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J

James C. Sacchettini

Rigshospitalet
H-index:94
Citation Count:3.0万
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Developing a Fluorescence-Based High-Throughput Screening Method for Natural Product Fractions to Identify Inhibitors of AR-V7 for Castration-Resistant Prostate Cancer

基于荧光的高通量筛选方法开发，用于从天然产物组分中鉴定去势抵抗性前列腺癌中AR-V7的抑制剂

Pharmaceutics
IF5.5
2026-09-160
OA
Neha Tyagi; Manish Rathi; Susan Ensel; Christopher C. Thornburg; Tanja Grkovic; Barry R. O’Keefe; James C. Sacchettini; Chendil Damodaran
Elesclomol-copper therapy improves neurodevelopment in two children with Menkes disease

Elesclomol-铜疗法改善了两位Menkes病患儿的神经发育。

JOURNAL OF CLINICAL INVESTIGATION
IF13.6
2025-10-010
OAAI
Godoy-Molina, Elena; Serrano, Natalia L.; Jimenez-Gonzalez, Aquilina; Villaronga, Miquel; Perez-Bryan, Rosa M. Marques; Varela-Fernandez, Ruben; Lotz-Esquivel, Stephanie; Tunon, Alba Hevia; Trivedi, Prachi P.; Horn, Nina; Standing, Joseph F.; Mangas-Sanjuan, Victor; Capdevila, Merce; Mateos, Aurora; Broun, Denis; Lutsenko, Svetlana; Medina-Rivera, Ines; Artuch, Rafael; Jou, Cristina; Roldan, Monica; Arango-Sancho, Pedro; Saez-Villafane, Monica; Ortiz-de-Urbina, Juan J.; Pieras-Lopez, Angela; Duero, Marta; Farre, Rosa; Pijuan, Jordi; Hoenicka, Janet; Sacchettini, James C.; Petris, Michael J.; Gohil, Vishal M.; Palau, Francesc
SuFEx-based antitubercular compound irreversibly inhibits Pks13

基于SuFEx的抗结核化合物不可逆地抑制Pks13

Nature
IF48.5
2025-07-300
PRE
Inna V. Krieger; Paridhi Sukheja; Baiyuan Yang; Su Tang; Daniel Selle; Ashley Woods; Curtis Engelhart; Pradeep Kumar; Michael B. Harbut; Dongdong Liu; Brendan Tsuda; Bo Qin; Grant A. L. Bare; Gencheng Li; Victor Chi; Julian Gambacurta; Janine Hvizdos; Matthew Reagan; Isabelle L. Jones; Lisa M. Massoudi; Lisa K. Woolhiser; Alessandro Cascioferro; Erica Kundrick; Parul Singh; William Reiley; Thomas R. Ioerger; Dilipkumar Reddy Kandula; Jacob W. McCabe; Taijie Guo; David Alland; Helena I. Boshoff; Dirk Schnappinger; Gregory T. Robertson; Khisi Mdluli; Kyoung-Jin Lee; Jiajia Dong; Shuangwei Li; Peter G. Schultz; Sean B. Joseph; Melissa S. Love; K. Barry Sharpless; H. Michael Petrassi; Arnab K. Chatterjee; James C. Sacchettini; Case W. McNamara
Thioquinazolinones as Antituberculosis Agents Targeting Phosphopantetheinyl Transferase

