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M

Mark Merchant

roche holding
H指数:48
被引数:1.0万

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PROTACs Targeting BRM (SMARCA2) Afford Selective In Vivo Degradation over BRG1 (SMARCA4) and Are Active in BRG1 Mutant Xenograft Tumor Models (vol 67, pg 1262, 2024)

PROTACs靶向BRM（SMARCA2）可在体内实现对BRG1（SMARCA4）的选择性降解，并在BRG1突变异种移植肿瘤模型中表现出活性（vol 67, pg 1262, 2024）

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2025-05-210
PRE
Berlin, Michael; Cantley, Jennifer; Bookbinder, Mark; Bortolon, Elizabeth; Broccatelli, Fabio; Cadelina, Greg; Chan, Emily W.; Chen, Huifen; Chen, Xin; Cheng, Yunxing; Cheung, Tommy K.; Crew, Andrew P.; Davenport, Kim; Dinicola, Dean; Dong, Hanqing; Gordon, Debbie; Hamman, Brian D.; Harbin, Alicia; Haskell, Roy; He, Mingtao; Hole, Alison J.; Januario, Thomas; Kerry, Philip S.; Koenig, Stefan G.; Li, Limei; Merchant, Mark; Perez-Dorado, Inmaculada; Pizzano, Jennifer; Quinn, Connor; Rose, Christopher M.; Rousseau, Emma; Snyder, Lawrence B.; Soto, Leofal; Staben, Leanna R.; Sun, Hongming; Tian, Qingping; Wang, Gan; Wang, Jing; Wang, Weifeng; Ye, Crystal S.; Ye, Xiaofen; Zhang, Penghong; Zhou, Yuhui; Yauch, Robert; Dragovich, Peter S.
Primary results and characterization of patients with exceptional outcomes in a phase 1b study combining PARP and MEK inhibition, with or without anti-PD-L1, for BRCA wild-type, platinum-sensitive, recurrent ovarian cancer

在1b期研究中，结合PARP和MEK抑制，有或没有anti-PD-L1，对BRCA野生型，铂敏感，复发性卵巢癌患者的主要结果和特征

CANCER
IF5.1
2024-01-301
OAAI
Mutch, David; Voulgari, Athina; Chen, Xian (Marissa); Bradley, William H.; Oaknin, Ana; Perez Fidalgo, Jose Alejandro; Montosa, Fernando Galvez; Herraez, Antonio Casado; Holloway, Robert W.; Powell, Matthew A.; Nowicka, Malgorzata; Schaefer, Gabriele; Merchant, Mark; Yan, Yibing
PROTACs Targeting BRM (SMARCA2) Afford Selective In Vivo Degradation over BRG1 (SMARCA4) and Are Active in BRG1 Mutant Xenograft Tumor Models
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-01-057
PRE
Berlin, Michael; Cantley, Jennifer; Bookbinder, Mark; Bortolon, Elizabeth; Broccatelli, Fabio; Cadelina, Greg; Chan, Emily W.; Chen, Huifen; Chen, Xin; Cheng, Yunxing; Cheung, Tommy K.; Davenport, Kim; DiNicola, Dean; Gordon, Debbie; Hamman, Brian D.; Harbin, Alicia; Haskell, Roy; He, Mingtao; Hole, Alison J.; Januario, Thomas; Kerry, Philip S.; Koenig, Stefan G.; Li, Limei; Merchant, Mark; Perez-Dorado, Inmaculada; Pizzano, Jennifer; Quinn, Connor; Rose, Christopher M.; Rousseau, Emma; Soto, Leofal; Staben, Leanna R.; Sun, Hongming; Tian, Qingping; Wang, Jing; Wang, Weifeng; Ye, Crystal S.; Ye, Xiaofen; Zhang, Penghong; Zhou, Yuhui; Yauch, Robert; Dragovich, Peter S.
Identification of GDC-1971 (RLY-1971), a SHP2 Inhibitor Designed for the Treatment of Solid Tumors
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2023-09-2916
PRE
Taylor, Alexander M.; Williams, Bret R.; Giordanetto, Fabrizio; Kelley, Elizabeth H.; Lescarbeau, Andre; Shortsleeves, Kelley; Tang, Yong; Walters, W. Patrick; Arrazate, Alfonso; Bowman, Christine; Brophy, Erin; Chan, Emily W.; Deshmukh, Gauri; Greisman, Jack B.; Hunsaker, Thomas L.; Kipp, D. Randal; Lopez-Larrocha, Pablo Saenz; Maddalo, Danilo; Martin, Iain J.; Maragakis, Paul; Merchant, Mark; Murcko, Mark; Nisonoff, Hunter; Nguyen, Vi; Nguyen, Vy; Orozco, Olivia; Owen, Christopher; Pierce, Levi; Schmidt, Molly; Shaw, David E.; Smith, Sherri; Therrien, Eric; Tran, John C.; Watters, Jim; Waters, Nigel J.; Wilbur, Jeremy; Willmore, Lindsay
Quantifying KRAS G12C Covalent Drug Inhibitor Activity in Mouse Tumors Using Mass Spectrometry
ANALYTICAL CHEMISTRY
IF6.7
2023-03-064
PRE
Tran, John C.; Hunsaker, Thomas; Bell, Christina; Ma, Taylur P.; Chan, Emily; Larrocha, Pablo Saenz-Lopez; Homyk, Kelsey; Liu, Liling; La, Hank; Mao, Jialin; de la Cruz, Cecile C.; Yu, Kebing; Beresini, Maureen; Forrest, William F.; Xiao, Yang; Jang, Anne; Samus, Natalia; Stesco, Nicholas Dupuis; Mentinova, Marija; Parent, Stephane; Pottiez, Gwenael; Schirm, Michael; Purkey, Hans E.; Liu, Yichin; Merchant, Mark
CD8+T cell-intrinsic IL-6 signaling promotes resistance to anti-PD-L1 immunotherapy

