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S

Sachel Mok

Columbia University Irving Medical Center
H指数:31
被引数:4,930

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荣誉奖项

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Identification of genetic markers of quinine partial resistance in Plasmodium falciparum

鉴定恶性疟原虫中奎宁部分耐药性的遗传标记

Nature Microbiology
IF19.4
2026-07-060
OAAI
Mariko Kanai; Sachel Mok; Tomas Yeo; Melanie J. Shears; Jin H. Jeon; Sunil K. Narwal; Leila S. Ross; Kharizta Wiradiputri; Meseret T. Haile; Abhai K. Tripathi; Godfree Mlambo; Jonathan Kim; Eva Gil-Iturbe; Heekuk Park; Tolla Ndiaye; John Okombo; Kurt E. Ward; Felix D. Rozenberg; Kate J. Fairhurst; Sydney M. Gavula; Talia S. Bloxham; Jessica L. Bridgford; Tanaya Sheth; Manuel Llinás; Marcus C. S. Lee; Jennifer L. Small-Saunders; Filippo Mancia; Matthias Quick; Anne-Catrin Uhlemann; Photini Sinnis; David Armand Fidock
Structure-Guided Optimization of Novel Inhibitors of Plasmodium Lysyl-tRNA Synthetase with Multistage Activity against Malaria Parasites

基于结构的优化新型恶性疟原虫赖氨酰-tRNA合成酶抑制剂，其对疟疾寄生虫具有多阶段活性

Journal of Medicinal Chemistry
IF6.8
2026-06-020
OA
Barbara Forte; Fiona Bellany; Peter S. Campbell; Giulia Chemi; Alice Dawson; Mark Anderson; Yaw Aniweh; Anna Y. Burkhard; Anna Caroline Campos Aguiar; Alisje Churchyard; Caitlin A. Cooper; Amália dos Santos Ferreira; Mufuliat Toyin Famodimu; Francis G. Fang; Xiao Hu; Tonnie Huijs; Delphine Baud; Chimed Jansen; María Belén Jiménez Díaz; Roger Bonnert; Susan Boyd; Benigno Crespo-Fernández; Branko Mitasev; Simone Montagna; Sachel Mok; Dinakaran Murugesan; Sunil K. Narwal; Neil R. Norcross; John Okombo; Heekuk Park; Caroline Peet; Dhelio B. Pereira; John M. Post; Janette Reader; Jennifer Riley; David A. Robinson; Raku Shinkyo; Frederick R.C. Simeons; Laura Simpson; Alasdair Smith; Dennis Smith; Josefine Striepen; Carolina B.G. Teles; Rianne van der Laak; Anne-Catrin Uhlemann; Amélie Vantaux; Caroline Wilson; Benoît Witkowski; Gavin Wood; Tomas Yeo; Fabio Zuccotto; Iñigo Angulo-Barturen; Jake Baum; Judith M. Bolscher; Rafael Victorio Carvalho Guido; Lyn-Marié Birkholtz; Michael J. Delves; Laurent Dembele; David A. Fidock; Francisco Javier Gamo; Dennis E. Kyle; Steven P. Maher; Jean Popovici; Chris Walpole; Fabian Gusovsky; Paul A. Willis; Kevin D. Read; Ian H. Gilbert; Beatriz Baragaña
Collateral hypersensitivity between ZY19489 and piperaquine neutralizes PfCRT-mediated drug efflux and Plasmodium falciparum resistance

