Not logged in Share Save
Share Save
Structural mimicry of UM171 and neomorphic cancer mutants co-opts E3 ligase KBTBD4 for HDAC1/2 recruitment Chen, Zhuoyao; Chi, Gamma; Balo, Timea; Chen, Xiangrong; Montes, Beatriz Ralsi; Clifford, Steven C.; D'Angiolella, Vincenzo; Szabo, Timea; Kiss, Arpad; Novak, Tibor; Herner, Andras; Kotschy, Andras; Bullock, Alex N. Share Save
Toward target 2035: EUbOPEN - a public-private partnership to enable & unlock biology in the open Tredup, Claudia; Ackloo, Suzanne; Beck, Hartmut; Brown, Peter J.; Bullock, Alex N.; Ciulli, Alessio; Dikic, Ivan; Edfeldt, Kristina; Edwards, Aled M.; Elkins, Jonathan M.; Farin, Henner F.; Fon, Edward A.; Gstaiger, Matthias; Guenther, Judith; Gustavsson, Anna-Lena; Haeberle, Sandra; Isigkeit, Laura; Huber, Kilian V. M.; Kotschy, Andras; Kraemer, Oliver; Leach, Andrew R.; Marsden, Brian D.; Matsui, Hisanori; Merk, Daniel; Montel, Florian; Mulder, Monique P. C.; Mueller, Susanne; Owen, Dafydd R.; Proschak, Ewgenij; Roehm, Sandra; Stolz, Alexandra; Sundstroem, Michael; von Delft, Frank; Willson, Timothy M.; Arrowsmith, Cheryl H.; Knapp, Stefan Share Save
Discovery of conformationally constrained ALK2 inhibitors for the treatment of Diffuse Intrinsic Pontine Glioma ( DIPG) Smil, David; Gonzalez-Alvarez, Hector; Ensan, Deeba; Wong, Jong Fu; Cros, Julien; Hoffer, Laurent; Kiyota, Taira; Wilson, Brian J.; Zepeda-Velazquez, Carlos A.; Aman, Ahmed; Isaac, Methvin B.; Xin, Tao; Bullock, Alex N.; Sampson, Peter B.; Al-awar, Rima Share Save
Covalent Inhibitors of KEAP1 with Exquisite Selectivity Fejes, Imre; Markacz, Piroska; Tatai, Janos; Rudas, Monika; Dunkel, Petra; Gyuris, Mario; Nyerges, Miklos; Provost, Nicolas; Duvivier, Valerie; Delerive, Philippe; Martiny, Virginie; Bristiel, Alexandra; Vidal, Brice; Richardson, William; Rothweiler, Elisabeth M.; Tranberg-Jensen, Jeppe; Manning, Charlotte E.; Sweeney, Melissa N.; Chalk, Rod; Huber, Kilian V. M.; Bullock, Alex N.; Herner, Andras; Seedorf, Klaus; Vinson, Cedric; Weber, Csaba; Kotschy, Andras Share Save
Structure-Guided Conformational Restriction Leading to High-Affinity, Selective, and Cell-Active Tetrahydroisoquinoline-Based Noncovalent Keap1-Nrf2 Inhibitors Qin, Yuting; Poulsen, Cecilie; Narayanan, Dilip; Chan, Camilla B.; Chen, Xiangrong; Montes, Beatriz Ralsi; Tran, Kim T.; Mukminova, Elina; Lin, Chunyu; Gajhede, Michael; Bullock, Alex N.; Olagnier, David; Bach, Anders Share Save
Discovery of Two Highly Selective Structurally Orthogonal Chemical Probes for Activin Receptor-like Kinases 1 and 2 Nemec, Vaclav; Remes, Marek; Benovsky, Petr; Boeck, Michael C.; Srankova, Eliska; Wong, Jong Fu; Cros, Julien; Williams, Eleanor; Tse, Lap Hang; Smil, David; Ensan, Deeba; Isaac, Methvin B.; Al-Awar, Rima; Gomolkova, Regina; Ursachi, Vlad-Constantin; Fafilek, Bohumil; Kahounova, Zuzana; Vichova, Rachel; Vacek, Ondrej; Berger, Benedict-Tilman; Wells, Carrow I.; Corona, Cesear R.; Vasta, James D.; Robers, Matthew B.; Krejci, Pavel; Soucek, Karel; Bullock, Alex N.; Knapp, Stefan; Paruch, Kamil Share Save
Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2 Bashore, Frances M.; Min, Sophia M.; Chen, Xiangrong; Howell, Stefanie; Rinderle, Caroline H.; Morel, Gabriel; Silvaroli, Josie A.; Wells, Carrow I.; Bunnell, Bruce A.; Drewry, David H.; Pabla, Navjot S.; Ultanir, Sila K.; Bullock, Alex N.; Axtman, Alison D. Share Save
Still in Search for an EAAT Activator: GT949 Does Not Activate EAAT2, nor EAAT3 in Impedance and Radioligand Uptake Assays van Veggel, Lieve; Mocking, Tamara A. M.; Sijben, Hubert J.; Liu, Rongfang; Gonzalez, Marina Gorostiola; Dilweg, Majlen A.; Royakkers, Jeroen; Li, Anna; Kumar, Vijay; Dong, Yin Yao; Bullock, Alex; Sauer, David B.; Dilien, Hanne; van Westen, Gerard J. P.; Schreiber, Rudy; Heitman, Laura H.; Vanmierlo, Tim Share Save
