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Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2) (vol 67, pg 4655, 2024) Day, James E. H.; Berdini, Valerio; Castro, Joan; Chessari, Gianni; Davies, Thomas G.; Day, Philip J.; Denis, Jeffrey D. St; Fujiwara, Hideto; Fukaya, Satoshi; Hamlett, Christopher C. F.; Hearn, Keisha; Hiscock, Steven D.; Holvey, Rhian S.; Ito, Satoru; Kandola, Navrohit; Kodama, Yasuo; Liebeschuetz, John W.; Martins, Vanessa; Matsuo, Kenichi; Mortenson, Paul N.; Muench, Sandra; Nakatsuru, Yoko; Ochiiwa, Hiroaki; Palmer, Nicholas; Peakman, Torren; Price, Amanda; Reader, Michael; Rees, David C.; Rich, Sharna J.; Shah, Alpesh; Shibata, Yoshihiro; Smyth, Tomoko; Twigg, David G.; Wallis, Nicola G.; Williams, Glyn; Wilsher, Nicola E.; Woodhead, Andrew; Shimamura, Tadashi; Johnson, Christopher N. Share Save
Fragment-Based Discovery of a Series of Allosteric-Binding Site Modulators of β-Glucocerebrosidase Palmer, Nick; Agnew, Christopher; Benn, Caroline; Buffham, William J.; Castro, Joan N.; Chessari, Gianni; Clark, Mellissa; Cons, Benjamin D.; Coyle, Joseph E.; Dawson, Lee A.; Hamlett, Christopher C. F.; Hodson, Charlotte; Holding, Finn; Johnson, Christopher N.; Liebeschuetz, John W.; Mahajan, Pravin; McCarthy, James M.; Murray, Christopher W.; O'Reilly, Marc; Peakman, Torren; Price, Amanda; Rapti, Magdalini; Reeks, Judith; Schopf, Patrick; St-Denis, Jeffrey D.; Valenzano, Chiara; Wallis, Nicola G.; Walser, Reto; Weir, Heather; Wilsher, Nicola E.; Woodhead, Andrew; Bento, Carla F.; Tisi, Dominic Share Save
Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2) Day, James E. H.; Berdini, Valerio; Castro, Joan; Chessari, Gianni; Davies, Thomas G.; Day, Philip J.; St. Denis, Jeffrey D.; Fujiwara, Hideto; Fukaya, Satoshi; Hamlett, Christopher C. F.; Hearn, Keisha; Hiscock, Steven D.; Holvey, Rhian S.; Ito, Satoru; Kandola, Navrohit; Kodama, Yasuo; Liebeschuetz, John W.; Martins, Vanessa; Matsuo, Kenichi; Mortenson, Paul N.; Muench, Sandra; Nakatsuru, Yoko; Ochiiwa, Hiroaki; Palmer, Nicholas; Peakman, Torren; Price, Amanda; Reader, Michael; Rees, David C.; Rich, Sharna J.; Shah, Alpesh; Shibata, Yoshihiro; Smyth, Tomoko; Twigg, David G.; Wallis, Nicola G.; Williams, Glyn; Wilsher, Nicola E.; Woodhead, Andrew; Shimamura, Tadashi; Johnson, Christopher N. Share Save
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Enabling synthesis in fragment-based drug discovery (FBDD): microscale high-throughput optimisation of the medicinal chemist's toolbox reactions Townley, Chloe; Branduardi, Davide; Chessari, Gianni; Cons, Benjamin D.; Griffiths-Jones, Charlotte; Hall, Richard J.; Johnson, Christopher N.; Ochi, Yuji; Whibley, Stuart; Grainger, Rachel Share Save
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Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein-Protein Interaction Chessari, Gianni; Hardcastle, Ian R.; Ahn, Jong Sook; Anil, Burcu; Anscombe, Elizabeth; Bawn, Ruth H.; Bevan, Luke D.; Blackburn, Timothy J.; Buck, Ildiko; Cano, Celine; Carbain, Benoit; Castro, Juan; Cons, Ben; Cully, Sarah J.; Endicott, Jane A.; Fazal, Lynsey; Golding, Bernard T.; Griffin, Roger J.; Haggerty, Karen; Harnor, Suzannah J.; Hearn, Keisha; Hobson, Stephen; Holvey, Rhian S.; Howard, Steven; Jennings, Claire E.; Johnson, Christopher N.; Lunec, John; Miller, Duncan C.; Newell, David R.; Noble, Martin E. M.; Reeks, Judith; Revill, Charlotte H.; Riedinger, Christiane; St Denis, Jeffrey D.; Tamanini, Emiliano; Thomas, Huw; Thompson, Neil T.; Vinkovic, Mladen; Wedge, Stephen R.; Williams, Pamela A.; Wilsher, Nicola E.; Zhang, Bian; Zhao, Yan Share Save
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A Fragment-Derived Clinical Candidate for Antagonism of X-Linked and Cellular Inhibitor of Apoptosis Proteins: 1-(6-[(4-Fluorophenyl)methyl]-5-(hydroxymethyl)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-1-yl)-2-[(2R,5R)-5-methyl-2-([(3R)-3-methylmorpholin-4-yl]methyl)piperazin-1-yl]ethan-1-one (ASTX660) Johnson, Christopher N.; Ahn, Jong Sook; Buck, Ildiko M.; Chiarparin, Elisabetta; Day, James E. H.; Hopkins, Anna; Howard, Steven; Lewis, Edward J.; Martins, Vanessa; Millemaggi, Alessia; Munck, Joanne M.; Page, Lee W.; Peakman, Torren; Reader, Michael; Rich, Sharna J.; Saxty, Gordon; Smyth, Tomoko; Thompson, Neil T.; Ward, George A.; Williams, Pamela A.; Wilsher, Nicola E.; Chessari, Gianni Share Save
ASTX660, a Novel Non-peptidomimetic Antagonist of cIAP1/2 and XIAP, Potently Induces TNFα-Dependent Apoptosis in Cancer Cell Lines and Inhibits Tumor Growth Ward, George A.; Lewis, Edward J.; Ahn, Jong Sook; Johnson, Christopher N.; Lyons, John F.; Martins, Vanessa; Munck, Joanne M.; Rich, Sharna J.; Smyth, Tomoko; Thompson, Neil T.; Williams, Pamela A.; Wilsher, Nicola E.; Wallis, Nicola G.; Chessari, Gianni Share Save
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Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X-Linked Inhibitor of Apoptosis Protein (XIAP) Tamanini, Emiliano; Buck, Ildiko M.; Chessari, Gianni; Chiarparin, Elisabetta; Day, James E. H.; Frederickson, Martyn; Griffiths-Jones, Charlotte M.; Hearn, Keisha; Heightman, Tom D.; Iqbal, Aman; Johnson, Christopher N.; Lewis, Edward J.; Martins, Vanessa; Peakman, Torren; Reader, Michael; Rich, Sharna J.; Ward, George A.; Williams, Pamela A.; Wilsher, Nicola E. Share Save
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