser, Hanspeter; Posner, Bruce A.; Laleu, Benoit; Charman, Susan A.; Fidock, David A.; Ready, Joseph M.; Phillips, Margaret A. Share Save
Pharmacokinetic-pharmacodynamic modeling of benznidazole and its antitrypanosomal activity in a murine model of chronic Chagas disease Assmus, Frauke; Adehin, Ayorinde; Hoglund, Richard M.; Francisco, Amanda Fortes; Lewis, Michael D.; Kelly, John M.; Charman, Susan A.; White, Karen L.; Shackleford, David M.; Escudie, Fanny; Chatelain, Eric; Scandale, Ivan; Tarning, Joel Share Save
Comparative Hydrophobicity, Solubility, and Metabolic Stability of 4(1H)-Pyridones, 4(1H)-Quinolones, and 9(10H)-Acridones Ren, Rongguo; Zhong, Longjin; Noack, Cassandra; Kaushik, Deepender; Leas, Derek A.; Wang, Xiaofang; Dong, Yuxiang; Charman, Susan A.; Vennerstrom, Jonathan L. Share Save
Structure-Based Discovery and Development of Highly Potent Dihydroorotate Dehydrogenase Inhibitors for Malaria Chemoprevention Nie, Zhe; Bonnert, Roger; Tsien, Jet; Deng, Xiaoyi; Higgs, Christopher; El Mazouni, Farah; Zhang, Xiaoyu; Li, Renzhe; Ho, Nhi; Feher, Victoria; Paulsen, Janet; Shackleford, David M.; Katneni, Kasiram; Chen, Gong; Ng, Alice C. F.; Mcinerney, Mitchell; Wang, Wen; Saunders, Jessica; Collins, Daniel; Yan, Dandan; Li, Peng; Campbell, Michael; Patil, Rahul; Ghoshal, Atanu; Mondal, Pallab; Kundu, Abhijit; Chittimalla, Rajesh; Mahadeva, Muralikumar; Kokkonda, Sreekanth; White, John; Das, Rishi; Mukherjee, Partha; Angulo-Barturen, Inigo; Belen Jimenez-Diaz, Maria; Malmstrom, Robert; Lawrenz, Morgan; Rodriguez-Granillo, Agustina; Rathod, Pradipsinh K.; Tomchick, Diana R.; Palmer, Michael J.; Laleu, Benoit; Qin, Tian; Charman, Susan A.; Phillips, Margaret A. Share Save
Single-Dose Drug Development Candidate for Schistosomiasis Leas, Derek A.; Keiser, Jennifer; Charman, Susan A.; Shackleford, David M.; Jones, Jeremy O.; Campbell, Michael; Chen, Gong; Katneni, Kasiram; Patil, Rahul; Hu, Meiyu; Pham, Thao; Haberli, Cecile; Schulze, Thomas T.; Neville, Andrew J.; Wang, Xiaofang; Dong, Yuxiang; Davis, Paul H.; Vennerstrom, Jonathan L. Share Save
Medium-Ring Keto Bislactams with Antischistosomal Activity Ren, Rongguo; Leas, Derek A.; Haberli, Cecile; Cal, Monica; Chen, Gong; Katneni, Kasiram; Dong, Yuxiang; Kaiser, Marcel; Keiser, Jennifer; Charman, Susan A.; Vennerstrom, Jonathan L. Share Save
Identification of potent and reversible piperidine carboxamides that are species-selective orally active proteasome inhibitors to treat malaria Lawong, Aloysus; Gahalawat, Suraksha; Ray, Sneha; Ho, Nhi; Han, Yan; Ward, Kurt E.; Deng, Xiaoyi; Chen, Zhe; Kumar, Ashwani; Xing, Chao; Hosangadi, Varun; Fairhurst, Kate J.; Tashiro, Kyuto; Liszczak, Glen; Shackleford, David M.; Katneni, Kasiram; Chen, Gong; Saunders, Jessica; Crighton, Elly; Casas, Arturo; Robinson, Joshua J.; Imlay, Leah S.; Zhang, Xiaoyu; Lemoff, Andrew; Zhao, Zhiyu; Angulo-Barturen, Inigo; Jimenez-Diaz, Maria Belen; Wittlin, Sergio; Campbell, Simon F.; Fidock, David A.; Laleu, Benoit; Charman, Susan A.; Ready, Joseph M.; Phillips, Margaret A. Share Save
