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G

Gabriele Schaefer

genentech, inc.
H指数:27
被引数:3,404

个人简介

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教育背景

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荣誉奖项

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Tumor-targeted bispecific antibodies effectively inhibit oncogenic pathways while minimizing toxicity

肿瘤靶向双特异性抗体可有效抑制致癌通路同时最小化毒性

Science Advances
IF12.5
2026-05-220
OA
Yvonne T. Kschonsak; Wei-Ching Liang; Joyce Chan; David Kan; Thao Nguyen; Karen Ruiz; Yee-Seir Kee; Wen-Ting K. Tsai; Hongkang Xi; Marina Moskalenko; Travis Morgenstern; Aurelie Herault; Lauriane Cabon; Ryo Okuda; Scott S. Stawicki; Jocelyn Chan; Matthew Grimmer; Diego Ellerman; James Mondo; Catherine F. Ruff; Gabriele Schaefer; Udi Segal; Robert Piskol; Nicholas J. Agard; Laetitia Comps-Agrar; Felipe de Sousa e Melo; James T. Koerber
Characterization of an anti-STEAP1 T-cell dependent bispecific antibody for the treatment of prostate cancer and associated toxicity in cynomolgus monkeys

抗STEAP1 T细胞依赖性双特异性抗体在前列腺癌治疗中的应用及其在食蟹猴中的相关性毒性表征

Toxicological Sciences
IF4.1
2026-03-010
PRE
Tonkin, Elizabeth G.; Lepherd, Michelle; Davies, John; Gampa, Gautham; Hotzel, Isidro; Koeppen, Hartmut; Liu, Wenyu; Melnikov, Fjodor; Niu, Xiang; Nickles, Dorothee; Romero-Lopez, Monica; Shao, Lily; Totpal, Klara; Schaefer, Gabriele
Primary results and characterization of patients with exceptional outcomes in a phase 1b study combining PARP and MEK inhibition, with or without anti-PD-L1, for BRCA wild-type, platinum-sensitive, recurrent ovarian cancer