噻唑并[3,2-a]喹唑啉酮类化合物作为靶向磷脂泛酰巯基乙胺转移酶的抗结核药物

Journal of Medicinal Chemistry
IF6.8
2025-07-010
PRE
Amrita Singh; Logan T. Zwerneman; Kyle Planck; Takushi Kaneko; Andrew J. Perkowski; Christine M. Suh; Alexander Alex; James Bean; Kristin Burns-Huang; David Zhang; Helena I. M. Boshoff; Christine Roubert; Inna Krieger; Mark Gardner; Bastien Cautain; Christopher B. Cooper; Zaid Tanvir; James Sacchettini; Ben S. Gold; Kyu Y. Rhee; Nader Fotouhi; Carl F. Nathan; Jeffrey Aubé
An oral non-covalent non-peptidic inhibitor of SARS-CoV-2 Mpro ameliorates viral replication and pathogenesis in vivo
CELL REPORTS
IF6.9
2024-11-010
PRE
Zhou, Nian E.; Tang, Su; Bian, Xuelin; Parai, Maloy K.; Krieger, Inna V.; Flores, Armando; Jaiswal, Pradeep K.; Bam, Radha; Wood, Jeremy L.; Shi, Zhe; Stevens, Laura J.; Scobey, Trevor; Diefenbacher, Meghan V.; Moreira, Fernando R.; Baric, Thomas J.; Acharya, Arjun; Shin, Joonyoung; Rathi, Manish M.; Wolff, Karen C.; Riva, Laura; Bakowski, Malina A.; Mcnamara, Case W.; Catanzaro, Nicholas J.; Graham, Rachel L.; Schultz, David C.; Cherry, Sara; Kawaoka, Yoshihiro; Halfmann, Peter J.; Baric, Ralph S.; Denison, Mark R.; Sheahan, Timothy P.; Sacchettini, James C.
Target-based discovery of antagonists of the tick (Rhipicephalus microplus) kinin receptor identifies small molecules that inhibit midgut contractions

基于靶标的tick (Rhipicephalus microplus) 激肽受体拮抗剂发现可抑制中肠收缩的小分子

PEST MANAGEMENT SCIENCE
IF3.8
2024-06-200
OA
Henriques-Santos, Bianca Monteiro; Baker, Dwight; Zhou, Nian; Snavely, Thomas; Sacchettini, James C.; Pietrantonio, Patricia V.
Mycobacterial biotin synthases require an auxiliary protein to convert dethiobiotin into biotin
NATURE COMMUNICATIONS
IF15.7
2024-05-160
OAAI
Qu, Di; Ge, Peng; Botella, Laure; Park, Sae Woong; Lee, Ha-Na; Thornton, Natalie; Bean, James M.; Krieger, Inna V.; Sacchettini, James C.; Ehrt, Sabine; Aldrich, Courtney C.; Schnappinger, Dirk
Inhibitors of the Thioesterase Activity of Mycobacterium tuberculosis Pks13 Discovered Using DNA-Encoded Chemical Library Screening
ACS INFECTIOUS DISEASES
IF3.8
2024-04-052
OAAI
Krieger, Inna V.; Yalamanchili, Subbarao; Dickson, Paige; Engelhart, Curtis A.; Zimmerman, Matthew D.; Wood, Jeremy; Clary, Ethan; Nguyen, Jasmine; Thornton, Natalie; Centrella, Paolo A.; Chan, Betty; Cuozzo, John W.; Gengenbacher, Martin; Guie, Marie-Aude; Guilinger, John P.; Bienstock, Corey; Hartl, Hajnalka; Hupp, Christopher D.; Jetson, Rachael; Satoh, Takashi; Yeoman, John T. S.; Zhang, Ying; Dartois, Veronique; Schnappinger, Dirk; Keefe, Anthony D.; Sacchettini, James C.
Redirecting raltitrexed from cancer cell thymidylate synthase to Mycobacterium tuberculosis phosphopantetheinyl transferase
SCIENCE ADVANCES
IF12.5
2024-03-151
OAAI
Singh, Amrita; Ottavi, Samantha; Krieger, Inna; Planck, Kyle; Perkowski, Andrew; Kaneko, Takushi; Davis, Andrew M.; Suh, Christine; Zhang, David; Goullieux, Laurent; Alex, Alexander; Roubert, Christine; Gardner, Mark; Preston, Marian; Smith, Dave M.; Ling, Yan; Roberts, Julia; Cautain, Bastien; Upton, Anna; Cooper, Christopher B.; Serbina, Natalya; Tanvir, Zaid; Mosior, John; Ouerfelli, Ouathek; Yang, Guangli; Gold, Ben S.; Rhee, Kyu Y.; Sacchettini, James C.; Fotouhi, Nader; Aube, Jeffrey; Nathan, Carl
Mycobacterium tuberculosis PptT Inhibitors Based on Heterocyclic Replacements of Amidinoureas
ACS MEDICINAL CHEMISTRY LETTERS
IF4
2023-06-264
PRE
Ottavi, Samantha; Li, Kelin; Cacioppo, Jackson G. G.; Perkowski, Andrew J. J.; Ramesh, Remya; Gold, Ben S. S.; Ling, Yan; Roberts, Julia; Singh, Amrita; Zhang, David; Mosior, John; Goullieux, Laurent; Roubert, Christine; Bacque, Eric; Sacchettini, James C. C.; Nathan, Carl F. F.; Aube, Jeffrey
1,3-Diarylpyrazolyl-acylsulfonamides Target HadAB/BC Complex in Mycobacterium tuberculosis