BTB domain mutations perturbing KCTD15 oligomerisation cause a distinctive frontonasal dysplasia syndrome Miller, Kerry A.; Cruz Walma, David A.; Pinkas, Daniel M.; Tooze, Rebecca S.; Bufton, Joshua C.; Richardson, William; Manning, Charlotte E.; Hunt, Alice E.; Cros, Julien; Hartill, Verity; Parker, Michael J.; Mcgowan, Simon J.; Twigg, Stephen R. F.; Chalk, Rod; Staunton, David; Johnson, David; Wilkie, Andrew O. M.; Bullock, Alex N. Share Save
PRMT5 inhibition shows in vitro efficacy against H3K27M-altered diffuse midline glioma, but does not extend survival in vivo Brown, Elizabeth J.; Balaguer-Lluna, Leire; Cribbs, Adam P.; Philpott, Martin; Campo, Leticia; Browne, Molly; Wong, Jong Fu; Oppermann, Udo; Carcaboso, angel M.; Bullock, Alex N.; Farnie, Gillian Share Save
CIS is a potent checkpoint in NK cell-mediated tumor immunity (vol 17, pg 816, 2016) Delconte, Rebecca B.; Kolesnik, Tatiana B.; Dagley, Laura F.; Rautela, Jai; Shi, Wei; Putz, Eva M.; Stannard, Kimberley; Zhang, Jian-Guo; Teh, Charis; Firth, Matt; Ushiki, Takashi; Andoniou, Christopher E.; Degli-Esposti, Mariapia A.; Sharp, Phillip P.; Sanvitale, Caroline E.; Infusini, Giuseppe; Liau, Nicholas P. D.; Linossi, Edmond M.; Burns, Christopher J.; Carotta, Sebastian; Gray, Daniel H. D.; Seillet, Cyril; Hutchinson, Dana S.; Belz, Gabrielle T.; Webb, Andrew I.; Alexander, Warren S.; Li, Shawn S.; Bullock, Alex N.; Babon, Jeffrey J.; Smyth, Mark J.; Nicholson, Sandra E.; Huntington, Nicholas D. Share Save
Share Save
Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective Ong, Han Wee; Liang, Yi; Richardson, William; Lowry, Emily R.; Wells, Carrow I.; Chen, Xiangrong; Silvestre, Margaux; Dempster, Kelvin; Silvaroli, Josie A.; Smith, Jeffery L.; Wichterle, Hynek; Pabla, Navjot S.; Ultanir, Sila K.; Bullock, Alex N.; Drewry, David H.; Axtman, Alison D. Share Save
Constitutively Active ALK2 Receptor Mutants Require Type II Receptor Cooperation Bagarova, Jana; Vonner, Ashley J.; Armstrong, Kelli A.; Boergermann, Jan; Lai, Carol S. C.; Deng, Donna Y.; Beppu, Hideyuki; Alfano, Ivan; Filippakopoulos, Panagis; Morrell, Nicholas W.; Bullock, Alex N.; Knaus, Petra; Mishina, Yuji; Yu, Paul B. Share Save
Constitutively Active ALK2 Receptor Mutants Require Type II Receptor Cooperation (vol 33, pg 2413, 2013) Bagarova, Jana; Vonner, Ashley J.; Armstrong, Kelli A.; Boergermann, Jan; Lai, Carol S. C.; Deng, Donna Y.; Beppu, Hideyuki; Alfano, Ivan; Filippakopoulos, Panagis; Morrell, Nicholas W.; Bullock, Alex N.; Knaus, Petra; Mishina, Yuji; Yu, Paul B. Share Save
Target 2035-an update on private sector contributions Ackloo, Suzanne; Antolin, Albert A.; Bartolome, Jose Manuel; Beck, Hartmut; Bullock, Alex; Betz, Ulrich A. K.; Boettcher, Jark.; Brown, Peter J.; Chaturvedi, Menorca; Crisp, Alisa; Daniels, Danette; Dreher, Jan; Edfeldt, Kristina; Edwards, Aled M.; Egner, Ursula; Elkins, Jon; Fischer, Christian; Glendorf, Tine; Goldberg, Steven; Hartung, Ingo V.; Hillisch, Alexander; Homan, Evert; Knapp, Stefan; Koester, Markus; Kraemer, Oliver; Llaveria, Josep; Lessel, Uta; Lindemann, Sven; Linderoth, Lars; Matsui, Hisanori; Michel, Maurice; Montel, Florian; Mueller-Fahrnow, Anke; Mueller, Susanne; Owen, Dafydd R.; Saikatendu, Kumar Singh; Santhakumar, Vijayaratnam; Sanderson, Wendy; Scholten, Cora; Schapira, Matthieu; Sharma, Sujata; Shireman, Brock; Sundstrom, Michael; Todd, Matthew H.; Tredup, Claudia; Venable, Jennifer; Willson, Timothy M.; Arrowsmith, Cheryl H. Share Save
Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation Chen, Zhuoyao; Ioris, Rafael M.; Richardson, Stacey; Van Ess, Ava N.; Vendrell, Iolanda; Kessler, Benedikt M.; Buffa, Francesca M.; Busino, Luca; Clifford, Steven C.; Bullock, Alex N.; D'Angiolella, Vincenzo Share Save
Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase Chen, Zhuoyao; Zhang, Jinwei; Murillo-de-Ozores, Adrian R.; Castaneda-Bueno, Maria; D'Amico, Francesca; Heilig, Raphael; Manning, Charlotte E.; Sorrell, Fiona J.; D'Angiolella, Vincenzo; Fischer, Roman; Mulder, Monique P. C.; Gamba, Gerardo; Alessi, Dario R.; Bullock, Alex N. Share Save
.png){kind=icon}
.png){kind=icon}
Not logged in.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