On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity Edgar, Rebecca C. S.; Malcolm, Tess R.; Siddiqui, Ghizal; Giannangelo, Carlo; Counihan, Natalie A.; Challis, Matthew; Duffy, Sandra; Chowdhury, Mrittika; Marfurt, Jutta; Dans, Madeline; Wirjanata, Grennady; Noviyanti, Rintis; Daware, Kajal; Suraweera, Chathura D.; Price, Ric N.; Wittlin, Sergio; Avery, Vicky M.; Drinkwater, Nyssa; Charman, Susan A.; Creek, Darren J.; de Koning-Ward, Tania F.; Scammells, Peter J.; McGowan, Sheena Share Save
Activity refinement of aryl amino acetamides that target the P. falciparum STAR-related lipid transfer 1 protein Nguyen, William; Boulet, Coralie; Dans, Madeline G.; Loi, Katie; Jarman, Kate E.; Watson, Gabrielle M.; Tham, Wai-Hong; Fairhurst, Kate J.; Yeo, Tomas; Fidock, David A.; Wittlin, Sergio; Chowdury, Mrittika; de Koning-Ward, Tania F.; Chen, Gong; Yan, Dandan; Charman, Susan A.; Baud, Delphine; Brand, Stephen; Jackson, Paul F.; Cowman, Alan F.; Gilson, Paul R.; Sleebs, Brad E. Share Save
DNDI-6174 is a preclinical candidate for visceral leishmaniasis that targets the cytochrome bc1 Braillard, Stephanie; Keenan, Martine; Breese, Karen J.; Heppell, Jacob; Abbott, Michael; Islam, Rafiqul; Shackleford, David M.; Katneni, Kasiram; Crighton, Elly; Chen, Gong; Patil, Rahul; Lee, Given; White, Karen L.; Carvalho, Sandra; Wall, Richard J.; Chemi, Giulia; Zuccotto, Fabio; Gonzalez, Silvia; Marco, Maria; Deakyne, Julianna; Standing, David; Brunori, Gino; Lyon, Jonathan J.; Castaneda-Casado, Pablo; Camino, Isabel; Martinez Martinez, Maria S.; Zulfiqar, Bilal; Avery, Vicky M.; Feijens, Pim-Bart; Van Pelt, Natascha; Matheeussen, An; Hendrickx, Sarah; Maes, Louis; Caljon, Guy; Yardley, Vanessa; Wyllie, Susan; Charman, Susan A.; Chatelain, Eric Share Save
Open Source Antibiotics: Simple Diarylimidazoles Are Potent against Methicillin-Resistant Staphylococcus aureus Klug, Dana M.; Tse, Edwin G.; Silva, Daniel G.; Cao, Yafeng; Charman, Susan A.; Chauhan, Jyoti; Crighton, Elly; Dichiara, Maria; Drake, Chris; Drewry, David; da Silva Emery, Flavio; Ferrins, Lori; Graves, Lee; Hopkins, Emily; Kresina, Thomas A. C.; Lorente-Macias, Alvaro; Perry, Benjamin; Phipps, Richard; Quiroga, Bruno; Quotadamo, Antonio; Sabatino, Giada N.; Sama, Anthony; Schatzlein, Andreas; Simpson, Quillon J.; Steele, Jonathan; Shanu-Wilson, Julia; Sjo, Peter; Stapleton, Paul; Swain, Christopher J.; Vaideanu, Alexandra; Xie, Huanxu; Zuercher, William; Todd, Matthew H. Share Save
