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Chasing Red Herrings: Palladium Metal Salt Impurities Feigning KRAS Activity in Biochemical Assays Gerstberger, Thomas; Berger, Helmut; Buettner, Frank H.; Gmachl, Michael; Kessler, Dirk; Koegl, Manfred; Lucas, Simon; Martin, Laetitia J.; Mayer, Moriz; McConnell, Darryl B.; Mitzner, Sophie; Scholz, Guido; Treu, Matthias; Wolkerstorfer, Bernhard; Zahn, Stephan; Zak, Krzysztof M.; Jaeger, Philipp A.; Ettmayer, Peter Share Save
Discovery of potent and selective HER2 inhibitors with efficacy against HER2 exon 20 insertion-driven tumors, which preserve wild-type EGFR signaling Wilding, Birgit; Scharn, Dirk; Boese, Dietrich; Baum, Anke; Santoro, Valeria; Chetta, Paolo; Schnitzer, Renate; Botesteanu, Dana A.; Reiser, Christoph; Kornigg, Stefan; Knesl, Petr; Hoermann, Alexandra; Koeferle, Anna; Corcokovic, Maja; Lieb, Simone; Scholz, Guido; Bruchhaus, Jens; Spina, Markus; Balla, Josef; Peric-Simov, Biljana; Zimmer, Jasmin; Mitzner, Sophie; Fett, Thomas N.; Beran, Alexandra; Lamarre, Lyne; Gerstberger, Thomas; Gerlach, Daniel; Bauer, Markus; Bergner, Andreas; Schlattl, Andreas; Bader, Gerd; Treu, Matthias; Engelhardt, Harald; Zahn, Stephan; Fuchs, Julian E.; Zuber, Johannes; Ettmayer, Peter; Pearson, Mark; Petronczki, Mark; Kraut, Norbert; McConnell, Darryl B.; Solca, Flavio; Neumuller, Ralph A. Share Save
opnMe.com: a digital initiative for sharing tools with the biomedical research community Gollner, Andreas; Koester, Markus; Nicklin, Paul; Trieselmann, Thomas; Klein, Elliott; Vlach, Jaromir; Heine, Claudia; Grundl, Marc; Ramharter, Juergen; Wyatt, David; Chaturvedi, Menorca; Ciulli, Alessio; Carter, Katharine C.; Mueller, Susanne; Bischoff, Daniel; Ettmayer, Peter; Haaksma, Eric; Mack, Juergen; McConnell, Darryl; Stenkamp, Dirk; Weinstabl, Harald; Zentgraf, Matthias; Wood, Clive R.; Montel, Florian Share Save
One Atom Makes All the Difference: Getting a Foot in the Door between SOS1 and KRAS Ramharter, Juergen; Kessler, Dirk; Ettmayer, Peter; Hofmann, Marco H.; Gerstberger, Thomas; Gmachl, Michael; Wunberg, Tobias; Kofink, Christiane; Sanderson, Michael; Arnhof, Heribert; Bader, Gerd; Rumpel, Klaus; Zoephel, Andreas; Schnitzer, Renate; Boettcher, Jark; O'Connell, Jonathan C.; Mendes, Rachel L.; Richard, David; Pototschnig, Nikolai; Weiner, Irene; Hela, Wolfgang; Hauer, Katja; Haering, Daniela; Lamarre, Lyne; Wolkerstorfer, Bernhard; Salamon, Christian; Werni, Patrick; Munico-Martinez, Silvia; Meyer, Reiner; Kennedy, Matthew D.; Kraut, Norbert; McConnell, Darryl B. Share Save
BI-3406, a Potent and Selective SOS1-KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition Hofmann, Marco H.; Gmachl, Michael; Ramharter, Juergen; Savarese, Fabio; Gerlach, Daniel; Marszalek, Joseph R.; Sanderson, Michael P.; Kessler, Dirk; Trapani, Francesca; Arnhof, Heribert; Rumpel, Klaus; Botesteanu, Dana-Adriana; Ettmayer, Peter; Gerstberger, Thomas; Kofink, Christiane; Wunberg, Tobias; Zoephel, Andreas; Fu, Szu-Chin; Teh, Jessica L.; Boettcher, Jark; Pototschnig, Nikolai; Schachinger, Franziska; Schipany, Katharina; Lieb, Simone; Vellano, Christopher P.; O'Connell, Jonathan C.; Mendes, Rachel L.; Moll, Jurgen; Petronczki, Mark; Heffernan, Timothy P.; Pearson, Mark; McConnell, Darryl B.; Kraut, Norbert Share Save
