Mudra Hegde - Publications, H-index & Citations

Mudra Hegde

Harvard University

19H指数

35论文数

9.4K被引数

收录论文 15

发表时间

Epigenetic tuning of PD-1 expression improves exhausted T cell function and viral control

NATURE IMMUNOLOGY

IF27.6

2024-09-17

PREAI

Weiss, Sarah A.; Huang, Amy Y.; Fung, Megan E.; Martinez, Daniela; Chen, Alex C. Y.; LaSalle, Thomas J.; Miller, Brian C.; Scharer, Christopher D.; Hegde, Mudra; Nguyen, Thao H.; Rowe, Jared H.; Osborn, Jossef F.; Patterson, Dillon G.; Sifnugel, Natalia; Mei-An Nolan, C.; Davidson, Richard A.; Schwartz, Marc A.; Bally, Alexander P. R.; Neeld, Dennis K.; LaFleur, Martin W.; Boss, Jeremy M.; Doench, John G.; Haining, W. Nicholas; Sharpe, Arlene H.; Sen, Debattama R.

Scanning mutagenesis of the voltage-gated sodium channel Na V 1.2 using base editing (Vol 42, 112563, 2023)

CELL REPORTS

IF6.9

2024-06-01

OAAI

Pablo, Juan Lorenzo B.; Cornett, Savannah L.; Wang, Lei A.; Jo, Sooyeon; Brunger, Tobias; Budnik, Nikita; Hegde, Mudra; Dekeyser, Jean -Marc; Thompson, Christopher H.; Doench, John G.; Lal, Dennis; George Jr, Alfred L.; Pan, Jen Q.

Post-translational modification-centric base editor screens to assess phosphorylation site functionality in high throughput 以翻译后修饰为中心的碱基编辑器筛选以评估高通量的磷酸化位点功能

NATURE METHODS

IF32.1

2024-04-29

PREAI

Kennedy, Patrick H.; Sheikh, Amin Alborzian Deh; Balakar, Matthew; Jones, Alexander C.; Olive, Meagan E.; Hegde, Mudra; Matias, Maria I.; Pirete, Natan; Burt, Rajan; Levy, Jonathan; Little, Tamia; Hogan, Patrick G.; Liu, David R.; Doench, John G.; Newton, Alexandra C.; Gottschalk, Rachel A.; de Boer, Carl G.; Alarcon, Suzie; Newby, Gregory A.; Myers, Samuel A.

Optimization of Cas12a for multiplexed genome-scale transcriptional activation

CELL GENOMICS

IF9

2023-09-01

OAAI

Griffith, Audrey L.; Zheng, Fengyi; Mcgee, Abby V.; Miller, Nathan W.; Szegletes, Zsofia M.; Reint, Ganna; Gademann, Fabian; Nwolah, Ifunanya; Hegde, Mudra; Liu, Yanjing V.; Goodale, Amy; Doench, John G.

Scanning mutagenesis of the voltage-gated sodium channel NaV1.2 using base editing

CELL REPORTS

IF6.9

2023-06-01

OAAI

Pablo, Juan Lorenzo B.; Cornett, Savannah L.; Wang, Lei A.; Jo, Sooyeon; Bruenger, Tobias; Budnik, Nikita; Hegde, Mudra; DeKeyser, Jean-Marc; Thompson, Christopher H.; Doench, John G.; Lal, Dennis; George Jr, Alfred L.; Pan, Jen Q.

Accounting for small variations in the tracrRNA sequence improves sgRNA activity predictions for CRISPR screening

NATURE COMMUNICATIONS

IF15.7

2022-09-06

OAAI

DeWeirdt, Peter C.; McGee, Abby V.; Zheng, Fengyi; Nwolah, Ifunanya; Hegde, Mudra; Doench, John G.

Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVs 双向全基因组CRISPR筛选揭示了调节SARS-CoV-2，mers-cov和季节性hcov的宿主因素

NATURE GENETICS

IF31.8

2022-07-25

OAAI

Rebendenne, Antoine; Roy, Priyanka; Bonaventure, Boris; Valadao, Ana Luiza Chaves; Desmarets, Lowiese; Arnaud-Arnould, Mary; Rouille, Yves; Tauziet, Marine; Giovannini, Donatella; Touhami, Jawida; Lee, Yenarae; DeWeirdt, Peter; Hegde, Mudra; Urbach, Serge; El Koulali, Khadija; de Gracia, Francisco Garcia; McKellar, Joe; Dubuisson, Jean; Wencker, Melanie; Belouzard, Sandrine; Moncorge, Olivier; Doench, John G.; Goujon, Caroline

Benchmarking of SpCas9 variants enables deeper base editor screens of BRCA1 and BCL2

NATURE COMMUNICATIONS

IF15.7

2022-03-14

OAAI

Sangree, Annabel K.; Griffith, Audrey L.; Szegletes, Zsofia M.; Roy, Priyanka; DeWeirdt, Peter C.; Hegde, Mudra; McGee, Abby, V; Hanna, Ruth E.; Doench, John G.

Optimization of AsCas12a for combinatorial genetic screens in human cells

NATURE BIOTECHNOLOGY

IF41.7

2020-07-13

OAAI

DeWeirdt, Peter C.; Sanson, Kendall R.; Sangree, Annabel K.; Hegde, Mudra; Hanna, Ruth E.; Feeley, Marissa N.; Griffith, Audrey L.; Teng, Teng; Borys, Samantha M.; Strand, Christine; Joung, J. Keith; Kleinstiver, Benjamin P.; Pan, Xuewen; Huang, Alan; Doench, John G.

Genome-wide In Vivo CNS Screening Identifies Genes that Modify CNS Neuronal Survival and mHTT Toxicity 全基因组体内CNS筛选鉴定改变CNS神经元存活和mHTT毒性的基因

NEURON

IF15

2020-04-01

OAAI

Wertz, Mary H.; Mitchem, Mollie R.; Pineda, S. Sebastian; Hachigian, Lea J.; Lee, Hyeseung; Lau, Vanessa; Powers, Alex; Kulicke, Ruth; Madan, Gurrein K.; Colic, Medina; Therrien, Martine; Vernon, Amanda; Beja-Glasser, Victoria F.; Hegde, Mudra; Gao, Fan; Kellis, Manolis; Hart, Traver; Doench, John G.; Heiman, Myriam

Genetic screens in isogenic mammalian cell lines without single cell cloning

NATURE COMMUNICATIONS

IF15.7

2020-02-06

OAAI

DeWeirdt, Peter C.; Sangree, Annabel K.; Hanna, Ruth E.; Sanson, Kendall R.; Hegde, Mudra; Strand, Christine; Persky, Nicole S.; Doench, John G.

Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities

NATURE COMMUNICATIONS

IF15.7

2018-12-21

543

OAAI

Sanson, Kendall R.; Hanna, Ruth E.; Hegde, Mudra; Donovan, Katherine F.; Strand, Christine; Sullender, Meagan E.; Vaimberg, Emma W.; Goodale, Amy; Root, David E.; Piccioni, Federica; Doench, John G.

Orthologous CRISPR-Cas9 enzymes for combinatorial genetic screens 用于组合遗传筛选的直系同源CRISPR-Cas9酶

NATURE BIOTECHNOLOGY

IF41.7

2017-12-18

221

OAAI

Najm, Fadi J.; Strand, Christine; Donovan, Katherine F.; Hegde, Mudra; Sanson, Kendall R.; Vaimberg, Emma W.; Sullender, Meagan E.; Hartenian, Ella; Kalani, Zohra; Fusi, Nicolo; Listgarten, Jennifer; Younger, Scott T.; Bernstein, Bradley E.; Root, David E.; Doench, John G.

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9 优化的sgRNA设计，以最大限度地提高活性并最大限度地减少CRISPR-Cas9的脱靶效应

NATURE BIOTECHNOLOGY

IF41.7

2016-01-18

3.0K

OAAI

Doench, John G.; Fusi, Nicolo; Sullender, Meagan; Hegde, Mudra; Vaimberg, Emma W.; Donovan, Katherine F.; Smith, Ian; Tothova, Zuzana; Wilen, Craig; Orchard, Robert; Virgin, Herbert W.; Listgarten, Jennifer; Root, David E.

Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation

NATURE BIOTECHNOLOGY

IF41.7

2014-09-03

1.5K

OAAI

Doench, John G.; Hartenian, Ella; Graham, Daniel B.; Tothova, Zuzana; Hegde, Mudra; Smith, Ian; Sullender, Meagan; Ebert, Benjamin L.; Xavier, Ramnik J.; Root, David E.

研究方向