Werner Siegmund - Publications, H-index & Citations

Werner Siegmund

university medicine greifswald

48H指数

256论文数

7.9K被引数

收录论文 68

发表时间

Impact of Efavirenz on Heme Protein Induction and Biomarkers: Insights From In Vitro Experiments and a Clinical Study 依非韦伦对血红素蛋白诱导和生物标志物的影响：体外实验和临床研究的见解

Clinical and Translational Science

IF2.8

2026-03-13

OAAI

Leila Potzel; Jonny Kinzi; Isabell Seibert; Markus Grube; Werner Siegmund; Henriette E. Meyer zu Schwabedissen

Increased coproporphyrin serum levels in healthy volunteers treated with the cholesterol uptake inhibitor ezetimibe

CTS-CLINICAL AND TRANSLATIONAL SCIENCE

IF2.8

2024-10-09

OAAI

Kinzi, Jonny; Grube, Markus; Seibert, Isabell; Siegmund, Werner; Zu Schwabedissen, Henriette E. Meyer

Phenotype-Genotype Correlation Applying a Cocktail Approach and an Exome Chip Analysis Reveals Further Variants Contributing to Variation of Drug Metabolism

CLINICAL PHARMACOLOGY & THERAPEUTICS

IF5.5

2024-04-18

OAAI

Boehm, Ruwen; Bruckmueller, Henrike; Oswald, Stefan; Huebenthal, Matthias; Kaehler, Meike; Ehmke, Lena; Hoecker, Jan; Siegmund, Werner; Franke, Andre; Cascorbi, Ingolf

Various effects of repeated rifampin dosing on coproporphyrin levels in humans

CTS-CLINICAL AND TRANSLATIONAL SCIENCE

IF2.8

2023-09-19

OAAI

Kinzi, Jonny; Grube, Markus; Brecht, Karin; Seibert, Isabell; Siegmund, Werner; Schwabedissen, Henriette E. Meyer Zu

Dependence of Bioavailability on Mean Absorption Time: What Does It Tell Us?

AAPS JOURNAL

IF3.7

2023-04-04

PREAI

Weiss, Michael; Siegmund, Werner

Analysis of Complex Absorption After Multiple Dosing: Application to the Interaction Between the P-glycoprotein Substrate Talinolol and Rifampicin

PHARMACEUTICAL RESEARCH

IF4.3

2022-09-26

OAAI

Weiss, Michael; D'Argenio, David Z.; Siegmund, Werner

Chiral Pharmacokinetics and Metabolite Profile of Prolonged-release Ketamine Tablets in Healthy Human Subjects

ANESTHESIOLOGY

IF9.1

2021-05-21

OAAI

Hasan, Mahmoud; Modess, Christiane; Roustom, Tarek; Dokter, Anne; Grube, Markus; Link, Andreas; Rey, Helene; Adler, Stefanie; Meissner, Konrad; Siegmund, Werner

Design and Optimization of a Novel Strategy for the Local Treatment of Helicobacter pylori Infections

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2021-03-01

PREAI

Ambay, Taddese Mekonnen; Schick, Philipp; Grimm, Michael; Sager, Maximilian; Schneider, Felix; Koziolek, Mirko; Siegmund, Werner; Schindele, Franziska; Haas, Rainer; Weitschies, Werner

Genetic variants of SLCO1B7 are of relevance for the transport function of OATP1B3-1B7

PHARMACOLOGICAL RESEARCH

IF10.5

2020-11-01

PREAI

zu Schwabedissen, Henriette E. Meyer; Seibert, Isabell; Grube, Markus; Alter, Claudio L.; Siegmund, Werner; Hussner, Janine

Simultaneous quantification of acidic and basic flupirtine metabolites by supercritical fluid chromatography according to European Medicines Agency validation 根据欧洲药品管理局的验证，通过超临界流体色谱法同时定量酸性和碱性氟吡汀代谢物

JOURNAL OF CHROMATOGRAPHY A

IF4

2019-10-01

PREAI

Hofstetter, Robert K.; Hasan, Mahmoud; Fassauer, Georg M.; Bock, Christian; Surur, Abdrrahman S.; Behnisch, Steven; Grathwol, Christoph W.; Potlitz, Felix; Oergel, Tobias; Siegmund, Werner; Link, Andreas

Preventable ADRs leading to hospitalization - results of a long-term prospective safety study with 6,427 ADR cases focusing on elderly patients

EXPERT OPINION ON DRUG SAFETY

IF3.1

2017-12-19

PREAI

Schmiedl, S.; Rottenkolber, M.; Szymanski, J.; Drewelow, B.; Siegmund, W.; Hippius, M.; Farker, K.; Guenther, I. R.; Hasford, J.; Thuermann, P. A.

Ketamine metabolites with antidepressant effects: Fast, economical, and eco-friendly enantioselective separation based on supercritical-fluid chromatography (SFC) and single quadrupole MS detection

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

IF3.1

2017-11-01

PREAI

Fassauer, Georg M.; Hofstetter, Robert; Hasan, Mahmoud; Oswald, Stefan; Modess, Christina; Siegmund, Werner; Link, Andreas

Quantitative chiral and achiral determination of ketamine and its metabolites by LC-MS/MS in human serum, urine and fecal samples

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

IF3.1

2017-05-01

PREAI

Hasan, Mahmoud; Hofstetter, Robert; Fassauer, Georg M.; Link, Andreas; Siegmund, Werner; Oswald, Stefan

Trospium chloride is absorbed from two intestinal absorption windows with different permeability in healthy subjects

INTERNATIONAL JOURNAL OF PHARMACEUTICS

IF5.2

2016-12-01

PREAI

Tadken, Tobias; Weiss, Michael; Modess, Christiane; Wegner, Danilo; Roustom, Tarek; Neumeister, Claudia; Schwantes, Ulrich; Schulz, Hans-Ulrich; Weitschies, Werner; Siegmund, Werner

Navigating the human gastrointestinal tract for oral drug delivery: Uncharted waters and new frontiers

ADVANCED DRUG DELIVERY REVIEWS

IF17.6

2016-06-01

142

PREAI

Koziolek, Mirko; Grimm, Michael; Schneider, Felix; Jedamzik, Philipp; Sager, Maximilian; Kuehn, Jens-Peter; Siegmund, Werner; Weitschies, Werner

Pharmacokinetics and pharmacodynamics of ch14.18/CHO in relapsed/refractory high-risk neuroblastoma patients treated by long-term infusion in combination with IL-2

MABS

IF7.3

2016-01-19

OAAI

Siebert, Nikolai; Eger, Christin; Seidel, Diana; Juettner, Madlen; Zumpe, Maxi; Wegner, Danilo; Kietz, Silke; Ehlert, Karoline; Veal, Gareth J.; Siegmund, Werner; Weiss, Michael; Loibner, Hans; Ladenstein, Ruth; Lode, Holger N.

Expression of drug metabolizing enzymes along the human gastrointestinal tract

PHARMACOLOGICAL REPORTS

IF3.8

2015-09-01

PREAI

Drozdzik, Marek; Peters, Jette; Lapczuk, Joanna; Ostrowski, Marek; Haenisch, Sierk; Siegmund, Werner; Oswald, Stefan

Expression of drug transporters along the human gastrointestinal tract

PHARMACOLOGICAL REPORTS

IF3.8

2015-09-01

PREAI

Lapczuk, Joanna; Peters, Jette; Ostrowski, Marek; Siegmund, Werner; Oswald, Stefan; Drozdzik, Marek