1，3-二芳基吡唑基酰基磺酰胺靶向结核分枝杆菌中的HadAB/BC复合物

ACS INFECTIOUS DISEASES
IF3.8
2022-11-034
OAAI
Singh, Vinayak; Grzegorzewicz, Anna E.; Fienberg, Stephen; Muller, Rudolf; Khonde, Lutete Peguy; Sanz, Olalla; Alfonso, Salvatore; Urones, Beatriz; Drewes, Gerard; Bantscheff, Marcus; Ghidelli-Disse, Sonja; Ioerger, Thomas R.; Angala, Bhanupriya; Liu, Jiuyu; Lee, Richard E.; Sacchettini, James C.; Krieger, Inna, V; Jackson, Mary; Chibale, Kelly; Ghorpade, Sandeep R.
Structural anatomy of Protein Kinase C C1 domain interactions with diacylglycerol and other agonists

蛋白激酶C C1结构域与甘油二酯和其他激动剂相互作用的结构解剖

NATURE COMMUNICATIONS
IF15.7
2022-05-1622
OAAI
Katti, Sachin S.; Krieger, Inna, V; Ann, Jihyae; Lee, Jeewoo; Sacchettini, James C.; Igumenova, Tatyana I.
Structural Basis of Agonist Capture by Regulatory Cl Domain of PKC
FASEB JOURNAL
IF4.2
2022-05-130
PRE
Katti, Sachin S.; Krieger, lnna V.; Sacchettini, James C.; Igumenova, Tatyana I.
CinA mediates multidrug tolerance in Mycobacterium tuberculosis
NATURE COMMUNICATIONS
IF15.7
2022-04-2224
OAAI
Kreutzfeldt, Kaj M.; Jansen, Robert S.; Hartman, Travis E.; Gouzy, Alexandre; Wang, Ruojun; Krieger, Inna, V; Zimmerman, Matthew D.; Gengenbacher, Martin; Sarathy, Jansy P.; Xie, Min; Dartois, Veronique; Sacchettini, James C.; Rhee, Kyu Y.; Schnappinger, Dirk; Ehrt, Sabine
Interplay between an ATP-binding cassette F protein and the ribosome from Mycobacterium tuberculosis
NATURE COMMUNICATIONS
IF15.7
2022-01-2113
OAAI
Cui, Zhicheng; Li, Xiaojun; Shin, Joonyoung; Gamper, Howard; Hou, Ya-Ming; Sacchettini, James C.; Zhang, Junjie
In Vitro and In Vivo Inhibition of the Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT by Amidinoureas
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2022-01-1916
OAAI
Ottavi, Samantha; Scarry, Sarah M.; Mosior, John; Ling, Yan; Roberts, Julia; Singh, Amrita; Zhang, David; Goullieux, Laurent; Roubert, Christine; Bacque, Eric; Lagiakos, H. Rachel; Vendome, Jeremie; Moraca, Francesca; Li, Kelin; Perkowski, Andrew J.; Ramesh, Remya; Bowler, Matthew M.; Tracy, William; Feher, Victoria A.; Sacchettini, James C.; Gold, Ben S.; Nathan, Carl F.; Aube, Jeffrey
Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2021-12-1518
OAAI
