Not logged in Share Save
Targeting PTPN22 at Nonorthosteric Binding Sites-A Fragment Approach Di Lello, Paola; Wells, Marta M.; Davis, Ben; Daniels, Zoe; Garner, Thomas P.; Gazzard, Lewis; Harris, Richard; Hubbard, Roderick E.; Landry, Matthew L.; Martin, Bryan; Morgan, Jacob L. W.; Patapoff, Alexander; Simmonite, Heather; Skelton, Nicholas; Ultsch, Mark; Walters, Benjamin T.; Wu, Ping; Dimitrova, Yoana N.; Huard, Kim Share Save
Share Save
Share Save
Structure-Atropisomer Stability Relationship in Selective MCL-1 Inhibitors Sipos, Szabolcs; Balazs, Barbara; Gati, Tamas; Csekei, Marton; Kovaacs, Mihaly; Szlavik, Zoltan; Paczal, Attila; Balint, Balazs; Murray, James B.; Davidson, James; Hubbard, Roderick E.; Le Toumelin-Braizat, Gaetane; Maragno, Ana Leticia; Geneste, Olivier; Stirling, Andras; Kotschy, Andras Share Save
Structure-Guided Discovery of Selective USP7 Inhibitors with In Vivo Activity Vasas, Attila; Ivanschitz, Lisa; Molnar, Balazs; Kiss, Arpad; Baker, Lisa; Fiumana, Andrea; Macias, Alba; Murray, James B.; Sanders, Emma; Whitehead, Neil; Hubbard, Roderick E.; Saunier, Carine; Monceau, Elodie; Girard, Anne Marie; Rousseau, Marion; Chanrion, Maia; Demarles, Didier; Geneste, Olivier; Weber, Csaba; Lewkowicz, Elodie; Kotschy, Andras Share Save
Identification of a Novel Subtype-Selective α1B-Adrenoceptor Antagonist Abdul-Ridha, Alaa; de Zhang, Lazarus A.; Betrie, Ashenafi Haileyesus; Deluigi, Mattia; Vaid, Tasneem M.; Whitehead, Alice; Zhang, Yifan; Davis, Ben; Harris, Richard; Simmonite, Heather; Hubbard, Roderick E.; Gooley, Paul R.; Plu''ckthun, Andreas; Bathgate, Ross A. D.; Chalmers, David K.; Scott, Daniel J. Share Save
Share Save
A covalent fragment-based strategy targeting a novel cysteine to inhibit activity of mutant EGFR kinase Kuki, Naoki; Walmsley, David L.; Kanai, Kazuo; Takechi, Sho; Yoshida, Masao; Murakami, Ryo; Takano, Kohei; Tominaga, Yuichi; Takahashi, Mizuki; Ito, Shuichiro; Nakao, Naoki; Angove, Hayley; Baker, Lisa M.; Carter, Edward; Dokurno, Pawel; Le Strat, Loic; Macias, Alba T.; Molyneaux, Carrie-Anne; Murray, James B.; Surgenor, Allan E.; Hamada, Tomoaki; Hubbard, Roderick E. Share Save
PAC-FragmentDEL - photoactivated covalent capture of DNA-encoded fragments for hit discovery Ma, Huiyong; Murray, James B.; Luo, Huadong; Cheng, Xuemin; Chen, Qiuxia; Song, Chao; Duan, Cong; Tan, Ping; Zhang, Lifang; Liu, Jian; Morgan, Barry A.; Li, Jin; Wan, Jinqiao; Baker, Lisa M.; Finnie, William; Guetzoyan, Lucie; Harris, Richard; Hendrickson, Nicole; Matassova, Natalia; Simmonite, Heather; Smith, Julia; Hubbard, Roderick E.; Liu, Guansai Share Save
Exploration of piperidine 3D fragment chemical space: synthesis and 3D shape analysis of fragments derived from 20 regio- and diastereoisomers of methyl substituted pipecolinates Jones, S. Paul; Firth, James D.; Wheldon, Mary C.; Atobe, Masakazu; Hubbard, Roderick E.; Blakemore, David C.; De Fusco, Claudia; Lucas, Simon C. C.; Roughley, Stephen D.; Vidler, Lewis R.; Whatton, Maria Ann; Woolford, Alison J-A; Wrigley, Gail L.; O'Brien, Peter Share Save