ZY19489与哌喹之间的交叉高敏性中和了PfCRT介导的药物外排和恶性疟原虫抗性

Nature Communications
IF15.7
2026-04-010
OAAI
John Okombo; Tolla Ndiaye; Tarrick Qahash; Igor M. R. Moura; Eva Gil-Iturbe; Laura M. Hagenah; Jessica L. Bridgford; Vinicius Bonatto; Kurt E. Ward; Tomas Yeo; Sunil K. Narwal; Lily V. Orta; Isla Anderson; Satish K. Dhingra; Charisse Flerida A. Pasaje; Heekuk Park; Jonathan Kim; Rafael V. C. Guido; Maria Belén Jiménez-Diaz; Iñigo Angulo-Barturen; Jacquin C. Niles; Filippo Mancia; Anne-Catrin Uhlemann; Sachel Mok; Matthias Quick; Elizabeth A. Winzeler; Didier Leroy; Manuel Llinás; Vandana Thathy; David A. Fidock
Gametocyte production and transmission fitness of African and Asian Plasmodium falciparum isolates with differential susceptibility to artemisinins
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
IF4.5
2025-04-010
OAAI
Proellochs, Nicholas I.; Andolina, Chiara; Ramjith, Jordache; Stoter, Rianne; van Gemert, Geert-Jan; Graumans, Wouter; Campino, Susana; Vanheer, Leen N.; Okitwi, Martin; Tumwebaze, Patrick K.; Conrad, Melissa D.; Clark, Taane G.; Fidock, David A.; Menard, Didier; Mok, Sachel; Bousema, Teun
Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness
SCIENCE ADVANCES
IF12.5
2023-11-105
OAAI
Mok, Sachel; Yeo, Tomas; Hong, Davin; Shears, Melanie J.; Ross, Leila S.; Ward, Kurt E.; Dhingra, Satish K.; Kanai, Mariko; Bridgford, Jessica L.; Tripathi, Abhai K.; Mlambo, Godfree; Burkhard, Anna Y.; Ansbro, Megan R.; Fairhurst, Kate J.; Gil-Iturbe, Eva; Park, Heekuk; Rozenberg, Felix D.; Kim, Jonathan; Mancia, Filippo; Fairhurst, Rick M.; Quick, Matthias; Uhlemann, Anne-Catrin; Sinnis, Photini; Fidock, David A.
Generation of a mutator parasite to drive resistome discovery in Plasmodium falciparum
NATURE COMMUNICATIONS
IF15.7
2023-05-2715
OAAI
Kumpornsin, Krittikorn; Kochakarn, Theerarat; Yeo, Tomas; Okombo, John; Luth, Madeline R.; Hoshizaki, Johanna; Rawat, Mukul; Pearson, Richard D.; Schindler, Kyra A.; Mok, Sachel; Park, Heekuk; Uhlemann, Anne-Catrin; Jana, Gouranga P.; Maity, Bikash C.; Laleu, Benoit; Chenu, Elodie; Duffy, James; Moliner Cubel, Sonia; Franco, Virginia; Gomez-Lorenzo, Maria G.; Gamo, Francisco Javier; Winzeler, Elizabeth A.; Fidock, David A.; Chookajorn, Thanat; Lee, Marcus C. S.
Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation
NATURE COMMUNICATIONS
IF15.7
2023-03-1610
OAAI
Bopp, Selina; Pasaje, Charisse Flerida A.; Summers, Robert L.; Magistrado-Coxen, Pamela; Schindler, Kyra A.; Corpas-Lopez, Victoriano; Yeo, Tomas; Mok, Sachel; Dey, Sumanta; Smick, Sebastian; Nasamu, Armiyaw S.; Demas, Allison R.; Milne, Rachel; Wiedemar, Natalie; Corey, Victoria; Gomez-Lorenzo, Maria De Gracia; Franco, Virginia; Early, Angela M.; Lukens, Amanda K.; Milner, Danny; Furtado, Jeremy; Gamo, Francisco-Javier; Winzeler, Elizabeth A.; Volkman, Sarah K.; Duffey, Maelle; Laleu, Benoit; Fidock, David A.; Wyllie, Susan; Niles, Jacquin C.; Wirth, Dyann F.
