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RUNX2 regulates leukemic cell metabolism and chemotaxis in high-risk T cell acute lymphoblastic leukemia Matthijssens, Filip; Sharma, Nitesh D.; Nysus, Monique; Nickl, Christian K.; Kang, Huining; Perez, Dominique R.; Lintermans, Beatrice; Van Loocke, Wouter; Roels, Juliette; Peirs, Sofie; Demoen, Lisa; Pieters, Tim; Reunes, Lindy; Lammens, Tim; De Moerloose, Barbara; Van Nieuwerburgh, Filip; Deforce, Dieter L.; Cheung, Laurence C.; Kotecha, Rishi S.; Risseeuw, Martijn D. P.; Van Calenbergh, Serge; Takarada, Takeshi; Yoneda, Yukio; van Delft, Frederik W.; Lock, Richard B.; Merkley, Seth D.; Chigaev, Alexandre; Sklar, Larry A.; Mullighan, Charles G.; Loh, Mignon L.; Winter, Stuart S.; Hunger, Stephen P.; Goossens, Steven; Castillo, Eliseo F.; Ornatowski, Wojciech; Van Vlierberghe, Pieter; Matlawska-Wasowska, Ksenia Share Save
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Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties Rai, Ganesha; Urban, Daniel J.; Mott, Bryan T.; Hu, Xin; Yang, Shyh-Ming; Benavides, Gloria A.; Johnson, Michelle S.; Squadrito, Giuseppe L.; Brimacombe, Kyle R.; Lee, Tobie D.; Cheff, Dorian M.; Zhu, Hu; Henderson, Mark J.; Pohida, Katherine; Sulikowski, Gary A.; Dranow, David M.; Kabir, Md; Shah, Pranav; Padilha, Elias; Tao, Dingyin; Fang, Yuhong; Christov, Plamen P.; Kim, Kwangho; Jana, Somnath; Muttil, Pavan; Anderson, Tamara; Kunda, Nitesh K.; Hathaway, Helen J.; Kusewitt, Donna F.; Oshima, Nobu; Cherukuri, Murali; Davies, Douglas R.; Norenberg, Jeffrey P.; Sklar, Larry A.; Moore, William J.; Dang, Chi, V; Stott, Gordon M.; Neckers, Leonard; Flint, Andrew J.; Darley-Usmar, Victor M.; Simeonov, Anton; Waterson, Alex G.; Jadhav, Ajit; Hall, Matthew D.; Maloney, David J. Share Save
Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy Oshima, Nobu; Ishida, Ryo; Kishimoto, Shun; Beebe, Kristin; Brender, Jeffrey R.; Yamamoto, Kazutoshi; Urban, Daniel; Rai, Ganesha; Johnson, Michelle S.; Benavides, Gloria; Squadrito, Giuseppe L.; Crooks, Dan; Jackson, Joseph; Joshi, Abhinav; Mott, Bryan T.; Shrimp, Jonathan H.; Moses, Michael A.; Lee, Min-Jung; Yuno, Akira; Lee, Tobie D.; Hu, Xin; Anderson, Tamara; Kusewitt, Donna; Hathaway, Helen H.; Jadhav, Ajit; Picard, Didier; Trepel, Jane B.; Mitchell, James B.; Stott, Gordon M.; Moore, William; Simeonov, Anton; Sklar, Larry A.; Norenberg, Jeffrey P.; Linehan, W. Marston; Maloney, David J.; Dang, Chi V.; Waterson, Alex G.; Hall, Matthew; Darley-Usmar, Victor M.; Krishna, Murali C.; Neckers, Leonard M. Share Save
A Selective Ligand for Estrogen Receptor Proteins Discriminates Rapid and Genomic Signaling Revankar, Chetana M.; Bologa, Cristian G.; Pepermans, Richard A.; Sharma, Geetanjali; Petrie, Whitney K.; Alcon, Sara N.; Field, Angela S.; Ramesh, Chinnasamy; Parker, Matthew A.; Savchuk, Nikolay P.; Sklar, Larry A.; Hathaway, Helen J.; Arterburn, Jeffrey B.; Oprea, Tudor, I; Prossnitz, Eric R. Share Save
