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Aijun Shen

lingang laboratory

H指数:24

被引数:1,977

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Design, Synthesis, and Anti-inflammatory Activity Evaluation for Hydrazide-Based HDAC6 Targeted Protein Degraders

基于酰肼的HDAC6靶向蛋白质降解剂的设计、合成及抗炎活性评价

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2025-11-010

PRE

An mRNA Vaccine for Herpes Zoster and Its Efficacy Evaluation in Naïve/Primed Murine Models

带状疱疹mRNA疫苗及其在初免/加强免疫小鼠模型中的疗效评价

IF3.4

2025-03-190

OA

Discovery, SAR Study of GST Inhibitors from a Novel Quinazolin-4(1H)-one Focused DNA-Encoded Library

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2023-08-085

PRE

Discovery of (S)-N-(2-Amino-4-fluorophenyl)-4-(1-(3-(4-((dimethylamino)methyl)phenyl)-6-oxopyridazin-1(6H)-yl)ethyl)benzamide as Potent Class I Selective HDAC Inhibitor for Oral Anticancer Drug Candidate

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2023-05-158

PRE

Adjusted degradation of BRD4 S and BRD4 L based on fine structural modifications of the pyrrolopyridone scaffold

基于吡咯并吡啶酮支架的精细结构修饰，调整了BRD4 S和BRD4 L的降解

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2022-06-0110

PRE

Single-cell lipidomics with high structural specificity by mass spectrometry

NATURE COMMUNICATIONS

IF15.7

2021-05-17114

OAAI

Discovery of selective HDAC/BRD4 dual inhibitors as epigenetic probes

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2021-01-0142

PREAI

Tumor cells suppress radiation-induced immunity by hijacking caspase 9 signaling (vol 21, pg 546, 2020)

NATURE IMMUNOLOGY

IF27.6

2020-09-161

OAAI

Targeting tumors with IL-21 reshapes the tumor microenvironment by proliferating PD-1intTim-3-CD8+ T cells

IF6.1

2020-04-0944

OA

Tumor cells suppress radiation-induced immunity by hijacking caspase 9 signaling

肿瘤细胞通过劫持caspase 9信号抑制辐射诱导的免疫

NATURE IMMUNOLOGY

IF27.6

2020-03-30100

PREAI

Targeting Hsp90 with FS-108 circumvents gefitinib resistance in EGFR mutant non-small cell lung cancer cells (vol 37, pg 1587, 2020)

ACTA PHARMACOLOGICA SINICA

IF8.4

2020-02-213

OAAI

A novel long non-coding RNA-ARA: Adriamycin resistance-associated (vol 87, pg 254, 2014)

BIOCHEMICAL PHARMACOLOGY

IF5.6

2020-02-010

PREAI

Hypofractionated EGFR tyrosine kinase inhibitor limits tumor relapse through triggering innate and adaptive immunity

SCIENCE IMMUNOLOGY

IF16.3

2019-08-0229

PREAI

NQO1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance

NATURE COMMUNICATIONS

IF15.7

2019-07-1964

OAAI

Notch 1/2/3 mutation as a potential biomarker for immunotherapy in smokers with non-small cell lung cancer via increasing tumor mutational burden

CANCER RESEARCH

IF16.6

2019-07-010

PRE

The Secretome Engages STAT3 to Favor a Cytokine-rich Microenvironment in Mediating Acquired Resistance to FGFR Inhibitors

MOLECULAR CANCER THERAPEUTICS

IF5.5

2019-03-0111

OAAI

EGFR tyrosine kinase inhibitor limits tumor relapse through enhancing anti-tumor T cell responses

CANCER RESEARCH

IF16.6

2018-07-010

PRE

Design, synthesis and pharmacological evaluation of ALK and Hsp90 dual inhibitors bearing resorcinol and 2,4-diaminopyrimidine motifs

带有间苯二酚和2，4-二氨基嘧啶基序的ALK和Hsp90双重抑制剂的设计，合成和药理评价

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2018-05-0129

PREAI

Identification and Therapeutic Intervention of Coactivated Anaplastic Lymphoma Kinase, Fibroblast Growth Factor Receptor 2, and Ephrin Type-A Receptor 5 Kinases in Hepatocellular Carcinoma

IF15.8

2018-03-2415

OAAI

A tightly controlled Src-YAP signaling axis determines therapeutic response to dasatinib in renal cell carcinoma

IF13.3

2018-01-0138

OAAI