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T

Toni Cathomen

medical center university of freiburg
H指数:52
被引数:1.1万

个人简介

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工作经历

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荣誉奖项

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Targeted insertion of an optimized donor DNA is effective in a humanized mouse model of dominant retinitis pigmentosa

在显性色素性视网膜变性的人源化小鼠模型中，靶向插入优化的供体DNA是有效的

Cell Reports Medicine
IF10.6
2026-09-110
OAAI
Federica Esposito; Arjun Padmanabhan; Manuel Rhiel; Mariangela Lupo; Elena Marrocco; Stefano Auricchio; Xabier Bujanda Cundin; Simona Pellecchia; Tatjana I. Cornu; Geoffroy Andrieux; Manel Llado-Santaeularia; Enrico Maria Surace; Ivana Trapani; Pasqualina Colella; Gennaro Gambardella; Toni Cathomen; Alberto Auricchio
Clinical development of tacrolimus-resistant regulatory T cells to enable simultaneous immunosuppression and immune regulation

他克莫司抵抗性调节性T细胞的临床开发以实现同时免疫抑制和免疫调节

MOLECULAR THERAPY ADVANCES
IF0
2026-05-012
OAAI
Zarrinrad, Ghazaleh; Burkhardt, Lisa-Marie; Beltran-Mestres, Claudia; Romero-Suarez, Silvina; Wagner, Dimitrios Laurin; Schlickeiser, Stephan; Stein, Maik; Wendering, Desiree Jacqueline; de la Cebosa, Ivan Juky Carrera Diaz; Ehlen, Lukas; Hamm, Frederik; Kurgan, Gavin L.; Durek, Pawel; Heinrich, Frederik; Giri, Anamika; Pu, Yaolin; Ou, Kristy; Hoffmann, Henrike; Muench, Sandra; Stuewe, Insa; Dolling, Sven; McCallion, Oliver; Kaeda, Jaspal; Kath, Jonas; Schulenberg, Sarah; Wiese, Niklas; Nazari, Abdolreza; Peter, Lena; Picht, Samira; Sanchez-Pena, Andrea; Usman, Olalekan; Brommel, Christian; Turk, Rolf; Rettig, Garrett; Sturgeon, Morgan; Osborne, Thomas L.; Jacobi, Ashley; Friedrich, Rebecca; Kaufmann, Masako Monika; Klermund, Julia; Fink, Simon; Templin, Markus F.; Roemhild, Andy; Kaiser, Daniel; Klein, Oliver; Cathomen, Toni; Mashreghi, Mir-Farzin; Issa, Fadi; Polansky, Julia K.; Volk, Hans-Dieter; Schmueck-Henneresse, Michael; Reinke, Petra; Amini, Leila
ERCC6L2 ensures repair fidelity for staggered-end DNA double-strand breaks

ERCC6L2 确保错位末端DNA双链断裂的修复保真度

Nature Communications
IF15.7
2026-02-250
OAAI
Eric J. Aird; Almudena Serrano-Benitez; Sebastian M. Siegner; Elda Cannavo; Rimma Belotserkovskaya; Nadia Gueorguieva; John Fielden; Grégoire Cullot; Sandra Ammann; Aldo S. Bader; Vipul Gupta; Geoffroy Andrieux; Rebecca Raab; Mónica Del Rey González; Toni Cathomen; Petr Cejka; Jacob E. Corn; Stephen P. Jackson
Base edited skin equivalents with clinical potential for ex vivo correction of Recessive Dystrophic Epidermolysis Bullosa

具有临床潜力的碱基编辑皮肤替代物，用于体外修复隐性营养不良型大疱性表皮松解症

Molecular Therapy
IF12
2025-11-170
PRE
Alex Bassons-Bascuñana; Blanca Duarte; Estela Méndez-Jiménez; Laura Ugalde; Paula Sanabria-Betrián; Clotilde Aussel; Irene Peña-Gutiérrez; Beatriz Olalla-Sastre; Sandra Ammann; Toni Cathomen; Marcela Del Rio; Paula Río; Fernando Larcher; Sergio López-Manzaneda
Targeted Inhibition of ELANE Expression Using Adenine Base Editing to Treat Severe Congenital Neutropenia

利用腺嘌呤碱基编辑靶向抑制ELANE表达以治疗重症先天性中性粒细胞减少症

Molecular Therapy Methods & Clinical Development
IF4.7
2025-11-050
OAAI
Betül Findik; Benjamin Dannenmann; Franka Bernhard; Masako Monika Kaufmann; Sandra Ammann; Sergey Kandabarau; Maksim Klimiankou; Fabian Mauch; Patrick Münzer; Oliver Borst; Isabel Klefenz; Doris Steinemann; Claudia Lengerke; Cornelia Zeidler; Toni Cathomen; Karl Welte; Masoud Nasri; Julia Skokowa
Prime editing as a promising therapeutic strategy for junctional epidermolysis bullosa