Autophagy, Inflammation, and Metabolism (AIM) Center in its second year Deretic, Vojo; Prossnitz, Eric; Burge, Mark; Campen, Matthew J.; Cannon, Judy; Liu, Ke Jian; Liu, Meilian; Hall, Pamela; Sklar, Larry A.; Allers, Lee; Mariscal, Luisa; Garcia, Sally Ann; Weaver, John; Baehrecke, Eric H.; Behrends, Christian; Cecconi, Francesco; Codogno, Patrice; Chen, Guang-Chao; Elazar, Zvulun; Eskelinen, Eeva-Liisa; Fourie, Bernard; Gozuacik, Devrim; Hong, Wanjin; Jo, Eun-Kyeong; Johansen, Terje; Juhasz, Gabor; Kimch, Adi; Ktistakis, Nicholas; Kroemer, Guido; Mizushima, Noboru; Muenz, Christian; Reggiori, Fulvio; Rubinsztein, David; Ryan, Kevin; Schroder, Kate; Shen, Han-Min; Simonsen, Anne; Tooze, Sharon A.; Vaccaro, Maria; Yoshimori, Tamotsu; Yu, Li; Zhang, Hong; Klionsky, Daniel J. Share Save
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Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence: supporting the next generation of autophagy researchers and fostering international collaborations Deretic, Vojo; Prossnitz, Eric; Burge, Mark; Campen, Matthew J.; Cannon, Judy; Liu, Ke Jian; Sklar, Larry A.; Allers, Lee; Garcia, Sally Ann; Baehrecke, Eric H.; Behrends, Christian; Cecconi, Francesco; Codogno, Patrice; Chen, Guang-Chao; Elazar, Zvulun; Eskelinen, Eeva-Liisa; Fourie, Bernard; Gozuacik, Devrim; Hong, Wanjin; Hotamisligi, Gokhan; Jaaettela, Marja; Jo, Eun-Kyeong; Johansen, Terje; Juhasz, Gabor; Kimchi, Adi; Ktistakis, Nicholas; Kroemer, Guido; MIzushima, Noboru; Munz, Christian; Reggiori, Fulvio; Rubinsztein, David; Ryan, Kevin; Schroder, Kate; Simonsen, Anne; Tooze, Sharon; Vaccaro, Maria I.; Yoshimori, Tamotsu; Yu, Li; Zhang, Hong; Klionsky, Daniel J. Share Save
Activation of Rho Family GTPases by Small Molecules Palsuledesai, Charuta C.; Suryiladze, Zurab; Waller, Anna; Miscioscia, T. Fabiola; Guo, Yuna; Wu, Yang; Strouse, Jake; Romero, Elsa; Salas, Virginia M.; Curpan, Ramona; Young, Susan; Carter, Mark; Foutz, Terry; Galochkina, Zhanna; Ames, Harold; Haynes, Mark K.; Edwards, Bruce S.; Nicolotti, Orazio; Luo, Li; Ursu, Oleg; Bologa, Cristian G.; Oprea, Tudor, I; Wandinger-Ness, Angela; Sklar, Larry A. Share Save
Unexplored therapeutic opportunities in the human genome (vol 17, pg 317, 2018) Oprea, Tudor I.; Bologa, Cristian G.; Brunak, Soren; Campbell, Allen; Gan, Gregory N.; Gaulton, Anna; Gomez, Shawn M.; Guha, Rajarshi; Hersey, Anne; Holmes, Jayme; Jadhav, Ajit; Jensen, Lars Juhl; Johnson, Gary L.; Karlson, Anneli; Leach, Andrew R.; Ma'ayan, Avi; Malovannaya, Anna; Mani, Subramani; Mathias, Steven L.; McManus, Michael T.; Meehan, Terrence F.; von Mering, Christian; Muthas, Daniel; Dac-Trung Nguyen; Overington, John P.; Papadatos, George; Qin, Jun; Reich, Christian; Roth, Bryan L.; Schurer, Stephan C.; Simeonov, Anton; Sklar, Larry A.; Southall, Noel; Tomita, Susumu; Tudose, Ilinca; Ursu, Oleg; Vidovic, Dusica; Waller, Anna; Westergaard, David; Yang, Jeremy J.; Zahoranszky-Kohalmi, Gergely Share Save
