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B

Benoı̂t Laleu

monash university
H指数:28
被引数:2,939

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Inhibition of prolyl-tRNA synthetase and efflux pumps as a dual-targeting strategy against multidrug-resistant bacteria

抑制脯氨酰-tRNA合成酶和外排泵作为对抗多药耐药细菌的双靶点策略

Journal of Enzyme Inhibition and Medicinal Chemistry
IF5.4
2026-05-230
OA
Tambascia, Cristiane; Silva, Jaqueline Cristina; dos Reis, Barbara Carvalho; Camilo, Camila Fernanda Silva; Tairum Junior, Carlos Abrunhosa; Hancio, Thais; Correia, Valquiria Graia; Pilli, Ronaldo Aloise; de Godoy, Andre Schutzer; Laleu, Benoit; Sforca, Mauricio Luis; Rocco, Silvana Aparecida; Benedetti, Celso Eduardo; Mercaldi, Gustavo Fernando
Optimization of Species-Selective Reversible Proteasome Inhibitors for the Treatment of Malaria
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2025-10-010
PRE
Gahalawat, Suraksha; Ray, Sneha; Zhang, Xiaoyu; Deng, Xiaoyi; Han, Yan; Chen, Zhe; Lawong, Aloysus; Shackleford, David M.; Katneni, Kasiram; Chen, Gong; Li, Peng; Ng, Alice; Zhong, Longjin; Hu, Meiyu; Mcinerney, Mitchell; Wang, Wen; Saunders, Jessica; Collins, Daniel; Jayaseelan, Jaya; Noack, Cassandra L.; Maity, Bikash; De, Nirupam; Laleu, Benoit; Campbell, Simon F.; Phillips, Margaret A.; Charman, Susan A.; Ready, Joseph M.
Antimicrobial potential of compounds from the MMV pandemic response box and COVID box against carbapenem-resistant Acinetobacter baumannii

来自MMV大流行应对盒和COVID盒的化合物的抗微生物潜力，对耐碳青霉烯鲍曼不动杆菌的作用

Brazilian Journal of Microbiology
IF1.9
2025-10-010
PRE
Melo, Andressa Leite Ferraz; Melo, Rita de Cassia Cerqueira; Martins, Aline Andrade; Sturaro, Mariana Carvalho; Arantes, Julia Pimentel; Vicente, Jean Carlos Pael; Laleu, Benoit; Besson, Dominique; Rossato, Luana; de Souza, Gleyce Hellen de Almeida; Simionatto, Simone
Identification of α-Azacyclic Acetamide-Based Inhibitors of P. falciparum Na+ Pump (PfATP4) with Fast-Killing Asexual Blood-Stage Antimalarial Activity by Phenotypic Screening

通过表型筛选鉴定具有快速杀灭无性血期抗疟活性的α-氮杂环乙酰胺基类P. falciparum Na+泵(PfATP4)抑制剂

ACS INFECTIOUS DISEASES
IF3.8
2025-09-010
PRE
Casas Jr, Arturo; Imlay, Leah S.; Thathy, Vandana; Fairhurst, Kate J.; Lehane, Adele M.; Lawong, Aloysus K.; Deni, Ioanna; Striepen, Josefine; Lee, Seungheon; Kumar, Ashwani; Xing, Chao; Niederstrasser, Hanspeter; Posner, Bruce A.; Laleu, Benoit; Charman, Susan A.; Fidock, David A.; Ready, Joseph M.; Phillips, Margaret A.
In vitro screening of the open-access Pandemic Response Box reveals ESI-09 as a compound with activity against Echinococcus multilocularis

