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Patrick O’Donoghue

western university (university of western ontario)

34H-index
96Paper Count
4.7KCitation Count
Published Papers 60
Publication Date
Mistranslation from an endogenous tRNA variant in human pan-genome cell lines
err2026-03-24
err0
PREAI
errRozik, Peter; Moore, Henry; Lant, Jeremy T.; Hoffman, Kyle S.; Schultz, Sarah K.; Afzal, Baasil; Chan, Patricia P.; Flynn, Lauren E.; Heinemann, Ilka U.; Lowe, Todd M.; O'Donoghue, Patrick
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High-fidelity and differential nonsense suppression in live cells and a frontotemporal dementia allele with human transfer RNAs
err2025-08-12
err1
PREAI
errBeharry, Aruun; Ward, Cian; Moore, Henry; Hoffman, Kyle S.; Chan, Patricia P.; Lowe, Todd M.; O'Donoghue, Patrick
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The IUBMB Focused Meeting on Aminoacyl-tRNA Synthetases 2023
err2025-07-28
err0
PREAI
errPatrick O'Donoghue; Ilka U. Heinemann
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Natural human tRNAAla anticodon variants mistranslate the genetic code
errRNA
IF5
err2025-03-21
err0
PREAI
errTennakoon, Rasangi; Bily, Teija M. I.; Hasan, Farah; Hoffman, Kyle S.; O'Donoghue, Patrick
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Glutamine missense suppressor transfer RNAs inhibit polyglutamine aggregation
err2025-03-01
err0
errOAAI
errTennakoon, Rasangi; Bily, Teija M. I.; Hasan, Farah; Syal, Sunidhi; Voigt, Aaron; Balci, Tugce B.; Hoffman, Kyle S.; O'Donoghue, Patrick
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Transfer RNA and small molecule therapeutics for aminoacyl-tRNA synthetase diseases
err2024-12-19
err0
errOAAI
errSamuels, Tristan N.; Wu, Fanqi; Mahmood, Maria; Abuzaid, Wajd A.; Sun, Nancy; Moresco, Angelica; Siu, Victoria M.; O'Donoghue, Patrick; Heinemann, Ilka U.
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Transfer RNA supplementation rescues HARS deficiency in a humanized yeast model of Charcot-Marie-Tooth disease
err2024-11-12
err1
errOAAI
errWilhelm, Sarah D. P.; Kakadia, Jenica H.; Beharry, Aruun; Kenana, Rosan; Hoffman, Kyle S.; O'Donoghue, Patrick; Heinemann, Ilka U.
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Delivery of AKT1 phospho-forms to human cells reveals differential substrate selectivity
err2024-05-13
err0
errOAAI
errSiddika, Tarana; Shao, Richard; Heinemann, Ilka U.; O'Donoghue, Patrick
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Mistranslating the genetic code with leucine in yeast and mammalian cells
err2024-04-17
err6
errOAAI
errDavey-Young, Josephine; Hasan, Farah; Tennakoon, Rasangi; Rozik, Peter; Moore, Henry; Hall, Peter; Cozma, Ecaterina; Genereaux, Julie; Hoffman, Kyle S.; Chan, Patricia P.; Lowe, Todd M.; Brandl, Christopher J.; O'Donoghue, Patrick
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Missense suppressor tRNA therapeutics correct disease-causing alleles by misreading the genetic code
err2024-02-01
err3
PREAI
errBily, Teija M. I.; Heinemann, Ilka U.; O'Donoghue, Patrick
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Delivery of Active AKT1 to Human Cells
errCELLS
IF5.2
err2022-11-29
err10
errOAAI
errSiddika, Tarana; Balasuriya, Nileeka; Frederick, Mallory I. I.; Rozik, Peter; Heinemann, Ilka U. U.; O'Donoghue, Patrick
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Ancestral archaea expanded the genetic code with pyrrolysine
err2022-11-01
err20
errOAAI
errGuo, Li -Tao; Amikura, Kazuaki; Jiang, Han -Kai; Mukai, Takahito; Fu, Xian; Wang, Yane-Shih; O'Donoghue, Patrick; Soell, Dieter; Tharp, Jeffery M.
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Delivery of the selenoprotein thioredoxin reductase 1 to mammalian cells
err2022-10-11
err3
errOAAI
errWright, David E.; Siddika, Tarana; Heinemann, Ilka U.; O'Donoghue, Patrick
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Expanding codon size
err2022-05-11
err0
errOAAI
errSiddika, Tarana; Heinemann, Ilka U.; O'Donoghue, Patrick
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Phosphate-regulated expression of the SARS-CoV-2 receptor-binding domain in the diatom Phaeodactylum tricornutum for pandemic diagnostics
err2022-04-29
err17
errOAAI
errSlattery, Samuel S.; Giguere, Daniel J.; Stuckless, Emily E.; Shrestha, Arina; Briere, Lee-Ann K.; Galbraith, Alexa; Reaume, Stephen; Boyko, Xenia; Say, Henry H.; Browne, Tyler S.; Frederick, Mallory, I; Lant, Jeremy T.; Heinemann, Ilka U.; O'Donoghue, Patrick; Dsouza, Liann; Martin, Steven; Howard, Peter; Jedeszko, Christopher; Ali, Kinza; Styba, Garth; Flatley, Martin; Karas, Bogumil J.; Gloor, Gregory B.; Edgell, David R.
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miRNA-Dependent Regulation of AKT1 Phosphorylation
errCELLS
IF5.2
err2022-02-26
err15
errOAAI
errFrederick, Mallory I.; Siddika, Tarana; Zhang, Pengcheng; Balasuriya, Nileeka; Turk, Matthew A.; O'Donoghue, Patrick; Heinemann, Ilka U.
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A novel fluorescent reporter sensitive to serine mis-incorporation
err2022-02-15
err13
errOAAI
errRozik, Peter; Szabla, Robert; Lant, Jeremy T.; Kiri, Rashmi; Wright, David E.; Junop, Murray; O'Donoghue, Patrick
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Formation and persistence of polyglutamine aggregates in mistranslating cells
err2021-10-28
err20
errOAAI
errLant, Jeremy T.; Kiri, Rashmi; Duennwald, Martin L.; O'Donoghue, Patrick
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Acetylated Thioredoxin Reductase 1 Resists Oxidative Inactivation
err2021-09-15
err8
errOAAI
errWright, David E.; Panaseiko, Nikolaus; O'Donoghue, Patrick
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