Wilson, Caroline; Ray, Peter; Zuccotto, Fabio; Hernandez, Jorge; Aggarwal, Anup; Mackenzie, Claire; Caldwell, Nicola; Taylor, Malcolm; Huggett, Margaret; Mathieson, Michael; Murugesan, Dinakaran; Smith, Alasdair; Davis, Susan; Cocco, Mattia; Parai, Maloy K.; Acharya, Arjun; Tamaki, Fabio; Scullion, Paul; Epemolu, Ola; Riley, Jennifer; Stojanovski, Laste; Lopez-Roman, Eva Maria; Torres-Gomez, Pedro Alfonso; Toledo, Ana Maria; Guijarro-Lopez, Laura; Camino, Isabel; Engelhart, Curtis A.; Schnappinger, Dirk; Massoudi, Lisa M.; Lenaerts, Anne; Robertson, Gregory T.; Walpole, Chris; Matthews, David; Floyd, David; Sacchettini, James C.; Read, Kevin D.; Encinas, Lourdes; Bates, Robert H.; Green, Simon R.; Wyatt, Paul G.
Characterization of Phosphopantetheinyl Hydrolase from Mycobacterium tuberculosis
MICROBIOLOGY SPECTRUM
IF3.8
2021-10-312
OAAI
Pandey, Shilpika; Singh, Amrita; Yang, Guangli; d'Andrea, Felipe B.; Jiang, Xiuju; Hartman, Travis E.; Mosior, John W.; Bourland, Ronnie; Gold, Ben; Roberts, Julia; Geiger, Annie; Tang, Su; Rhee, Kyu; Ouerfelli, Ouathek; Sacchettini, James C.; Nathan, Carl F.; Burns-Huang, Kristin
Mechanism-Based Inactivation of Mycobacterium tuberculosis Isocitrate Lyase 1 by (2R,3S)-2-Hydroxy-3-(nitromethyl)succinic acid
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
2021-10-195
PREAI
Mellott, Drake M.; Torres, Dan; Krieger, Inna, V; Cameron, Scott A.; Moghadamchargari, Zahra; Laganowsky, Arthur; Sacchettini, James C.; Meek, Thomas D.; Harris, Lawrence D.
The Tuberculosis Drug Accelerator at year 10: what have we learned?
NATURE MEDICINE
IF50
2021-07-0539
OAAI
Aldridge, Bree B.; Barros-Aguirre, David; Barry, Clifton E., III; Bates, Robert H.; Berthel, Steven J.; Boshoff, Helena I.; Chibale, Kelly; Chu, Xin-Jie; Cooper, Christopher B.; Dartois, Veronique; Duncan, Ken; Fotouhi, Nader; Gusovsky, Fabian; Hipskind, Philip A.; Kempf, Dale J.; Lelievre, Joel; Lenaerts, Anne J.; McNamara, Case W.; Mizrahi, Valerie; Nathan, Carl; Olsen, David B.; Parish, Tanya; Petrassi, H. Michael; Pym, Alexander; Rhee, Kyu Y.; Robertson, Gregory T.; Rock, Jeremy Michael; Rubin, Eric J.; Russell, Betsy; Russell, David G.; Sacchettini, James C.; Schnappinger, Dirk; Schrimpf, Michael; Upton, Anna M.; Warner, Peter; Wyatt, Paul Graham; Yuan, Ying

Research Directions

The data has not been retrieved yet.
T
Thomas R. Ioerger
H-index:60Papers:325Citations:1.8万
I
Inna V. Krieger
H-index:17Papers:69Citations:1,127
E
Eric J. Rubin
H-index:90Papers:850Citations:2.9万
S
S.K. Palaninathan
H-index:16Papers:49Citations:1,569
K
Kyu Y. Rhee
H-index:55Papers:197Citations:9,194
J
Jeffery W. Kelly
H-index:119Papers:617Citations:5.2万
B
Ben Gold
H-index:19Papers:35Citations:1,853
C
Carl Nathan
H-index:127Papers:425Citations:9.0万
D
Dirk Schnappinger
H-index:56Papers:242Citations:1.5万
V
Véronique Dartois
H-index:72Papers:299Citations:1.8万