体外筛选公开获取的Pandemic Response Box显示ESI-09是一种对Echinococcus multilocularis具有活性的化合物

international journal for parasitology drugs and drug resistance
IF0
2025-08-230
OAAI
Pascal Zumstein; Anissa Bartetzko; Marc Kaethner; Laura Vetter; Andrew Hemphill; Trix Zumkehr; Benoît Laleu; Matías Preza; Britta Lundström-Stadelmann
Structure-Based Discovery and Development of Highly Potent Dihydroorotate Dehydrogenase Inhibitors for Malaria Chemoprevention
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-12-230
PRE
Nie, Zhe; Bonnert, Roger; Tsien, Jet; Deng, Xiaoyi; Higgs, Christopher; El Mazouni, Farah; Zhang, Xiaoyu; Li, Renzhe; Ho, Nhi; Feher, Victoria; Paulsen, Janet; Shackleford, David M.; Katneni, Kasiram; Chen, Gong; Ng, Alice C. F.; Mcinerney, Mitchell; Wang, Wen; Saunders, Jessica; Collins, Daniel; Yan, Dandan; Li, Peng; Campbell, Michael; Patil, Rahul; Ghoshal, Atanu; Mondal, Pallab; Kundu, Abhijit; Chittimalla, Rajesh; Mahadeva, Muralikumar; Kokkonda, Sreekanth; White, John; Das, Rishi; Mukherjee, Partha; Angulo-Barturen, Inigo; Belen Jimenez-Diaz, Maria; Malmstrom, Robert; Lawrenz, Morgan; Rodriguez-Granillo, Agustina; Rathod, Pradipsinh K.; Tomchick, Diana R.; Palmer, Michael J.; Laleu, Benoit; Qin, Tian; Charman, Susan A.; Phillips, Margaret A.
Optimization of pyrazolopyridine 4-carboxamides with potent antimalarial activity for which resistance is associated with the P. falciparum transporter ABCI3