Safety, pharmacokinetics, and antimalarial activity of the novel triaminopyrimidine ZY-19489: a first-in-human, randomised, placebo-controlled, double-blind, single ascending dose study, pilot food-effect study, and volunteer infection study
LANCET INFECTIOUS DISEASES
IF31
2022-06-0119
OAAI
Barber, Bridget E.; Fernandez, Melissa; Patel, Hardik Babubhai; Barcelo, Catalina; Woolley, Stephen D.; Patel, Harilal; Llewellyn, Stacey; Abd-Rahman, Azrin N.; Sharma, Sunil; Jain, Mukul; Ghoghari, Ashok; Di Resta, Ilaria; Fuchs, Aline; Deni, Ioanna; Yeo, Tomas; Mok, Sachel; Fidock, David A.; Chalon, Stephan; Moehrle, Joerg J.; Parmar, Deven; McCarthy, James S.; Kansagra, Kevinkumar
The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance
CELL CHEMICAL BIOLOGY
IF7.2
2022-05-0118
OAAI
Murithi, James M.; Deni, Ioanna; Pasaje, Charisse Flerida A.; Okombo, John; Bridgford, Jessica L.; Gnadig, Nina F.; Edwards, Rachel L.; Yeo, Tomas; Mok, Sachel; Burkhard, Anna Y.; Coburn-Flynn, Olivia; Istvan, Eva S.; Sakata-Kato, Tomoyo; Gomez-Lorenzo, Maria G.; Cowell, Annie N.; Wicht, Kathryn J.; Le Manach, Claire; Kalantarov, Gavreel F.; Dey, Sumanta; Duffey, Maelle; Laleu, Benoit; Lukens, Amanda K.; Ottilie, Sabine; Vanaerschot, Manu; Trakht, Ilya N.; Gamo, Francisco-Javier; Wirth, Dyann F.; Goldberg, Daniel E.; John, Audrey R. Odom; Chibale, Kelly; Winzeler, Elizabeth A.; Niles, Jacquin C.; Fidock, David A.
The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance
SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2021-07-2130
OA
Murithi, James M.; Pascal, Cecile; Bath, Jade; Boulenc, Xavier; Gnadig, Nina F.; Pasaje, Charisse Flerida A.; Rubiano, Kelly; Yeo, Tomas; Mok, Sachel; Klieber, Sylvie; Desert, Paul; Jimenez-Diaz, Maria Belen; Marfurt, Jutta; Rouillier, Melanie; Cherkaoui-Rbati, Mohammed H.; Gobeau, Nathalie; Wittlin, Sergio; Uhlemann, Anne-Catrin; Price, Ric N.; Wirjanata, Grennady; Noviyanti, Rintis; Tumwebaze, Patrick; Cooper, Roland A.; Rosenthal, Philip J.; Sanz, Laura M.; Gamo, Francisco Javier; Joseph, Jayan; Singh, Shivendra; Bashyam, Sridevi; Augereau, Jean Michel; Giraud, Elie; Bozec, Tanguy; Vermat, Thierry; Tuffal, Gilles; Guillon, Jean-Michel; Menegotto, Jerome; Salle, Laurent; Louit, Guillaume; Cabanis, Marie-Jose; Nicolas, Marie Francoise; Doubovetzky, Michel; Merino, Rita; Bessila, Nadir; Angulo-Barturen, Inigo; Baud, Delphine; Bebrevska, Lidiya; Escudie, Fanny; Niles, Jacquin C.; Blasco, Benjamin; Campbell, Simon; Courtemanche, Gilles; Fraisse, Laurent; Pellet, Alain; Fidock, David A.; Leroy, Didier
Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness
ELIFE
IF0
2021-07-1997
OA
