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Discovery of Novel TYRO3/MERTK Dual Inhibitors Kong, Deyu; Zhao, Jichen; Huang, Daowei; Stashko, Michael A.; Yan, Dan; Ding, Ransheng; Guduru, Shiva K. R.; Zhou, Yubai; Kania, Catherine E.; Earp III, H. Shelton; Frye, Stephen V.; Huelse, Justus M.; Kireev, Dmitri; Deryckere, Deborah; Graham, Douglas K.; Wang, Xiaodong Share Save
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MERTK inhibition selectively activates a DC - T-cell axis to provide anti-leukemia immunity Huelse, Justus M.; Bhasin, Swati S.; Jacobsen, Kristen M.; Yim, Juhye; Thomas, Beena E.; Branella, Gianna M.; Bakhtiari, Mojtaba; Chimenti, Madison L.; Baxter, Travon A.; Raikar, Sunil S.; Wang, Xiaodong; Frye, Stephen V.; Henry, Curtis J.; Earp, H. Shelton; Bhasin, Manoj; DeRyckere, Deborah; Graham, Douglas K. Share Save
Discovery of Novel Macrocyclic MERTK/AXL Dual Inhibitors Kong, Deyu; Tian, Qiang; Chen, Zhilong; Zheng, Hongchao; Stashko, Michael A.; Yan, Dan; Earp, H. Shelton; Frye, Stephen V.; Deryckere, Deborah; Kireev, Dmitri; Graham, Douglas K.; Wang, Xiaodong Share Save
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Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease Du, Yuhong; Bradshaw, William J.; Leisner, Tina M.; Annor-Gyamfi, Joel K.; Qian, Kun; Bashore, Frances M.; Sikdar, Arunima; Nwogbo, Felix O.; Ivanov, Andrey A.; Frye, Stephen, V; Gileadi, Opher; Brennan, Paul E.; Levey, Allan I.; Axtman, Alison D.; Pearce, Kenneth H.; Fu, Haian; Katis, Vittorio L. Share Save
Fused Tetrahydroquinolines Are Interfering with Your Assay Bashore, Frances M.; Annor-Gyamfi, Joel; Du, Yuhong; Katis, Vittorio; Nwogbo, Felix; Flax, Raymond G.; Frye, Stephen V.; Pearce, Kenneth H.; Fu, Haian; Willson, Timothy M.; Drewry, David H.; Axtman, Alison D. Share Save
Discovery of a 53BP1 Small Molecule Antagonist Using a Focused DNA-Encoded Library Screen Shell, Devan J.; Foley, Caroline A.; Wang, Qinhong; Smith, Chelsea M.; Guduru, Shiva K. R.; Zeng, Hong; Dong, Aiping; Norris-Drouin, Jacqueline L.; Axtman, Matthew; Hardy, P. Brian; Gupta, Gaorav; Halabelian, Levon; Frye, Stephen V.; James, Lindsey I.; Pearce, Kenneth H. Share Save
An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering Cui, Gaofeng; Botuyan, Maria Victoria; Drane, Pascal; Hu, Qi; Bragantini, Benoit; Thompson, James R.; Schuller, David J.; Detappe, Alexandre; Perfetti, Michael T.; James, Lindsey I.; Frye, Stephen V.; Chowdhury, Dipanjan; Mer, Georges Share Save
SETDB1 Triple Tudor Domain Ligand, (R,R)-59, Promotes Methylation of Akt1 in Cells Uguen, Melanie; Deng, Yu; Li, Fengling; Shell, Devan J.; Norris-Drouin, Jacqueline L.; Stashko, Michael A.; Ackloo, Suzanne; Arrowsmith, Cheryl H.; James, Lindsey I.; Liu, Pengda; Pearce, Kenneth H.; Frye, Stephen V. Share Save
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Inhibiting efferocytosis reverses macrophage-mediated immunosuppression in the leukemia microenvironment Cruz, Joselyn Cruz; Allison, Kristen C.; Page, Lauren S.; Jenkins, Alexis J.; Wang, Xiaodong; Earp, H. Shelton; Frye, Stephen V.; Graham, Douglas K.; Verneris, Michael R.; Lee-Sherick, Alisa B. Share Save
PROTAC Linkerology Leads to an Optimized Bivalent Chemical Degrader of Polycomb Repressive Complex 2 (PRC2) Components Bashore, Frances M.; Foley, Caroline A.; Ong, Han Wee; Rectenwald, Justin M.; Hanley, Ronan P.; Norris-Drouin, Jacqueline L.; Cholensky, Stephanie H.; Mills, Christine A.; Pearce, Kenneth H.; Herring, Laura E.; Kireev, Dmitri; Frye, Stephen, V; James, Lindsey I. Share Save
Structural basis of paralog-specific KDM2A/B nucleosome recognition Spangler, Cathy J.; Skrajna, Aleksandra; Foley, Caroline A.; Nguyen, Anh; Budziszewski, Gabrielle R.; Azzam, Dalal N.; Arteaga, Eyla C.; Simmons, Holly C.; Smith, Charlotte B.; Wesley, Nathaniel A.; Wilkerson, Emily M.; McPherson, Jeanne-Marie E.; Kireev, Dmitri; James, Lindsey I.; Frye, Stephen V.; Goldfarb, Dennis; McGinty, Robert K. Share Save
MS0621, a novel small-molecule modulator of Ewing sarcoma chromatin accessibility, interacts with an RNA-associated macromolecular complex and influences RNA splicing Vital, Tamara; Wali, Aminah; Butler, Kyle V. V.; Xiong, Yan; Foster II, Joseph P.; Marcel, Shelsa S.; McFadden, Andrew W.; Nguyen, Valerie U.; Bailey, Benton M.; Lamb, Kelsey N.; James, Lindsey I.; Frye, Stephen V.; Mosely, Amber L.; Jin, Jian; Pattenden, Samantha G.; Davis, Ian J. Share Save
MERTK activation drives osimertinib resistance in EGFR-mutant non small cell lung cancer Yan, Dan; Huelse, Justus M.; Kireev, Dmitri; Tan, Zikang; Chen, Luxiao; Goyal, Subir; Wang, Xiaodong; Frye, Stephen, V; Behera, Madhusmita; Schneider, Frank; Ramalingam, Suresh S.; Owonikoko, Taofeek; Earp, H. Shelton; DeRyckere, Deborah; Graham, Douglas K. Share Save
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