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T

Thomas J. Cradick

excision biotherapeutics

H指数:22

被引数:8,916

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Serum factors create species-specific barriers to hepatic gene transfer by lipid nanoparticles in liver-humanized mice

血清因子通过脂质纳米颗粒在人类化小鼠肝脏中形成种属特异性屏障，阻碍肝脏基因转移。

MOLECULAR THERAPY METHODS & CLINICAL DEVELOPMENT

IF4.7

2025-06-010

OAAI

Strategic self-limiting production of infectious HIV particles by CRISPR in permissive cells

MOLECULAR THERAPY NUCLEIC ACIDS

IF6.1

2023-06-015

OAAI

Base Editors Flex Sights on Sickle-Cell Disease

基础编辑对镰状细胞病的关注

IF4

2021-04-010

PRE

Evaluation of Homology-Independent CRISPR-Cas9 Off-Target Assessment Methods

同源性非依赖性CRISPR-Cas9脱靶评估方法的评价

IF4

2020-12-0132

OAAI

The Neisseria meningitidis CRISPR-Cas9 System Enables Specific Genome Editing in Mammalian Cells

MOLECULAR THERAPY

IF12

2016-03-01213

OAAI

Streptococcus thermophilus CRISPR-Cas9 Systems Enable Specific Editing of the Human Genome

MOLECULAR THERAPY

IF12

2016-03-01215

OA

Nuclease Target Site Selection for Maximizing On-target Activity and Minimizing Off-target Effects in Genome Editing

MOLECULAR THERAPY

IF12

2016-03-01106

OAAI

A Burden of Rare Variants Associated with Extremes of Gene Expression in Human Peripheral Blood

AMERICAN JOURNAL OF HUMAN GENETICS

IF8.1

2016-02-0172

OAAI

TALENs Facilitate Single-step Seamless SDF Correction of F508del CFTR in Airway Epithelial Submucosal Gland Cell-derived CF-iPSCs

MOLECULAR THERAPY-NUCLEIC ACIDS

IF0

2016-01-0140

OAAI

Development of Neisseria meningitidis CRISPR/Cas9 Systems for Efficient and Specific Genome Editing

MOLECULAR THERAPY

IF12

2015-05-010

OAAI

Codon Swapping of Zinc Finger Nucleases Confers Expression in Primary Cells and In Vivo from a Single Lentiviral Vector

CURRENT GENE THERAPY

IF3.3

2014-09-269

PRE

Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5Δ32 mutation confers resistance to HIV infection

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2014-06-09304

OAAI

CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequences

NUCLEIC ACIDS RESEARCH

IF13.1

2014-05-16584

OAAI

TALENs facilitate targeted genome editing in human cells with high specificity and low cytotoxicity

NUCLEIC ACIDS RESEARCH

IF13.1

2014-05-03184

OAAI

SAPTA: a new design tool for improving TALE nuclease activity

NUCLEIC ACIDS RESEARCH

IF13.1

2014-01-1646

OAAI

COSMID: A Web-based Tool for Identifying and Validating CRISPR/Cas Off-target Sites

COSMID: 一种基于网络的工具，用于识别和验证CRISPR/Cas脱靶位点

MOLECULAR THERAPY-NUCLEIC ACIDS

IF0

2014-01-01320

OAAI

An online bioinformatics tool predicts zinc finger and TALE nuclease off-target cleavage

NUCLEIC ACIDS RESEARCH

IF13.1

2013-12-30113

OAAI

Nanomedicine: Tiny Particles and Machines Give Huge Gains

ANNALS OF BIOMEDICAL ENGINEERING

IF5.4

2013-12-0322

OA

CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity

NUCLEIC ACIDS RESEARCH

IF13.1

2013-08-10615

OAAI

DNA targeting specificity of RNA-guided Cas9 nucleases

RNA引导的Cas9核酸酶的DNA靶向特异性

NATURE BIOTECHNOLOGY

IF41.7

2013-07-214.5K

OA