Discovery of a highly potent, selective, orally bioavailable inhibitor of KAT6A/B histone acetyltransferases with efficacy against KAT6A-high ER+ breast cancer Sharma, Shikhar; Chung, Chi-Yeh; Uryu, Sean; Petrovic, Jelena; Cao, Joan; Rickard, Amanda; Nady, Nataliya; Greasley, Samantha; Johnson, Eric; Brodsky, Oleg; Khan, Showkhin; Wang, Hui; Wang, Zhenxiong; Zhang, Yong; Tsaparikos, Konstantinos; Chen, Lei; Mazurek, Anthony; Lapek, John; Kung, Pei-Pei; Sutton, Scott; Richardson, Paul F.; Greenwald, Eric C.; Yamazaki, Shinji; Jones, Rhys; Maegley, Karen A.; Bingham, Patrick; Lam, Hieu; Stupple, Alexandra E.; Kamal, Aileen; Chueh, Anderly; Cuzzupe, Anthony; Morrow, Benjamin J.; Ren, Bin; Carrasco-Pozo, Catalina; Tan, Chin Wee; Bhuva, Dharmesh D.; Allan, Elizabeth; Surgenor, Elliot; Vaillant, Francois; Pehlivanoglu, Havva; Falk, Hendrik; Whittle, James R.; Newman, Janet; Cursons, Joseph; Doherty, Judy P.; White, Karen L.; Macpherson, Laura; Devlin, Mark; Dennis, Matthew L.; Hattarki, Meghan K.; De Silva, Melanie; Camerino, Michelle A.; Butler, Miriam S.; Dolezal, Olan; Pilling, Patricia; Foitzik, Richard; Stupple, Paul A.; Lagiakos, H. Rachel; Walker, Scott R.; Hediyeh-Zadeh, Soroor; Nuttall, Stewart; Spall, Sukhdeep; Charman, Susan A.; Connor, Theresa; Peat, Thomas S.; Avery, Vicky M.; Bozikis, Ylva E.; Yang, Yuqing; Zhang, Ming; Monahan, Brendon J.; Voss, Anne K.; Street, Ian P.; Dawson, Sarah-Jane; Dawson, Mark A.; Lindeman, Geoffrey J.; Davis, Melissa J.; Visvader, Jane E.; Paul, Thomas A. Share Save
Antimalarial Dibenzannulated Medium-Ring Keto Lactams Ren, Rongguo; Wang, Xiaofang; Leas, Derek A.; Scheurer, Christian; Hoevel, Sarah; Cal, Monica; Chen, Gong; Zhong, Longjin; Katneni, Kasiram; Pham, Thao; Patil, Rahul; Sil, Diptesh; Walters, Matthias J.; Schulze, Thomas T.; Neville, Andrew J.; Dong, Yuxiang; Wittlin, Sergio; Kaiser, Marcel; Davis, Paul H.; Charman, Susan A.; Vennerstrom, Jonathan L. Share Save
Development and application of a PBPK modeling strategy to support antimalarial drug development Abla, Nada; Howgate, Eleanor; Rowland-Yeo, Karen; Dickins, Maurice; Bergagnini-Kolev, Mackenzie C. C.; Chen, Kuan-Fu; McFeely, Savannah; Bonner, Jennifer J. J.; Santos, Laura G. A.; Gobeau, Nathalie; Burt, Howard; Barter, Zoe; Jones, Hannah M. M.; Wesche, David; Charman, Susan A. A.; Moehrle, Jorg J.; Burrows, Jeremy N. N.; Almond, Lisa M. M. Share Save
Share Save
In Vitro and In Vivo Antischistosomal Activity Profiling and Pharmacokinetics of Ozonide Carboxylic Acids Biendl, Stefan; Haeberli, Cecile; Chen, Gong; Wang, Wen; Zhong, Longjin; Saunders, Jessica; Pham, Thao; Wang, Xiaofang; Wu, Jianbo; Charman, Susan A.; Vennerstrom, Jonathan L.; Keiser, Jennifer Share Save
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
Share.png){kind=icon}
Save
Not logged in.png){kind=icon}