BI-3406 and BI 1701963: Potent and selective SOS1::KRAS inhibitors induce regressions in combination with MEK inhibitors or irinotecan Gerlach, Daniel; Gmachl, Michael; Ramharter, Juergen; Teh, Jessica; Fu, Szu-Chin; Trapani, Francesca; Kessler, Dirk; Rumpel, Klaus; Botesteanu, Dana-Adriana; Ettmayer, Peter; Arnhof, Heribert; Gerstberger, Thomas; Kofink, Christiane; Wunberg, Tobias; Vellano, Christopher P.; Heffernan, Timothy P.; Marszalek, Joseph R.; Pearson, Mark; McConnell, Darryl B.; Kraut, Norbert; Hofmann, Marco H. Share Save
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Selective and Potent CDK8/19 Inhibitors Enhance NK-Cell Activity and Promote Tumor Surveillance Hofmann, Marco H.; Mani, Rajeswaran; Engelhardt, Harald; Impagnatiello, Maria A.; Carotta, Sebastian; Kerenyi, Marc; Lorenzo-Herrero, Seila; Boettcher, Jark; Scharn, Dirk; Arnhof, Heribert; Zoephel, Andreas; Schnitzer, Renate; Gerstberger, Thomas; Sanderson, Michael P.; Rajgolikar, Girish; Goswami, Swagata; Vasu, Sumithira; Ettmayer, Peter; Gonzalez, Segundo; Pearson, Mark; McConnell, Darryl B.; Kraut, Norbert; Muthusamy, Natarajan; Moll, Juergen Share Save
Discovery of BI-3406: A potent and selective SOS1::KRAS inhibitor opens a new approach for treating KRAS-driven tumors Hofmann, Marco H.; Gmachl, Michael; Ramharter, Juergen; Savarese, Fabio; Gerlach, Daniel; Marszalek, Joseph R.; Sanderson, Michael P.; Trapani, Francesca; Kessler, Dirk; Rumpel, Klaus; Botesteanu, Dana-Adriana; Ettmayer, Peter; Arnhof, Heribert; Gerstberger, Thomas; Kofink, Christiane; Wunberg, Tobias; Fu, Szu-Chin; Teh, Jessica; Vellano, Christopher P.; O'Connell, Jonathan C.; Mendes, Rachel L.; Moll, Juergen; Heffernan, Timothy P.; Pearson, Mark; McConnell, Darryl B.; Kraut, Norbert Share Save
Effective targeting of KRAS-driven tumors by the first-in-class, orally bioavailable SOS1::KRAS inhibitor BI-3406 Hofmann, Marco H.; Gmachl, Michael; Ramharter, Jurgen; Savarese, Fabio; Sanderson, Michael P.; Gerlach, Daniel; Trapani, Francesca; Botesteanu, Dana-Adriana; Kessler, Dirk; Ettmayer, Peter; Arnhof, Heribert; Gerstberger, Thomas; Schnitzer, Renate; Kofink, Christiane; Stadtmueller, Heinz; Wunberg, Tobias; O'Connell, Jonathan C.; Mendes, Rachel L.; Richard, David; Saldanha, Adrian S.; Moll, Juergen; Pearson, Mark; McConnell, Darryl B.; Kraut, Norbert Share Save