在1b期研究中，结合PARP和MEK抑制，有或没有anti-PD-L1，对BRCA野生型，铂敏感，复发性卵巢癌患者的主要结果和特征

CANCER
IF5.1
2024-01-301
OAAI
Mutch, David; Voulgari, Athina; Chen, Xian (Marissa); Bradley, William H.; Oaknin, Ana; Perez Fidalgo, Jose Alejandro; Montosa, Fernando Galvez; Herraez, Antonio Casado; Holloway, Robert W.; Powell, Matthew A.; Nowicka, Malgorzata; Schaefer, Gabriele; Merchant, Mark; Yan, Yibing
Discovery of a Noncovalent, Mutant-Selective Epidermal Growth Factor Receptor Inhibitor
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2016-09-1232
PREAI
Chan, Bryan K.; Hanan, Emily J.; Bowman, Krista K.; Bryan, Marian C.; Burdick, Daniel; Chan, Emily; Chen, Yuan; Clausen, Saundra; Dela Vega, Trisha; Dotson, Jennafer; Eigenbrot, Charles; Elliott, Richard L.; Heald, Robert A.; Jackson, Philip S.; Knight, Jamie D.; La, Hank; Lainchbury, Michael D.; Malek, Shiva; Purkey, Hans E.; Schaefer, Gabriele; Schmidt, Stephen; Seward, Eileen M.; Sideris, Steve; Shao, Lily; Wang, Shumei; Yeap, Siew Kuen; Yen, Ivana; Yu, Christine; Heffron, Timothy P.
Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study (vol 58, pg 8877, 2015)
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2016-03-110
OAAI
Heald, Robert; Bowman, Krista K.; Bryan, Marian C.; Burdick, Daniel; Chan, Bryan; Chan, Emily; Chen, Yuan; Clausen, Saundra; -Fernandez, Belen Dominguez; Eigenbrot, Charles; Elliott, Richard; Hanan, Emily J.; Jackson, Philip; Knight, Jamie; La, Hank; Lainchbury, Michael; Malek, Shiva; Mann, Sam; Merchant, Mark; Mortara, Kyle; Purkey, Hans; Schaefer, Gabriele; Schmidt, Stephen; Seward, Eileen; Sideris, Steve; Shao, Lily; Wang, Shumei; Yeap, Kuen; Yen, Ivana; Yu, Christine; Heffron, Timothy P.
Pyridones as Highly Selective, Noncovalent Inhibitors of T790M Double Mutants of EGFR
ACS MEDICINAL CHEMISTRY LETTERS
IF4
2015-12-2137
OAAI
Bryan, Marian C.; Burdick, Daniel J.; Chan, Bryan K.; Chen, Yuan; Clausen, Saundra; Dotson, Jennafer; Eigenbrot, Charles; Elliott, Richard; Hanan, Emily J.; Heald, Robert; Jackson, Philip; La, Hank; Lainchbury, Michael; Malek, Shiva; Mann, Sam E.; Purkey, Hans E.; Schaefer, Gabriele; Schmidt, Stephen; Seward, Eileen; Sideris, Steve; Wang, Shumei; Yen, Ivana; Yu, Christine; Heffron, Timothy P.
Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2015-11-1252
PREAI
Heald, Robert; Bowman, Krista K.; Bryan, Marian C.; Burdick, Daniel; Chan, Bryan; Chan, Emily; Chen, Yuan; Clausen, Saundra; Dominguez-Fernandez, Belen; Eigenbrot, Charles; Elliott, Richard; Hanan, Emily J.; Jackson, Philip; Knight, Jamie; La, Hank; Lainchbury, Michael; Malek, Shiva; Mann, Sam; Merchant, Mark; Mortara, Kyle; Purkey, Hans; Schaefee, Gabriele; Schmidt, Stephen; Seward, Eileen; Sideris, Steve; Shao, Lily; Wang, Shumei; Yeap, Kuen; Yen, Ivana; Yu, Christine; Heffron, Timothy P.
Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2014-11-2072
OAAI
Hanan, Emily J.; Eigenbrot, Charles; Bryan, Marian C.; Burdick, Daniel J.; Chan, Bryan K.; Chen, Yuan; Dotson, Jennafer; Heald, Robert A.; Jackson, Philip S.; La, Hank; Lainchbury, Michael D.; Malek, Shiva; Purkey, Hans E.; Schaefer, Gabriele; Schmidt, Stephen; Seward, Eileen M.; Sideris, Steve; Tam, Christine; Wang, Shumei; Yeap, Siew Kuen; Yen, Ivana; Yin, Jianping; Yu, Christine; Zilberleyb, Inna; Heffron, Timothy P.
Dual Targeting of HER2-Positive Cancer with Trastuzumab Emtansine and Pertuzumab: Critical Role for Neuregulin Blockade in Antitumor Response to Combination Therapy

曲妥珠单抗Emtansine和帕妥珠单抗双重靶向HER2-Positive: 神经调节素阻断在联合治疗抗肿瘤反应中的关键作用

CLINICAL CANCER RESEARCH
IF10.2
2014-01-16168
OAAI
Phillips, Gail D. Lewis; Fields, Carter T.; Li, Guangmin; Dowbenko, Donald; Schaefer, Gabriele; Miller, Kathy; Andre, Fabrice; Burris, Howard A., III; Albain, Kathy S.; Harbeck, Nadia; Dieras, Veronique; Crivellari, Diana; Fang, Liang; Guardino, Ellie; Olsen, Steven R.; Crocker, Lisa M.; Sliwkowski, Mark X.

研究方向

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L
Lily Shao
H 指数:9论文数:54被引数:860
M
Mark Merchant
H 指数:48论文数:380被引数:1.0万
S
Shiva Malek
H 指数:36论文数:216被引数:7,389
C
Charles Eigenbrot
H 指数:61论文数:242被引数:1.6万
T
Timothy P. Heffron
H 指数:29论文数:155被引数:2,612
E
Emily J. Hanan
H 指数:21论文数:58被引数:1,243
C
Christine Yu
H 指数:24论文数:43被引数:3,074
M
Mark X. Sliwkowski
H 指数:61论文数:358被引数:3.1万
S
Stephen Schmidt
H 指数:19论文数:63被引数:1,418
S
Steve Sideris
H 指数:30论文数:97被引数:4,467