未登录 Generation of precision preclinical cancer models using regulated in vivo base editing Katti, Alyna; Vega-Perez, Adrian; Foronda, Miguel; Zimmerman, Jill; Zafra, Maria Paz; Granowsky, Elizabeth; Goswami, Sukanya; Gardner, Eric E.; Diaz, Bianca J.; Simon, Janelle M.; Wuest, Alexandra; Luan, Wei; Fernandez, Maria Teresa Calvo; Kadina, Anastasia P.; Walker II, John A.; Holden, Kevin; Lowe, Scott W.; Sanchez Rivera, Francisco J.; Dow, Lukas E. 分享 收藏
分享 收藏
Drag-and-drop genome insertion of large sequences without double-strand DNA cleavage using CRISPR-directed integrases 使用CRISPR指导的整合酶在没有双链DNA切割的情况下拖放大序列的基因组插入 Yarnall, Matthew T. N.; Ioannidi, Eleonora I.; Schmitt-Ulms, Cian; Krajeski, Rohan N.; Lim, Justin; Villiger, Lukas; Zhou, Wenyuan; Jiang, Kaiyi; Garushyants, Sofya K.; Roberts, Nathaniel; Zhang, Liyang; Vakulskas, Christopher A.; Walker, John A. I. I. I. I.; Kadina, Anastasia P.; Zepeda, Adrianna E.; Holden, Kevin; Ma, Hong; Xie, Jun; Gao, Guangping; Foquet, Lander; Bial, Greg; Donnelly, Sara K.; Miyata, Yoshinari; Radiloff, Daniel R.; Henderson, Jordana M.; Ujita, Andrew; Abudayyeh, Omar O.; Gootenberg, Jonathan S. 分享 收藏
Viral E protein neutralizes BET protein-mediated post-entry antagonism of SARS-CoV-2 Chen, Irene P.; Longbotham, James E.; McMahon, Sarah; Suryawanshi, Rahul K.; Khalid, Mir M.; Taha, Taha Y.; Tabata, Takako; Hayashi, Jennifer M.; Soveg, Frank W.; Carlson-Stevermer, Jared; Gupta, Meghna; Zhang, Meng Yao; Lam, Victor L.; Li, Yang; Yu, Zanlin; Titus, Erron W.; Diallo, Amy; Oki, Jennifer; Holden, Kevin; Krogan, Nevan; Fujimori, Danica Galonie; Ott, Melanie 分享 收藏
Broad-spectrum CRISPR-mediated inhibition of SARS-CoV-2 variants and endemic coronaviruses in vitro 广谱CRISPR介导的体外SARS-CoV-2变体和地方性冠状病毒的抑制 Zeng, Leiping; Liu, Yanxia; Nguyenla, Xammy Huu; Abbott, Timothy R.; Han, Mengting; Zhu, Yanyu; Chemparathy, Augustine; Lin, Xueqiu; Chen, Xinyi; Wang, Haifeng; Rane, Draven A.; Spatz, Jordan M.; Jain, Saket; Rustagi, Arjun; Pinsky, Benjamin; Zepeda, Adrianna E.; Kadina, Anastasia P.; Walker, John A., III; Holden, Kevin; Temperton, Nigel; Cochran, Jennifer R.; Barron, Annelise E.; Connolly, Michael D.; Blish, Catherine A.; Lewis, David B.; Stanley, Sarah A.; La Russa, Marie F.; Qi, Lei S. 分享 收藏
Identification of DAXX as a restriction factor of SARS-CoV-2 through a CRISPR/Cas9 screen Mac Kain, Alice; Maarifi, Ghizlane; Aicher, Sophie-Marie; Arhel, Nathalie; Baidaliuk, Artem; Munier, Sandie; Donati, Flora; Vallet, Thomas; Quang Dinh Tran; Hardy, Alexandra; Chazal, Maxime; Porrot, Francoise; OhAinle, Molly; Carlson-Stevermer, Jared; Oki, Jennifer; Holden, Kevin; Zimmer, Gert; Simon-Loriere, Etienne; Bruel, Timothee; Schwartz, Olivier; van der Werf, Sylvie; Jouvenet, Nolwenn; Nisole, Sebastien; Vignuzzi, Marco; Roesch, Ferdinand 分享 收藏
分享 收藏
Inference of CRISPR Edits from Sanger Trace Data 从Sanger Trace数据推断CRISPR编辑 Conant, David; Hsiau, Tim; Rossi, Nicholas; Oki, Jennifer; Maures, Travis; Waite, Kelsey; Yang, Joyce; Joshi, Sahil; Kelso, Reed; Holden, Kevin; Enzmann, Brittany L.; Stoner, Rich 分享 收藏
BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2 Samelson, Avi J.; Quang Dinh Tran; Robinot, Remy; Carrau, Lucia; Rezelj, Veronica V.; Mac Kain, Alice; Chen, Merissa; Ramadoss, Gokul N.; Guo, Xiaoyan; Lim, Shion A.; Lui, Irene; Nunez, James K.; Rockwood, Sarah J.; Wang, Jianhui; Liu, Na; Carlson-Stevermer, Jared; Oki, Jennifer; Maures, Travis; Holden, Kevin; Weissman, Jonathan S.; Wells, James A.; Conklin, Bruce R.; TenOever, Benjamin R.; Chakrabarti, Lisa A.; Vignuzzi, Marco; Tian, Ruilin; Kampmann, Martin 分享 收藏
分享 收藏
In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels 猕猴体内PCSK9的腺嘌呤碱基编辑可降低LDL胆固醇水平 Rothgangl, Tanja; Dennis, Melissa K.; Lin, Paulo J. C.; Oka, Rurika; Witzigmann, Dominik; Villiger, Lukas; Qi, Weihong; Hruzova, Martina; Kissling, Lucas; Lenggenhager, Daniela; Borrelli, Costanza; Egli, Sabina; Frey, Nina; Bakker, Noelle; Walker, John A., II; Kadina, Anastasia P.; Victorov, Denis V.; Pacesa, Martin; Kreutzer, Susanne; Kontarakis, Zacharias; Moor, Andreas; Jinek, Martin; Weissman, Drew; Stoffel, Markus; van Boxtel, Ruben; Holden, Kevin; Pardi, Norbert; Thoeny, Beat; Haeberle, Johannes; Tam, Ying K.; Semple, Sean C.; Schwank, Gerald 分享 收藏
Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression 小鼠中的Prime编辑揭示了单个碱基在驱动组织特异性基因表达中的重要性 Gao, Pan; Lyu, Qing; Ghanam, Amr R.; Lazzarotto, Cicera R.; Newby, Gregory A.; Zhang, Wei; Choi, Mihyun; Slivano, Orazio J.; Holden, Kevin; Walker, John A., II; Kadina, Anastasia P.; Munroe, Rob J.; Abratte, Christian M.; Schimenti, John C.; Liu, David R.; Tsai, Shengdar Q.; Long, Xiaochun; Miano, Joseph M. 分享 收藏
.png){kind=icon}
未登录.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