Start Selective and Rigidify: The Discovery Path toward a Next Generation of EGFR Tyrosine Kinase Inhibitors Engelhardt, Harald; Boese, Dietrich; Petronczki, Mark; Scharn, Dirk; Bader, Gerd; Baum, Anke; Bergner, Andreas; Chong, Eugene; Doebel, Sandra; Egger, Georg; Engelhardt, Christian; Ettmayer, Peter; Fuchs, Julian E.; Gerstberger, Thomas; Gonnella, Nina; Grimm, Andreas; Grondal, Elisabeth; Haddad, Nizar; Hopfgartner, Barbara; Kousek, Roland; Krawiec, Mariusz; Kriz, Monika; Lamarre, Lyne; Leung, Joyce; Mayer, Moriz; Patel, Nitinchandra D.; Simov, Biljana Peric; Reeves, Jonathan T.; Schnitzer, Renate; Schrenk, Andreas; Sharps, Bernadette; Solca, Flavio; Stadtmueller, Heinz; Tan, Zhulin; Wunberg, Tobias; Zoephel, Andreas; McConnell, Darryl B. Share Save
Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) Inhibitor BI-4924 Disrupts Serine Biosynthesis Weinstabl, Harald; Treu, Matthias; Rinnenthal, Joerg; Zahn, Stephan K.; Ettmayer, Peter; Bader, Gerd; Dahmann, Georg; Kessler, Dirk; Rumpel, Klaus; Mischerikow, Nikolai; Savarese, Fabio; Gerstberger, Thomas; Mayer, Moriz; Zoephel, Andreas; Schnitzer, Renate; Sommergruber, Wolfgang; Martinelli, Paola; Arnhof, Heribert; Peric-Simov, Biljana; Hofbauer, Karin S.; Garavel, Geraldine; Scherbantin, Yvonne; Mitzner, Sophie; Fett, Thomas N.; Scholz, Guido; Bruchhaus, Jens; Burkard, Michelle; Kousek, Roland; Ciftci, Tuncay; Sharps, Bernadette; Schrenk, Andreas; Harrer, Christoph; Haerinsg, Daniela; Wolkerstorfer, Bernhard; Zhang, Xuechun; Lv, Xiaobing; Du, Alicia; Li, Dongyang; Li, Yali; Quant, Jens; Pearson, Mark; McConnell, Darryl B. Share Save
BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design (vol 15, pg 672, 2019) Farnaby, William; Koegl, Manfred; Roy, Michael J.; Whitworth, Claire; Diers, Emelyne; Trainor, Nicole; Zollman, David; Steurer, Steffen; Karolyi-Oezguer, Jale; Riedmueller, Carina; Gmaschitz, Teresa; Wachter, Johannes; Dank, Christian; Galant, Michael; Sharps, Bernadette; Rumpel, Klaus; Traxler, Elisabeth; Gerstberger, Thomas; Schnitzer, Renate; Petermann, Oliver; Greb, Peter; Weinstabl, Harald; Bader, Gerd; Zoephel, Andreas; Weiss-Puxbaum, Alexander; Ehrenhofer-Wolfer, Katharina; Wohrle, Simon; Boehmelt, Guido; Rinnenthal, Joerg; Arnhof, Heribert; Wiechens, Nicola; Wu, Meng-Ying; Owen-Hughes, Tom; Ettmayer, Peter; Pearson, Mark; McConnell, Darryl B.; Ciulli, Alessio Share Save
Structure-based PROTAC design demonstrates BAF complex ATPase vulnerabilities in cancer Koegl, Manfred; Farnaby, William; Whitworth, Claire; Roy, Michael; Diers, Emelyne; Trainor, Nicole; Steurer, Steffen; Riedmueller, Carina; Gmaschitz, Teresa; Wachter, Johannes; Dank, Christian; Gallant, Michael; Sharps, Bernadette; Rumpel, Klaus; Traxler, Elisabeth; Lorenz, Romario; Petermann, Oliver; Greb, Peter; Weinstabl, Harald; Bader, Gerd; Zoephel, Andreas; Weiss-Puxbaum, Alexander; Rinnenthal, Joerg; Arnnhof, Heribert; Wiechens, Nicola; Wu, Meng-Ying; Owen-Hughes, Tom; Ettmayer, Peter; Pearson, Mark; McConnell, Darryl B.; Ciulli, Alessio Share Save
