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Alfred H. Schinkel

netherlands cancer institute

95H-index
432Paper Count
3.8WCitation Count
Published Papers 163
Publication Date
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Daraxonrasib (RMC-6236) pharmacokinetics: impact of transporters and drug-metabolizing enzymes on a first-in-class pan-RAS molecular glue
errPharmacological Research
IF10.5
err2026-05-08
err0
errOAAI
errAlfred Schinkel; Davinia Arguedas; Viët Bui; Tjon Law; Jamie Rijmers; Renaud Tissier; Jos H. Beijnen; Olaf van Tellingen; M. Cristina Lebre
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Resistance mutations and the blood–brain barrier: Key challenges in targeted treatment of brain metastatic non-small cell lung cancer
errActa Pharmaceutica Sinica B
IF14.6
err2025-06-07
err0
errOAAI
errJamie Rijmers; Maria C. Lebre; Jos H. Beijnen; Alfred H. Schinkel
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Intestinal human carboxylesterase 2 (CES2) expression rescues drug metabolism and most metabolic syndrome phenotypes in global Ces2 cluster knockout mice
errACTA PHARMACOLOGICA SINICA
IF8.4
err2024-11-04
err0
errOAAI
errWang, Yao-geng; Gan, Chang-pei; Beukers-Korver, Joke; Rosing, Hilde; Li, Wen-long; Wagenaar, Els; Lebre, Maria C.; Song, Ji-ying; Pritchard, Colin; Bin Ali, Rahmen; Huijbers, Ivo; Beijnen, Jos H.; Schinkel, Alfred H.
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The role of drug efflux and uptake transporters in the plasma pharmacokinetics and tissue disposition of morphine and its main metabolites
errTOXICOLOGY AND APPLIED PHARMACOLOGY
IF3.4
err2024-09-01
err1
PREAI
errMartins, Margarida L. F.; Heydari, Paniz; Li, Wenlong; Martinez-Chavez, Alejandra; el Yattouti, Malika; Lebre, Maria C.; Beijnen, Jos H.; Schinkel, Alfred H.
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ABCB1 attenuates brain exposure to the KRASG12C inhibitor opnurasib whereas binding to mouse carboxylesterase 1c influences its plasma exposure
errBIOMEDICINE & PHARMACOTHERAPY
IF7.5
err2024-06-01
err0
errOAAI
errRijmers, Jamie; Retmana, Irene A.; Bui, Viet; Arguedas, Davinia; Lebre, Maria C.; Sparidans, Rolf W.; Beijnen, Jos H.; Schinkel, Alfred H.
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The ABCB1 and ABCG2 efflux transporters limit brain disposition of the SYK inhibitors entospletinib and lanraplenib
errTOXICOLOGY AND APPLIED PHARMACOLOGY
IF3.4
err2024-04-01
err1
errOAAI
errLoos, Nancy H. C.; Sparidans, Rolf W.; Heydari, Paniz; Bui, Viet; Lebre, Maria C.; Beijnen, Jos H.; Schinkel, Alfred H.
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Coadministration of ABCB1/P-glycoprotein inhibitor elacridar improves tissue distribution of ritonavir-boosted oral cabazitaxel in mice
errINTERNATIONAL JOURNAL OF PHARMACEUTICS
IF5.2
err2024-01-01
err3
PREAI
errLoos, Nancy H. C.; Martins, Margarida L. F.; de Jong, Danielle; Lebre, Maria C.; Tibben, Matthijs; Beijnen, Jos H.; Schinkel, Alfred H.
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Predictability of human exposure by human-CYP3A4-transgenic mouse models: A meta-analysis
errCTS-CLINICAL AND TRANSLATIONAL SCIENCE
IF2.8
err2023-12-01
err1
errOAAI
errDamoiseaux, David; Schinkel, Alfred H.; Beijnen, Jos H.; Huitema, Alwin D. R.; Dorlo, Thomas P. C.
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Validated LC-MS/MS method for simultaneous quantification of KRASG12C inhibitor sotorasib and its major circulating metabolite (M24) in mouse matrices and its application in a mouse pharmacokinetic study
errJOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
IF3.1
err2023-10-01
err2
errOAAI
errRetmana, Irene A.; Loos, Nancy H. C.; Schinkel, Alfred H.; Beijnen, Jos H.; Sparidans, Rolf W.
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Pharmacokinetics of the KRASG12C inhibitor adagrasib is limited by CYP3A and ABCB1, and influenced by binding to mouse plasma carboxylesterase 1c
errBIOMEDICINE & PHARMACOTHERAPY
IF7.5
err2023-10-01
err6
errOAAI
errLoos, Nancy H. C.; Retmana, Irene A.; Rijmers, Jamie; Wang, Yaogeng; Gan, Changpei; Lebre, Maria C.; Sparidans, Rolf W.; Beijnen, Jos H.; Schinkel, Alfred H.
