Not logged in Elesclomol-copper therapy improves neurodevelopment in two children with Menkes disease Godoy-Molina, Elena; Serrano, Natalia L.; Jimenez-Gonzalez, Aquilina; Villaronga, Miquel; Perez-Bryan, Rosa M. Marques; Varela-Fernandez, Ruben; Lotz-Esquivel, Stephanie; Tunon, Alba Hevia; Trivedi, Prachi P.; Horn, Nina; Standing, Joseph F.; Mangas-Sanjuan, Victor; Capdevila, Merce; Mateos, Aurora; Broun, Denis; Lutsenko, Svetlana; Medina-Rivera, Ines; Artuch, Rafael; Jou, Cristina; Roldan, Monica; Arango-Sancho, Pedro; Saez-Villafane, Monica; Ortiz-de-Urbina, Juan J.; Pieras-Lopez, Angela; Duero, Marta; Farre, Rosa; Pijuan, Jordi; Hoenicka, Janet; Sacchettini, James C.; Petris, Michael J.; Gohil, Vishal M.; Palau, Francesc Share Save
An oral non-covalent non-peptidic inhibitor of SARS-CoV-2 Mpro ameliorates viral replication and pathogenesis in vivo Zhou, Nian E.; Tang, Su; Bian, Xuelin; Parai, Maloy K.; Krieger, Inna V.; Flores, Armando; Jaiswal, Pradeep K.; Bam, Radha; Wood, Jeremy L.; Shi, Zhe; Stevens, Laura J.; Scobey, Trevor; Diefenbacher, Meghan V.; Moreira, Fernando R.; Baric, Thomas J.; Acharya, Arjun; Shin, Joonyoung; Rathi, Manish M.; Wolff, Karen C.; Riva, Laura; Bakowski, Malina A.; Mcnamara, Case W.; Catanzaro, Nicholas J.; Graham, Rachel L.; Schultz, David C.; Cherry, Sara; Kawaoka, Yoshihiro; Halfmann, Peter J.; Baric, Ralph S.; Denison, Mark R.; Sheahan, Timothy P.; Sacchettini, James C. Share Save
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Mycobacterial biotin synthases require an auxiliary protein to convert dethiobiotin into biotin Qu, Di; Ge, Peng; Botella, Laure; Park, Sae Woong; Lee, Ha-Na; Thornton, Natalie; Bean, James M.; Krieger, Inna V.; Sacchettini, James C.; Ehrt, Sabine; Aldrich, Courtney C.; Schnappinger, Dirk Share Save
Inhibitors of the Thioesterase Activity of Mycobacterium tuberculosis Pks13 Discovered Using DNA-Encoded Chemical Library Screening Krieger, Inna V.; Yalamanchili, Subbarao; Dickson, Paige; Engelhart, Curtis A.; Zimmerman, Matthew D.; Wood, Jeremy; Clary, Ethan; Nguyen, Jasmine; Thornton, Natalie; Centrella, Paolo A.; Chan, Betty; Cuozzo, John W.; Gengenbacher, Martin; Guie, Marie-Aude; Guilinger, John P.; Bienstock, Corey; Hartl, Hajnalka; Hupp, Christopher D.; Jetson, Rachael; Satoh, Takashi; Yeoman, John T. S.; Zhang, Ying; Dartois, Veronique; Schnappinger, Dirk; Keefe, Anthony D.; Sacchettini, James C. Share Save
Redirecting raltitrexed from cancer cell thymidylate synthase to Mycobacterium tuberculosis phosphopantetheinyl transferase Singh, Amrita; Ottavi, Samantha; Krieger, Inna; Planck, Kyle; Perkowski, Andrew; Kaneko, Takushi; Davis, Andrew M.; Suh, Christine; Zhang, David; Goullieux, Laurent; Alex, Alexander; Roubert, Christine; Gardner, Mark; Preston, Marian; Smith, Dave M.; Ling, Yan; Roberts, Julia; Cautain, Bastien; Upton, Anna; Cooper, Christopher B.; Serbina, Natalya; Tanvir, Zaid; Mosior, John; Ouerfelli, Ouathek; Yang, Guangli; Gold, Ben S.; Rhee, Kyu Y.; Sacchettini, James C.; Fotouhi, Nader; Aube, Jeffrey; Nathan, Carl Share Save
Mycobacterium tuberculosis PptT Inhibitors Based on Heterocyclic Replacements of Amidinoureas Ottavi, Samantha; Li, Kelin; Cacioppo, Jackson G. G.; Perkowski, Andrew J. J.; Ramesh, Remya; Gold, Ben S. S.; Ling, Yan; Roberts, Julia; Singh, Amrita; Zhang, David; Mosior, John; Goullieux, Laurent; Roubert, Christine; Bacque, Eric; Sacchettini, James C. C.; Nathan, Carl F. F.; Aube, Jeffrey Share Save