CD8 T细胞内源性IL-6信号促进对anti-PD-L1免疫疗法的抵抗

CELL REPORTS MEDICINE
IF10.6
2023-01-0170
OAAI
Huseni, Mahrukh A.; Wang, Lifen; Klementowicz, Joanna E.; Yuen, Kobe; Breart, Beatrice; Orr, Christine; Liu, Li-fen; Li, Yijin; Gupta, Vinita; Li, Congfen; Rishipathak, Deepali; Peng, Jing; Senbabaoglu, Yasin; Modrusan, Zora; Keerthivasan, Shilpa; Madireddi, Shravan; Chen, Ying-Jiun; Fraser, Eleanor J.; Leng, Ning; Hamidi, Habib; Koeppen, Hartmut; Ziai, James; Hashimoto, Kenji; Fasso, Marcella; Williams, Patrick; McDermott, David F.; Rosenberg, Jonathan E.; Powles, Thomas; Emens, Leisha A.; Hegde, Priti S.; Mellman, Ira; Turley, Shannon J.; Wilson, Mark S.; Mariathasan, Sanjeev; Molinero, Luciana; Merchant, Mark; West, Nathaniel R.
Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers
NATURE COMMUNICATIONS
IF15.7
2022-11-1050
OAAI
Cantley, Jennifer; Ye, Xiaofen; Rousseau, Emma; Januario, Tom; Hamman, Brian D.; Rose, Christopher M.; Cheung, Tommy K.; Hinkle, Trent; Soto, Leofal; Quinn, Connor; Harbin, Alicia; Bortolon, Elizabeth; Chen, Xin; Haskell, Roy; Lin, Eva; Yu, Shang-Fan; Del Rosario, Geoff; Chan, Emily; Dunlap, Debra; Koeppen, Hartmut; Martin, Scott; Merchant, Mark; Grimmer, Matt; Broccatelli, Fabio; Wang, Jing; Pizzano, Jennifer; Dragovich, Peter S.; Berlin, Michael; Yauch, Robert L.
Loss of the intracellular enzyme QPCTL limits chemokine function and reshapes myeloid infiltration to augment tumor immunity
NATURE IMMUNOLOGY
IF27.6
2022-03-2125
OA
da Silva, Rosa Barreira; Leitao, Ricardo M.; Pechuan-Jorge, Ximo; Werneke, Scott; Oeh, Jason; Javinal, Vincent; Wang, Yingyun; Phung, Wilson; Everett, Christine; Nonomiya, Jim; Arnott, David; Lu, Cheng; Hsiao, Yi-Chun; Koerber, James T.; Hotzel, Isidro; Ziai, James; Modrusan, Zora; Pillow, Thomas H.; Roose-Girma, Merone; Schartner, Jill M.; Merchant, Mark; Rutz, Sascha; Eidenschenk, Celine; Mellman, Ira; Albert, Matthew L.
CRAF dimerization with ARAF regulates KRAS-driven tumor growth
CELL REPORTS
IF6.9
2022-02-0119
OA
Venkatanarayan, Avinashnarayan; Liang, Jason; Yen, Ivana; Shanahan, Frances; Haley, Benjamin; Phu, Lilian; Verschueren, Erik; Hinkle, Trent B.; Kan, David; Segal, Ehud; Long, Jason E.; Lima, Tony; Liau, Nicholas P. D.; Sudhamsu, Jawahar; Li, Jason; Klijn, Christiaan; Piskol, Robert; Junttila, Melissa R.; Shaw, Andrey S.; Merchant, Mark; Chang, Matthew T.; Kirkpatrick, Donald S.; Malek, Shiva
Phase I/II Trial of Vemurafenib in Dogs with Naturally Occurring, BRAF-mutated Urothelial Carcinoma
MOLECULAR CANCER THERAPEUTICS
IF5.5
2021-08-2520
OA
Rossman, Paul; Zabka, Tanja S.; Ruple, Audrey; Tuerck, Dietrich; Ramos-Vara, Jose A.; Liu, Liling; Mohallem, Rodrigo; Merchant, Mark; Franco, Jackeline; Fulkerson, Christopher M.; Bhide, Ketaki P.; Breen, Matthew; Aryal, Uma K.; Murray, Elaine; Dybdal, Noel; Utturkar, Sagar M.; Fourez, Lindsey M.; Enstrom, Alexander W.; Dhawan, Deepika; Knapp, Deborah W.
Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a 5-Fluoro-4-(3H)-quinazolinone Aryl Urea pan-RAF Kinase Inhibitor
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2021-03-2920
PRE
Huestis, Malcolm P.; Dela Cruz, Darlene; DiPasquale, Antonio G.; Durk, Matthew R.; Eigenbrot, Charles; Gibbons, Paul; Gobbi, Alberto; Hunsaker, Thomas L.; La, Hank; Leung, Dennis H.; Liu, Wendy; Malek, Shiva; Merchant, Mark; Moffat, John G.; Muli, Christine S.; Orr, Christine J.; Parr, Brendan T.; Shanahan, Frances; Sneeringer, Christopher J.; Wang, Weiru; Yen, Ivana; Yin, Jianping; Siu, Michael; Rudolph, Joachim
Venetoclax Increases Intratumoral Effector T Cells and Antitumor Efficacy in Combination with Immune Checkpoint Blockade
CANCER DISCOVERY
IF33.3
2021-01-0684
OAAI
Kohlhapp, Frederick J.; Haribhai, Dipica; Mathew, Rebecca; Duggan, Ryan; Ellis, Paul A.; Wang, Rui; Lasater, Elisabeth A.; Shi, Yan; Dave, Nimita; Riehm, Jacob J.; Robinson, Valerie A.; Do, An D.; Li, Yijin; Orr, Christine J.; Sampath, Deepak; Raval, Aparna; Merchant, Mark; Bhathena, Anahita; Salem, Ahmed Hamed; Hamel, Keith M.; Leverson, Joel D.; Donawho, Cherrie; Pappano, William N.; Uziel, Tamar
Selective, chemically-induced degradation of BRM (SMARCA2) enables in vivo efficacy in BRG1 (SMARCA4)-deficient xenograft tumor models
CANCER RESEARCH
IF16.6
2020-08-150
PRE
Berlin, Michael; Cantley, Jennifer; Wang, Jing; Bookbinder, Mark; Cadelina, Gregory; Chan, Emily; Chen, Huifen; Chen, Xin; Davenport, Kim; Fernando, Tharu; Gordon, Debbie; Hamman, Brian; Haskell, Roy; Ishchenko, Alexey; Kirkpatrick, Donald S.; Maher, Jonathan; Merchant, Mark; Moffat, John; Morgan, Alicia; Nguyen, An; Pizzano, Jennifer; Quinn, Connor; Rose, Christopher M.; Rousseau, Emma; Sethuraman, Vijay; Staben, Leanna; Wilson, Catherine; Ye, Xiaofen; Broccatelli, Fabio; Yauch, Robert; Dragovich, Peter S.
IRE1α Disruption in Triple-Negative Breast Cancer Cooperates with Antiangiogenic Therapy by Reversing ER Stress Adaptation and Remodeling the Tumor Microenvironment
CANCER RESEARCH
IF16.6
2020-06-0254
OAAI
Harnoss, Jonathan M.; Le Thomas, Adrien; Reichelt, Mike; Guttman, Ofer; Wu, Thomas D.; Marsters, Scot A.; Shemorry, Anna; Lawrence, David A.; Kan, David; Segal, Ehud; Merchant, Mark; Totpal, Klara; Crocker, Lisa M.; Mesh, Kathryn; Dohse, Monika; Solon, Margaret; Modrusan, Zora; Rudolph, Joachim; Koeppen, Hartmut; Walter, Peter; Ashkenazi, Avi

研究方向

暂未获取到该数据
E
Emily Chan
H 指数:45论文数:211被引数:1.1万
T
Thomas Hunsaker
H 指数:20论文数:76被引数:2,057
C
Christine Orr
H 指数:19论文数:76被引数:2,470
G
Gabriele Schaefer
H 指数:27论文数:123被引数:3,404
J
John G. Moffat
H 指数:31论文数:123被引数:5,839
R
Robert L. Yauch
H 指数:46论文数:244被引数:1.6万
S
Shiva Malek
H 指数:36论文数:216被引数:7,389
M
Marcia Belvin
H 指数:46论文数:266被引数:1.2万
E
Emily Chan
H 指数:25论文数:125被引数:4,536
H
Hank La
H 指数:25论文数:128被引数:2,277