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Natural deletion of mouse carboxylesterases Ces1c/d/e impacts drug metabolism and metabolic syndrome development
errBIOMEDICINE & PHARMACOTHERAPY
IF7.5
err2023-08-01
err2
errOAAI
errGan, Changpei; Wang, Jing; Wang, Yaogeng; Martinez-Chavez, Alejandra; Hillebrand, Michel; de Vries, Niels; Beukers, Joke; Lebre, Maria C.; Wagenaar, Els; Rosing, Hilde; Klarenbeek, Sjoerd; Bleijerveld, Onno B.; Song, Ji-Ying; Altelaar, Maarten; Beijnen, Jos H.; Schinkel, Alfred H.
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P-glycoprotein (MDR1/ABCB1) Restricts Brain Penetration of the Main Active Heroin Metabolites 6-monoacetylmorphine (6-MAM) and Morphine in Mice
errPHARMACEUTICAL RESEARCH
IF4.3
err2023-06-21
err3
PREAI
errMartins, Margarida L. F.; Loos, Nancy H. C.; el Yattouti, Malika; Offeringa, Lianda; Heydari, Paniz; Hillebrand, Michel J. X.; Lebre, Maria C.; Beijnen, Jos H.; Schinkel, Alfred H.
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errSave
The inhibitory and inducing effects of ritonavir on hepatic and intestinal CYP3A and other drug-handling proteins
errBIOMEDICINE & PHARMACOTHERAPY
IF7.5
err2023-06-01
err15
errOAAI
errLoos, Nancy H. C.; Beijnen, Jos H.; Schinkel, Alfred H.
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Organic anion-transporting polypeptide 2B1 knockout and humanized mice; insights into the handling of bilirubin and drugs
errPHARMACOLOGICAL RESEARCH
IF10.5
err2023-04-01
err6
errOAAI
errLi, Wenlong; Iusuf, Dilek; Sparidans, Rolf W.; Wagenaar, Els; Wang, Yaogeng; de Waart, Dirk R.; Martins, Margarida L. F.; van Hoppe, Stephanie; Lebre, Maria C.; van Tellingen, Olaf; Beijnen, Jos H.; Schinkel, Alfred H.
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Reduced hepatic uptake and intestinal excretion of organic cations in mice with a targeted disruption of the organic cation transporter 1 (Oct1 [Slc22a1]) gene
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-28
err203
errOAAI
errJonker, JW; Wagenaar, E; Mol, CAAM; Buitelaar, M; Koepsell, H; Smit, JW; Schinkel, AH
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Deficiency in the organic cation transporters 1 and 2 (Oct1/Oct2 [Slc22a1/Slc22a2]) in mice abolishes renal secretion of organic cations
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err253
errOAAI
errJonker, JW; Wagenaar, E; van Eijl, S; Schinkel, AH
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Multidrug transporter ABCG2/breast cancer resistance protein secretes riboflavin (vitamin B2) into milk
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err193
errOAAI
errvan Herwaarden, Antonius E.; Wagenaar, Els; Merino, Gracia; Jonker, Johan W.; Rosing, Hilde; Beijnen, Jos H.; Schinkel, Alfred H.
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Carboxylesterase 1 family knockout alters drug disposition and lipid metabolism
errACTA PHARMACEUTICA SINICA B
IF14.6
err2023-02-01
err9
errOAAI
errGan, Changpei; Wang, Jing; Martinez-Chavez, Alejandra; Hillebrand, Michel; de Vries, Niels; Beukers, Joke; Wagenaar, Els; Wang, Yaogeng; Lebre, Maria C.; Rosing, Hilde; Klarenbeek, Sjoerd; Ali, Rahmen Bin; Pritchard, Colin; Huijbers, Ivo; Beijnen, Jos H.; Schinkel, Alfred H.
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errSave
P-Glycoprotein (MDR1/ABCB1) Restricts Brain Accumulation of the Novel EGFR Inhibitor EAI045 and Oral Elacridar Coadministration Enhances Its Brain Accumulation and Oral Exposure
errPHARMACEUTICALS
IF4.8
err2022-09-08
err0
errOAAI
errWang, Jing; Susam, M. Merve; Gan, Changpei; Sparidans, Rolf W.; Lebre, Maria C.; Beijnen, Jos H.; Schinkel, Alfred H.
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errSave
Predictiveness of the Human-CYP3A4-Transgenic Mouse Model (Cyp3aXAV) for Human Drug Exposure of CYP3A4-Metabolized Drugs
errPHARMACEUTICALS
IF4.8
err2022-07-13
err5
errOAAI
errDamoiseaux, David; Li, Wenlong; Martinez-Chavez, Alejandra; Beijnen, Jos H.; Schinkel, Alfred H.; Huitema, Alwin D. R.; Dorlo, Thomas P. C.
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errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
P
Piet Borst
H-index: 134 · Papers: 621
M
Mary V. Relling
H-index: 133 · Papers: 638
J
Jos H. Beijnen
H-index: 129 · Papers: 1.8K
A
Amalio Telenti
H-index: 117 · Papers: 640
Y
Yuichi Sugiyama
H-index: 112 · Papers: 1.1K
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