具有有效抗疟活性的吡唑并吡啶4-甲酰胺的优化，其抗性与恶性疟原虫转运蛋白ABCI3相关

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2024-10-013
OAAI
Calic, Petar P. S.; Ashton, Trent D.; Mansouri, Mahta; Loi, Katie; Jarman, Kate E.; Qiu, Deyun; Lehane, Adele M.; Roy, Sayantan; Rao, Gunturu P.; Maity, Bikash; Wittlin, Sergio; Crespo, Benigno; Gamo, Franciso-Javier; Deni, Ioanna; Fidock, David A.; Chowdury, Mrittika; de Koning-Ward, Tania F.; Cowman, Alan F.; Jackson, Paul F.; Baud, Delphine; Brand, Stephen; Laleu, Benoit; Sleebs, Brad E.
Identification of potent and reversible piperidine carboxamides that are species-selective orally active proteasome inhibitors to treat malaria
CELL CHEMICAL BIOLOGY
IF7.2
2024-08-012
PRE
Lawong, Aloysus; Gahalawat, Suraksha; Ray, Sneha; Ho, Nhi; Han, Yan; Ward, Kurt E.; Deng, Xiaoyi; Chen, Zhe; Kumar, Ashwani; Xing, Chao; Hosangadi, Varun; Fairhurst, Kate J.; Tashiro, Kyuto; Liszczak, Glen; Shackleford, David M.; Katneni, Kasiram; Chen, Gong; Saunders, Jessica; Crighton, Elly; Casas, Arturo; Robinson, Joshua J.; Imlay, Leah S.; Zhang, Xiaoyu; Lemoff, Andrew; Zhao, Zhiyu; Angulo-Barturen, Inigo; Jimenez-Diaz, Maria Belen; Wittlin, Sergio; Campbell, Simon F.; Fidock, David A.; Laleu, Benoit; Charman, Susan A.; Ready, Joseph M.; Phillips, Margaret A.
Generation of a mutator parasite to drive resistome discovery in Plasmodium falciparum
NATURE COMMUNICATIONS
IF15.7
2023-05-2715
OAAI
Kumpornsin, Krittikorn; Kochakarn, Theerarat; Yeo, Tomas; Okombo, John; Luth, Madeline R.; Hoshizaki, Johanna; Rawat, Mukul; Pearson, Richard D.; Schindler, Kyra A.; Mok, Sachel; Park, Heekuk; Uhlemann, Anne-Catrin; Jana, Gouranga P.; Maity, Bikash C.; Laleu, Benoit; Chenu, Elodie; Duffy, James; Moliner Cubel, Sonia; Franco, Virginia; Gomez-Lorenzo, Maria G.; Gamo, Francisco Javier; Winzeler, Elizabeth A.; Fidock, David A.; Chookajorn, Thanat; Lee, Marcus C. S.
Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation
NATURE COMMUNICATIONS
IF15.7
2023-03-1610
OAAI
Bopp, Selina; Pasaje, Charisse Flerida A.; Summers, Robert L.; Magistrado-Coxen, Pamela; Schindler, Kyra A.; Corpas-Lopez, Victoriano; Yeo, Tomas; Mok, Sachel; Dey, Sumanta; Smick, Sebastian; Nasamu, Armiyaw S.; Demas, Allison R.; Milne, Rachel; Wiedemar, Natalie; Corey, Victoria; Gomez-Lorenzo, Maria De Gracia; Franco, Virginia; Early, Angela M.; Lukens, Amanda K.; Milner, Danny; Furtado, Jeremy; Gamo, Francisco-Javier; Winzeler, Elizabeth A.; Volkman, Sarah K.; Duffey, Maelle; Laleu, Benoit; Fidock, David A.; Wyllie, Susan; Niles, Jacquin C.; Wirth, Dyann F.
Fast-Killing Tyrosine Amide ((S)-SW228703) with Blood- and Liver-Stage Antimalarial Activity Associated with the Cyclic Amine Resistance Locus (Pf CARL)
ACS INFECTIOUS DISEASES
IF3.8
2023-02-104
OA
Imlay, Leah S.; Lawong, Aloysus K.; Gahalawat, Suraksha; Kumar, Ashwani; Xing, Chao; Mittal, Nimisha; Wittlin, Sergio; Churchyard, Alisje; Niederstrasser, Hanspeter; Crespo-Fernandez, Benigno; Posner, Bruce A.; Gamo, Francisco-Javier; Baum, Jake; Winzeler, Elizabeth A.; Laleu, Benoit; Ready, Joseph M.; Phillips, Margaret A.
Exploring a Tetrahydroquinoline Antimalarial Hit from the Medicines for Malaria Pathogen Box and Identification of its Mode of Resistance as PfeEF2
CHEMMEDCHEM
IF3.4
2022-10-137
OAAI
Laleu, Benoit; Rubiano, Kelly; Yeo, Tomas; Hallyburton, Irene; Anderson, Mark; Crespo-Fernandez, Benigno; Gamo, Francisco-Javier; Antonova-Koch, Yevgeniya; Orjuela-Sanchez, Pamela; Wittlin, Sergio; Jana, Gouranga P.; Maity, Bikash C.; Chenu, Elodie; Duffy, James; Sjo, Peter; Waterson, David; Winzeler, Elizabeth; Guantai, Eric; Fidock, David A.; Hansson, Thomas G.

研究方向

暂未获取到该数据
D
David A. Fidock
H 指数:95论文数:427被引数:3.3万
E
Elizabeth A. Winzeler
H 指数:83论文数:356被引数:3.6万
J
Jeremy N. Burrows
H 指数:46论文数:187被引数:9,650
S
Sergio Wittlin
H 指数:49论文数:250被引数:8,887
S
Susan A. Charman
H 指数:62论文数:280被引数:1.5万
F
Francisco‐Javier Gamo
H 指数:40论文数:153被引数:7,829
M
Margaret A. Phillips
H 指数:54论文数:229被引数:1.0万
T
Tomas Yeo
H 指数:23论文数:77被引数:2,120
S
Sachel Mok
H 指数:31论文数:73被引数:4,948
J
Jérôme Lacour
H 指数:53论文数:620被引数:1.0万