1,3-Diarylpyrazolyl-acylsulfonamides Target HadAB/BC Complex in Mycobacterium tuberculosis Singh, Vinayak; Grzegorzewicz, Anna E.; Fienberg, Stephen; Muller, Rudolf; Khonde, Lutete Peguy; Sanz, Olalla; Alfonso, Salvatore; Urones, Beatriz; Drewes, Gerard; Bantscheff, Marcus; Ghidelli-Disse, Sonja; Ioerger, Thomas R.; Angala, Bhanupriya; Liu, Jiuyu; Lee, Richard E.; Sacchettini, James C.; Krieger, Inna, V; Jackson, Mary; Chibale, Kelly; Ghorpade, Sandeep R. Share Save
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CinA mediates multidrug tolerance in Mycobacterium tuberculosis Kreutzfeldt, Kaj M.; Jansen, Robert S.; Hartman, Travis E.; Gouzy, Alexandre; Wang, Ruojun; Krieger, Inna, V; Zimmerman, Matthew D.; Gengenbacher, Martin; Sarathy, Jansy P.; Xie, Min; Dartois, Veronique; Sacchettini, James C.; Rhee, Kyu Y.; Schnappinger, Dirk; Ehrt, Sabine Share Save
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In Vitro and In Vivo Inhibition of the Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT by Amidinoureas Ottavi, Samantha; Scarry, Sarah M.; Mosior, John; Ling, Yan; Roberts, Julia; Singh, Amrita; Zhang, David; Goullieux, Laurent; Roubert, Christine; Bacque, Eric; Lagiakos, H. Rachel; Vendome, Jeremie; Moraca, Francesca; Li, Kelin; Perkowski, Andrew J.; Ramesh, Remya; Bowler, Matthew M.; Tracy, William; Feher, Victoria A.; Sacchettini, James C.; Gold, Ben S.; Nathan, Carl F.; Aube, Jeffrey Share Save
Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target Wilson, Caroline; Ray, Peter; Zuccotto, Fabio; Hernandez, Jorge; Aggarwal, Anup; Mackenzie, Claire; Caldwell, Nicola; Taylor, Malcolm; Huggett, Margaret; Mathieson, Michael; Murugesan, Dinakaran; Smith, Alasdair; Davis, Susan; Cocco, Mattia; Parai, Maloy K.; Acharya, Arjun; Tamaki, Fabio; Scullion, Paul; Epemolu, Ola; Riley, Jennifer; Stojanovski, Laste; Lopez-Roman, Eva Maria; Torres-Gomez, Pedro Alfonso; Toledo, Ana Maria; Guijarro-Lopez, Laura; Camino, Isabel; Engelhart, Curtis A.; Schnappinger, Dirk; Massoudi, Lisa M.; Lenaerts, Anne; Robertson, Gregory T.; Walpole, Chris; Matthews, David; Floyd, David; Sacchettini, James C.; Read, Kevin D.; Encinas, Lourdes; Bates, Robert H.; Green, Simon R.; Wyatt, Paul G. Share Save
Characterization of Phosphopantetheinyl Hydrolase from Mycobacterium tuberculosis Pandey, Shilpika; Singh, Amrita; Yang, Guangli; d'Andrea, Felipe B.; Jiang, Xiuju; Hartman, Travis E.; Mosior, John W.; Bourland, Ronnie; Gold, Ben; Roberts, Julia; Geiger, Annie; Tang, Su; Rhee, Kyu; Ouerfelli, Ouathek; Sacchettini, James C.; Nathan, Carl F.; Burns-Huang, Kristin Share Save
Mechanism-Based Inactivation of Mycobacterium tuberculosis Isocitrate Lyase 1 by (2R,3S)-2-Hydroxy-3-(nitromethyl)succinic acid Mellott, Drake M.; Torres, Dan; Krieger, Inna, V; Cameron, Scott A.; Moghadamchargari, Zahra; Laganowsky, Arthur; Sacchettini, James C.; Meek, Thomas D.; Harris, Lawrence D. Share Save
The Tuberculosis Drug Accelerator at year 10: what have we learned? Aldridge, Bree B.; Barros-Aguirre, David; Barry, Clifton E., III; Bates, Robert H.; Berthel, Steven J.; Boshoff, Helena I.; Chibale, Kelly; Chu, Xin-Jie; Cooper, Christopher B.; Dartois, Veronique; Duncan, Ken; Fotouhi, Nader; Gusovsky, Fabian; Hipskind, Philip A.; Kempf, Dale J.; Lelievre, Joel; Lenaerts, Anne J.; McNamara, Case W.; Mizrahi, Valerie; Nathan, Carl; Olsen, David B.; Parish, Tanya; Petrassi, H. Michael; Pym, Alexander; Rhee, Kyu Y.; Robertson, Gregory T.; Rock, Jeremy Michael; Rubin, Eric J.; Russell, Betsy; Russell, David G.; Sacchettini, James C.; Schnappinger, Dirk; Schrimpf, Michael; Upton, Anna M.; Warner, Peter; Wyatt, Paul Graham; Yuan, Ying Share Save
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