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B

Bart L. Staker

center for global infectious disease research seattle childrens research institute
H指数:31
被引数:6,021

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Structural and Functional Analyses of Trypanosoma brucei Nucleoside Diphosphate Kinase

锥虫布鲁斯氏体核苷二磷酸激酶的结构与功能分析

ACS Omega
IF4.3
2026-03-090
OA
Patricia Makori; Michael P. Boeckman; Heidi S. David; Finley Payne; Markenya Gatling; Colby Greer; Dylan Hayes; Alexandra Jefferson; Micaela Maxwell; Christian Smith; Jamilah Watson; London Williams; Jazmin Barkley; Caitlyn Pepper; Tawanda Zininga; Sandhya Subramanian; Ariel Abramov; Anna S. Gardberg; Thomas E. Edwards; Bart L. Staker; Lance J. Stewart; Peter J. Myler; Oluwatoyin A Asojo; Olamide Jeje; Sylvia Fanucchi; Ikechukwu Achilonu; Craig L. Smith; Graham Chakafana
Discovery and mechanism of a highly selective, antifungal acetyl-CoA synthetase inhibitor

一种高选择性、抗真菌的乙酰辅酶A合成酶抑制剂的发现与机制。Nat Commun 16:9118

Nature Communications
IF15.7
2025-10-140
OAAI
Andrew J. Jezewski; Katy M. Alden; Jonah Propp; Drashti G. Daraji; Charles L. Lail; Michael E. Heene; Andrew J. Fuller; Jeffery C. Ferreira; Lijun Liu; Kevin P. Battaile; Noelle S. Williams; Bart L. Staker; Scott Lovell; Timothy J. Hagen; Damian J. Krysan
Architecture of Pseudomonas aeruginosa glutamyl-tRNA synthetase defines a subfamily of dimeric class Ib aminoacyl-tRNA synthetases

铜绿假单胞菌谷氨酰-tRNA合成酶的结构定义了一类二聚体Ib型氨酰-tRNA合成酶的亚家族。

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2025-05-090
OA
Fenwick, Michael K.; Mayclin, Stephen J.; Seibold, Steve; DeRocher, Amy E.; Subramanian, Sandhya; Phan, Isabelle Q.; Dranow, David M.; Lorimer, Donald D.; Abramov, Ariel B.; Choi, Ryan; Hewitt, Stephen Nakazawa; Edwards, Thomas E.; Bullard, James M.; Battaile, Kevin P.; Wower, Iwona K.; Soe, Aimee C.; Tsutakawa, Susan E.; Lovell, Scott; Myler, Peter J.; Wower, Jacek; Staker, Bart L.
Structure guided modification of 2-chloro-5-(ethyl-phenyl-sulfamoyl)-N-[2-(2-oxo-pyrrolidin-1-yl)-phenyl]-benzamide to afford selective inhibitors of Cryptosporidium parvum N-myristoyltransferase