Unexplored therapeutic opportunities in the human genome Oprea, Tudor I.; Bologa, Cristian G.; Brunak, Soren; Campbell, Allen; Gan, Gregory N.; Gaulton, Anna; Gomez, Shawn M.; Guha, Rajarshi; Hersey, Anne; Holmes, Jayme; Jadhav, Ajit; Jensen, Lars Juhl; Johnson, Gary L.; Karlson, Anneli; Leach, Andrew R.; Ma'ayan, Avi; Malovannaya, Anna; Mani, Subramani; Mathias, Stephen L.; McManus, Michael T.; Meehan, Terrence F.; von Mering, Christian; Muthas, Daniel; Dac-Trung Nguyen; Overington, John P.; Papadatos, George; Qin, Jun; Reich, Christian; Roth, Bryan L.; Schurer, Stephan C.; Simeonov, Anton; Sklar, Larry A.; Southall, Noel; Tomita, Susumu; Tudose, Ilinca; Ursu, Oleg; Vidovic, Dusica; Waller, Anna; Westergaard, David; Yang, Jeremy J.; Zahoranszky-Kohalmi, Gergely Share Save
Functional and clinical relevance of VLA-4 (CD49d/CD29) in ibrutinib-treated chronic lymphocytic leukemia Tissino, Erika; Benedetti, Dania; Herman, Sarah E. M.; ten Hacken, Elisa; Ahn, Inhye E.; Chaffee, Kari G.; Rossi, Francesca Maria; Dal Bo, Michele; Bulian, Pietro; Bomben, Riccardo; Bayer, Elisabeth; Haerzschel, Andrea; Gutjahr, Julia Christine; Postorino, Massimiliano; Santinelli, Enrico; Ayed, Ayed; Zaja, Francesco; Chiarenza, Annalisa; Pozzato, Gabriele; Chigaev, Alexandre; Sklar, Larry A.; Burger, Jan A.; Ferrajoli, Alessandra; Shanafelt, Tait D.; Wiestner, Adrian; Del Poeta, Giovanni; Hartmann, Tanja Nicole; Gattei, Valter; Zucchetto, Antonella Share Save
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Pharos: Collating protein information to shed light on the druggable genome Dac-Trung Nguyen; Mathias, Stephen; Bologa, Cristian; Brunak, Soren; Fernandez, Nicolas; Gaulton, Anna; Hersey, Anne; Holmes, Jayme; Jensen, Lars Juhl; Karlsson, Anneli; Liu, Guixia; Ma'ayan, Avi; Mandava, Geetha; Mani, Subramani; Mehta, Saurabh; Overington, John; Patel, Juhee; Rouillard, Andrew D.; Schurer, Stephan; Sheils, Timothy; Simeonov, Anton; Sklar, Larry A.; Southall, Noel; Ursu, Oleg; Vidovic, Dusica; Waller, Anna; Yang, Jeremy; Jadhav, Ajit; Oprea, Tudor I.; Guha, Rajarshi Share Save
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Pharmaceutical screen identifies novel target processes for activation of autophagy with a broad translational potential Chauhan, Santosh; Ahmed, Zahra; Bradfute, Steven B.; Arko-Mensah, John; Mandell, Michael A.; Choi, Seong Won; Kimura, Tomonori; Blanchet, Fabien; Waller, Anna; Mudd, Michal H.; Jiang, Shanya; Sklar, Larry; Timmins, Graham S.; Maphis, Nicole; Bhaskar, Kiran; Piguet, Vincent; Deretic, Vojo Share Save
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