连接性表皮松解症的潜在治疗策略：碱基编辑

Molecular Therapy
IF12
2025-10-300
OAAI
Markus Hierl; Johannes Bischof; Bernadette Liemberger; Thomas Kocher; Stefan Hainzl; Stefanie Gruner; Lisa Trattner; Victoria Reichl; Alfred Klausegger; Clotilde Aussel; Sandra Ammann; Rebecca Raab; Geoffroy Andrieux; Martin Wolf; Sarah Hochmann; Patricia Ebner; Verena Wally; Roland Zauner; Christina Guttmann-Gruber; Iris K. Gratz; Josefina Piñón Hofbauer; Toni Cathomen; Dirk Strunk; Johann W. Bauer; Ulrich Koller
Targeted gene editing and near-universal cDNA insertion of CYBA and CYBB as a treatment for chronic granulomatous disease

靶向基因编辑和近全基因组cDNA插入CYBA和CYBB作为慢性肉芽肿病的治疗方法

Nature Communications
IF15.7
2025-08-120
OAAI
Jonas Holst Wolff; Thomas Wisbech Skov; Didde Haslund; Sofie Rahbek Dorset; Anne Louise S. Revenfeld; Clotilde Aussel; Sofie E. Jørgensen; Mette Holm; Martin K. Thomsen; Sandra Ammann; Toni Cathomen; Trine H. Mogensen; Bjarne Kuno Møller; Rasmus O. Bak; Jacob Giehm Mikkelsen
Senescence and inflammation are unintended adverse consequences of CRISPR-Cas9/AAV6-mediated gene editing in hematopoietic stem cells

衰老和炎症是CRISPR-Cas9/AAV6介导的造血干细胞基因编辑的非预期不良后果。

Cell Reports Medicine
IF10.6
2025-06-030
OA
Anastasia Conti; Kety Giannetti; Federico Midena; Stefano Beretta; Nicolò Gualandi; Rosaria De Marco; Edoardo Carsana; Angelica Varesi; Teresa Tavella; Laura Alessandrini; Parinaz Zarghamian; Alessandra Weber; Samuele Ferrari; Chiara Brombin; Diego Gilioli; Lucrezia della Volpe; Stephanie Z. Xie; Ivan Merelli; Toni Cathomen; Luigi Naldini; Raffaella Di Micco
Donor insertion into CX3CR1 allows epigenetic modulation of a constitutive promoter on hematopoietic stem cells and its activation upon myeloid differentiation

供体插入CX3CR1中允许对造血干细胞中组成型启动子进行表观遗传调控，并在髓系分化时激活该启动子。

NUCLEIC ACIDS RESEARCH
IF13.1
2025-04-290
OA
Ramos-Hernandez, Iris; Fuster-Garcia, Carla; Aguilar-Gonzalez, Araceli; Lozano-Vinagre, Maria L.; Guenechea-Amurrio, Guillermo; Sanchez-Luque, Francisco J.; Goncalves, Manuel A. F., V; Cathomen, Toni; Munoz, Pilar; Molina-Estevez, Francisco J.; Martin, Francisco
Gene editing of CD3 epsilon to redirect regulatory T cells for adoptive T cell transfer

CD3 epsilon基因编辑以重定向调节性T细胞用于过继性T细胞转移

MOLECULAR THERAPY
IF12
2025-02-011
OAAI
Du, Weijie; Noyan, Fatih; Mccallion, Oliver; Drosdek, Vanessa; Kath, Jonas; Glaser, Viktor; Fuster-Garcia, Carla; Yang, Mingxing; Stein, Maik; Franke, Clemens; Pu, Yaolin; Weber, Olaf; Polansky, Julia K.; Cathomen, Toni; Jaeckel, Elmar; Hester, Joanna; Issa, Fadi; Volk, Hans-Dieter; Schmueck-Henneresse, Michael; Reinke, Petra
Genome editing with the HDR-enhancing DNA-PKcs inhibitor AZD7648 causes large-scale genomic alterations

使用增强HDR的dna-pkcs抑制剂AZD7648进行基因组编辑会导致大规模的基因组改变

NATURE BIOTECHNOLOGY
IF41.7
2024-11-270
OA
Cullot, Gregoire; Aird, Eric J.; Schlapansky, Moritz F.; Yeh, Charles D.; van de Venn, Lilly; Vykhlyantseva, Iryna; Kreutzer, Susanne; Mailaender, Dominic; Lewkow, Bohdan; Klermund, Julia; Montellese, Christian; Biserni, Martina; Aeschimann, Florian; Vonarburg, Cedric; Gehart, Helmuth; Cathomen, Toni; Corn, Jacob E.
CRISPR/Cas9 editing of NKG2A improves the efficacy of primary CD33-directed chimeric antigen receptor natural killer cells
NATURE COMMUNICATIONS
IF15.7
2024-09-303
OAAI
Bexte, Tobias; Albinger, Nawid; Al Ajami, Ahmad; Wendel, Philipp; Buchinger, Leon; Gessner, Alec; Alzubi, Jamal; Saerchen, Vinzenz; Vogler, Meike; Rasheed, Hadeer Mohamed; Jung, Beate Anahita; Wolf, Sebastian; Bhayadia, Raj; Oellerich, Thomas; Klusmann, Jan-Henning; Penack, Olaf; Moeker, Nina; Cathomen, Toni; Rieger, Michael A.; Imkeller, Katharina; Ullrich, Evelyn

研究方向

暂未获取到该数据
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J
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J
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M
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