在2-氯-5-（乙基苯磺酰氨基）-N-[2-（2-氧代吡咯烷-1-基）苯基]苯甲酰胺的指导下进行结构修饰，以制备隐孢子虫微小种N-豆蔻酰转移酶的选择性抑制剂

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
IF2.2
2025-04-010
PRE
Sigalapalli, Dilep K.; Groustra, Sophia; Fenwick, Michael K.; Zigweid, Rachael; Hulverson, Matthew A.; Owsley, Eric; Khim, Monique; Shibata, Sayaka; Van Voorhis, Wesley C.; Staker, Bart L.; Fan, Erkang
Exquisite selectivity of griselimycin extends to beta subunit of DNA polymerases from Gram-negative bacterial pathogens
COMMUNICATIONS BIOLOGY
IF5.1
2024-12-050
OAAI
Fenwick, Michael K.; Pierce, Phillip G.; Abendroth, Jan; Barrett, Kayleigh F.; Barrett, Lynn K.; Bowatte, Kalinga; Choi, Ryan; Chun, Ian; Conrady, Deborah G.; Craig, Justin K.; Dranow, David M.; Hammerson, Bradley; Higgins, Tate; Lorimer, Donald D.; Lukat, Peer; Mayclin, Stephen J.; Hewitt, Stephen Nakazawa; Peng, Ying Po; Shanbhogue, Ashwini; Smutney, Hayden; Stigliano, Matthew Z. Z.; Tillery, Logan M.; Udell, Hannah S.; Wallace, Ellen G.; Derocher, Amy E.; Phan, Isabelle Q.; Staker, Bart L.; Subramanian, Sandhya; Van Voorhis, Wesley C.; Blankenfeldt, Wulf; Mueller, Rolf; Edwards, Thomas E.; Myler, Peter J.
Rational Exploration of 2,4-Diaminopyrimidines as DHFR Inhibitors Active against Mycobacterium abscessus and Mycobacterium avium, Two Emerging Human Pathogens
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-10-290
PRE
Andrade Meirelles, Matheus; Almeida, Vitor M.; Sullivan, Jaryd R.; de Toledo, Ian; dos Reis, Caio Vinicius; Cunha, Micael Rodrigues; Zigweid, Rachel; Shim, Abraham; Sankaran, Banumathi; Woodward, Elijah L.; Seibold, Steve; Liu, Lijun; Mian, Mohammad Rasel; Battaile, Kevin P.; Riley, Jennifer; Duncan, Christina; Simeons, Frederick R. C.; Ferguson, Liam; Joji, Halimatu; Read, Kevin D.; Lovell, Scott; Staker, Bart L.; Behr, Marcel A.; Pilli, Ronaldo A.; Counago, Rafael M.
Enolase inhibitors as therapeutic leads for Naegleria fowleri infection
PLOS PATHOGENS
IF4.9
2024-08-013
OAAI
Milanes, Jillian E.; Yan, Victoria C.; Pham, Cong-Dat; Muller, Florian; Kwain, Samuel; Rees, Kerrick C.; Dominy, Brian N.; Whitehead, Daniel C.; Millward, Steven W.; Bolejack, Madison; Shek, Roger; Tillery, Logan; Phan, Isabelle Q.; Staker, Bart; Moseman, E. Ashley; Zhang, Xiang; Ma, Xipeng; Jebet, Audriy; Yin, Xinmin; Morris, James C.
Structure-Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials (vol 67, pg 3467, 2024)
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-07-100
PRE
Gilleran, John A.; Ashraf, Kutub; Delvillar, Melvin; Eck, Tyler; Fondekar, Raheel; Miller, Edward B.; Hutchinson, Ashley; Dong, Aiping; Seitova, Alma; De Souza, Mariana Laureano; Augeri, David; Halabelian, Levon; Siekierka, John; Rotella, David P.; Gordon, John; Childers, Wayne E.; Grier, Mark C.; Staker, Bart L.; Roberge, Jacques Y.; Bhanot, Purnima
Structure-Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-02-193
PRE
Gilleran, John A.; Ashraf, Kutub; Delvillar, Melvin; Eck, Tyler; Fondekar, Raheel; Miller, Edward B.; Hutchinson, Ashley; Dong, Aiping; Seitova, Alma; De Souza, Mariana Laureano; Augeri, David; Halabelian, Levon; Siekierka, John; Rotella, David P.; Gordon, John; Childers, Wayne E.; Grier, Mark C.; Staker, Bart L.; Roberge, Jacques Y.; Bhanot, Purnima
In silico detection of SARS-CoV-2 specific B-cell epitopes and validation in ELISA for serological diagnosis of COVID-19
SCIENTIFIC REPORTS
IF3.9
2021-02-2218
OAAI
Phan, Isabelle Q.; Subramanian, Sandhya; Kim, David; Murphy, Michael; Pettie, Deleah; Carter, Lauren; Anishchenko, Ivan; Barrett, Lynn K.; Craig, Justin; Tillery, Logan; Shek, Roger; Harrington, Whitney E.; Koelle, David M.; Wald, Anna; Veesler, David; King, Neil; Boonyaratanakornkit, Jim; Isoherranen, Nina; Greninger, Alexander L.; Jerome, Keith R.; Chu, Helen; Staker, Bart; Stewart, Lance; Myler, Peter J.; Van Voorhis, Wesley C.
Identification of Selective Inhibitors of Plasmodium N-Myristoyltransferase by High-Throughput Screening
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2019-12-1818
PREAI
Harupa, Anke; De Las Heras, Laura; Colinenarejo, Gonzalo; Lyons-Abbott, Sally; Reers, Alexandra; Caballero Hernandez, Ivan; Chung, Chun-Wa; Charter, David; Myler, Peter J.; Fernandez-Menendez, Raquel M.; Calderon, Felix; Palomo, Sara; Rodriguez, Beatriz; Berlanga, Manuela; Herreros-Aviles, Esperanza; Staker, Bart L.; Alvaro, Elena Fernandez; Kaushansky, Alexis

研究方向

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P
Peter J. Myler
H 指数:56论文数:391被引数:1.5万
T
Thomas E. Edwards
H 指数:34论文数:256被引数:4,927
L
Lance Stewart
H 指数:56论文数:227被引数:1.4万
I
Isabelle Phan
H 指数:26论文数:85被引数:4,080
J
Jan Abendroth
H 指数:28论文数:163被引数:3,232
W
Wesley C. Van Voorhis
H 指数:72论文数:547被引数:1.8万
M
Michael K. Fenwick
H 指数:21论文数:73被引数:1,113
S
Stephen J. Mayclin
H 指数:9论文数:40被引数:508
B
Banumathi Sankaran
H 指数:52论文数:281被引数:1.0万
K
K.P. Battaile
H 指数:38论文数:355被引数:4,940