Stokes, Barbara H.; Dhingra, Satish K.; Rubiano, Kelly; Mok, Sachel; Straimer, Judith; Gnadig, Nina F.; Deni, Ioanna; Schindler, Kyra A.; Bath, Jade R.; Ward, Kurt E.; Striepen, Josefine; Yeo, Tomas; Ross, Leila S.; Legrand, Eric; Ariey, Frederic; Cunningham, Clark H.; Souleymane, Issa M.; Gansane, Adama; Nzoumbou-Boko, Romaric; Ndayikunda, Claudette; Kabanywanyi, Abdunoor M.; Uwimana, Aline; Smith, Samuel J.; Kolley, Olimatou; Ndounga, Mathieu; Warsame, Marian; Leang, Rithea; Nosten, Francois; Anderson, Timothy J. C.; Rosenthal, Philip J.; Menard, Didier; Fidock, David A.
Repositioning and Characterization of 1-(Pyridin-4-yl)pyrrolidin-2-one Derivatives as Plasmodium Cytoplasmic Prolyl-tRNA Synthetase Inhibitors
ACS INFECTIOUS DISEASES
IF3.8
2021-04-3018
OAAI
Okaniwa, Masanori; Shibata, Akira; Ochida, Atsuko; Akao, Yuichiro; White, Karen L.; Shackleford, David M.; Duffy, Sandra; Lucantoni, Leonardo; Dey, Sumanta; Striepen, Josefine; Yeo, Tomas; Mok, Sachel; Aguiar, Anna Caroline C.; Sturm, Angelika; Crespo, Benigno; Sanz, Laura M.; Churchyard, Alisje; Baum, Jake; Pereira, Dhelio B.; Guido, Rafael V. C.; Dechering, Koen J.; Wittlin, Sergio; Uhlemann, Anne-Catrin; Fidock, David A.; Niles, Jacquin C.; Avery, Vicky M.; Charman, Susan A.; Laleu, Benoit
Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2021-04-2028
OAAI
Palmer, Michael J.; Deng, Xiaoyi; Watts, Shawn; Krilov, Goran; Gerasyuto, Aleksey; Kokkonda, Sreekanth; El Mazouni, Farah; White, John; White, Karen L.; Striepen, Josefine; Bath, Jade; Schindler, Kyra A.; Yeo, Tomas; Shackleford, David M.; Mok, Sachel; Deni, Ioanna; Lawong, Aloysus; Huang, Ann; Chen, Gong; Wang, Wen; Jayaseelan, Jaya; Katneni, Kasiram; Patil, Rahul; Saunders, Jessica; Shahi, Shatrughan P.; Chittimalla, Rajesh; Angulo-Barturen, Inigo; Jimenez-Diaz, Maria Belen; Wittlin, Sergio; Tumwebaze, Patrick K.; Rosenthal, Philip J.; Cooper, Roland A.; Aguiar, Anna Caroline Campos; Guido, Rafael V. C.; Pereira, Dhelio B.; Mittal, Nimisha; Winzeler, Elizabeth A.; Tomchick, Diana R.; Laleu, Benoit; Burrows, Jeremy N.; Rathod, Pradipsinh K.; Fidock, David A.; Charman, Susan A.; Phillips, Margaret A.
Novel Antimalarial Tetrazoles and Amides Active against the Hemoglobin Degradation Pathway in Plasmodium falciparum
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2021-02-2315
OA
Lawong, Aloysus; Gahalawat, Suraksha; Okombo, John; Striepen, Josefine; Yeo, Tomas; Mok, Sachel; Deni, Ioanna; Bridgford, Jessica L.; Niederstrasser, Hanspeter; Zhou, Anwu; Posner, Bruce; Wittlin, Sergio; Javier Gamo, Francisco; Crespo, Benigno; Churchyard, Alisje; Baum, Jake; Mittal, Nimisha; Winzeler, Elizabeth; Laleu, Benoit; Palmer, Michael J.; Charman, Susan A.; Fidock, David A.; Ready, Joseph M.; Phillips, Margaret A.

研究方向

暂未获取到该数据
D
David A. Fidock
H 指数:95论文数:427被引数:3.3万
T
Tomas Yeo
H 指数:23论文数:77被引数:2,110
Z
Zbynek Bozdech
H 指数:0论文数:2被引数:16
E
Elizabeth A. Winzeler
H 指数:83论文数:356被引数:3.6万
A
Anne‐Catrin Uhlemann
H 指数:62论文数:310被引数:1.3万
J
John Okombo
H 指数:24论文数:81被引数:1,728
P
Peter R. Preiser
H 指数:51论文数:280被引数:9,310
K
Kathryn J. Wicht
H 指数:21论文数:59被引数:1,878
F
François Nosten
H 指数:131论文数:1,094被引数:6.8万
B
Benoı̂t Laleu
H 指数:28论文数:101被引数:2,935