Selective and potent CDK8 inhibitors enhance NK cell activity and promote tumor surveillance Hofmann, Marco H.; Mani, Rajeswaran; Engelhardt, Harald; Impagnatiello, Maria A.; Carotta, Sebastian; Kerenyi, Marc A.; Lorenzo-Herrero, Seila; Boettcher, Jark; Scharn, Dirk; Arnhof, Heribert; Zoephel, Andreas; Schnitzer, Renate; Gerstberger, Thomas; Rajgolikar, Girish; Goswami, Swagata; Vasu, Sumithira; Ettmayer, Peter; Gonzalez, Segundo R.; Pearson, Mark; McConnell, Darryl B.; Kraut, Norbert; Muthusamy, Natarajan; Moll, Juergen Share Save
BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design Farnaby, William; Koegl, Manfred; Roy, Michael J.; Whitworth, Claire; Diers, Emelyne; Trainor, Nicole; Zollman, David; Steurer, Steffen; Karolyi-Oezguer, Jale; Riedmueller, Carina; Gmaschitz, Teresa; Wachter, Johannes; Dank, Christian; Galante, Michael; Sharps, Bernadette; Rumpel, Klaus; Traxler, Elisabeth; Gerstberger, Thomas; Schnitzer, Renate; Petermann, Oliver; Grebe, Peter; Weinstabl, Harald; Bader, Gerd; Zoephel, Andreas; Weiss-Puxbaum, Alexander; Ehrenhoefer-Woelfer, Katharina; Woehrle, Simon; Boehmelt, Guido; Rinnenthal, Joerg; Arnhof, Heribert; Wiechens, Nicola; Wu, Meng-Ying; Owen-Hughes, Tom; Ettmayer, Peter; Pearson, Mark; McConnell, Darryl B.; Ciulli, Alessio Share Save
Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions Popow, Johannes; Arnhof, Heribert; Bader, Gerd; Berger, Helmut; Ciulli, Alessio; Covini, David; Dank, Christian; Gmaschitz, Teresa; Greb, Peter; Karolyi-Ozguer, Jale; Koegl, Manfred; McConnell, Darryl B.; Pearson, Mark; Rieger, Maria; Rinnenthal, Joerg; Roessler, Vanessa; Schrenk, Andreas; Spina, Markus; Steurer, Steffen; Trainor, Nicole; Traxler, Elisabeth; Wieshofer, Corinna; Zoephel, Andreas; Ettmayer, Peter Share Save
Chemically induced degradation of the transcription factor BCL6 Kerres, Nina; Steurer, Steffen; Schlager, Stefanie; Bader, Gerd; Caligiuri, Maureen; Dank, Christian; Engen, John R.; Ettmayer, Peter; Gerlach, Daniel; Gerstberger, Thomas; Han, Bingsong; Iacob, Roxana E.; Kessler, Dirk; Lancia, David R.; Moriz, Mayer; Mischerikow, Nikolai; Rumpel, Klaus; Schnitzer, Renate; Voss, Tilman; Zheng, Xiaozhang; Zoephel, Andreas; Kraut, Norbert; McConnell, Darryl; Pearson, Mark; Koegl, Manfred Share Save
Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6 Kerres, Nina; Steurer, Steffen; Schlager, Stefanie; Bader, Gerd; Berger, Helmut; Caligiuri, Maureen; Dank, Christian; Engen, John R.; Ettmayer, Peter; Fischerauer, Bernhard; Flotzinger, Gerlinde; Gerlach, Daniel; Gerstberger, Thomas; Gmaschitz, Teresa; Greb, Peter; Han, Bingsong; Heyes, Elizabeth; Iacob, Roxana E.; Kessler, Dirk; Koelle, Heike; Lamarre, Lyne; Lancia, David R.; Lucas, Simon; Mayer, Moriz; Mayr, Katharina; Mischerikow, Nikolai; Mueck, Katja; Peinsipp, Christoph; Petermann, Oliver; Reiser, Ulrich; Rudolph, Dorothea; Rumpel, Klaus; Salomon, Carina; Scharn, Dirk; Schnitzer, Renate; Schrenk, Andreas; Schweifer, Norbert; Thompson, Diane; Traxler, Elisabeth; Varecka, Roland; Voss, Tilman; Weiss-Puxbaum, Alexander; Winkler, Sandra; Zheng, Xiaozhang; Zoephel, Andreas; Kraut, Norbert; McConnell, Darryl; Pearson, Mark; Koegl, Manfred Share Save
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