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An exonuclease-resistant chain-terminating nucleotide analogue targeting the SARS-CoV-2 replicase complex Shannon, Ashleigh; Chazot, Aurelie; Feracci, Mikael; Falcou, Camille; Fattorini, Veronique; Selisko, Barbara; Good, Steven; Moussa, Adel; Sommadossi, Jean-Pierre; Ferron, Francois; Alvarez, Karine; Canard, Bruno Share Save
Structure-guided optimization of adenosine mimetics as selective and potent inhibitors of coronavirus nsp14 N7-methyltransferases Hausdorff, Marcel; Delpal, Adrien; Barelier, Sarah; Nicollet, Laura; Canard, Bruno; Touret, Franck; Colmant, Agathe; Coutard, Bruno; Vasseur, Jean-Jacques; Decroly, Etienne; Debart, Francoise Share Save
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Internal RNA 2′O-methylation in the HIV-1 genome counteracts ISG20 nuclease-mediated antiviral effect El Kazzi, Priscila; Rabah, Nadia; Chamontin, Celia; Poulain, Lina; Ferron, Francois; Debart, Francoise; Canard, Bruno; Misse, Dorothee; Coutard, Bruno; Nisole, Sebastien; Decroly, Etienne Share Save
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A Versatile Class of 1,4,4-Trisubstituted Piperidines Block Coronavirus Replication In Vitro De Castro, Sonia; Stevaert, Annelies; Maldonado, Miguel; Delpal, Adrien; Vandeput, Julie; Van Loy, Benjamin; Eydoux, Cecilia; Guillemot, Jean-Claude; Decroly, Etienne; Gago, Federico; Canard, Bruno; Camarasa, Maria-Jose; Velazquez, Sonsoles; Naesens, Lieve Share Save
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Potent Inhibition of SARS-CoV-2 nsp14 N7-Methyltransferase bySulfonamide-Based Bisubstrate Analogues Ahmed-Belkacem, Rostom; Hausdorff, Marcel; Delpal, Adrien; Sutto-Ortiz, Priscila; Colmant, Agathe M. G.; Touret, Franck; Ogando, Natacha S.; Snijder, Eric J.; Canard, Bruno; Coutard, Bruno; Vasseur, Jean-Jacques; Decroly, Etienne; Debart, Francoise Share Save
Synthesis, Structure-Activity Relationships, and Antiviral Profiling of 1-Heteroaryl-2-Alkoxyphenyl Analogs as Inhibitors of SARS-CoV-2 Replication Bardiot, Dorothee; Vangeel, Laura; Koukni, Mohamed; Arzel, Philippe; Zwaagstra, Marleen; Lyoo, Heyrhyoung; Wanningen, Patrick; Ahmad, Shamshad; Zhang, Linlin; Sun, Xinyuanyuan; Delpal, Adrien; Eydoux, Cecilia; Guillemot, Jean-Claude; Lescrinier, Eveline; Klaassen, Hugo; Leyssen, Pieter; Jochmans, Dirk; Castermans, Karolien; Hilgenfeld, Rolf; Robinson, Colin; Decroly, Etienne; Canard, Bruno; Snijder, Eric J.; van Hemert, Martijn J.; van Kuppeveld, Frank; Chaltin, Patrick; Neyts, Johan; De Jonghe, Steven; Marchand, Arnaud Share Save
A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase Shannon, Ashleigh; Fattorini, Veronique; Sama, Bhawna; Selisko, Barbara; Feracci, Mikael; Falcou, Camille; Gauffre, Pierre; El Kazzi, Priscila; Delpal, Adrien; Decroly, Etienne; Alvarez, Karine; Eydoux, Cecilia; Guillemot, Jean-Claude; Moussa, Adel; Good, Steven S.; La Colla, Paolo; Lin, Kai; Sommadossi, Jean-Pierre; Zhu, Yingxiao; Yan, Xiaodong; Shi, Hui; Ferron, Francois; Canard, Bruno Share Save
Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes a ring-shaped hexameric complex Hurdiss, Daniel L.; El Kazzi, Priscila; Bauer, Lisa; Papageorgiou, Nicolas; Ferron, Francois P.; Donselaar, Tim; van Vliet, Arno L. W.; Shamorkina, Tatiana M.; Snijder, Joost; Canard, Bruno; Decroly, Etienne; Brancale, Andrea; Zeev-Ben-Mordehai, Tzviya; Forster, Friedrich; van Kuppeveld, Frank J. M.; Coutard, Bruno Share Save
Structure-function analysis of the nsp14 N7-guanine methyltransferase reveals an essential role in Betacoronavirus replication Ogando, Natacha S.; El Kazzi, Priscila; Zevenhoven-Dobbe, Jessika C.; Bontes, Brenda W.; Decombe, Alice; Posthuma, Clara C.; Thiel, Volker; Canard, Bruno; Ferron, Francois; Decroly, Etienne; Snijder, Eric J. Share Save
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Evaluation of AT-752, a Double Prodrug of a Guanosine Nucleotide Analog with In Vitro and In Vivo Activity against Dengue and Other Flaviviruses Good, Steven S.; Shannon, Ashleigh; Lin, Kai; Moussa, Adel; Julander, Justin G.; La Colla, Paolo; Collu, Gabriella; Canard, Bruno; Sommadossi, Jean-Pierre Share Save
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