Share Save
The Effect of Core Replacement on S64315, a Selective MCL-1 Inhibitor, and Its Analogues Sipos, Szabolcs; Balint, Balazs; Szabo, Zoltan B.; Ondi, Levente; Csekei, Marton; Szlavik, Zoltan; Proszenyak, Agnes; Murray, James B.; Davidson, James; Chen, Ijen; Dokurno, Pawel; Surgenor, Allan E.; Pedder, Christopher; Hubbard, Roderick E.; Maragno, Ana-Leticia; Chanrion, Maia; Colland, Frederic; Geneste, Olivier; Kotschy, Andras Share Save
Fragment-Derived Selective Inhibitors of Dual-Specificity Kinases DYRK1A and DYRK1B Walmsley, David Lee; Murray, James B.; Dokurno, Pawel; Massey, Andrew J.; Benwell, Karen; Fiumana, Andrea; Foloppe, Nicolas; Ray, Stuart; Smith, Julia; Surgenor, Allan E.; Edmonds, Thomas; Demarles, Didier; Burbridge, Mike; Cruzalegui, Francisco; Kotschy, Andras; Hubbard, Roderick E. Share Save
Structure-Guided Discovery of Potent and Selective DYRK1A Inhibitors Weber, Csaba; Sipos, Melinda; Paczal, Attila; Balint, Balazs; Kun, Vilibald; Foloppe, Nicolas; Dokurno, Pawel; Massey, Andrew J.; Walmsley, David Lee; Hubbard, Roderick E.; Murray, James; Benwell, Karen; Edmonds, Thomas; Demarles, Didier; Bruno, Alain; Burbridge, Mike; Cruzalegui, Francisco; Kotschy, Andras Share Save
Share Save
Fragment-Based Discovery of Novel Non-Hydroxamate LpxC Inhibitors with Antibacterial Activity Yamada, Yousuke; Takashima, Hajime; Walmsley, David Lee; Ushiyama, Fumihito; Matsuda, Yohei; Kanazawa, Harumi; Yamaguchi-Sasaki, Toru; Tanaka-Yamamoto, Nozomi; Yamagishi, Junya; Kurimoto-Tsuruta, Risa; Ogata, Yuya; Ohtake, Norikazu; Angove, Hayley; Baker, Lisa; Harris, Richard; Macias, Alba; Robertson, Alan; Surgenor, Allan; Watanabe, Hayato; Nakano, Koichiro; Mima, Masashi; Iwamoto, Kunihiko; Okada, Atsushi; Takata, Iichiro; Hitaka, Kosuke; Tanaka, Akihiro; Fujita, Kiyoko; Sugiyama, Hiroyuki; Hubbard, Roderick E. Share Save
Discovery of S64315, a Potent and Selective Mcl-1 Inhibitor Szlavik, Zoltan; Csekei, Marton; Paczal, Attila; Szabo, Zoltan B.; Sipos, Szabolcs; Radics, Gabor; Proszenyak, Agnes; Balint, Balazs; Murray, James; Davidson, James; Chen, Ijen; Dokurno, Pawel; Surgenor, Allan E.; Daniels, Zoe Marie; Hubbard, Roderick E.; Le Toumelin-Braizat, Gaetane; Claperon, Audrey; Lysiak-Auvity, Gaelle; Girard, Anne-Marie; Bruno, Alain; Chanrion, Maia; Colland, Frederic; Maragno, Ana-Leticia; Demarles, Didier; Geneste, Olivier; Kotschy, Andras Share Save
Rapid optimisation of fragments and hits to lead compounds from screening of crude reaction mixtures Baker, Lisa M.; Aimon, Anthony; Murray, James B.; Surgenor, Allan E.; Matassova, Natalia; Roughley, Stephen D.; Collins, Patrick M.; Krojer, Tobias; von Delft, Frank; Hubbard, Roderick E. Share Save
.png){kind=icon}
.png){kind=icon}
Not logged in.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
