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T

Tanja Rothgangl

University of Zurich
H指数:10
被引数:858

个人简介

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教育背景

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工作经历

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荣誉奖项

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RNA-LNP–mediated in vivo prime editing corrects disease phenotypes in a mouse model of citrullinemia type I

RNA-LNP介导的在体基础编辑纠正了鸟氨酸氨甲酰转移酶缺乏症小鼠模型的疾病表型

Science Translational Medicine
IF14.6
2026-05-130
PRE
András Tálas; Eleonora I. Ioannidi; Yanik Weber; Tatjana Haenggi; Péter István Kulcsár; Nadia Zürcher; Erica Faccin; Woohyun J. Moon; Lucas Kissling; Elina Andrea Villiger; Mai Matsushita; Tanja Rothgangl; Sharan Janjuha; Paulo J. C. Lin; Martin Poms; Hiromi Muramatsu; Máté Vadovics; Andreas Reichmuth; Manfred Kopf; Norbert Pardi; Ying K. Tam; Johannes Häberle; Gerald Schwank
Prime editing of the β1 adrenoceptor in the brain restores physiological REM sleep in a mouse model of Alzheimer’s disease

脑内β1肾上腺素受体的碱基编辑恢复了阿尔茨海默病小鼠模型中的生理性快速眼动睡眠

Nature Communications
IF15.7
2025-12-090
OAAI
Desirée Böck; Lisa Tidecks; Maria Wilhelm; Waleed ElGrawani; Sian Duss; Chiara Trevisan; Dalila Vena; Anna Maria Reuss; Lucas Kissling; Matteo Ranucci; Mattia Privitera; Lisa K. Polzer; Athena E. Economides; Eleonora I. Ioannidi; Raquel Mendes; Yanik Weber; Justine Leonardi; Jonas Mumenthaler; Elina Villiger; Romain Goutagny; Chantal Mathis; Lukas Schmidheini; Tanja Rothgangl; Sharan Janjuha; Tommaso Patriarchi; Johannes Bohacek; Yaroslav Sych; Adriano Aguzzi; Jochen Winterer; Konstantinos Kompotis; Gerald Schwank
Treatment of a metabolic liver disease in mice with a transient prime editing approach

使用暂时性碱基编辑方法治疗小鼠的代谢性肝病

NATURE BIOMEDICAL ENGINEERING
IF26.6
2025-05-200
OA
Rothgangl, Tanja; Talas, Andras; Ioannidi, Eleonora I.; Weber, Yanik; Bock, Desiree; Matsushita, Mai; Villiger, Elina Andrea; Schmidheini, Lukas; Moon, Woohyun J.; Lin, Paulo J. C.; Fan, Steven H. Y.; Marquart, Kim F.; Schwerdel, Cornelia; Rimann, Nicole; Faccin, Erica; Villiger, Lukas; Muramatsu, Hiromi; Vadovics, Mate; Cremonesi, Alessio; Kulcsar, Peter Istvan; Thoeny, Beat; Kopf, Manfred; Haberle, Johannes; Pardi, Norbert; Tam, Ying K.; Schwank, Gerald
Effective genome editing with an enhanced ISDra2 TnpB system and deep learning-predicted ωRNAs

使用增强的ISDra2 TnpB系统和深度学习预测的 ω rna进行有效的基因组编辑

NATURE METHODS
IF32.1
2024-09-231
PRE
Marquart, Kim Fabiano; Mathis, Nicolas; Mollaysa, Amina; Mueller, Saphira; Kissling, Lucas; Rothgangl, Tanja; Schmidheini, Lukas; Kulcsar, Peter Istvan; Allam, Ahmed; Kaufmann, Masako M.; Matsushita, Mai; Haenggi, Tatjana; Cathomen, Toni; Kopf, Manfred; Krauthammer, Michael; Schwank, Gerald
In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels

猕猴体内PCSK9的腺嘌呤碱基编辑可降低LDL胆固醇水平

NATURE BIOTECHNOLOGY
IF41.7
2021-05-19246
OAAI
Rothgangl, Tanja; Dennis, Melissa K.; Lin, Paulo J. C.; Oka, Rurika; Witzigmann, Dominik; Villiger, Lukas; Qi, Weihong; Hruzova, Martina; Kissling, Lucas; Lenggenhager, Daniela; Borrelli, Costanza; Egli, Sabina; Frey, Nina; Bakker, Noelle; Walker, John A., II; Kadina, Anastasia P.; Victorov, Denis V.; Pacesa, Martin; Kreutzer, Susanne; Kontarakis, Zacharias; Moor, Andreas; Jinek, Martin; Weissman, Drew; Stoffel, Markus; van Boxtel, Ruben; Holden, Kevin; Pardi, Norbert; Thoeny, Beat; Haeberle, Johannes; Tam, Ying K.; Semple, Sean C.; Schwank, Gerald

研究方向

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G
Gerald Schwank
H 指数:33论文数:85被引数:8,512
K
Kim Fabiano Marquart
H 指数:12论文数:29被引数:602
L
Lucas Kissling
H 指数:11论文数:25被引数:944
L
Lukas Schmidheini
H 指数:9论文数:19被引数:543
N
Nicolas Mathis
H 指数:9论文数:24被引数:607
L
Lukas Villiger
H 指数:17论文数:32被引数:3,541
S
Sharan Janjuha
H 指数:12论文数:28被引数:1,274
M
Manfred Köpf
H 指数:104论文数:325被引数:3.6万
N
Norbert Pardi
H 指数:56论文数:177被引数:1.7万
Y
Ying K. Tam
H 指数:62论文数:188被引数:2.0万